Could Colchicine Be the New Aspirin? Could Colchicine Be the New Aspirin?
Michel Zeitouni talks to Jean-Claude Tardif about the COLCOT series of clinical trials testing colchicine, an anti-inflammatory gout drug, for the prevention and treatment of cardiovascular disease.theheart.org on Medscape (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 27, 2020 Category: Consumer Health News Tags: Cardiology Expert Interview Source Type: news

What Is the Classic Clinical Presentation of Pericarditis?
Discussion The pericardium is a bi-layered membrane that envelops the heart and provides a barrier to prevent disease and also decreases friction as the heart moves. Pericarditis is the inflammation of pericardium. The incidence is underreported as asymptomatic or mild disease may go unrecognized. From hospitalized patient data, 0.2-5% of patients with various cardiac disease had pericarditis. An incidence rate for hospitalizations of 3.32 per 100,000 person years has been cited. Percarditis occurs more often in adolescent males. Treatment of the underlying cause or suspected cause is important, along with close monitorin...
Source: PediatricEducation.org - January 13, 2020 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Drug used to treat gout cuts odds of new heart attack, stroke in heart attack survivors
The inflammation-fighting drug colchicine, already a treatment for gout, dramatically reduces the odds of future cardiovascular problems in people who have just survived a heart attack, a large new study by a Montreal researcher has concluded. (Source: CBC | Health)
Source: CBC | Health - November 18, 2019 Category: Consumer Health News Tags: News/Health Source Type: news

Colchicine cuts odds of new heart attack, stroke in heart attack survivors
(Reuters Health) - The inflammation-fighting drug colchicine, already a treatment for gout, dramatically reduces the odds of future cardiovascular problems in people who have just survived a heart attack, a large new study has concluded. (Source: Reuters: Health)
Source: Reuters: Health - November 18, 2019 Category: Consumer Health News Tags: healthNews Source Type: news

Cheap, Older Gout Drug Could Be a Lifesaver After Heart Attack
In the new trial, colchicine reduced by as much as 34% a heart attack survivor's combined risk of either dying from heart disease or having cardiac arrest, a heart attack, a stroke or angioplasty. (Source: WebMD Health)
Source: WebMD Health - November 18, 2019 Category: Consumer Health News Source Type: news

AHA: Risk for Ischemic CV Events Lower With Colchicine After MI
MONDAY, Nov. 18, 2019 -- Patients with recent myocardial infarction have a lower risk for ischemic cardiovascular events with colchicine versus placebo, according to a study published online Nov. 16 in the New England Journal of Medicine to coincide... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - November 18, 2019 Category: Pharmaceuticals Source Type: news

Colchicine Before PCI Cuts Inflammatory Markers but Not MACE Colchicine Before PCI Cuts Inflammatory Markers but Not MACE
Although colchicine did not significantly reduce major adverse cardiovascular events after PCI, the researchers are encouraged by significant decreases in markers of inflammation vs placebo.Medscape Medical News (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - November 18, 2019 Category: Cardiology Tags: Cardiology News Source Type: news

Older Gout Drug Colchicine Could Be a Lifesaver After Heart Attack
SUNDAY, Nov. 17, 2019 -- A cheap drug that's been around for centuries as a gout treatment might also shield heart attack survivors from future heart crises, new trial results show. The drug, colchicine, is derived from a plant called the autumn... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - November 17, 2019 Category: General Medicine Source Type: news

COLCOT: Colchicine Shows Promise to Reduce Events After MI COLCOT: Colchicine Shows Promise to Reduce Events After MI
A widely available anti-inflammatory agent used to treat pericarditis and gout may have value in secondary prevention after myocardial infarction, new trial results suggest.Medscape Medical News (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - November 16, 2019 Category: Cardiology Tags: Cardiology News Source Type: news

Rapid identification of Gloriosa superba and Colchicum autumnale by melting curve analysis: application to a suicide case involving massive ingestion of G. superba - Sakurada M, Yoshioka N, Kuse A, Nakagawa K, Morichika M, Takahashi M, Kondo T, Asano M, Ueno Y.
The plant species Gloriosa superba and Colchicum autumnale produce extremely poisonous colchicine as a major toxic metabolite. Almost all previous studies on colchicine poisoning have focused on drug analysis and clinical and pathological aspects. In this ... (Source: SafetyLit)
Source: SafetyLit - May 2, 2019 Category: International Medicine & Public Health Tags: Poisoning Source Type: news

Colchicine May Improve Obesity-Induced Inflammation
FRIDAY, April 12, 2019 -- Colchicine is safe and effective at improving obesity-associated inflammatory measures among adults with obesity and metabolic syndrome (MetS) without diabetes, according to a pilot study published online March 14 in... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - April 12, 2019 Category: Pharmaceuticals Source Type: news

