Combining Mini-Mental State Examination and Montreal Cognitive Assessment for assessing the clinical efficacy of cholinesterase inhibitors in mild Alzheimer's disease: a pilot study
Aging Clin Exp Res. 2024 Apr 17;36(1):95. doi: 10.1007/s40520-024-02744-4.ABSTRACTCurrent drugs for Alzheimer's Disease (AD), such as cholinesterase inhibitors (ChEIs), exert only symptomatic activity. Different psychometric tools are needed to assess cognitive and non-cognitive dimensions during pharmacological treatment. In this pilot study, we monitored 33 mild-AD patients treated with ChEIs. Specifically, we evaluated the effects of 6 months (Group 1 = 17 patients) and 9 months (Group 2 = 16 patients) of ChEIs administration on cognition with the Mini-Mental State Examination (MMSE), the Montreal Cognitive Assessment (...
Source: Aging Clinical and Experimental Research - April 17, 2024 Category: Geriatrics Authors: Giovanna Furneri Simone Varrasi Claudia Savia Guerrera Giuseppe Alessio Platania Vittoria Torre Francesco Maria Boccaccio Maria Federica Testa Federica Martelli Alessandra Privitera Grazia Razza Mario Santagati Santo Di Nuovo Concetta Pirrone Sabrina Cast Source Type: research
Predicting the efficacy of donepezil intervention in Alzheimer's disease patients using regional homogeneity in the inferior orbitofrontal cortex
CONCLUSIONS: These findings deepen our understanding of the brain mechanisms underlying the clinical efficacy of donepezil in AD patients, and provide a novel way to predict its clinical efficacy in such patients.PMID:38630202 | PMC:PMC11024046 | DOI:10.1007/s40520-023-02691-6 (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - April 17, 2024 Category: Geriatrics Authors: Min Dai Zhongwei Guo Honglian Xia Hong Zhu Jiapeng Li Hongtao Hou Guizhi Zhao Xiaozheng Liu Source Type: research
Association of serum uric acid with functional disability in older subjects: a population-based study
CONCLUSIONS: In older subjects, SUA levels are associated with disability; the cut off level above 5.5 mg/dL might be adopted in pharmacological trials aiming at reducing the incidence and progression of disability by reducing SUA, and for identifying subjects at increased risk of disability.PMID:38630352 | PMC:PMC11023951 | DOI:10.1007/s40520-024-02746-2 (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - April 17, 2024 Category: Geriatrics Authors: Alice Laudisio Agnese Dorizzi Fabio Villeggia Francesca Latino Daniele Filippucci Giuseppe Zuccal à Source Type: research
Elucidating the influence of familial interactions on geriatric depression: A comprehensive nationwide multi-center investigation leveraging machine learning
CONCLUSION: Prolonging the duration of nocturnal sleep, and elevating the frequency of communication with offspring have been identified as measures conducive to mitigating the onset of geriatric depression.PMID:38631151 | DOI:10.1016/j.actpsy.2024.104274 (Source: Acta Psychologica)
Source: Acta Psychologica - April 17, 2024 Category: Psychiatry & Psychology Authors: Boyang Sheng Shina Zhang Yuan Gao Shuaishuai Xia Yong Zhu Junfeng Yan Source Type: research
'Letting it be': a grounded theory about dementia care in Fiji
CONCLUSION: In Fiji, support for dementia centres on the integration of community understandings, and promotion of cultural values of wellbeing and care, with service provision. It also focuses on support for families and communities through social welfare, community networks, and education.PMID:38629413 | DOI:10.1080/13607863.2024.2340737 (Source: Aging and Mental Health)
Source: Aging and Mental Health - April 17, 2024 Category: Geriatrics Authors: Karen Johnston Sefanaia Qaloewai Taniela Rasavuka Robyn Preston Edward Strivens Sarah Larkins Source Type: research
Combining Mini-Mental State Examination and Montreal Cognitive Assessment for assessing the clinical efficacy of cholinesterase inhibitors in mild Alzheimer's disease: a pilot study
Aging Clin Exp Res. 2024 Apr 17;36(1):95. doi: 10.1007/s40520-024-02744-4.ABSTRACTCurrent drugs for Alzheimer's Disease (AD), such as cholinesterase inhibitors (ChEIs), exert only symptomatic activity. Different psychometric tools are needed to assess cognitive and non-cognitive dimensions during pharmacological treatment. In this pilot study, we monitored 33 mild-AD patients treated with ChEIs. Specifically, we evaluated the effects of 6 months (Group 1 = 17 patients) and 9 months (Group 2 = 16 patients) of ChEIs administration on cognition with the Mini-Mental State Examination (MMSE), the Montreal Cognitive Assessment (...
