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Probenecid and Colchicine (Probenecid and Colchicine) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - December 25, 2016 Category: Drugs & Pharmacology Source Type: news

IL-1 Blocking Agent Succeeds in Resistant FMF (CME/CE)
(MedPage Today) -- First randomized trial among colchicine-resistant patients (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - November 28, 2016 Category: Primary Care Source Type: news

COLCHICINE Tablet [Amneal Pharmaceuticals Of New York, LLC]
Updated Date: Sep 30, 2016 EST (Source: DailyMed Drug Label Updates)
Source: DailyMed Drug Label Updates - September 30, 2016 Category: Drugs & Pharmacology Source Type: news

PROBENECID AND COLCHICINE Tablet [Ingenus Pharmaceuticals NJ, LLC]
Updated Date: Sep 14, 2016 EST (Source: DailyMed Drug Label Updates)
Source: DailyMed Drug Label Updates - September 14, 2016 Category: Drugs & Pharmacology Source Type: news

Colchicine (Colchicine) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - August 31, 2016 Category: Drugs & Pharmacology Source Type: news

Pyridine based antitumor compounds acting at the colchicine site
(Bentham Science Publishers) Tubulin inhibitors are among the most successful anti-cancer, anti-parasitic and herbicidal agents. Lessons from the achievements and failures have been extracted and future perspectives delineated. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - June 30, 2016 Category: Biology Source Type: news

colchicine, Colcrys
Title: colchicine, ColcrysCategory: MedicationsCreated: 12/31/1997 12:00:00 AMLast Editorial Review: 6/29/2016 12:00:00 AM (Source: MedicineNet Arthritis General)
Source: MedicineNet Arthritis General - June 29, 2016 Category: Rheumatology Source Type: news

Case report: a rare case of attempted homicide with Gloriosa superba seeds - Kande Vidanalage CJ, Ekanayeka R, Wijewardane DK.
BACKGROUND: Gloriosa superba, well known as the glory lily or superb lily, is a tropical climbing plant that features an exotic red flower. The plant is poisonous because of high concentrations of colchicine in all parts of the plant. It is commercially gr... (Source: SafetyLit)
Source: SafetyLit - June 25, 2016 Category: Global & Universal Tags: Poisoning Source Type: news

COLCHICINE Capsule [West-Ward Pharmaceuticals Corp]
Updated Date: May 3, 2016 EST (Source: DailyMed Drug Label Updates)
Source: DailyMed Drug Label Updates - May 3, 2016 Category: Drugs & Pharmacology Source Type: news

Mitigare (Colchicine Capsules) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - April 25, 2016 Category: Drugs & Pharmacology Source Type: news

Colchicine-induced rhabdomyolysis: an autopsy case - Arslan MN, Özgün A, Daş T, Kumru D, Sam B, Koç S.
Colchicine is derived from Colchicum autumnale and Gloriosa superba and is used to treat acute gout and familial Mediterranean fever (FMF). Musculoskeletal adverse effects range from myopathy to rhabdomyolysis. An 18-year-old woman, with a 2-year history o... (Source: SafetyLit)
Source: SafetyLit - April 11, 2016 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news

COLCRYS (Colchicine) Tablet, Film Coated [Avera McKennan Hospital]
Updated Date: Mar 2, 2016 EST (Source: DailyMed Drug Label Updates)
Source: DailyMed Drug Label Updates - March 2, 2016 Category: Drugs & Pharmacology Source Type: news

Rely on Colchicine for FMF, Experts Say (CME/CE)
(MedPage Today) -- New guideline for treatment of familial Mediterranean fever (Source: MedPage Today Pediatrics)
Source: MedPage Today Pediatrics - January 27, 2016 Category: Pediatrics Source Type: news

Accidental poisoning with a plant colchicum autumnale: report of two cases - Bajramović-Omeragić L, Čalkić L, Hadžić E, Aličkovič I.
Colchicine poisonings are serious and highly fatal conditions that occur as a result of food poisoning from plants that contain this alkaloid or overdose with drug containing colchicine. The leaves of edible wild garlic because of their similarity are ofte... (Source: SafetyLit)
Source: SafetyLit - January 23, 2016 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news