10 New Drugs for Primary Care: Q1 2019
Highlights:  The first liquid solution of colchicine for prophylaxis of gout, the first generic version of Advair Diskus,® and 8 more new and approved drugs. (Source: ConsultantLive)
Source: ConsultantLive - April 11, 2019 Category: Internal Medicine Authors: Sydney Jennings Tags: ADHD Asthma COPD Depression Gout Headache and Migraine HIV AIDS Source Type: news

Gout treatment may help prevent obesity-related type 2 diabetes, suggests small NIH study
Colchicine may potentially reduce complications accompanying metabolic syndrome. (Source: National Institutes of Health (NIH) News Releases)
Source: National Institutes of Health (NIH) News Releases - April 2, 2019 Category: American Health Source Type: news

Gout treatment may help prevent obesity-related type 2 diabetes, suggests small NIH study
(NIH/Eunice Kennedy Shriver National Institute of Child Health and Human Development) The drug colchicine, used to treat the arthritic condition gout, could potentially reduce complications accompanying metabolic syndrome, a combination of high blood pressure, high blood sugar and other conditions that increase the risk of heart disease and type 2 diabetes, according to researchers at the National Institutes of Health. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 2, 2019 Category: International Medicine & Public Health Source Type: news

colchicine (Colcrys)
Title: colchicine (Colcrys)Category: MedicationsCreated: 12/31/1997 12:00:00 AMLast Editorial Review: 3/26/2019 12:00:00 AM (Source: MedicineNet Arthritis General)
Source: MedicineNet Arthritis General - March 26, 2019 Category: Rheumatology Source Type: news

Epidemiology, toxicokinetics and biomarkers after self-poisoning with Gloriosa superba - Wijerathna TM, Gawarammana IB, Mohamed F, Dissanayaka DM, Dargan PI, Chathuranga U, Jayathilaka C, Buckley NA.
The objective of this study was to describe the epidemiology, toxicokinetics and selected ... (Source: SafetyLit)
Source: SafetyLit - March 24, 2019 Category: International Medicine & Public Health Tags: Poisoning Source Type: news

FDA OKs First Liquid Form of Gout Drug Colchicine (Gloperba) FDA OKs First Liquid Form of Gout Drug Colchicine (Gloperba)
Liquid colchicine for prophylaxis of gout flares in adults will be available in the US this summer.FDA Approvals (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - February 27, 2019 Category: Consumer Health News Tags: Rheumatology News Alert Source Type: news

FDA Approves Gloperba (colchicine) for Prophylaxis of Adult Gout Flares
WOBURN, Mass.--(BUSINESS WIRE)--February 26, 2019 ROMEG Therapeutics, an innovative drug development company focused on alternative formulations to better meet clinical and patient needs, today announced that the U.S. Food and Drug Administration... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - February 26, 2019 Category: Drugs & Pharmacology Source Type: news

Gloperba (Colchicine Oral Solution) - new on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - February 6, 2019 Category: Drugs & Pharmacology Source Type: news

Mitigare (Colchicine Capsules) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - December 17, 2018 Category: Drugs & Pharmacology Source Type: news

Colchicine extract suicidal lethal poisoning confirmation using high-resolution accurate mass spectrometry: a case study - Schreiber L, Morovi č M, Špacayová K, Halko R.
A case of suspected acute and lethal intoxication caused by colchicine has been reported. The woman was hospitalized after her suspicion of suicidal poisoning by a rare autumn crocus (Colchicum autumnale). Suspected colchicine poisoning was confirmed using... (Source: SafetyLit)
Source: SafetyLit - December 13, 2018 Category: International Medicine & Public Health Tags: Poisoning Source Type: news

Zydus Cadila gets USFDA nod for generic gout attacks drug
The company has received the tentative approval from the USFDA to market Colchicine tablets USP in the strength of 0.6 mg, Zydus Cadila said in a statement. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - October 18, 2018 Category: Pharmaceuticals Source Type: news

Canakinumab Efficacy Confirmed In Recurrent Fever Disorders Canakinumab Efficacy Confirmed In Recurrent Fever Disorders
Canakinumab controlled flares in colchicine-resistant familial Mediterranean fever, mevalonate kinase deficiency, and tumor necrosis factor receptor-associated periodic syndrome.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 23, 2018 Category: Consumer Health News Tags: Rheumatology News Source Type: news

Colcrys (Colchicine Tablets) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - March 6, 2018 Category: Drugs & Pharmacology Source Type: news

