Evaluation of Glycogen Synthase Kinase Pathway for Assessing the Antidepressant-like Effect of Glucosamine as a Radioprotector in Rats: Behavioral and Biochemical Studies
Dose Response. 2023 Nov 21;21(4):15593258231217845. doi: 10.1177/15593258231217845. eCollection 2023 Oct-Dec.ABSTRACTRadiotherapy is a very important tool in the treatment of cancer; nevertheless, its side effects are a hindrance to its use. The present study is designed to evaluate glucosamine effects against radiation-induced brain oxidative stress and depression-like effect in rats. Four groups of female Wister rats were used as control, irradiated (4 × 2 Gy), glucosamine (1 g/kg P.O), and glucosamine + irradiated group. The behavioral responses are estimated. The brain hippocampi of the rats are separated to evaluate ...
Source: Dose Response - November 29, 2023 Category: Drugs & Pharmacology Authors: Mai H Mekkawy Heba M Karam Marwa A Mohamed Dina M Lotfy Source Type: research
Evaluation of Glycogen Synthase Kinase Pathway for Assessing the Antidepressant-like Effect of Glucosamine as a Radioprotector in Rats: Behavioral and Biochemical Studies
Dose Response. 2023 Nov 21;21(4):15593258231217845. doi: 10.1177/15593258231217845. eCollection 2023 Oct-Dec.ABSTRACTRadiotherapy is a very important tool in the treatment of cancer; nevertheless, its side effects are a hindrance to its use. The present study is designed to evaluate glucosamine effects against radiation-induced brain oxidative stress and depression-like effect in rats. Four groups of female Wister rats were used as control, irradiated (4 × 2 Gy), glucosamine (1 g/kg P.O), and glucosamine + irradiated group. The behavioral responses are estimated. The brain hippocampi of the rats are separated to evaluate ...
Source: Dose Response - November 29, 2023 Category: Drugs & Pharmacology Authors: Mai H Mekkawy Heba M Karam Marwa A Mohamed Dina M Lotfy Source Type: research
Evaluation of Glycogen Synthase Kinase Pathway for Assessing the Antidepressant-like Effect of Glucosamine as a Radioprotector in Rats: Behavioral and Biochemical Studies
Dose Response. 2023 Nov 21;21(4):15593258231217845. doi: 10.1177/15593258231217845. eCollection 2023 Oct-Dec.ABSTRACTRadiotherapy is a very important tool in the treatment of cancer; nevertheless, its side effects are a hindrance to its use. The present study is designed to evaluate glucosamine effects against radiation-induced brain oxidative stress and depression-like effect in rats. Four groups of female Wister rats were used as control, irradiated (4 × 2 Gy), glucosamine (1 g/kg P.O), and glucosamine + irradiated group. The behavioral responses are estimated. The brain hippocampi of the rats are separated to evaluate ...
Source: Dose Response - November 29, 2023 Category: Drugs & Pharmacology Authors: Mai H Mekkawy Heba M Karam Marwa A Mohamed Dina M Lotfy Source Type: research
Evaluation of Glycogen Synthase Kinase Pathway for Assessing the Antidepressant-like Effect of Glucosamine as a Radioprotector in Rats: Behavioral and Biochemical Studies
Dose Response. 2023 Nov 21;21(4):15593258231217845. doi: 10.1177/15593258231217845. eCollection 2023 Oct-Dec.ABSTRACTRadiotherapy is a very important tool in the treatment of cancer; nevertheless, its side effects are a hindrance to its use. The present study is designed to evaluate glucosamine effects against radiation-induced brain oxidative stress and depression-like effect in rats. Four groups of female Wister rats were used as control, irradiated (4 × 2 Gy), glucosamine (1 g/kg P.O), and glucosamine + irradiated group. The behavioral responses are estimated. The brain hippocampi of the rats are separated to evaluate ...
Source: Dose Response - November 29, 2023 Category: Drugs & Pharmacology Authors: Mai H Mekkawy Heba M Karam Marwa A Mohamed Dina M Lotfy Source Type: research
Evaluation of Glycogen Synthase Kinase Pathway for Assessing the Antidepressant-like Effect of Glucosamine as a Radioprotector in Rats: Behavioral and Biochemical Studies
Dose Response. 2023 Nov 21;21(4):15593258231217845. doi: 10.1177/15593258231217845. eCollection 2023 Oct-Dec.ABSTRACTRadiotherapy is a very important tool in the treatment of cancer; nevertheless, its side effects are a hindrance to its use. The present study is designed to evaluate glucosamine effects against radiation-induced brain oxidative stress and depression-like effect in rats. Four groups of female Wister rats were used as control, irradiated (4 × 2 Gy), glucosamine (1 g/kg P.O), and glucosamine + irradiated group. The behavioral responses are estimated. The brain hippocampi of the rats are separated to evaluate ...
