Associations between serum levels of insulin-like growth factor-I and bone mineral acquisition in pubertal children: a 3-year follow-up study in Hamamatsu, Japan
Epidemiological data regarding the association between serum levels of IGF-I and bone mineral acquisition during childhood are scarce. Here, we investigated the association between serum levels of IGF-I and bo... (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - December 5, 2019 Category: Physiology Authors: Katsuyasu Kouda, Masayuki Iki, Kumiko Ohara, Harunobu Nakamura, Yuki Fujita and Toshimasa Nishiyama Tags: Original article Source Type: research

Reliability of Physiological Responses Induced by Basic Emotions: A Pilot Study
Although emotion-specific autonomic responses based on the discrete theory of emotion have been widely studied, studies on the reliability of physiological responses to emotional stimuli are limited. In this s... (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - November 28, 2019 Category: Physiology Authors: Eun-Hye Jang, Sangwon Byun, Mi-Sook Park and Jin-Hun Sohn Tags: Original article Source Type: research

Performance of newly developed body mass index cut-off for diagnosing obesity among Ethiopian adults
Obesity is defined as unhealthy excess body fat, which increases the risk of premature mortality from noncommunicable diseases. Early screening and prevention of obesity is critical for averting associated mor... (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - October 26, 2019 Category: Physiology Authors: Makeda Sinaga, Tilahun Yemane, Elsah Tegene, David Lidstrom and Tefera Belachew Tags: Original article Source Type: research

Estimation of stature from finger and phalange lengths in a Korean adolescent
(Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - October 22, 2019 Category: Physiology Authors: Ilsun Rhiu and Wonjoon Kim Tags: Original article Source Type: research

Longevity-associated mitochondrial DNA 5178 C/A polymorphism modifies effect of aging on renal function in male Japanese health checkup examinees: an exploratory cross-sectional study
The objective of this study was to investigate whether Mt5178 C/A polymorphism influences th... (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - September 5, 2019 Category: Physiology Authors: Iichiro Ohtsu, Mamoru Ishikawa, Naomi Matsunaga, Kanae Karita, Masao Yoshida, Hirotaka Ochiai, Takako Shirasawa, Takahiko Yoshimoto, Akira Minoura, Shogo Sai and Akatsuki Kokaze Tags: Original article Source Type: research

Non-visual effects of diurnal exposure to an artificial skylight, including nocturnal melatonin suppression
Recently, more consideration is being given to the beneficial effects of lighting on the maintenance and promotion of the health and well-being of office occupants in built environments. A new lighting technol... (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - August 28, 2019 Category: Physiology Authors: Akira Yasukouchi, Takafumi Maeda, Kazuyoshi Hara and Hiroyuki Furuune Tags: Original article Source Type: research

The effects of toe grip training on physical performance and cognitive function of nursing home residents
Toe grip-related training requires individuals to actively exercise muscles that are not frequently used; therefore, it may improve not only toe grip strength but also cognitive function. The purpose of this s... (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - August 28, 2019 Category: Physiology Authors: Ryota Tsuyuguchi, Satoshi Kurose, Takayuki Seto, Nana Takao, Aya Fujii, Hiromi Tsutsumi, Shingo Otsuki and Yutaka Kimura Tags: Original article Source Type: research

An overview of hand postures and aging on morphological changes of the median nerve
High-resolution ultrasound is being widely used in carpal tunnel examination to understand morphological and biomechanical characteristics of the median nerve and surrounding anatomy structures. (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - August 8, 2019 Category: Physiology Authors: Ping Yeap Loh, Wen Liang Yeoh and Satoshi Muraki Tags: Short report Source Type: research

Effect of food intake on respiratory chemosensitivity to CO2 in young adults
We examined the effect of ... (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - July 8, 2019 Category: Physiology Authors: Keiji Hayashi, Misato Suekuni and Koji Sugiyama Tags: Short report Source Type: research

Effects of fat distribution on lung function in young adults
To study the associations between fat distribution and lung functions in healthy subjects of young adults and to explore potential gender difference in these correlations. (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - June 24, 2019 Category: Physiology Authors: Liqian Huang, Ziliang Ye, Jingjing Lu, Cunqing Kong, Qingqing Zhu, Binbin Huang, Zerong Wang, Lin Xu, Qiongying Deng, Jiangu Gong and Peng Liu Tags: Original article Source Type: research

Association of taller stature with lower cardiovascular disease mortality in Asian people: a systematic review
Adult height can serve as a disease marker. While taller stature has been reported to be linked to a decreased risk of cardiovascular disease (CVD), an influence of the height on CVD is not fully understood in... (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - June 7, 2019 Category: Physiology Authors: Hiroyuki Teraura, Tatsuya Suzuki and Kazuhiko Kotani Tags: Review Source Type: research

