Diosgenyl glucosamine conjugates increase pro-apoptotic and selective activities in cancer cell lines
CONCLUSIONS: Altogether, these results demonstrate that diosgenin glucosamine compounds exert an antiproliferative effect on cancer cell lines and induce apoptotic effects more efficiently than diosgenin alone without affecting non-tumour cells.SIGNIFICANCE: This study evidences the pro-apoptotic and selective activities of diosgenyl glucosamine compounds in cancer cell lines.PMID:38408271 | DOI:10.1111/boc.202300052 (Source: Biology of the Cell)
Source: Biology of the Cell - February 26, 2024 Category: Cytology Authors: Mart ínez Mata Sergio Iván Escobar S ánchez María Luisa L ópez Muñoz Hugo Hilario Mart ínez Jazmín Ciciolil Sandoval Ram írez Jesús Aparicio S ánchez Uriel Yair S ánchez Sánchez Luis Source Type: research
Diosgenyl glucosamine conjugates increase pro-apoptotic and selective activities in cancer cell lines
CONCLUSIONS: Altogether, these results demonstrate that diosgenin glucosamine compounds exert an antiproliferative effect on cancer cell lines and induce apoptotic effects more efficiently than diosgenin alone without affecting non-tumour cells.SIGNIFICANCE: This study evidences the pro-apoptotic and selective activities of diosgenyl glucosamine compounds in cancer cell lines.PMID:38408271 | DOI:10.1111/boc.202300052 (Source: Biology of the Cell)
Source: Biology of the Cell - February 26, 2024 Category: Cytology Authors: Mart ínez Mata Sergio Iván Escobar S ánchez María Luisa L ópez Muñoz Hugo Hilario Mart ínez Jazmín Ciciolil Sandoval Ram írez Jesús Aparicio S ánchez Uriel Yair S ánchez Sánchez Luis Source Type: research
Diosgenyl glucosamine conjugates increase pro-apoptotic and selective activities in cancer cell lines
CONCLUSIONS: Altogether, these results demonstrate that diosgenin glucosamine compounds exert an antiproliferative effect on cancer cell lines and induce apoptotic effects more efficiently than diosgenin alone without affecting non-tumour cells.SIGNIFICANCE: This study evidences the pro-apoptotic and selective activities of diosgenyl glucosamine compounds in cancer cell lines.PMID:38408271 | DOI:10.1111/boc.202300052 (Source: Biology of the Cell)
Source: Biology of the Cell - February 26, 2024 Category: Cytology Authors: Mart ínez Mata Sergio Iván Escobar S ánchez María Luisa L ópez Muñoz Hugo Hilario Mart ínez Jazmín Ciciolil Sandoval Ram írez Jesús Aparicio S ánchez Uriel Yair S ánchez Sánchez Luis Source Type: research
Diosgenyl glucosamine conjugates increase pro-apoptotic and selective activities in cancer cell lines
CONCLUSIONS: Altogether, these results demonstrate that diosgenin glucosamine compounds exert an antiproliferative effect on cancer cell lines and induce apoptotic effects more efficiently than diosgenin alone without affecting non-tumour cells.SIGNIFICANCE: This study evidences the pro-apoptotic and selective activities of diosgenyl glucosamine compounds in cancer cell lines.PMID:38408271 | DOI:10.1111/boc.202300052 (Source: Biology of the Cell)
Source: Biology of the Cell - February 26, 2024 Category: Cytology Authors: Mart ínez Mata Sergio Iván Escobar S ánchez María Luisa L ópez Muñoz Hugo Hilario Mart ínez Jazmín Ciciolil Sandoval Ram írez Jesús Aparicio S ánchez Uriel Yair S ánchez Sánchez Luis Source Type: research
Designing, DFT, biological, & amp; molecular docking analysis of new Iron(III) & amp; copper(II) complexes incorporating 1-{[-(2-Hydroxyphenyl)methylene]amino}-5,5-diphenylimidazolidine-2,4-dione (PHNS)
Comput Biol Chem. 2024 Feb 13;109:108031. doi: 10.1016/j.compbiolchem.2024.108031. Online ahead of print.ABSTRACTThe exploration encompassed the synthesis and characterization of two innovative complexes, namely FePHNS and CuPHNS, employing a diverse array of analytical techniques such as elemental analysis, infrared and ultraviolet-visible spectroscopy, mass spectrometry, molar conductivity measurements, magnetic susceptibility assessments, and thermal analysis (TGA). In the spectral domain, infrared spectroscopy substantiated the tridentate ONS coordination of the PHNS ligand to the central metal atom. Thermal analysis o...