Gout: Colchicine Linked to Reduced CV RiskGout: Colchicine Linked to Reduced CV Risk
Colchicine use was associated with a 49% lower risk for cardiovascular events and a 73% reduction in all-cause mortality in patients with gout. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - January 22, 2016 Category: Consumer Health News Tags: Rheumatology News Source Type: news

Could Old Gout Drug Offer New CV Benefits? (CME/CE)
(MedPage Today) -- Colchicine use was associated with fewer cardiovascular events and lower all-cause mortality (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - November 20, 2015 Category: Cardiology Source Type: news

Gout: Sleep apnea may raise your risk
Gout is the most common type of inflammatory arthritis and affects more than 8 million adults. Men are at a higher risk than women. And according to a new study, your risk for gout also climbs if you suffer from sleep apnea, a condition where your breathing repeatedly pauses while you sleep. What exactly is gout? Gout is triggered by the crystallization of uric acid within the joints. It happens like this: Your body produces uric acid from breaking down purines, a natural waste product of living cells. Normally, uric acid is dissolved in your blood and passes through your kidneys into your urine. However, sometimes your bo...
Source: New Harvard Health Information - November 17, 2015 Category: Consumer Health News Authors: Matthew Solan Tags: Arthritis Health Sleep gout sleep apnea Source Type: news

Colchicine in acute gout: high-dose or low-dose or no-dose?
3.5 out of 5 stars Does Colchicine Improve Pain in an Acute Gout Flare? Turner J, Cooper D. Ann Emerg Med 2015 sep;66:260-1. Reference The 7th edition of Tintinalli’s Emergency Medicine (2011) has this to say about using colchicine to treat gout: Oral colchicine is typically administered in a dose of 0.6 milligrams/h until intolerable side effects (vomiting or diarrhea) or efficacy ensues. This “typical” dosing schedule goes back decades, and even when I was a medical student who didn’t know an Ewald tube from an Ewok it never made sense to me. The instructions might as well have been &ldq...
Source: The Poison Review - September 11, 2015 Category: Toxicology Authors: Leon Tags: Medical acute gout adverse events cochrane review colchicine toxicity dosing Source Type: news

Case report: use of ECMO in colchicine poisoning
Colchicum autumnale (Autumn crocus) 3.5 out of 5 stars Extracorporeal life support in the treatment of colchicine poisoning. Boisramé-Helms J et al. Clin Toxicol 2015;53:827-829. Abstract Colchicine toxicity occurs roughly in 3 phases. During the initial 24 hours, severe gastrointestinal symptoms — nausea, vomiting, and diarrhea — can cause hypotension and shock if fluid losses are not adequately replaced. During the second phase, severe toxicity can manifest with pancytopenia, sepsis, rhabdomyolysis, and renal failure. In addition, within days after ingestion, patients can develop cardiogenic shock...
Source: The Poison Review - September 11, 2015 Category: Toxicology Authors: Leon Tags: Medical autumn crocus colchicine poisoning colchicum autumnale ECLS ECMO extracorporeal life support extracorporeal membrane oxygenation Source Type: news

Lupus Pericarditis Yields to Gout Drug (CME/CE)
(MedPage Today) -- Colchicine resolved pericarditis in a small French study of lupus patients. (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - July 24, 2015 Category: Cardiology Source Type: news

A potentially fatal intoxication with colchicine - Boonstra JJ, Kan AA, de Vries I, Deneer VH, Meinders AJ.
BACKGROUND: Approximately ten times a year the Dutch National Poisons Information Centre (NVIC) is consulted regarding a colchicine intoxication or overdose. CASE DESCRIPTION: An 18-year old woman was admitted to the intensive care unit after a suicide att... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - March 28, 2015 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news

COLCRYS (Colchicine) Tablet, Film Coated [Proficient Rx LP]
Updated Date: Mar 20, 2015 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - March 20, 2015 Category: Drugs & Pharmacology Source Type: news

COLCHICINE Tablet, Film Coated [Prasco Laboratories]
Updated Date: Jan 14, 2015 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - January 14, 2015 Category: Drugs & Pharmacology Source Type: news

