Systems-wide analysis of the ROK-family regulatory gene < em > rokL6 < /em > and its role in the control of glucosamine toxicity in < em > Streptomyces coelicolor < /em >
Appl Environ Microbiol. 2023 Nov 20:e0167423. doi: 10.1128/aem.01674-23. Online ahead of print.ABSTRACTCentral metabolism plays a key role in the control of growth and antibiotic production in streptomycetes. Specifically, aminosugars act as signaling molecules that affect development and antibiotic production, via metabolic interference with the global repressor DasR. While aminosugar metabolism directly connects to other major metabolic routes such as glycolysis and cell wall synthesis, several important aspects of their metabolism are yet unresolved. Accumulation of N-acetylglucosamine 6-phosphate or glucosamine 6-phosp...
Source: Applied and Environmental Microbiology - November 20, 2023 Category: Microbiology Authors: Chao Li Mia Urem Chao Du Le Zhang Gilles P van Wezel Source Type: research
The chemical structure of the O-antigen and enterobacterial common antigen of Pectobacterium brasiliense NCPPB 4609 < sup > TS < /sup >
Carbohydr Res. 2023 Nov 10;534:108983. doi: 10.1016/j.carres.2023.108983. Online ahead of print.ABSTRACTPectobacterium brasiliense is a widely distributed phytopathogenic bacterium that causes diseases such as soft rot and blackleg, leading to significant yield losses in potatoes as well as other vegetables and ornamental plants. Lipopolysaccharide (LPS) is an important virulence factor that plays an essential role in colonisation of plant tissues and overcoming the host defence mechanisms. The O-polysaccharide from the LPS of P. brasiliense strain NCPPB 4609TS (=CFBP 6617TS = LMG 21371TS = IFB5390) was structurally charac...
Source: Carbohydrate Research - November 19, 2023 Category: Genetics & Stem Cells Authors: Agnieszka Kowalczyk Natalia Kaczy ńska Agata Motyka-Pomagruk Wojciech Śledź Ewa Łojkowska Zbigniew Kaczy ński Source Type: research
Berberine protects mice against type 2 diabetes by promoting PPAR γ-FGF21-GLUT2-regulated insulin sensitivity and glucose/lipid homeostasis
Biochem Pharmacol. 2023 Nov 16:115928. doi: 10.1016/j.bcp.2023.115928. Online ahead of print.ABSTRACTType 2 diabetes (T2D) is a chronic, burdensome disease that is characterized by disordered insulin sensitivity and disturbed glucose/lipid homeostasis. Berberine (BBR) has multiple therapeutic actions on T2D, including regulation of glucose and lipid metabolism, improvement of insulin sensitivity and energy expenditure. Recently, the function of BBR on fibroblast growth factor 21 (FGF21) has been identified. However, if BBR ameliorates T2D through FGF21, the underlying mechanisms remain unknown. Herein, we used T2D wild typ...
Source: Biochemical Pharmacology - November 18, 2023 Category: Drugs & Pharmacology Authors: Yi Chen Qi Li Shiwei Zhao Lei Sun Zequn Yin Xiaolin Wang Xiaoju Li Yasuko Iwakiri Jihong Han Yajun Duan Source Type: research
Development of a two-enzyme system in Aspergillus niger for efficient production of N-acetyl- β-D-glucosamine from powdery chitin
This study may provide an excellent chitinase as well as a double enzyme cocktail system for efficient biological conversion of chitin materials.PMID:37972902 | DOI:10.1016/j.biortech.2023.130024 (Source: Bioresource Technology)
Source: Bioresource Technology - November 16, 2023 Category: Biotechnology Authors: Susu Han Yibing Xue Qiaojuan Yan Zhengqiang Jiang Shaoqing Yang Source Type: research
Development of a two-enzyme system in Aspergillus niger for efficient production of N-acetyl- β-D-glucosamine from powdery chitin
This study may provide an excellent chitinase as well as a double enzyme cocktail system for efficient biological conversion of chitin materials.PMID:37972902 | DOI:10.1016/j.biortech.2023.130024 (Source: Bioresource Technology)
Source: Bioresource Technology - November 16, 2023 Category: Biotechnology Authors: Susu Han Yibing Xue Qiaojuan Yan Zhengqiang Jiang Shaoqing Yang Source Type: research
Glucosamine increases macrophage lipid accumulation by regulating the mammalian target of rapamycin signaling pathway
BMB Rep. 2023 Nov 14:6039. Online ahead of print.ABSTRACTElevation of blood glucose is associated with increased risk of atherosclerosis development. Data from the current study showed that glucosamine (GlcN), a normal glucose metabolite of the hexosamine biosynthetic pathway (HBP), promoted lipid accumulation in RAW264.7 macrophage cells. Oleic acid- and lipopolysaccharide (LPS)-induced lipid accumulation was further enhanced by GlcN in RAW264.7 cells, although the rate of fatty acid uptake was not significantly changed. GlcN increased acetyl CoA carboxylase (ACC), fatty acid synthase (FAS), scavenger receptor class A, li...
