Brain age of rhesus macaques over the lifespan
In this study, we present the methodology of constructing a rhesus macaque brain age model using a machine learning algorithm and discuss the key predictive brain regions in comparison to the human brain, to shed light on cross-species primate similarities and differences. Structural information of the brain (e.g., parcellated volumes) from brain magnetic resonance imaging of 43 rhesus macaques were used to develop brain atlas-based features to build a brain age model that predicts biological age. The best-performing model used 22 selected features and achieved an R2 of 0.72. We also identified interpretable predictive bra...
Source: Neurobiology of Aging - April 21, 2024 Category: Geriatrics Authors: Yang S Liu Madhura Baxi Christopher R Madan Kevin Zhan Nikolaos Makris Douglas L Rosene Ronald J Killiany Suheyla Cetin-Karayumak Ofer Pasternak Marek Kubicki Bo Cao Source Type: research
Evidence for age-related decline in spatial memory in a novel allocentric memory task
. (Source: Aging, Neuropsychology, and Cognition)
Source: Aging, Neuropsychology, and Cognition - April 21, 2024 Category: Geriatrics Authors: Luisanna Reinoso MedinaChristina A. ThrasherLauren L. HarburgerDepartment of Psychology, Purchase College, State University of New York, Purchase, NY, USA Source Type: research
Management and confusion in an elderly trauma patient
As the UK population continues to age, healthcare providers encounter a growing number of geriatric patients in most medical and surgical specialties. In the realm of orthopaedic care, this demographic shift presents distinctive challenges, with delirium emerging as a prominent complicating factor of many orthopaedic admissions. Acute confusion or delirium frequently complicates the treatment of older trauma patients, significantly influencing hospital stays, requiring tailored interventions, an d negatively impacting overall recovery. (Source: Surgery (Medicine Publishing))
Source: Surgery (Medicine Publishing) - April 21, 2024 Category: Surgery Authors: Claire Eastick, Ivan Aganin, Samson Thongs-George, Andrew Oswell Tags: Orthopaedics: Spine, pelvis and general trauma Source Type: research
Beyond the stethoscope: Reflections from a dementia unit
Australas J Ageing. 2024 Apr 19. doi: 10.1111/ajag.13319. Online ahead of print.NO ABSTRACTPMID:38641891 | DOI:10.1111/ajag.13319 (Source: Australasian Journal on Ageing)
Source: Australasian Journal on Ageing - April 20, 2024 Category: Geriatrics Authors: Eleanor Tkh Dunn Source Type: research
Beyond the stethoscope: Reflections from a dementia unit
Australas J Ageing. 2024 Apr 19. doi: 10.1111/ajag.13319. Online ahead of print.NO ABSTRACTPMID:38641891 | DOI:10.1111/ajag.13319 (Source: Australasian Journal on Ageing)
Source: Australasian Journal on Ageing - April 20, 2024 Category: Geriatrics Authors: Eleanor Tkh Dunn Source Type: research
Beyond the stethoscope: Reflections from a dementia unit
Australas J Ageing. 2024 Apr 19. doi: 10.1111/ajag.13319. Online ahead of print.NO ABSTRACTPMID:38641891 | DOI:10.1111/ajag.13319 (Source: Australasian Journal on Ageing)
Source: Australasian Journal on Ageing - April 20, 2024 Category: Geriatrics Authors: Eleanor Tkh Dunn Source Type: research
Beyond the stethoscope: Reflections from a dementia unit
Australas J Ageing. 2024 Apr 19. doi: 10.1111/ajag.13319. Online ahead of print.NO ABSTRACTPMID:38641891 | DOI:10.1111/ajag.13319 (Source: Australasian Journal on Ageing)
Source: Australasian Journal on Ageing - April 20, 2024 Category: Geriatrics Authors: Eleanor Tkh Dunn Source Type: research
Beyond the stethoscope: Reflections from a dementia unit
Australas J Ageing. 2024 Apr 19. doi: 10.1111/ajag.13319. Online ahead of print.NO ABSTRACTPMID:38641891 | DOI:10.1111/ajag.13319 (Source: Australasian Journal on Ageing)
Source: Australasian Journal on Ageing - April 20, 2024 Category: Geriatrics Authors: Eleanor Tkh Dunn Source Type: research
Clinical impact of an individualised clinical pharmacy programme into the memory care pathway of older people: an observational study
ConclusionThe integration of clinical pharmacist secured the Memory care pathway of older patients with a cognitive complaint by identifying an important number of DRPs and PIMs with potential cognitive iatrogenic risk. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - April 20, 2024 Category: Drugs & Pharmacology Source Type: research
Role of NT-proBNP and lung ultrasound in diagnosing and classifying heart failure in a hospitalized oldest-old population: a cross-sectional study
Diagnosing and classifying heart failure (HF) in the oldest-old patients has technical and interpretation issues, especially in the acute setting. We assessed the usefulness of both N-terminal pro-brain natriu... (Source: BMC Geriatrics)