ERP study on the associations of peripheral oxytocin and prolactin with inhibitory processes involving emotional distraction
Child maltreatment is a major health and social welfare problem, with serious and longstanding consequences. Impulse control ability plays an important role in reducing the risk of child maltreatment. The aim ... (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - May 17, 2019 Category: Physiology Authors: Sayuri Hayashi, Ayami Tsuru, Fumi Kishida, Yeon-Kyu Kim, Shigekazu Higuchi and Yuki Motomura Tags: Original article Source Type: research

NR3C1 gene polymorphisms are associated with high-altitude pulmonary edema in Han Chinese
High-altitude pulmonary edema (HAPE) is a life-threatening form of non-cardiogenic edema which occurs in unacclimatized individuals after rapid ascent to high altitude. NR3C1 gene encodes for glucocorticoid recep... (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - April 18, 2019 Category: Physiology Authors: Yingzhong Yang, Hui Du, Yuhong Li, Wei Guan, Feng Tang, Qin Ga and Ri-Li Ge Tags: Original article Source Type: research

Pitfalls of assessment of autonomic function by heart rate variability
Although analysis of heart rate variability is widely used for the assessment of autonomic function, its fundamental framework linking low-frequency and high-frequency components of heart rate variability with... (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - March 13, 2019 Category: Physiology Authors: Junichiro Hayano and Emi Yuda Tags: Review Source Type: research

A review of the studies on nonvisual lighting effects in the field of physiological anthropology
Here, we review the history and the trends in the research on the nonvisual effect of light in the field of physiological anthropology. Research on the nonvisual effect of light in the field of physiological a... (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - January 22, 2019 Category: Physiology Authors: Tetsuo Katsuura and Soomin Lee Tags: Review Source Type: research

Effects of the differences in mental states on the mirror system activities when observing hand actions
It is known that the activities of the mirror system are related to imitation and understanding of the intention of an action. It has been reported that the activity of the mirror system is higher for observat... (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - January 3, 2019 Category: Physiology Authors: Yuki Ikeda, Yuki Nishimura and Shigekazu Higuchi Tags: Original article Source Type: research

Correction to: Eye movements and brain oscillations to symbolic safety signs with different comprehensibility
After the publication of the original article [1] it was highlighted that there was an omission regarding the online resources for the traffic signs in the section of “Experimental stimuli”. (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - December 20, 2018 Category: Physiology Authors: Yohana Siswandari and Shuping Xiong Tags: Correction Source Type: research

Do green-blocking glasses enhance the nonvisual effects of white polychromatic light?
It is well known that light containing the blue component stimulates the intrinsically photosensitive retinal ganglion cells (ipRGCs) and plays a role in melatonin suppression and pupillary constriction. In ou... (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - December 18, 2018 Category: Physiology Authors: Soomin Lee, Naoshi Kakitsuba and Tetso Katsuura Tags: Short report Source Type: research

Evaluation of postural stability based on a force plate and inertial sensor during static balance measurements
Previous research on balance mostly focused on the assessment, training, and improvements of balance through interventions. We investigated tools commonly used to study static balance. Differences in postural ... (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - December 13, 2018 Category: Physiology Authors: Chia-Hsuan Lee and Tien-Lung Sun Tags: Original article Source Type: research

Stress, migration, and allostatic load: a model based on Mexican migrants in Columbus, Ohio
Immigration is a disruptive event with multiple implications for health. Stressors, including family separation, acculturation, job insecurity, restricted mobility, sojourns, dangerous border crossings, stigma... (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - December 13, 2018 Category: Physiology Authors: Alexandra C. Tuggle, Jeffrey H. Cohen and Douglas E. Crews Tags: Original article Source Type: research

Developing an equation for estimating body height from linear body measurements of Ethiopian adults
Measurements of erect height in older people, hospitalized and bedridden patients, and people with skeletal deformity is difficult. As a result, using body mass index for assessing nutritional status is not va... (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - November 26, 2018 Category: Physiology Authors: Alemayehu Digssie, Alemayehu Argaw and Tefera Belachew Tags: Original article Source Type: research

Impact of season on the association between muscle strength/volume and physical activity among community-dwelling elderly people living in snowy-cold regions
Although the benefits of physical activity are well-known, levels of physical inactivity are increasing in many countries. Physical activity, particularly for preventive care of the elderly, must be encouraged... (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - November 13, 2018 Category: Physiology Authors: Junko Hasegawa, Hideki Suzuki and Taro Yamauchi Tags: Original article Source Type: research

The relationship between inhibition of automatic imitation and personal cognitive styles
Previous studies have demonstrated the importance of the inhibition of automatic imitation in social interactions. Additionally, cognitive traits are known to vary among individuals. According to the empathizi... (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - October 29, 2018 Category: Physiology Authors: Yuki Nishimura, Yuki Ikeda and Shigekazu Higuchi Tags: Original article Source Type: research