Source: BMB Reports - November 15, 2023 Category: Biochemistry Authors: Sang-Min Kim Dong Yeol Kim Jiwon Park Young-Ah Moon Inn-Oc Han Source Type: research
Glucosamine increases macrophage lipid accumulation by regulating the mammalian target of rapamycin signaling pathway
BMB Rep. 2023 Nov 14:6039. Online ahead of print.ABSTRACTElevation of blood glucose is associated with increased risk of atherosclerosis development. Data from the current study showed that glucosamine (GlcN), a normal glucose metabolite of the hexosamine biosynthetic pathway (HBP), promoted lipid accumulation in RAW264.7 macrophage cells. Oleic acid- and lipopolysaccharide (LPS)-induced lipid accumulation was further enhanced by GlcN in RAW264.7 cells, although the rate of fatty acid uptake was not significantly changed. GlcN increased acetyl CoA carboxylase (ACC), fatty acid synthase (FAS), scavenger receptor class A, li...
Source: Atherosclerosis - November 15, 2023 Category: Cardiology Authors: Sang-Min Kim Dong Yeol Kim Jiwon Park Young-Ah Moon Inn-Oc Han Source Type: research
Glucosamine increases macrophage lipid accumulation by regulating the mammalian target of rapamycin signaling pathway
BMB Rep. 2023 Nov 14:6039. Online ahead of print.ABSTRACTElevation of blood glucose is associated with increased risk of atherosclerosis development. Data from the current study showed that glucosamine (GlcN), a normal glucose metabolite of the hexosamine biosynthetic pathway (HBP), promoted lipid accumulation in RAW264.7 macrophage cells. Oleic acid- and lipopolysaccharide (LPS)-induced lipid accumulation was further enhanced by GlcN in RAW264.7 cells, although the rate of fatty acid uptake was not significantly changed. GlcN increased acetyl CoA carboxylase (ACC), fatty acid synthase (FAS), scavenger receptor class A, li...
Source: BMB Reports - November 15, 2023 Category: Biochemistry Authors: Sang-Min Kim Dong Yeol Kim Jiwon Park Young-Ah Moon Inn-Oc Han Source Type: research
Glucosamine increases macrophage lipid accumulation by regulating the mammalian target of rapamycin signaling pathway
BMB Rep. 2023 Nov 14:6039. Online ahead of print.ABSTRACTElevation of blood glucose is associated with increased risk of atherosclerosis development. Data from the current study showed that glucosamine (GlcN), a normal glucose metabolite of the hexosamine biosynthetic pathway (HBP), promoted lipid accumulation in RAW264.7 macrophage cells. Oleic acid- and lipopolysaccharide (LPS)-induced lipid accumulation was further enhanced by GlcN in RAW264.7 cells, although the rate of fatty acid uptake was not significantly changed. GlcN increased acetyl CoA carboxylase (ACC), fatty acid synthase (FAS), scavenger receptor class A, li...
Source: Atherosclerosis - November 15, 2023 Category: Cardiology Authors: Sang-Min Kim Dong Yeol Kim Jiwon Park Young-Ah Moon Inn-Oc Han Source Type: research
Glucosamine increases macrophage lipid accumulation by regulating the mammalian target of rapamycin signaling pathway
BMB Rep. 2023 Nov 14:6039. Online ahead of print.ABSTRACTElevation of blood glucose is associated with increased risk of atherosclerosis development. Data from the current study showed that glucosamine (GlcN), a normal glucose metabolite of the hexosamine biosynthetic pathway (HBP), promoted lipid accumulation in RAW264.7 macrophage cells. Oleic acid- and lipopolysaccharide (LPS)-induced lipid accumulation was further enhanced by GlcN in RAW264.7 cells, although the rate of fatty acid uptake was not significantly changed. GlcN increased acetyl CoA carboxylase (ACC), fatty acid synthase (FAS), scavenger receptor class A, li...