Source: Computational Biology and Chemistry - February 21, 2024 Category: Bioinformatics Authors: Mai M Khalaf Hany M Abd El-Lateef Mohamed Gouda Antar A Abdelhamid Mohamed Abdelbaset Abdulelah H Alsulami Mohammed N Almarri Aly Abdou Source Type: research
Gelatin/O-carboxymethyl chitosan injectable self-healing hydrogels for ibuprofen and naproxen dual release
Int J Biol Macromol. 2024 Feb 16:130266. doi: 10.1016/j.ijbiomac.2024.130266. Online ahead of print.ABSTRACTRecently, a significantly greater clinical benefit has been reported with a combination of glucosamine sulfate and nonsteroidal anti-inflammatory drugs (NSAIDs) compared to either treatment alone for the growing osteoarthritis (OA) disease. So, this study introduces hydrogels using O-carboxymethyl chitosan (O-CMC, structurally akin glucosamine glycan), and Gelatin type A (GA) in a 1:2 ratio with β-glycerophosphate (βGPh) at varying percentages (5 %, 12.5 %, and 15 %). We show that hydrogel properties, adaptable for...
Source: International Journal of Biological Macromolecules - February 18, 2024 Category: Biochemistry Authors: Mahshad Mohseni Parvin Shokrollahi Jalal Barzin Source Type: research
Gelatin/O-carboxymethyl chitosan injectable self-healing hydrogels for ibuprofen and naproxen dual release
Int J Biol Macromol. 2024 Feb 16:130266. doi: 10.1016/j.ijbiomac.2024.130266. Online ahead of print.ABSTRACTRecently, a significantly greater clinical benefit has been reported with a combination of glucosamine sulfate and nonsteroidal anti-inflammatory drugs (NSAIDs) compared to either treatment alone for the growing osteoarthritis (OA) disease. So, this study introduces hydrogels using O-carboxymethyl chitosan (O-CMC, structurally akin glucosamine glycan), and Gelatin type A (GA) in a 1:2 ratio with β-glycerophosphate (βGPh) at varying percentages (5 %, 12.5 %, and 15 %). We show that hydrogel properties, adaptable for...
Source: International Journal of Biological Macromolecules - February 18, 2024 Category: Biochemistry Authors: Mahshad Mohseni Parvin Shokrollahi Jalal Barzin Source Type: research
Ultrasound-assisted polysaccharide extraction from Fritillaria ussuriensis Maxim. and its structural characterization, antioxidant and immunological activity
Ultrason Sonochem. 2024 Feb 5;103:106800. doi: 10.1016/j.ultsonch.2024.106800. Online ahead of print.ABSTRACTFritillaria ussuriensis Maxim. (F.M.) has been widely used in both food and medication for more than 2000 years. In order to achieve its comprehensive utilization and investigate the structural characterization and biology activity, response surface methodology (RSM) was used to optimize the ultrasound-assisted extraction conditions of F.M. polysaccharides. The optimal extraction conditions were ultrasonic power of 174.2 W, ratio of liquid to material of 40.7 mL/g and ultrasonic time of 82.0 min. In addition, a neut...
Source: Ultrasonics Sonochemistry - February 15, 2024 Category: Chemistry Authors: Shuang Jiang Qianbo Wang Zhibin Wang Gilwa Borjigin Jiahui Sun Yue Zhao Qi Li Xuepeng Shi Syed Faizan Ali Shah Xiaotong Wang Chunli Gan Yanli Wu Xiaodan Song Qian Li Chunjuan Yang Source Type: research
Ultrasound-assisted polysaccharide extraction from Fritillaria ussuriensis Maxim. and its structural characterization, antioxidant and immunological activity
Ultrason Sonochem. 2024 Feb 5;103:106800. doi: 10.1016/j.ultsonch.2024.106800. Online ahead of print.ABSTRACTFritillaria ussuriensis Maxim. (F.M.) has been widely used in both food and medication for more than 2000 years. In order to achieve its comprehensive utilization and investigate the structural characterization and biology activity, response surface methodology (RSM) was used to optimize the ultrasound-assisted extraction conditions of F.M. polysaccharides. The optimal extraction conditions were ultrasonic power of 174.2 W, ratio of liquid to material of 40.7 mL/g and ultrasonic time of 82.0 min. In addition, a neut...