Severe hypertriglyceridemia and colchicine intoxication following suicide attempt - Lev S, Snyder D, Azran C, Zolotarsky V, Dahan A.
We report a case of an 18-year-old female who ingested 18 mg (~0.4 mg/kg) of colchicine in a suicide att... (Source: SafetyLit)
Source: SafetyLit - December 8, 2017 Category: International Medicine & Public Health Tags: Suicide and Self-Harm Source Type: news

Should Colchicine Join the Anti-Inflammatory Toolbox? Should Colchicine Join the Anti-Inflammatory Toolbox?
The commonly used drug was shown for the first time on serial CT imaging to modify coronary plaque morphology, but experts question whether these changes will translate into improved hard clinical events.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 7, 2017 Category: Consumer Health News Tags: Cardiology News Source Type: news

CardioBrief: Imaging Offers Insight Into Inflammation in CV Disease
(MedPage Today) -- Preliminary evidence that colchicine may reduce coronary plaque (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - October 19, 2017 Category: Cardiology Source Type: news

Probenecid and Colchicine (Probenecid and Colchicine) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - December 25, 2016 Category: Drugs & Pharmacology Source Type: news

IL-1 Blocking Agent Succeeds in Resistant FMF (CME/CE)
(MedPage Today) -- First randomized trial among colchicine-resistant patients (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - November 28, 2016 Category: Primary Care Source Type: news

Colchicine (Colchicine) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - August 31, 2016 Category: Drugs & Pharmacology Source Type: news

Pyridine based antitumor compounds acting at the colchicine site
(Bentham Science Publishers) Tubulin inhibitors are among the most successful anti-cancer, anti-parasitic and herbicidal agents. Lessons from the achievements and failures have been extracted and future perspectives delineated. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - June 30, 2016 Category: Biology Source Type: news

colchicine, Colcrys
Title: colchicine, ColcrysCategory: MedicationsCreated: 12/31/1997 12:00:00 AMLast Editorial Review: 6/29/2016 12:00:00 AM (Source: MedicineNet Arthritis General)
Source: MedicineNet Arthritis General - June 29, 2016 Category: Rheumatology Source Type: news

Case report: a rare case of attempted homicide with Gloriosa superba seeds - Kande Vidanalage CJ, Ekanayeka R, Wijewardane DK.
BACKGROUND: Gloriosa superba, well known as the glory lily or superb lily, is a tropical climbing plant that features an exotic red flower. The plant is poisonous because of high concentrations of colchicine in all parts of the plant. It is commercially gr... (Source: SafetyLit)
Source: SafetyLit - June 25, 2016 Category: Global & Universal Tags: Poisoning Source Type: news

Mitigare (Colchicine Capsules) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - April 25, 2016 Category: Drugs & Pharmacology Source Type: news

Colchicine-induced rhabdomyolysis: an autopsy case - Arslan MN, Özgün A, Daş T, Kumru D, Sam B, Koç S.
Colchicine is derived from Colchicum autumnale and Gloriosa superba and is used to treat acute gout and familial Mediterranean fever (FMF). Musculoskeletal adverse effects range from myopathy to rhabdomyolysis. An 18-year-old woman, with a 2-year history o... (Source: SafetyLit)
Source: SafetyLit - April 11, 2016 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news

Rely on Colchicine for FMF, Experts Say (CME/CE)
(MedPage Today) -- New guideline for treatment of familial Mediterranean fever (Source: MedPage Today Pediatrics)
Source: MedPage Today Pediatrics - January 27, 2016 Category: Pediatrics Source Type: news

Accidental poisoning with a plant colchicum autumnale: report of two cases - Bajramović-Omeragić L, Čalkić L, Hadžić E, Aličkovič I.
Colchicine poisonings are serious and highly fatal conditions that occur as a result of food poisoning from plants that contain this alkaloid or overdose with drug containing colchicine. The leaves of edible wild garlic because of their similarity are ofte... (Source: SafetyLit)
Source: SafetyLit - January 23, 2016 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news

Gout: Colchicine Linked to Reduced CV RiskGout: Colchicine Linked to Reduced CV Risk
Colchicine use was associated with a 49% lower risk for cardiovascular events and a 73% reduction in all-cause mortality in patients with gout. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - January 22, 2016 Category: Consumer Health News Tags: Rheumatology News Source Type: news

Could Old Gout Drug Offer New CV Benefits? (CME/CE)
(MedPage Today) -- Colchicine use was associated with fewer cardiovascular events and lower all-cause mortality (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - November 20, 2015 Category: Cardiology Source Type: news

Gout: Sleep apnea may raise your risk
Gout is the most common type of inflammatory arthritis and affects more than 8 million adults. Men are at a higher risk than women. And according to a new study, your risk for gout also climbs if you suffer from sleep apnea, a condition where your breathing repeatedly pauses while you sleep. What exactly is gout? Gout is triggered by the crystallization of uric acid within the joints. It happens like this: Your body produces uric acid from breaking down purines, a natural waste product of living cells. Normally, uric acid is dissolved in your blood and passes through your kidneys into your urine. However, sometimes your bo...
Source: New Harvard Health Information - November 17, 2015 Category: Consumer Health News Authors: Matthew Solan Tags: Arthritis Health Sleep gout sleep apnea Source Type: news

