SGLT2 is upregulated to acquire cisplatin resistance and SGLT2 inhibition reduces cisplatin resistance in hepatoblastoma

ConclusionsCisplatin-resistant hepatoblastoma cells exhibited upregulated SGLT2 expression and activated glucose uptake to survive under cisplatin stress. SGLT2 inhibition decreased cellular resistance to cisplatin. SGLT2 inhibition with cisplatin therapy could be a novel therapeutic strategy for cisplatin-resistant hepatoblastoma patients.

Source: Journal of Hepato-Biliary-Pancreatic Sciences - November 6, 2023 Category: Gastroenterology Authors: Sunao Fujiyoshi, Shohei Honda, Momoko Ara, Takafumi Kondo, Nozomi Kobayashi, Akinobu Taketomi Tags: ORIGINAL ARTICLE Source Type: research