Crystal structure of the GH-46 subclass III chitosanase from Bacillus circulans MH-K1 in complex with chitotetraose
CONCLUSIONS: Although GH-46 chitosanases vary in the finer details of the subsites defining cleavage specificity, they share similar structural characteristics in substrate-binding, catalytic processes, and potentially in conformational change.GENERAL SIGNIFICANCE: The precise binding of a GlcN residue to the -2 subsite is essential for the conformational shift that occurs in all GH-46 chitosanases, as shown by the crystal structures of the apo- and substrate-bound forms of MH-K1 chitosanase.PMID:38158023 | DOI:10.1016/j.bbagen.2023.130549 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - December 29, 2023 Category: Biochemistry Authors: Michihiko Suzuki Akihiro Saito Mariko Kobayashi Tomofumi Yokoyama Shoko Omiya Jian Li Kei Sugita Kunio Miki Jun-Ichi Saito Akikazu Ando Source Type: research
In vitro characterization of alternative l-threonate and d-erythronate catabolic pathways
Biochem Biophys Res Commun. 2023 Dec 25;695:149440. doi: 10.1016/j.bbrc.2023.149440. Online ahead of print.ABSTRACTl-threonate is the metabolite of vitamin C, while d-erythronate is the metabolite of N-acetyl-d-glucosamine, the nutritional supplement for joint health. They are widely distributed in the environment and human biofluids. Nevertheless, the catabolisms of l-threonate and d-erythronate are sparsely reported. Here we explored the functional diversity of an acid sugar kinase family (Pfam families PF07005-PF17042), and discovered a novel 2-oxo-tetronate kinase. The conserved genome neighborhood of the 2-oxo-tetrona...
Source: Biochemical and Biophysical Research communications - December 29, 2023 Category: Biochemistry Authors: Yibo Guo Ke Shen Xinshuai Zhang Hua Huang Source Type: research
Rheumatoid arthritis knowledge gap and intervention in Nigeria study
ConclusionThis study highlights the importance of interventions in closing the knowledge gap about RA diagnosis and management. We recommend the implementation of a comprehensive approach to rheumatology education and services by policymakers. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - December 19, 2023 Category: Rheumatology Authors: Olaosebikan B. Hakeem,
Yerima Abubakar,
Uhunmwangho Courage,
Odunlami Gbenga Joshua,
Shodipo Olujimi,
Umar Abdulaziz,
Ima ‐Edomwonyi Uyi,
Osaze Ojo,
Olufemi Adelowo,
Oguntona A. Olusegun,
Henry Nwankwo,
Dedeke Ibukunoluwa,
Daiyabu Ibrahim,
Tags: ORIGINAL ARTICLE Source Type: research
Correction: π-Facial selectivity in the Diels–Alder reaction of glucosamine-based chiral furans and maleimides
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Cornelis H. M. van der Loo, Rutger Schim van der Loeff, Avelino Mart ín, Pilar Gomez-Sal, Mark L. G. Borst, Kees Pouwer, Adriaan J. Minnaard To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 15, 2023 Category: Molecular Biology Authors: Cornelis H. M. van der Loo Source Type: research
Effects of emulsified and non-emulsified palm tocotrienol on bone and joint health in ovariectomised rats with monosodium iodoacetate-induced osteoarthritis
This study justifies clinical trials for the use of EPT in postmenopausal women with both conditions.PMID:38091638 | DOI:10.1016/j.biopha.2023.115998 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 13, 2023 Category: Drugs & Pharmacology Authors: Sophia Ogechi Ekeuku Muhamed Lahtif Nor Muhamad Alya Aqilah Aminuddin Fairus Ahmad Sok Kuan Wong Wun Fui Mark-Lee Kok-Yong Chin Source Type: research
Effects of emulsified and non-emulsified palm tocotrienol on bone and joint health in ovariectomised rats with monosodium iodoacetate-induced osteoarthritis
This study justifies clinical trials for the use of EPT in postmenopausal women with both conditions.PMID:38091638 | DOI:10.1016/j.biopha.2023.115998 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 13, 2023 Category: Drugs & Pharmacology Authors: Sophia Ogechi Ekeuku Muhamed Lahtif Nor Muhamad Alya Aqilah Aminuddin Fairus Ahmad Sok Kuan Wong Wun Fui Mark-Lee Kok-Yong Chin Source Type: research
Effects of emulsified and non-emulsified palm tocotrienol on bone and joint health in ovariectomised rats with monosodium iodoacetate-induced osteoarthritis
This study justifies clinical trials for the use of EPT in postmenopausal women with both conditions.PMID:38091638 | DOI:10.1016/j.biopha.2023.115998 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 13, 2023 Category: Drugs & Pharmacology Authors: Sophia Ogechi Ekeuku Muhamed Lahtif Nor Muhamad Alya Aqilah Aminuddin Fairus Ahmad Sok Kuan Wong Wun Fui Mark-Lee Kok-Yong Chin Source Type: research
Molecules, Vol. 28, Pages 8068: Investigation of Drug-Interaction Potential for Arthritis Dietary Supplements: Chondroitin Sulfate, Glucosamine, and Methylsulfonylmethane
In this study, these dietary supplements were incubated with cytochrome P450 isozyme-specific substrates in human liver microsomes, and the formation of marker metabolites was measured to investigate their inhibitory potential on cytochrome P450 enzyme activities. The results revealed no significant inhibitory effects on seven CYPs, consistent with established related research data. Therefore, these substances are anticipated to have a low potential for cytochrome P450-mediated drug interactions with osteoarthritis medications that are likely to be co-administered. However, given the previous reports of interaction cases i...
