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A Decline in Stemness in Many Human Stem Cell Populations with Aging
In conclusion, we assigned stemness scores to human samples and show evidence of a pan-tissue loss of stemness during human aging, which adds weight to the idea that stem cell deterioration may contribute to human aging. (Source: Fight Aging!)
Source: Fight Aging! - April 22, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Too many older adults are taking risky sedative medications
A recent investigation in Quebec uncovered a concerning trend: benzodiazepines — medications commonly used for sleep or anxiety — are being overprescribed. This investigation has prompted the Quebec College of Physicians to closely examine the usage of these medications. But this issue extends beyond Quebec’s borders; across Canada, these medications are being prescribed at alarming rates. Read more… Too many older adults are taking risky sedative medications originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - April 14, 2024 Category: General Medicine Authors: Tags: Meds Geriatrics Medications Source Type: blogs

Polypharmacy and prescribing cascades [PODCAST]
Subscribe to The Podcast by KevinMD. Watch on YouTube. Catch up on old episodes! Join us for a discussion on medication awareness and prescribing cascades with Paula Rochon, a geriatrician. As we embark on a new year, many focus on diet and exercise resolutions, but overlooking medication management can have profound implications for health. With Read more… Polypharmacy and prescribing cascades [PODCAST] originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - April 11, 2024 Category: General Medicine Authors: Tags: Podcast Geriatrics Medications Source Type: blogs

Fight Aging! Newsletter, April 8th 2024
In this study, we tested a stem cell secretome product, which contains extracellular vesicles and growth factors, cytoskeletal remodeling factors, and immunomodulatory factors. We examined the effects of 4 weeks of 2×/week unilateral intramuscular secretome injections (quadriceps) in ambulatory aged male C57BL/6 mice (22-24 months) compared to saline-injected aged-matched controls. Secretome delivery substantially increased whole-body lean mass and decreased fat mass, corresponding to higher myofiber cross-sectional area and smaller adipocyte size, respectively. Secretome-treated mice also had greater whole-bod...
Source: Fight Aging! - April 7, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Raised Inflammatory Markers Somewhat Correlate with Incidence of Age-Related Disease
Onset, progression, and resolution of inflammation are all driven by the interaction of many different complex signaling processes. The immune system as a whole is highly complex, an array of many different interacting populations of specialized cells. Nonetheless, there are a few individual circulating signal proteins that, to some degree at least, tend to reflect overall inflammatory status. Not reliably, but enough to produce correlations in patient populations of any reasonable size. Today's open access paper is a survey of the literature on inflammatory cytokines IL-6, TNF, and IL-1β, pulling reported measures...
Source: Fight Aging! - April 3, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Gen Z ’s Mid-Life Crisis
By KIM BELLARD These are not happy times in America. Now, I’m not thinking about the increasing cultural wars, the endless political bickering, the troubles in the Med-East or Ukraine, the looming threat of climate crisis, or the omnipresent campaigning for the November 2024 elections, although all those play a part. I’m talking about quantifiable data, from the latest World Happiness Report. It found that America has slipped out of the top 20 countries for the first time, falling to 23rd – behind countries like Slovenia and the U.A.E. and barely ahead of Mexico or Uruguay. Even worse, the fall in U.S. score...
Source: The Health Care Blog - March 27, 2024 Category: Consumer Health News Authors: matthew holt Tags: Health Policy Happiness Kim Bellard Mental Health Social Media Source Type: blogs

Microplastics, Major Problem
By KIM BELLARD It’s been almost four years since I first wrote about microplastics; long story short, they’re everywhere. In the ground, in the oceans (even at the very bottom), in the atmosphere. More to the point, they’re in the air you breathe and in the food you eat. They’re in you, and no one thinks that is a good thing. But we’re only starting to understand the harm they cause. The Washington Post recently reported: Scientists have found microplastics — or their tinier cousins, nanoplastics — embedded in the human placenta, in blood, in the heart and in the liver and bowels. In one re...
Source: The Health Care Blog - March 19, 2024 Category: Consumer Health News Authors: matthew holt Tags: Health Tech Kim Bellard Microplastics Source Type: blogs