Source: Dose Response - November 29, 2023 Category: Drugs & Pharmacology Authors: Mai H Mekkawy Heba M Karam Marwa A Mohamed Dina M Lotfy Source Type: research
Evaluation of Glycogen Synthase Kinase Pathway for Assessing the Antidepressant-like Effect of Glucosamine as a Radioprotector in Rats: Behavioral and Biochemical Studies
Dose Response. 2023 Nov 21;21(4):15593258231217845. doi: 10.1177/15593258231217845. eCollection 2023 Oct-Dec.ABSTRACTRadiotherapy is a very important tool in the treatment of cancer; nevertheless, its side effects are a hindrance to its use. The present study is designed to evaluate glucosamine effects against radiation-induced brain oxidative stress and depression-like effect in rats. Four groups of female Wister rats were used as control, irradiated (4 × 2 Gy), glucosamine (1 g/kg P.O), and glucosamine + irradiated group. The behavioral responses are estimated. The brain hippocampi of the rats are separated to evaluate ...
Source: Dose Response - November 29, 2023 Category: Drugs & Pharmacology Authors: Mai H Mekkawy Heba M Karam Marwa A Mohamed Dina M Lotfy Source Type: research
Evaluation of Glycogen Synthase Kinase Pathway for Assessing the Antidepressant-like Effect of Glucosamine as a Radioprotector in Rats: Behavioral and Biochemical Studies
Dose Response. 2023 Nov 21;21(4):15593258231217845. doi: 10.1177/15593258231217845. eCollection 2023 Oct-Dec.ABSTRACTRadiotherapy is a very important tool in the treatment of cancer; nevertheless, its side effects are a hindrance to its use. The present study is designed to evaluate glucosamine effects against radiation-induced brain oxidative stress and depression-like effect in rats. Four groups of female Wister rats were used as control, irradiated (4 × 2 Gy), glucosamine (1 g/kg P.O), and glucosamine + irradiated group. The behavioral responses are estimated. The brain hippocampi of the rats are separated to evaluate ...
Source: Dose Response - November 29, 2023 Category: Drugs & Pharmacology Authors: Mai H Mekkawy Heba M Karam Marwa A Mohamed Dina M Lotfy Source Type: research
Evaluation of Glycogen Synthase Kinase Pathway for Assessing the Antidepressant-like Effect of Glucosamine as a Radioprotector in Rats: Behavioral and Biochemical Studies
Dose Response. 2023 Nov 21;21(4):15593258231217845. doi: 10.1177/15593258231217845. eCollection 2023 Oct-Dec.ABSTRACTRadiotherapy is a very important tool in the treatment of cancer; nevertheless, its side effects are a hindrance to its use. The present study is designed to evaluate glucosamine effects against radiation-induced brain oxidative stress and depression-like effect in rats. Four groups of female Wister rats were used as control, irradiated (4 × 2 Gy), glucosamine (1 g/kg P.O), and glucosamine + irradiated group. The behavioral responses are estimated. The brain hippocampi of the rats are separated to evaluate ...
Source: Dose Response - November 29, 2023 Category: Drugs & Pharmacology Authors: Mai H Mekkawy Heba M Karam Marwa A Mohamed Dina M Lotfy Source Type: research
Evaluation of Glycogen Synthase Kinase Pathway for Assessing the Antidepressant-like Effect of Glucosamine as a Radioprotector in Rats: Behavioral and Biochemical Studies
Dose Response. 2023 Nov 21;21(4):15593258231217845. doi: 10.1177/15593258231217845. eCollection 2023 Oct-Dec.ABSTRACTRadiotherapy is a very important tool in the treatment of cancer; nevertheless, its side effects are a hindrance to its use. The present study is designed to evaluate glucosamine effects against radiation-induced brain oxidative stress and depression-like effect in rats. Four groups of female Wister rats were used as control, irradiated (4 × 2 Gy), glucosamine (1 g/kg P.O), and glucosamine + irradiated group. The behavioral responses are estimated. The brain hippocampi of the rats are separated to evaluate ...
Source: Dose Response - November 29, 2023 Category: Drugs & Pharmacology Authors: Mai H Mekkawy Heba M Karam Marwa A Mohamed Dina M Lotfy Source Type: research
Development of an impedance-based biosensor for determination of IgG galactosylation levels
Biosens Bioelectron. 2023 Nov 14;245:115793. doi: 10.1016/j.bios.2023.115793. Online ahead of print.ABSTRACTThe glycan profile of immunoglobulin G (IgG) molecule and its changes are associated with a number of different diseases. Galactosylation of IgG was recently suggested as a potential biomarker for rheumatoid arthritis, inflammatory bowel disease and many cancers. In this paper, we propose a portable impedance-based biosensor that utilizes lectin array technology to detect glycans in IgG. Biotinylated Griffonia simplicifolia (GSL II) and Ricinus communis agglutinin I (RCA I) lectins were used in our biosensor design f...