Source: Molecules - December 13, 2023 Category: Chemistry Authors: Su Min Kim So Young Jo Ho-Young Park Yu Ra Lee Jun Sang Yu Hye Hyun Yoo Tags: Communication Source Type: research
Characterization of a novel exopolysaccharide from Acinetobacter rhizosphaerae with ability to enhance the salt stress resistance of rice seedlings
Int J Biol Macromol. 2023 Nov 30:128438. doi: 10.1016/j.ijbiomac.2023.128438. Online ahead of print.ABSTRACTWe here describe the isolation of a novel exopolysaccharide from Acinetobacter rhizosphaerae, named ArEPS. The structure of ArEPS was characterized by analysis of the monosaccharide composition, molecular weight, infrared spectrum, methylation, and nuclear magnetic resonance spectrum. ArEPS was found to be an acidic heteropolysaccharide composed of glucose, galactose, galacturonic acid, glucuronic acid, mannose, and glucosamine; the molecular weight was 1533 kDa. Structural analysis showed that the main-chain structu...
Source: International Journal of Biological Macromolecules - December 2, 2023 Category: Biochemistry Authors: Sun Ke Li Zhen Lian Mengyu Li Quan Wang Rui Gu Yian Lei Peng He Hongjie Xu Hong Sha Feng Sun Liang Source Type: research
Characterization of a novel exopolysaccharide from Acinetobacter rhizosphaerae with ability to enhance the salt stress resistance of rice seedlings
Int J Biol Macromol. 2023 Nov 30:128438. doi: 10.1016/j.ijbiomac.2023.128438. Online ahead of print.ABSTRACTWe here describe the isolation of a novel exopolysaccharide from Acinetobacter rhizosphaerae, named ArEPS. The structure of ArEPS was characterized by analysis of the monosaccharide composition, molecular weight, infrared spectrum, methylation, and nuclear magnetic resonance spectrum. ArEPS was found to be an acidic heteropolysaccharide composed of glucose, galactose, galacturonic acid, glucuronic acid, mannose, and glucosamine; the molecular weight was 1533 kDa. Structural analysis showed that the main-chain structu...
Source: International Journal of Biological Macromolecules - December 2, 2023 Category: Biochemistry Authors: Sun Ke Li Zhen Lian Mengyu Li Quan Wang Rui Gu Yian Lei Peng He Hongjie Xu Hong Sha Feng Sun Liang Source Type: research
Evaluation of Glycogen Synthase Kinase Pathway for Assessing the Antidepressant-like Effect of Glucosamine as a Radioprotector in Rats: Behavioral and Biochemical Studies
Dose Response. 2023 Nov 21;21(4):15593258231217845. doi: 10.1177/15593258231217845. eCollection 2023 Oct-Dec.ABSTRACTRadiotherapy is a very important tool in the treatment of cancer; nevertheless, its side effects are a hindrance to its use. The present study is designed to evaluate glucosamine effects against radiation-induced brain oxidative stress and depression-like effect in rats. Four groups of female Wister rats were used as control, irradiated (4 × 2 Gy), glucosamine (1 g/kg P.O), and glucosamine + irradiated group. The behavioral responses are estimated. The brain hippocampi of the rats are separated to evaluate ...