Wound Care Education for Medical Doctors: Filling the Gap
Whenever I ask a group of doctors, “How many of you have had any training in care and treatment of chronic wounds?” it is the rare person who raises their hand. Despite the urgent need for medical doctors to know how to assess and treat pressure injuries and chronic wounds, there is no formal medical or surgical specialty in wound care. This has resulted in a gap in education, training, and research, with extensive variation in clinical practice. The medical education establishment has simply not caught up to the realities of care for the chronically ill patient. Filling the education gap in wound care is one of my pro...
Source: Jeffrey M. Levine MD | Geriatric Specialist | Wound Care | Pressure Ulcers - March 18, 2024 Category: Geriatrics Authors: Jeffrey M Levine Tags: An Aging World Geriatric Medicine Long-Term Care Pressure Injuries & Wound Care Risk Management aging skin bedsore bedsores decubiti decubitus ulcer end-of-life care geriatrics Healthcare Quality Improving Medical Care Jeff Lev Source Type: blogs

A geriatrician ’ s transformative walk in Italy
I just walked about 90 km in six days along the Via Matildica del Volto Santo between Mantua and Lucca through the Appenine mountains in the Emilia Romagna region of northern Italy. This beautiful, lesser-known route, crossing regions once ruled by the formidable Countess Matilda of Canossa, offered a unique blend of physical challenges and Read more… A geriatrician’s transformative walk in Italy originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - March 16, 2024 Category: General Medicine Authors: Tags: Physician Geriatrics Source Type: blogs

Exploring the benefits of Dry January for older adults [PODCAST]
Subscribe to The Podcast by KevinMD. Watch on YouTube. Catch up on old episodes! We sit down with Michael Pessman, a gerontologist, to discuss the unique risks older adults face with alcohol consumption. We’ll explore the enhanced physical and mental health benefits of participating in Dry January, as well as the challenges of adopting new Read more… Exploring the benefits of Dry January for older adults [PODCAST] originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - March 12, 2024 Category: General Medicine Authors: Tags: Podcast Geriatrics Source Type: blogs

Fight Aging! Newsletter, March 4th 2024
In conclusion, HSV (but not CMV) infection may be indicative of doubled dementia risk. « Back to Top Increased Dietary Leucine Activates mTOR Signaling in Macrophages, Accelerating Atherosclerosis https://www.fightaging.org/archives/2024/02/increased-dietary-leucine-activates-mtor-signaling-in-macrophages-accelerating-atherosclerosis/ Leucine is an essential amino acid, only obtained from the diet rather than synthesized by our cells. Leucine supplementation has been proposed as a way to slow the loss of muscle mass with age, as leucine processing becomes dysregulated with aging in a way...
Source: Fight Aging! - March 3, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Telomere Length as a Target for Therapy
Average telomere length in a tissue is some reflection of (a) stem cell activity and (b) pace of cell division. Telomeres, repeated DNA sequences at the ends of chromosomes, lose some of their length with each cell division, and cells self-destruct or become senescent when telomeres become too short. This limits the ability of somatic cells to replicate, reducing the odds that a given cell will mutate to become cancerous by imposing a limit on cell activity and cell life span, enforcing turnover of cells in tissues. Stem cells, in comparison, are a small, well protected, privileged set of cell populations that use telomera...
Source: Fight Aging! - February 26, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Dry January ’ s untold value for older adults: a health revolution beyond youth
As Dry January gains popularity and inspires millions of people to abstain from alcohol for a month, its focus appears to be geared towards young adults. A demographic that is often overlooked, but is likely to benefit significantly from this movement, is older adults. The National Survey on Drug Use and Heavy Drinking found that Read more… Dry January’s untold value for older adults: a health revolution beyond youth originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - February 20, 2024 Category: General Medicine Authors: Tags: Conditions Geriatrics Source Type: blogs

Now is a good time to reassess your medications with your clinician
Now that we are embarking on a new year, many of us take on annual resolutions with a focus on diet and exercise.  Overlooked is another important way to improve our health: increasing awareness of our medications. Nearly 4 in 10 adults over the age of 65 living in the United States are prescribed five Read more… Now is a good time to reassess your medications with your clinician originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - February 12, 2024 Category: General Medicine Authors: Tags: Meds Geriatrics Source Type: blogs

Nursing homes: How they impact the dignity of older adults
Call it what you want: nursing home, skilled nursing facility, rehab center, convalescent home, or post-acute care. They are all the same and a common destination should you survive a recent hospitalization. But they all have an existing reputation and can ultimately diminish the dignity of older adults. Never in my four decades of practice Read more… Nursing homes: How they impact the dignity of older adults originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - January 30, 2024 Category: General Medicine Authors: Tags: Physician Geriatrics Source Type: blogs