Genetically determined type 1 diabetes mellitus and risk of osteoporosis
CONCLUSIONS: This study shows a causal relationship between T1DM and the risk of some sites of OP (FN-BMD, LS-BMD), allowing for continued research to discover the clinical and experimental mechanisms of T1DM and OP. It also contributes to the recommendation if patients with T1DM need targeted care to promote bone health and timely prevention of osteoporosis.PMID:38636571 | DOI:10.1016/j.exger.2024.112434 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 18, 2024 Category: Geriatrics Authors: Ting Cheng Jia-Lin Hou Zi-Yi Han Xin-Lei Geng Yao-Chen Zhang Ke-Yi Fan Liu Liu He-Yi Zhang Yue-Hong Huo Xiao-Feng Li Sheng-Xiao Zhang Source Type: research
Influence of age and sex on physical, cardiac electrical and functional alterations in progressive hyperoxia treatment: A time course study in a murine model
In this study, both young and aged mice (male and female) underwent 72 h of hyperoxia exposure and were monitored at 24-hour intervals for cardiac electrophysiological and functional parameters using ECG and electrocardiogram data. Our analysis showed that young male mice experienced significant weight loss as well as significant lung edema by 48 h. Although young male mice were highly susceptible to physical changes, they were resistant to early cardiac functional and electrophysiological changes compared to the other groups. Both young and aged female and aged males developed functional impairments by 24 h of hyperoxia e...
Source: Experimental Gerontology - April 18, 2024 Category: Geriatrics Authors: Yashwant Ayalasomayajula Anagha Hesaraghatta Neha Dantuluri Jenna Yassine Faizan Saleem Hussein Mansour Chayapatou Chayawatto Nishank Rangarajan Sashank Rangarajan Smrithi Krishnan Siva Kumar Panguluri Source Type: research
LncRNA NEAT1 promotes MPP+ induced injury of PC12 cells and accelerates the progression of Parkinson's disease in mice through FUS mediated inhibition of PI3K/AKT/mTOR signalling pathway
In conclusion, NEAT1 is involved in PD progression through FUS-mediated inhibition of the PI3K/AKT/mTOR signalling pathway.PMID:38636570 | DOI:10.1016/j.exger.2024.112436 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 18, 2024 Category: Geriatrics Authors: Yonghui Wang Zhuo Li Jiwen Li Chao Sun Source Type: research
The role of Ottawa ankle rules in geriatric emergency department visits
CONCLUSION: This study demonstrates that the OAR is highly sensitive in the geriatric population but shows some limitations in terms of specificity and positive predictive value. These results support the effectiveness of using the OAR in evaluating ankle injuries in the geriatric population but also highlight the need for cautious application due to the potential for false-positive outcomes.PMID:38634845 | DOI:10.14744/tjtes.2024.39240 (Source: Turkish Journal of Trauma and Emergency Surgery : TJTES)
Source: Turkish Journal of Trauma and Emergency Surgery : TJTES - April 18, 2024 Category: Emergency Medicine Authors: Avni Uygar Seyhan Rohat Ak Faruk Şimşek Senem Ayvac ı O ğuzhan Açıkgöz Source Type: research
A Two-Phased Pilot Study Evaluating the Feasibility and Acceptability of the Cognitively Enriched Walking Program "Take a Walk with Your Brain" for Older Adults
J Aging Res. 2024 Apr 10;2024:2438067. doi: 10.1155/2024/2438067. eCollection 2024.ABSTRACTGiven the aging population, finding solutions to retain optimal cognitive capacity is a research priority. The potential of physical activity to reduce the risk of cognitive decline and to enhance cognitive functioning is established. Combining physical with cognitive activity has been put forward as a potentially even more effective way to promote healthy cognitive aging. Most studies on combined interventions have however been conducted in laboratory settings. This paper reports on a two-phased pilot study evaluating the acceptabil...