Source: Biosensors and Bioelectronics - November 20, 2023 Category: Biotechnology Authors: Ahmed A Khorshed Oleksandra Savchenko Jing Liu Lian Shoute Jie Zeng Shifang Ren Jianxing Gu Naresh Jha Zhong Yang Jiucun Wang Li Jin Jie Chen Source Type: research
Systems-wide analysis of the ROK-family regulatory gene < em > rokL6 < /em > and its role in the control of glucosamine toxicity in < em > Streptomyces coelicolor < /em >
Appl Environ Microbiol. 2023 Nov 20:e0167423. doi: 10.1128/aem.01674-23. Online ahead of print.ABSTRACTCentral metabolism plays a key role in the control of growth and antibiotic production in streptomycetes. Specifically, aminosugars act as signaling molecules that affect development and antibiotic production, via metabolic interference with the global repressor DasR. While aminosugar metabolism directly connects to other major metabolic routes such as glycolysis and cell wall synthesis, several important aspects of their metabolism are yet unresolved. Accumulation of N-acetylglucosamine 6-phosphate or glucosamine 6-phosp...
Source: Applied and Environmental Microbiology - November 20, 2023 Category: Microbiology Authors: Chao Li Mia Urem Chao Du Le Zhang Gilles P van Wezel Source Type: research
Development of an impedance-based biosensor for determination of IgG galactosylation levels
Biosens Bioelectron. 2023 Nov 14;245:115793. doi: 10.1016/j.bios.2023.115793. Online ahead of print.ABSTRACTThe glycan profile of immunoglobulin G (IgG) molecule and its changes are associated with a number of different diseases. Galactosylation of IgG was recently suggested as a potential biomarker for rheumatoid arthritis, inflammatory bowel disease and many cancers. In this paper, we propose a portable impedance-based biosensor that utilizes lectin array technology to detect glycans in IgG. Biotinylated Griffonia simplicifolia (GSL II) and Ricinus communis agglutinin I (RCA I) lectins were used in our biosensor design f...
Source: Biosensors and Bioelectronics - November 20, 2023 Category: Biotechnology Authors: Ahmed A Khorshed Oleksandra Savchenko Jing Liu Lian Shoute Jie Zeng Shifang Ren Jianxing Gu Naresh Jha Zhong Yang Jiucun Wang Li Jin Jie Chen Source Type: research
Systems-wide analysis of the ROK-family regulatory gene < em > rokL6 < /em > and its role in the control of glucosamine toxicity in < em > Streptomyces coelicolor < /em >
Appl Environ Microbiol. 2023 Nov 20:e0167423. doi: 10.1128/aem.01674-23. Online ahead of print.ABSTRACTCentral metabolism plays a key role in the control of growth and antibiotic production in streptomycetes. Specifically, aminosugars act as signaling molecules that affect development and antibiotic production, via metabolic interference with the global repressor DasR. While aminosugar metabolism directly connects to other major metabolic routes such as glycolysis and cell wall synthesis, several important aspects of their metabolism are yet unresolved. Accumulation of N-acetylglucosamine 6-phosphate or glucosamine 6-phosp...
Source: Applied and Environmental Microbiology - November 20, 2023 Category: Microbiology Authors: Chao Li Mia Urem Chao Du Le Zhang Gilles P van Wezel Source Type: research
Systems-wide analysis of the ROK-family regulatory gene < em > rokL6 < /em > and its role in the control of glucosamine toxicity in < em > Streptomyces coelicolor < /em >
Appl Environ Microbiol. 2023 Nov 20:e0167423. doi: 10.1128/aem.01674-23. Online ahead of print.ABSTRACTCentral metabolism plays a key role in the control of growth and antibiotic production in streptomycetes. Specifically, aminosugars act as signaling molecules that affect development and antibiotic production, via metabolic interference with the global repressor DasR. While aminosugar metabolism directly connects to other major metabolic routes such as glycolysis and cell wall synthesis, several important aspects of their metabolism are yet unresolved. Accumulation of N-acetylglucosamine 6-phosphate or glucosamine 6-phosp...
Source: Applied and Environmental Microbiology - November 20, 2023 Category: Microbiology Authors: Chao Li Mia Urem Chao Du Le Zhang Gilles P van Wezel Source Type: research
Systems-wide analysis of the ROK-family regulatory gene < em > rokL6 < /em > and its role in the control of glucosamine toxicity in < em > Streptomyces coelicolor < /em >
Appl Environ Microbiol. 2023 Nov 20:e0167423. doi: 10.1128/aem.01674-23. Online ahead of print.ABSTRACTCentral metabolism plays a key role in the control of growth and antibiotic production in streptomycetes. Specifically, aminosugars act as signaling molecules that affect development and antibiotic production, via metabolic interference with the global repressor DasR. While aminosugar metabolism directly connects to other major metabolic routes such as glycolysis and cell wall synthesis, several important aspects of their metabolism are yet unresolved. Accumulation of N-acetylglucosamine 6-phosphate or glucosamine 6-phosp...
Source: Applied and Environmental Microbiology - November 20, 2023 Category: Microbiology Authors: Chao Li Mia Urem Chao Du Le Zhang Gilles P van Wezel Source Type: research