Source: BMB Reports - November 15, 2023 Category: Biochemistry Authors: Sang-Min Kim Dong Yeol Kim Jiwon Park Young-Ah Moon Inn-Oc Han Source Type: research
Glucosamine increases macrophage lipid accumulation by regulating the mammalian target of rapamycin signaling pathway
BMB Rep. 2023 Nov 14:6039. Online ahead of print.ABSTRACTElevation of blood glucose is associated with increased risk of atherosclerosis development. Data from the current study showed that glucosamine (GlcN), a normal glucose metabolite of the hexosamine biosynthetic pathway (HBP), promoted lipid accumulation in RAW264.7 macrophage cells. Oleic acid- and lipopolysaccharide (LPS)-induced lipid accumulation was further enhanced by GlcN in RAW264.7 cells, although the rate of fatty acid uptake was not significantly changed. GlcN increased acetyl CoA carboxylase (ACC), fatty acid synthase (FAS), scavenger receptor class A, li...
Source: BMB Reports - November 15, 2023 Category: Biochemistry Authors: Sang-Min Kim Dong Yeol Kim Jiwon Park Young-Ah Moon Inn-Oc Han Source Type: research
Glucosamine increases macrophage lipid accumulation by regulating the mammalian target of rapamycin signaling pathway
BMB Rep. 2023 Nov 14:6039. Online ahead of print.ABSTRACTElevation of blood glucose is associated with increased risk of atherosclerosis development. Data from the current study showed that glucosamine (GlcN), a normal glucose metabolite of the hexosamine biosynthetic pathway (HBP), promoted lipid accumulation in RAW264.7 macrophage cells. Oleic acid- and lipopolysaccharide (LPS)-induced lipid accumulation was further enhanced by GlcN in RAW264.7 cells, although the rate of fatty acid uptake was not significantly changed. GlcN increased acetyl CoA carboxylase (ACC), fatty acid synthase (FAS), scavenger receptor class A, li...
Source: BMB Reports - November 15, 2023 Category: Biochemistry Authors: Sang-Min Kim Dong Yeol Kim Jiwon Park Young-Ah Moon Inn-Oc Han Source Type: research
Glucosamine increases macrophage lipid accumulation by regulating the mammalian target of rapamycin signaling pathway
BMB Rep. 2023 Nov 14:6039. Online ahead of print.ABSTRACTElevation of blood glucose is associated with increased risk of atherosclerosis development. Data from the current study showed that glucosamine (GlcN), a normal glucose metabolite of the hexosamine biosynthetic pathway (HBP), promoted lipid accumulation in RAW264.7 macrophage cells. Oleic acid- and lipopolysaccharide (LPS)-induced lipid accumulation was further enhanced by GlcN in RAW264.7 cells, although the rate of fatty acid uptake was not significantly changed. GlcN increased acetyl CoA carboxylase (ACC), fatty acid synthase (FAS), scavenger receptor class A, li...
Source: BMB Reports - November 15, 2023 Category: Biochemistry Authors: Sang-Min Kim Dong Yeol Kim Jiwon Park Young-Ah Moon Inn-Oc Han Source Type: research
Glucosamine increases macrophage lipid accumulation by regulating the mammalian target of rapamycin signaling pathway
BMB Rep. 2023 Nov 14:6039. Online ahead of print.ABSTRACTElevation of blood glucose is associated with increased risk of atherosclerosis development. Data from the current study showed that glucosamine (GlcN), a normal glucose metabolite of the hexosamine biosynthetic pathway (HBP), promoted lipid accumulation in RAW264.7 macrophage cells. Oleic acid- and lipopolysaccharide (LPS)-induced lipid accumulation was further enhanced by GlcN in RAW264.7 cells, although the rate of fatty acid uptake was not significantly changed. GlcN increased acetyl CoA carboxylase (ACC), fatty acid synthase (FAS), scavenger receptor class A, li...
Source: BMB Reports - November 15, 2023 Category: Biochemistry Authors: Sang-Min Kim Dong Yeol Kim Jiwon Park Young-Ah Moon Inn-Oc Han Source Type: research
Glucosamine increases macrophage lipid accumulation by regulating the mammalian target of rapamycin signaling pathway
BMB Rep. 2023 Nov 14:6039. Online ahead of print.ABSTRACTElevation of blood glucose is associated with increased risk of atherosclerosis development. Data from the current study showed that glucosamine (GlcN), a normal glucose metabolite of the hexosamine biosynthetic pathway (HBP), promoted lipid accumulation in RAW264.7 macrophage cells. Oleic acid- and lipopolysaccharide (LPS)-induced lipid accumulation was further enhanced by GlcN in RAW264.7 cells, although the rate of fatty acid uptake was not significantly changed. GlcN increased acetyl CoA carboxylase (ACC), fatty acid synthase (FAS), scavenger receptor class A, li...
Source: BMB Reports - November 15, 2023 Category: Biochemistry Authors: Sang-Min Kim Dong Yeol Kim Jiwon Park Young-Ah Moon Inn-Oc Han Source Type: research