Source: Journal of Aging Research - April 18, 2024 Category: Geriatrics Authors: Pauline Hotterbeex Melanie Beeckman Pieter-Jan Marent Julie Latomme Fien De Block Lauren De Baets Sebastien Chastin Greet Cardon Jannique G Z van Uffelen Source Type: research
Efficacy and Safety of Computed Tomography-Guided Percutaneous Balloon Compression under Local Anesthesia for Recurrent Trigeminal Neuralgia: A Prospective Study
CONCLUSIONS: CT-guided PBC under local anesthesia is safe and effective for the treatment of recurrent TN and thus acts as an effective alternative for geriatric patients and those with high-risk factors.PMID:38633819 | PMC:PMC11022504 | DOI:10.1155/2024/8885274 (Source: Pain Research and Management)
Source: Pain Research and Management - April 18, 2024 Category: Anesthesiology Authors: Lulu Xi Xiaohui Liu Hongchen Shi Wenbiao Han Liqin Gao Li Wang Junpeng Liu Yue Ren Yuanyuan Du Guangzhao Liu Source Type: research
Genetic Susceptibility Variants of Vascular Dementia among Asians: A Systematic Review and Meta-Analysis
CONCLUSION: Our findings provide evidence that genetic polymorphisms of the APOE ε4 allele and MTHFR rs1801133 T allele increase the risk of developing VaD in Asians. However, future large-scale investigations examining particularly on South-Eastern and West-Asian populations are highly recommended.PMID:38636474 | DOI:10.1159/000538864 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - April 18, 2024 Category: Psychiatry Authors: Vasudevan Ramachandran Nur Afiqah Mohamad Mohd Nazil Salleh Wan Aliaa Wan Sulaiman Liyana Najwa Inche Mat Mohd Hazmi Mohamed Ching Siew Mooi Abdul Hanif Khan Yusof Khan Hamidon Basri Pannerselvam Periasamy Vajiravelu Suganthi Narenkumar Jayaraman Source Type: research
Psychological interventions designed to reduce relocation stress for older people transitioning into permanent residential aged care: a systematic scoping review
CONCLUSION: The transition to residential aged care is an inherently distressing experience. The absence of interventions implemented during the pre- and mid-transition phases presents a gap in the literature and suggests an opportunity for early intervention. As population ageing continues to increase, there is a pressing need for the development and implementation of interventions aimed at reducing symptoms of depression and anxiety for older people undertaking this major life transition.PMID:38634443 | DOI:10.1080/13607863.2024.2340731 (Source: Aging and Mental Health)
Source: Aging and Mental Health - April 18, 2024 Category: Geriatrics Authors: Shanna Fealy Suzanne McLaren Melissa Nott Claire Ellen Seaman Belinda Cash Lorraine Rose Source Type: research
Informal Invitation from Climacteric
Climacteric. 2024 Apr 18:1-2. doi: 10.1080/13697137.2024.2343612. Online ahead of print.NO ABSTRACTPMID:38634465 | DOI:10.1080/13697137.2024.2343612 (Source: Climacteric)
Source: Climacteric - April 18, 2024 Category: Geriatrics Authors: Tim Hillard Nigel Crowther Nicole Jaff Source Type: research
Genetically determined type 1 diabetes mellitus and risk of osteoporosis
CONCLUSIONS: This study shows a causal relationship between T1DM and the risk of some sites of OP (FN-BMD, LS-BMD), allowing for continued research to discover the clinical and experimental mechanisms of T1DM and OP. It also contributes to the recommendation if patients with T1DM need targeted care to promote bone health and timely prevention of osteoporosis.PMID:38636571 | DOI:10.1016/j.exger.2024.112434 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 18, 2024 Category: Geriatrics Authors: Ting Cheng Jia-Lin Hou Zi-Yi Han Xin-Lei Geng Yao-Chen Zhang Ke-Yi Fan Liu Liu He-Yi Zhang Yue-Hong Huo Xiao-Feng Li Sheng-Xiao Zhang Source Type: research
LncRNA NEAT1 promotes MPP+ induced injury of PC12 cells and accelerates the progression of Parkinson's disease in mice through FUS mediated inhibition of PI3K/AKT/mTOR signalling pathway