'Generic' Colchicine to Hit Market
(MedPage Today) -- May provide some price relief for gout patients. (Source: MedPage Today Emergency Medicine)
Source: MedPage Today Emergency Medicine - January 12, 2015 Category: Emergency Medicine Source Type: news

Mitigare (Colchicine Capsules) - new on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - October 20, 2014 Category: Drugs & Pharmacology Source Type: news

COLCHICINE Capsule [West-Ward Pharmaceutical Corp]
Updated Date: Oct 9, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - October 9, 2014 Category: Drugs & Pharmacology Source Type: news

MITIGARE (Colchicine) Capsule [Hikma Americas, Inc.]
Updated Date: Oct 1, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - October 1, 2014 Category: Drugs & Pharmacology Source Type: news

Colchicine 'Useless' for Postop Pericardial Effusion: POPE-2Colchicine 'Useless' for Postop Pericardial Effusion: POPE-2
In yet another trial, colchicine did not reduce complications after cardiac surgery; specifically, the drug failed to decrease postoperative pericardial effusion volume or prevent cardiac tamponade. Heartwire (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 31, 2014 Category: Consumer Health News Tags: Cardiology News Source Type: news

ESC: Gout Drug Gets Thumbs Down in Heart Surgery
BARCELONA (MedPage Today) -- Findings from two trials suggested the gout drug colchicine may not be all that useful for heart surgery patients, researchers said here. (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - August 30, 2014 Category: Cardiology Source Type: news

ESC: Gout Drug Little Help in Heart Surgery (CME/CE)
BARCELONA (MedPage Today) -- Giving the gout drug colchicine perioperatively to cardiac surgery patients reduced the incidence of postpericardiotomy syndrome, but didn't protect against later atrial fibrillation or pericardial/pleural effusion, researchers reported here. (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - August 30, 2014 Category: Cardiology Source Type: news

COPPS-2: Colchicine Stops Postop Pericarditis, Troubles GutCOPPS-2: Colchicine Stops Postop Pericarditis, Troubles Gut
In COPPS-2, patients taking colchicine had a high rate of adverse GI events, and this likely explains why there was no overall benefit in preventing AF after cardiac surgery; but it was effective for pericarditis of postpericardiotomy syndrome. Heartwire (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 30, 2014 Category: Consumer Health News Tags: Cardiology News Source Type: news

Medication shows mixed results in reducing complications from cardiac surgery
(The JAMA Network Journals) Administration of colchicine, a plant-based medication commonly used to treat gout, before and after cardiac surgery showed mixed results in reducing potential complications from this type of surgery, but it did increase the risk of gastrointestinal adverse effects, according to a study published by JAMA. The study is being released early online to coincide with its presentation at the European Society of Cardiology Congress. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 30, 2014 Category: Global & Universal Source Type: news

COLCRYS (Colchicine) Tablet, Film Coated [Cardinal Health]
Updated Date: Aug 26, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - August 26, 2014 Category: Drugs & Pharmacology Source Type: news

Featured in NEJM Journal Watch: Mounting Evidence Supports Colchicine for Pericarditis (FREE)
By the NEJM Journal Watch Editors In a new … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - May 20, 2014 Category: Primary Care Source Type: news

COLCRYS (Colchicine) Tablet, Film Coated [Aphena Pharma Solutions - Tennessee, LLC]
Updated Date: Apr 29, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - April 29, 2014 Category: Drugs & Pharmacology Source Type: news

ACC: Gout Drug Tames the Heart
WASHINGTON (MedPage Today) -- Colchicine may be as effective at reducing multiple recurrences of pericarditis as it is in treating acute episodes and first recurrences. (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - March 30, 2014 Category: Cardiology Source Type: news

Colchicine reduces recurrence risk among patients with recurrent pericarditis
Read the full story on MD Consult: Colchicine reduces recurrence risk among patients with recurrent pericarditis (Source: MD Consult: News: Top Stories)
Source: MD Consult: News: Top Stories - March 29, 2014 Category: Journals (General) Source Type: news

How changes in the organized cell membrane network of heart muscle lead to heart failure
Colchicine, a drug that's used to treat gout, has the beneficial side effect of lowering the risk of heart attack in patients taking it. Conversely, taxol, a drug for treating cancer, has the opposite effect; raising the risk of heart failure.What both these drugs have in common is that they act on microtubules - a network of fibers inside heart cells that provide internal structural support. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - March 10, 2014 Category: Consumer Health News Tags: Heart Disease Source Type: news