Colchicine in acute gout: high-dose or low-dose or no-dose?
3.5 out of 5 stars Does Colchicine Improve Pain in an Acute Gout Flare? Turner J, Cooper D. Ann Emerg Med 2015 sep;66:260-1. Reference The 7th edition of Tintinalli’s Emergency Medicine (2011) has this to say about using colchicine to treat gout: Oral colchicine is typically administered in a dose of 0.6 milligrams/h until intolerable side effects (vomiting or diarrhea) or efficacy ensues. This “typical” dosing schedule goes back decades, and even when I was a medical student who didn’t know an Ewald tube from an Ewok it never made sense to me. The instructions might as well have been &ldq...
Source: The Poison Review - September 12, 2015 Category: Toxicology Authors: Leon Tags: Medical acute gout adverse events cochrane review colchicine toxicity dosing Source Type: news

Case report: use of ECMO in colchicine poisoning
Colchicum autumnale (Autumn crocus) 3.5 out of 5 stars Extracorporeal life support in the treatment of colchicine poisoning. Boisramé-Helms J et al. Clin Toxicol 2015;53:827-829. Abstract Colchicine toxicity occurs roughly in 3 phases. During the initial 24 hours, severe gastrointestinal symptoms — nausea, vomiting, and diarrhea — can cause hypotension and shock if fluid losses are not adequately replaced. During the second phase, severe toxicity can manifest with pancytopenia, sepsis, rhabdomyolysis, and renal failure. In addition, within days after ingestion, patients can develop cardiogenic shock...
Source: The Poison Review - September 11, 2015 Category: Toxicology Authors: Leon Tags: Medical autumn crocus colchicine poisoning colchicum autumnale ECLS ECMO extracorporeal life support extracorporeal membrane oxygenation Source Type: news

Lupus Pericarditis Yields to Gout Drug (CME/CE)
(MedPage Today) -- Colchicine resolved pericarditis in a small French study of lupus patients. (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - July 24, 2015 Category: Cardiology Source Type: news

A potentially fatal intoxication with colchicine - Boonstra JJ, Kan AA, de Vries I, Deneer VH, Meinders AJ.
BACKGROUND: Approximately ten times a year the Dutch National Poisons Information Centre (NVIC) is consulted regarding a colchicine intoxication or overdose. CASE DESCRIPTION: An 18-year old woman was admitted to the intensive care unit after a suicide att... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - March 28, 2015 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news

'Generic' Colchicine to Hit Market
(MedPage Today) -- May provide some price relief for gout patients. (Source: MedPage Today Emergency Medicine)
Source: MedPage Today Emergency Medicine - January 12, 2015 Category: Emergency Medicine Source Type: news

Mitigare (Colchicine Capsules) - new on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - October 20, 2014 Category: Drugs & Pharmacology Source Type: news

Colchicine 'Useless' for Postop Pericardial Effusion: POPE-2Colchicine 'Useless' for Postop Pericardial Effusion: POPE-2
In yet another trial, colchicine did not reduce complications after cardiac surgery; specifically, the drug failed to decrease postoperative pericardial effusion volume or prevent cardiac tamponade. Heartwire (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 31, 2014 Category: Consumer Health News Tags: Cardiology News Source Type: news

ESC: Gout Drug Gets Thumbs Down in Heart Surgery
BARCELONA (MedPage Today) -- Findings from two trials suggested the gout drug colchicine may not be all that useful for heart surgery patients, researchers said here. (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - August 30, 2014 Category: Cardiology Source Type: news

ESC: Gout Drug Little Help in Heart Surgery (CME/CE)
BARCELONA (MedPage Today) -- Giving the gout drug colchicine perioperatively to cardiac surgery patients reduced the incidence of postpericardiotomy syndrome, but didn't protect against later atrial fibrillation or pericardial/pleural effusion, researchers reported here. (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - August 30, 2014 Category: Cardiology Source Type: news

COPPS-2: Colchicine Stops Postop Pericarditis, Troubles GutCOPPS-2: Colchicine Stops Postop Pericarditis, Troubles Gut
In COPPS-2, patients taking colchicine had a high rate of adverse GI events, and this likely explains why there was no overall benefit in preventing AF after cardiac surgery; but it was effective for pericarditis of postpericardiotomy syndrome. Heartwire (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 30, 2014 Category: Consumer Health News Tags: Cardiology News Source Type: news