In conclusion, NEAT1 is involved in PD progression through FUS-mediated inhibition of the PI3K/AKT/mTOR signalling pathway.PMID:38636570 | DOI:10.1016/j.exger.2024.112436 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 18, 2024 Category: Geriatrics Authors: Yonghui Wang Zhuo Li Jiwen Li Chao Sun Source Type: research
Influence of age and sex on physical, cardiac electrical and functional alterations in progressive hyperoxia treatment: A time course study in a murine model
In this study, both young and aged mice (male and female) underwent 72 h of hyperoxia exposure and were monitored at 24-hour intervals for cardiac electrophysiological and functional parameters using ECG and electrocardiogram data. Our analysis showed that young male mice experienced significant weight loss as well as significant lung edema by 48 h. Although young male mice were highly susceptible to physical changes, they were resistant to early cardiac functional and electrophysiological changes compared to the other groups. Both young and aged female and aged males developed functional impairments by 24 h of hyperoxia e...
Source: Experimental Gerontology - April 18, 2024 Category: Geriatrics Authors: Yashwant Ayalasomayajula Anagha Hesaraghatta Neha Dantuluri Jenna Yassine Faizan Saleem Hussein Mansour Chayapatou Chayawatto Nishank Rangarajan Sashank Rangarajan Smrithi Krishnan Siva Kumar Panguluri Source Type: research
Positive aging-How does it work? : Contribution of resilience to the prevention of depressive disorders in old age
CONCLUSION: Age-specific aspects of resilience can be specifically used for the prevention of depressive disorders in old age. They enable a framework to establish resource-promoting and activating interventions, to counteract the deficit perspective on ageing. At the same time, there are clear limits to individual prevention and resilience. The responsibility cannot be seen solely for each individual but above all social structures and framework conditions must enable successful implementation in old age.PMID:38634908 | DOI:10.1007/s00391-024-02296-2 (Source: Zeitschrift fur Gerontologie und Geriatrie)
Source: Zeitschrift fur Gerontologie und Geriatrie - April 18, 2024 Category: Geriatrics Authors: Katharina Geschke Alexandra Wuttke Source Type: research
The role of Ottawa ankle rules in geriatric emergency department visits
CONCLUSION: This study demonstrates that the OAR is highly sensitive in the geriatric population but shows some limitations in terms of specificity and positive predictive value. These results support the effectiveness of using the OAR in evaluating ankle injuries in the geriatric population but also highlight the need for cautious application due to the potential for false-positive outcomes.PMID:38634845 | DOI:10.14744/tjtes.2024.39240 (Source: Turkish Journal of Trauma and Emergency Surgery : TJTES)
Source: Turkish Journal of Trauma and Emergency Surgery : TJTES - April 18, 2024 Category: Emergency Medicine Authors: Avni Uygar Seyhan Rohat Ak Faruk Şimşek Senem Ayvac ı O ğuzhan Açıkgöz Source Type: research
The Association of Plasma Leptin, Soluble Leptin Receptor and Total and High-Molecular Weight Adiponectin With the Risk of Perioperative Neurocognitive Disorders
CONCLUSIONS: We did not find consistent evidence for the role of leptin, its receptor, and total and hmw adiponectin in POD and POCD risk. Future research should be used to support or refute our findings and to fully characterize any differences in the associations of these hormones with POD/POCD between obese and nonobese individuals.PMID:38637191 | DOI:10.1016/j.jagp.2024.03.015 (Source: Am J Geriatr Psychia...)
Source: Am J Geriatr Psychia... - April 18, 2024 Category: Geriatrics Authors: Insa Feinkohl J ürgen Janke Arjen J C Slooter Georg Winterer Claudia Spies Tobias Pischon Source Type: research