Colchicine: Old drug with a new trick
Read the full story on MD Consult: Colchicine: Old drug with a new trick (Source: MD Consult: News: Top Stories)
Source: MD Consult: News: Top Stories - February 13, 2014 Category: Journals (General) Source Type: news

Fatal colchicine poisoning by accidental ingestion of colchicum persicum: A case report - Amrollahi-Sharifabadi M, Seghatoleslami A, Amrollahi-Sharifabadi M, Bayani F, Mirjalili M.
Colchicine poisoning can occur not only by taking dosage form but also by ingesting a plant containing colchicine. A 39-year-old man presented to the emergency room with nausea, vomiting, and diarrhea 9 hours after ingestion of wild garlic. Symptoms attrib... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - November 15, 2013 Category: Global & Universal Tags: Home and Consumer Product Safety Source Type: news

Colchicine Found Effective in Acute Pericarditis
Although colchicine has been shown to be beneficial in patients with recurrent pericarditis, which is thought to have a large inflammatory component related to an immune response, until now its efficacy in a first episode of acute pericarditis has been uncertain, as these episodes are thought to usually have a viral component that might benefit from an inflammatory response. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - September 12, 2013 Category: Pharmaceuticals Authors: Larry Husten Source Type: news

The Shocking Truth About Medication Errors
Let’s say a physician writes a prescription for Colchicine and accidentally orders “10.0 mg,” when he should have ordered “1.0 mg.” That’s a tiny decimal error, a mistake even the best doctor could make. But it can be catastrophic for the patient. The higher dose could cause Colchicine poisoning, similar to arsenic poisoning: burning in the mouth and throat, excruciating abdominal pain. Internal organs would melt away and death would likely occur within 24 to 72 hours. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - September 3, 2013 Category: Pharmaceuticals Authors: Leah Binder Source Type: news

ESC: Colchicine Effective in Acute Pericarditis (CME/CE)
AMSTERDAM (MedPage Today) -- The anti-inflammatory agent colchicine -- used mostly in the treatment of gout -- appears to be effective for treating acute pericarditis and in preventing recurrences of the condition, researchers reported here. (Source: MedPage Today Infectious Disease)
Source: MedPage Today Infectious Disease - September 1, 2013 Category: Infectious Diseases Source Type: news

COLCRYS (Colchicine) Tablet, Film Coated [REMEDYREPACK INC. ]
Updated Date: May 7, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - May 7, 2013 Category: Drugs & Pharmacology Source Type: news

COLCRYS (Colchicine) Tablet, Film Coated [Takeda Pharmaceuticals America, Inc.]
Updated Date: Apr 22, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - April 22, 2013 Category: Drugs & Pharmacology Source Type: news

Colchicine Prevents Bare-Metal Stent Restenosis in DiabeticsColchicine Prevents Bare-Metal Stent Restenosis in Diabetics
Colchicine reduces neointimal hyperplasia and in-stent restenosis in diabetics who receive bare-metal coronary stents, Greek researchers say. Reuters Health Information (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - April 19, 2013 Category: Cardiology Tags: Cardiology News Source Type: news

COLCRYS (Colchicine) Tablet, Film Coated [REMEDYREPACK INC. ]
Updated Date: Feb 22, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - February 22, 2013 Category: Drugs & Pharmacology Source Type: news

CHMP recommends extension of canakinumab (Ilaris®) license to include treatment of gouty arthritis
Source: European Medicines Agency Area: News The Committee for Medicinal Products for Human Use (CHMP) has recommended the adoption of a new indication for canakinumab (Ilaris®), as follows:   "Ilaris is indicated for the symptomatic treatment of adults patients with frequent gouty arthritis attacks (at least 3 attacks in the previous 12 months) in whom non-steroidal anti-inflammatory drugs (NSAIDs) and colchicine are contraindicated, are not tolerated, or do not provide an adequate response, and in whom repeated courses of corticosteroids are not appropriate".   Detailed conditions for th...
Source: NeLM - News - January 21, 2013 Category: Drugs & Pharmacology Source Type: news