Source: Ultrasonics Sonochemistry - February 15, 2024 Category: Chemistry Authors: Shuang Jiang Qianbo Wang Zhibin Wang Gilwa Borjigin Jiahui Sun Yue Zhao Qi Li Xuepeng Shi Syed Faizan Ali Shah Xiaotong Wang Chunli Gan Yanli Wu Xiaodan Song Qian Li Chunjuan Yang Source Type: research
Cancers, Vol. 16, Pages 695: Hypoxia-Derived Exosomes Promote Lung Adenocarcinoma by Regulating HS3ST1-GPC4-Mediated Glycolysis
Conclusions: The hypoxia-derived exosomal lncRNA OIP5-AS1 promotes LUAD by regulating HS3ST1-GPC4-mediated glycolysis via miR-200c-3p. (Source: Cancers)
Source: Cancers - February 6, 2024 Category: Cancer & Oncology Authors: Xianxiu Ji Ren Zhu Caixia Gao Huikang Xie Xiaomei Gong Jie Luo Tags: Article Source Type: research
Caffeine-induced protein kinase A activation restores cognitive deficits induced by sleep deprivation by regulating < em > O < /em > -GlcNAc cycling in adult zebrafish
In this study, intraperitoneal caffeine administration significantly ameliorated the learning and memory (L/M) deficits induced by SD and reduced aggressive behaviors in adult zebrafish. SD led to a reduction in PKA phosphorylation, phosphorylated-cAMP response element-binding protein (p-CREB) and c-Fos expression in zebrafish brain. Notably, these alterations were effectively reversed by caffeine. Additionally, caffeine mitigated neuroinflammation induced by SD, as evident from suppression of the SD-mediated increase in GFAP and NF-κB activation. Caffeine restored normal O-GlcNAcylation and O-GlcNAc transferase (OGT) lev...
Source: Am J Physiol Cell Ph... - February 5, 2024 Category: Cytology Authors: Thuy-Duong Thi Tran Jiwon Park Dong Yeol Kim Inn-Oc Han Source Type: research
Caffeine-induced protein kinase A activation restores cognitive deficits induced by sleep deprivation by regulating < em > O < /em > -GlcNAc cycling in adult zebrafish
In this study, intraperitoneal caffeine administration significantly ameliorated the learning and memory (L/M) deficits induced by SD and reduced aggressive behaviors in adult zebrafish. SD led to a reduction in PKA phosphorylation, phosphorylated-cAMP response element-binding protein (p-CREB) and c-Fos expression in zebrafish brain. Notably, these alterations were effectively reversed by caffeine. Additionally, caffeine mitigated neuroinflammation induced by SD, as evident from suppression of the SD-mediated increase in GFAP and NF-κB activation. Caffeine restored normal O-GlcNAcylation and O-GlcNAc transferase (OGT) lev...
Source: American Journal of Physiology. Cell Physiology - February 5, 2024 Category: Cytology Authors: Thuy-Duong Thi Tran Jiwon Park Dong Yeol Kim Inn-Oc Han Source Type: research
Inclusion of a < em > Bacillus < /em > -based probiotic in non-starch polysaccharides-rich broiler diets
In conclusion, the applied Bacillus strains appeared to have a limited capacity to produce arabinoxylan-degrading enzymes and were only partially effective in mitigating the negative impacts of rye arabinoxylans on broilers.PMID:38303140 | DOI:10.1080/1745039X.2023.2284530 (Source: Archives of Animal Nutrition)
Source: Archives of Animal Nutrition - February 2, 2024 Category: Nutrition Authors: Farshad Goodarzi Boroojeni Yada Duangnumsawang Damian J ózefiak Marta Pachocka Dorthe Sandvang J ürgen Zentek Source Type: research
Isolation, Purification, and Properties of Glycoprotein from Sheep Intestinal Mucous Membrane
A glycoprotein inhibiting the growth of colon cancer cells was isolated from sheep intestinal mucous membrane. The glycoprotein, designated IGP, was purified by a combination of ion-exchange chromatography over DEAE-650M and gel-filtration over HW-55F. Purified IGP had a molecular mass of ~60 kDa and consisted of 68.72 ± 2.10% protein and 32.09 ± 1.52% carbohydrates. The monosaccharide composition of the carbohydrate part consisted of glucose (31.28% of the total carbohydrate content), glucosamine (22.28%) andN-acetylgalactosamine (19.38%), mannose (11.14%), fucose (11.28%), and rhamnose (4.64%). The amino-acid compositi...
Source: Chemistry of Natural Compounds - January 30, 2024 Category: Chemistry Source Type: research
Microbial production of N-acetyl-D-glucosamine (GlcNAc) for versatile applications: Biotechnological strategies for green process development
Carbohydr Res. 2024 Jan 17;536:109039. doi: 10.1016/j.carres.2024.109039. Online ahead of print.ABSTRACTN-acetyl-d-glucosamine (GlcNAc) is a commercially important amino sugar for its wide range of applications in pharmaceutical, food, cosmetics and biofuel industries. In nature, GlcNAc is polymerised into chitin biopolymer, which is one of the major constituents of fungal cell wall and outer shells of crustaceans. Sea food processing industries generate a large volume of chitin as biopolymeric waste. Because of its high abundance, chitinaceous shellfish wastes have been exploited as one of the major precursor substrates o...
Source: Carbohydrate Research - January 26, 2024 Category: Genetics & Stem Cells Authors: Sancharini Das Chiranjit Chowdhury S Pavan Kumar Debasis Roy Suresh W Gosavi Ramkrishna Sen Source Type: research