Source: Dose Response - November 29, 2023 Category: Drugs & Pharmacology Authors: Mai H Mekkawy Heba M Karam Marwa A Mohamed Dina M Lotfy Source Type: research
Evaluation of Glycogen Synthase Kinase Pathway for Assessing the Antidepressant-like Effect of Glucosamine as a Radioprotector in Rats: Behavioral and Biochemical Studies
Dose Response. 2023 Nov 21;21(4):15593258231217845. doi: 10.1177/15593258231217845. eCollection 2023 Oct-Dec.ABSTRACTRadiotherapy is a very important tool in the treatment of cancer; nevertheless, its side effects are a hindrance to its use. The present study is designed to evaluate glucosamine effects against radiation-induced brain oxidative stress and depression-like effect in rats. Four groups of female Wister rats were used as control, irradiated (4 × 2 Gy), glucosamine (1 g/kg P.O), and glucosamine + irradiated group. The behavioral responses are estimated. The brain hippocampi of the rats are separated to evaluate ...
Source: Dose Response - November 29, 2023 Category: Drugs & Pharmacology Authors: Mai H Mekkawy Heba M Karam Marwa A Mohamed Dina M Lotfy Source Type: research
Evaluation of Glycogen Synthase Kinase Pathway for Assessing the Antidepressant-like Effect of Glucosamine as a Radioprotector in Rats: Behavioral and Biochemical Studies
Dose Response. 2023 Nov 21;21(4):15593258231217845. doi: 10.1177/15593258231217845. eCollection 2023 Oct-Dec.ABSTRACTRadiotherapy is a very important tool in the treatment of cancer; nevertheless, its side effects are a hindrance to its use. The present study is designed to evaluate glucosamine effects against radiation-induced brain oxidative stress and depression-like effect in rats. Four groups of female Wister rats were used as control, irradiated (4 × 2 Gy), glucosamine (1 g/kg P.O), and glucosamine + irradiated group. The behavioral responses are estimated. The brain hippocampi of the rats are separated to evaluate ...
Source: Dose Response - November 29, 2023 Category: Drugs & Pharmacology Authors: Mai H Mekkawy Heba M Karam Marwa A Mohamed Dina M Lotfy Source Type: research
Evaluation of Glycogen Synthase Kinase Pathway for Assessing the Antidepressant-like Effect of Glucosamine as a Radioprotector in Rats: Behavioral and Biochemical Studies
Dose Response. 2023 Nov 21;21(4):15593258231217845. doi: 10.1177/15593258231217845. eCollection 2023 Oct-Dec.ABSTRACTRadiotherapy is a very important tool in the treatment of cancer; nevertheless, its side effects are a hindrance to its use. The present study is designed to evaluate glucosamine effects against radiation-induced brain oxidative stress and depression-like effect in rats. Four groups of female Wister rats were used as control, irradiated (4 × 2 Gy), glucosamine (1 g/kg P.O), and glucosamine + irradiated group. The behavioral responses are estimated. The brain hippocampi of the rats are separated to evaluate ...
Source: Dose Response - November 29, 2023 Category: Drugs & Pharmacology Authors: Mai H Mekkawy Heba M Karam Marwa A Mohamed Dina M Lotfy Source Type: research
Evaluation of Glycogen Synthase Kinase Pathway for Assessing the Antidepressant-like Effect of Glucosamine as a Radioprotector in Rats: Behavioral and Biochemical Studies
Dose Response. 2023 Nov 21;21(4):15593258231217845. doi: 10.1177/15593258231217845. eCollection 2023 Oct-Dec.ABSTRACTRadiotherapy is a very important tool in the treatment of cancer; nevertheless, its side effects are a hindrance to its use. The present study is designed to evaluate glucosamine effects against radiation-induced brain oxidative stress and depression-like effect in rats. Four groups of female Wister rats were used as control, irradiated (4 × 2 Gy), glucosamine (1 g/kg P.O), and glucosamine + irradiated group. The behavioral responses are estimated. The brain hippocampi of the rats are separated to evaluate ...
Source: Dose Response - November 29, 2023 Category: Drugs & Pharmacology Authors: Mai H Mekkawy Heba M Karam Marwa A Mohamed Dina M Lotfy Source Type: research