Source: BMC Geriatrics - April 20, 2024 Category: Geriatrics Authors: Matteo Landolfo, Francesco Spannella, Federico Giulietti, Chiara Di Pentima, Piero Giordano, Elisabetta Borioni, Laura Landi, Mirko Di Rosa, Roberta Galeazzi and Riccardo Sarzani Tags: Research Source Type: research
Allostatic load and frailty do not covary significantly among older residents of Greater Poland
Physiological dysregulation/allostatic load and the geriatric syndrome frailty increase with age. As a neurophysiological response system, allostasis supports survival by limiting stressor-related damage. Frai... (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - April 20, 2024 Category: Physiology Authors: Jan Jeszka, Darian Hummel, Malgorzata Wo źniewicz, Tomoko Morinaka, Yoshiaki Sone and Douglas E. Crews Tags: Original article Source Type: research
Risk of sleep problems in middle-aged and older adults experiencing bodily pains: Serial multiple mediation estimates of emotion distress and activity limitations
Sleep is essential for cognitive and physiological adjustment and well-being across the lifespan. However, the quantity and quality of sleep reduce significantly with increasing age, chiefly due, in part, to circadian rhythm fatigue [1,2]. Indeed, less than one-half of older adults meet the clinical recommendations for 7-9 hours of sleep [3]. Those in middle ages and older cohorts, particularly in low- and middle-income countries (LMICs), experience worse sleep problems (SP) due to environmental and age-related changes in melatonin secretion, sleep-wake homeostasis, and circadian rhythm [4]. (Source: The American Journal o...
Source: The American Journal of Geriatric Psychiatry - April 20, 2024 Category: Geriatrics Authors: Razak M. Gyasi, Emelia Aikins, Gift Dumedah, Nelson Gyasi-Boadu, Prince Boakye Frimpong, Mary Sefa Boampong, Daniel Buor, Simon Mariwah, Francis Naab, David R. Phillips Tags: Regular Research Article Source Type: research
Association of regular opioid use with incident dementia and neuroimaging markers of brain health in chronic pain patients: analysis of UK Biobank
Opioid analgesics have proven essential for relieving acute pain, cancer-related pain, and in palliative care inverventions.1 Over the past two decades, there has been a significant increase in the prescription of opioids for various chronic non-cancer pain (CNCP) conditions.2,3 This has become worrisome, especially given the limited evidence regarding the efficacy of opioids over non-opioid analgesics for CNCP4 and the potential cognitive detriments associated with their use. (Source: The American Journal of Geriatric Psychiatry)
Source: The American Journal of Geriatric Psychiatry - April 20, 2024 Category: Geriatrics Authors: Yaqing Gao, Binbin Su, Lei Ding, Danial Qureshi, Shenda Hong, Jie Wei, Chao Zeng, Guanghua Lei, Junqing Xie Tags: Regular Research Article Source Type: research
Probiotics Supplements Improve the Sarcopenia-Related Quality of Life in Older Adults with Age-Related Muscle Decline
AbstractA pathological increase in intestinal leak is implicated in age-associated muscle loss, termed sarcopenia, and reduced sarcopenia-related quality-of-life (SarQoL). However, the potential therapies remain elusive. We investigated the effects of probiotic supplementation on sarcopenia and SarQoL in geriatric older adults. We randomized sarcopenic men into placebo (age = 71.4 ± 3.9 years,n = 63) and probiotic (age = 73 ± 4.1 years,n = 60) groups for 16 weeks. The probiotic used was one capsule daily of Vivomix 112 billion for 16 weeks. We measured sarcopenia parameters of handgrip strength (HGS) and s...
Source: Calcified Tissue International - April 20, 2024 Category: Orthopaedics Source Type: research
The effects of simultaneous aerobic exercise and video game training on executive functions and brain connectivity in older adults
Executive functions (EFs) encompass a set of higher-level cognitive control abilities, including inhibition, cognitive flexibility, and working memory.1 These functions are crucial for facilitating action control and adaptive responses to dynamic environmental changes.2 Consensus suggests that executive functions (EFs) decline noticeably with age, often associated with dysfunctions in the prefrontal cortex (PFC) regions and their associated networks, including the bilateral frontoparietal networks (FPN). (Source: The American Journal of Geriatric Psychiatry)
Source: The American Journal of Geriatric Psychiatry - April 20, 2024 Category: Geriatrics Authors: Wenjun Gui, Xiaoyu Cui, Jingwen Miao, Xinyi Zhu, Juan Li Tags: Regular Research Article Source Type: research
