Synthesis, urease inhibitory and anticancer evaluation of glucosamine-sulfonylurea conjugates
AbstractUrease catalyses the hydrolysis of urea to ammonia and carbon dioxide. This enzyme is important in the virulence of several human pathogens and urease activity in soil can cleave urea fertilisers prematurely, leading to waste of agricultural nitrogen. A series of arylsulfonylurea-glucosamine hybrid compounds were synthesised. Reaction of arylsulfonamides with phenyl chloroformate and 4-dimethylaminopyridine gave either phenyl N-(2,4-arylsulfonyl)carbamate 4-dimethylaminopyridinium salts or N-(4-arylsulfonyl)-4-dimethylaminopyridinium-1-carboxamide inner salts, depending on the substitution on the arylsulfonamide. B...
Source: Medicinal Chemistry Research - March 7, 2024 Category: Chemistry Source Type: research
Resveratrol alleviates inflammatory bowel disease by inhibiting JAK2/STAT3 pathway activity via the reduction of O-GlcNAcylation of STAT3 in intestinal epithelial cells
Toxicol Appl Pharmacol. 2024 Mar 2:116882. doi: 10.1016/j.taap.2024.116882. Online ahead of print.ABSTRACTThe role of O-linked N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) in the pathogenesis of inflammatory bowel disease (IBD) has been increasingly highlighted in recent studies. It's been reported that signal transducer and activator of transcription 3 (STAT3) O-GlcNAcylation can affect the activity of the Janus kinase2 (JAK2)/STAT3 pathway.Our recent study showed that resveratrol repairsIBDin mice.On this basis,the present study aimed to explore whether the mechanism of IBD repair by resveratrol is assoc...
Source: Toxicology and Applied Pharmacology - March 4, 2024 Category: Toxicology Authors: Zhang Yaqin Wu Kehan Zhu Yi Wang Naijian Qiu Wei Mao Fei Source Type: research
Sugar Utilization-Associated Food-Grade Selection Markers in Lactic Acid Bacteria and Yeast
Pol J Microbiol. 2024 Mar 4;73(1):3-10. doi: 10.33073/pjm-2024-011. eCollection 2024 Mar 1.ABSTRACTThis comprehensive review explores the development of food-grade selection markers in lactic acid bacteria and yeast; some of their strains are precisely defined as safe microorganisms and are crucial in the food industry. Lactic acid bacteria, known for their ability to ferment carbohydrates into lactic acid, provide essential nutrients and contribute to immune responses. With its strong fermentation capabilities and rich nutritional profile, yeast finds use in various food products. Genetic engineering in these microorganis...
Source: Polish Journal of Microbiology - March 4, 2024 Category: Microbiology Authors: Zhiwen Liang Ke Zheng Guifeng Xie Xiongsheng Luo Huangjin Li Source Type: research
Resveratrol alleviates inflammatory bowel disease by inhibiting JAK2/STAT3 pathway activity via the reduction of O-GlcNAcylation of STAT3 in intestinal epithelial cells
Toxicol Appl Pharmacol. 2024 Mar 2;484:116882. doi: 10.1016/j.taap.2024.116882. Online ahead of print.ABSTRACTThe role of O-linked N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) in the pathogenesis of inflammatory bowel disease (IBD) has been increasingly highlighted in recent studies. It's been reported that signal transducer and activator of transcription 3 (STAT3) O-GlcNAcylation can affect the activity of the Janus kinase2 (JAK2)/STAT3 pathway.Our recent study showed that resveratrol repairsIBDin mice.On this basis,the present study aimed to explore whether the mechanism of IBD repair by resveratrol is a...
Source: Toxicology and Applied Pharmacology - March 4, 2024 Category: Toxicology Authors: Zhang Yaqin Wu Kehan Zhu Yi Wang Naijian Qiu Wei Mao Fei Source Type: research
Sugar Utilization-Associated Food-Grade Selection Markers in Lactic Acid Bacteria and Yeast
Pol J Microbiol. 2024 Mar 4;73(1):3-10. doi: 10.33073/pjm-2024-011. eCollection 2024 Mar 1.ABSTRACTThis comprehensive review explores the development of food-grade selection markers in lactic acid bacteria and yeast; some of their strains are precisely defined as safe microorganisms and are crucial in the food industry. Lactic acid bacteria, known for their ability to ferment carbohydrates into lactic acid, provide essential nutrients and contribute to immune responses. With its strong fermentation capabilities and rich nutritional profile, yeast finds use in various food products. Genetic engineering in these microorganis...
Source: Polish Journal of Microbiology - March 4, 2024 Category: Microbiology Authors: Zhiwen Liang Ke Zheng Guifeng Xie Xiongsheng Luo Huangjin Li Source Type: research