Source: Aging Clinical and Experimental Research - April 17, 2024 Category: Geriatrics Authors: Giovanna Furneri Simone Varrasi Claudia Savia Guerrera Giuseppe Alessio Platania Vittoria Torre Francesco Maria Boccaccio Maria Federica Testa Federica Martelli Alessandra Privitera Grazia Razza Mario Santagati Santo Di Nuovo Concetta Pirrone Sabrina Cast Source Type: research
Association of serum uric acid with functional disability in older subjects: a population-based study
CONCLUSIONS: In older subjects, SUA levels are associated with disability; the cut off level above 5.5 mg/dL might be adopted in pharmacological trials aiming at reducing the incidence and progression of disability by reducing SUA, and for identifying subjects at increased risk of disability.PMID:38630352 | DOI:10.1007/s40520-024-02746-2 (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - April 17, 2024 Category: Geriatrics Authors: Alice Laudisio Agnese Dorizzi Fabio Villeggia Francesca Latino Daniele Filippucci Giuseppe Zuccal à Source Type: research
Predicting the efficacy of donepezil intervention in Alzheimer's disease patients using regional homogeneity in the inferior orbitofrontal cortex
CONCLUSIONS: These findings deepen our understanding of the brain mechanisms underlying the clinical efficacy of donepezil in AD patients, and provide a novel way to predict its clinical efficacy in such patients.PMID:38630202 | DOI:10.1007/s40520-023-02691-6 (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - April 17, 2024 Category: Geriatrics Authors: Min Dai Zhongwei Guo Honglian Xia Hong Zhu Jiapeng Li Hongtao Hou Guizhi Zhao Xiaozheng Liu Source Type: research
The SaVe project - Sarcopenia and Vertigo in aging patients with colorectal cancer: A study protocol for three randomized controlled trials
DISCUSSION: Trial enrollment began in April 2023 and is the first trial to evaluate reasons for dizziness, decline in walking balance, and sarcopenia in older patients receiving chemotherapy. The trial will provide new and valuable knowledge in how to assess, manage, and prevent dizziness, decline in walking balance, and sarcopenia in older patients with colorectal cancer.TRIAL REGISTRATION: The Regional Ethics Committee (j.nr. H-22064206). Danish Data Protection Agency (P-2023-86) and ClinicalTrials.gov (NCT05710809).PMID:38631243 | DOI:10.1016/j.jgo.2024.101770 (Source: Cancer Control)
Source: Cancer Control - April 17, 2024 Category: Cancer & Oncology Authors: Katrine Storm Piper Charlotte Suetta Jakob Vasehus Schou Jesper Ryg Hanne Elkj ær Andersen Line Vind Langevad Delaney Evering Marta Kramer Mikkelsen Cecilia Lund Jan Christensen Source Type: research
Short-Term Effect of Ambient Temperature in Acute Ischemic Stroke with Endovascular Treatment Due to Large Vessel Occlusion
(Source: Clinical Interventions in Aging)
Source: Clinical Interventions in Aging - April 17, 2024 Category: Geriatrics Tags: Clinical Interventions in Aging Source Type: research
Conditional survival and annual hazard of death in older patients with esophageal cancer receiving definitive chemoradiotherapy
Definitive chemoradiotherapy is one of the primary treatment modalities for older patients with esophageal cancer (EC). However, the evolution of prognosis over time and the factors affected non-EC deaths rema... (Source: BMC Geriatrics)
Source: BMC Geriatrics - April 17, 2024 Category: Geriatrics Authors: Xiao Chang, Wei Deng, Rong Yu and Weihu Wang Tags: Research Source Type: research
Which Comprehensive Geriatric Assessment (CGA) instruments are currently used in Germany: a survey
The Comprehensive Geriatric Assessment (CGA) records geriatric syndromes in a standardized manner, allowing individualized treatment tailored to the patient ’s needs and resources. Its use has shown a beneficia... (Source: BMC Geriatrics)
Source: BMC Geriatrics - April 17, 2024 Category: Geriatrics Authors: Jennifer Kudelka, Malte Ollenschl äger, Richard Dodel, Bjoern M. Eskofier, Markus A. Hobert, Klaus Jahn, Jochen Klucken, Bendix Labeit, M. Cristina Polidori, Tino Prell, Tobias Warnecke, Christine A. F. von Arnim, Walter Maetzler and Andreas H. Jacobs Tags: Research Source Type: research
Older people ’s views and usage of recreational spaces in parks with age-friendly outdoor exercise equipment
. (Source: International Journal of Environmental Health Research)
Source: International Journal of Environmental Health Research - April 17, 2024 Category: Environmental Health Authors: Pazit LevingerBronwyn L. DreherBriony DowFrances BatchelorKeith D. Hilla Clinical Gerontology, National Ageing Research Institute, Melbourne, Australiab Institute for Health and Sport, Victoria University, Melbourne, Australiac Ageing and Independent Livi Source Type: research
Should researchers use AI to write papers? Group aims for community-driven standards
When and how should text-generating artificial intelligence (AI) programs such as ChatGPT help write research papers? In the coming months, 4000 researchers from a variety of disciplines and countries will weigh in on guidelines that could be adopted widely across academic publishing,
which has been grappling with chatbots and other AI issues for the past year and a half
. The group behind the effort wants to replace the piecemeal landscape of current guidelines with a single set of standards that represents a consensus of the research community.
Known as CANGARU, the initiative is a partnership between res...
Source: Science of Aging Knowledge Environment - April 16, 2024 Category: Geriatrics Source Type: research
Plans to expand African vaccine production face steep hurdles
In March 2022, when the pandemic was still raging, the messenger RNA (mRNA) company Moderna announced it would build a $500 million plant in Kenya to manufacture half a billion doses of its COVID-19 vaccine annually. “
This is major
,” Kenyan President William Ruto said at the time. The plant would help reduce Africa’s dependence on vaccines produced elsewhere, Ruto said—a situation that had turned disastrous during the pandemic—and bring economic benefits as well.
But Moderna may never break ground on the Kenya factory. On 11 April, the company said it had
“paused its efforts”
becau...
Source: Science of Aging Knowledge Environment - April 16, 2024 Category: Geriatrics Source Type: research