Suppression of salivary melatonin secretion under 100-Hz flickering and non-flickering blue light
Bright light at night is known to suppress melatonin secretion. Novel photoreceptors named intrinsically photosensitive retinal ganglion cells (ipRGCs) are mainly responsible for projecting dark/bright informa... (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - October 19, 2018 Category: Physiology Authors: Tomoaki Kozaki, Yuki Hidaka, Jun-ya Takakura and Yosuke Kusano Tags: Original article Source Type: research

Characteristics of cardiovascular responses to an orthostatic challenge in trained spinal cord-injured individuals
We investigated cardiovascular responses to an orthostatic challenge in trained spinal cord-injured (SCI) individuals compared to able-bodied (AB) individuals. (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - September 29, 2018 Category: Physiology Authors: Masahiro Itoh, Masako Yamaoka Endo, Tatsuya Hojo, Miho Yoshimura and Yoshiyuki Fukuoka Tags: Original article Source Type: research

Correction to: Effect of simultaneous exposure to extremely short pulses of blue and green light on human pupillary constriction
Following publication of the original article [1], the authors reported that the abstract was missing from this article. (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - August 30, 2018 Category: Physiology Authors: Soomin Lee, Shougo Ishibashi, Yoshihiro Shimomura and Tetsuo Katsuura Tags: Correction Source Type: research

Current health status and its risk factors of the Tsarang villagers living at high altitude in the Mustang district of Nepal
This study aims to investigate the prevalence of NCDs and ... (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - August 29, 2018 Category: Physiology Authors: Sweta Koirala, Masayuki Nakano, Hiroaki Arima, Shouhei Takeuchi, Tomo Ichikawa, Takayuki Nishimura, Hiromu Ito, Basu Dev Pandey, Kishor Pandey, Takayuki Wada and Taro Yamamoto Tags: Original article Source Type: research

Concordance between appendicular skeletal muscle mass measured with DXA and estimated with mathematical models in middle-aged women
Appendicular skeletal muscle mass (ASMM) is a measure of body muscle content, and it correlates with nutrition and physical status. Estimation of ASMM using anthropometric models is a well-established strategy... (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - July 31, 2018 Category: Physiology Authors: Nirmala Rathnayake, Gayani Alwis, Janaka Lenora and Sarath Lekamwasam Tags: Original article Source Type: research

Energy cost and lower leg muscle activities during erect bipedal locomotion under hyperoxia
Energy cost of transport per unit distance (CoT) against speed shows U-shaped fashion in walking and linear fashion in running, indicating that there exists a specific walking speed minimizing the CoT, being d... (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - June 19, 2018 Category: Physiology Authors: Daijiro Abe, Yoshiyuki Fukuoka, Takafumi Maeda and Masahiro Horiuchi Tags: Original article Source Type: research

Non-cotton swab sample collection may not affect salivary melatonin assay results
Salivary melatonin levels have been analyzed in many research fields, including physiological anthropology. Although various devices have been utilized for saliva collection, cotton swabs are among the most co... (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - June 18, 2018 Category: Physiology Authors: Tomoaki Kozaki and Yuki Hidaka Tags: Methodology article Source Type: research

Effect of visual orientation on mu suppression in children: a comparative EEG study with adults
The human mirror neuron system exists in adults, and even in children. However, a significant, unanswered question in the literature concerns age differences in the effect of visual orientation of human body m... (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - June 8, 2018 Category: Physiology Authors: Yuki Nishimura, Yuki Ikeda, Airi Suematsu and Shigekazu Higuchi Tags: Original article Source Type: research

The importance of the exposome and allostatic load in the planetary health paradigm
In 1980, Jonas Salk (1914 –1995) encouraged professionals in anthropology and related disciplines to consider the interconnections between “planetary health,” sociocultural changes associated with technological... (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - June 4, 2018 Category: Physiology Authors: Alan C. Logan, Susan L. Prescott, Tari Haahtela and David L. Katz Tags: Review Source Type: research

l-Menthol attenuates the magnitude of cold-induced vasodilation on the extremities of young females
Menthol chemically triggers cold-sensitive receptors in the skin without conductive skin cooling. We investigated the effects of menthol-induced activation of cutaneous cold receptors on the cold-induced vasod... (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - May 9, 2018 Category: Physiology Authors: Siyeon Kim and Joo-Young Lee Tags: Original article Source Type: research

Effects of feet warming using bed socks on sleep quality and thermoregulatory responses in a cool environment
As a way of helping to sleep in winter, methods of warming the feet through footbaths or heating pads before bedtime are tried. In particular, bed socks are popular during winter sleeping in Korea, but scienti... (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - April 24, 2018 Category: Physiology Authors: Yelin Ko and Joo-Young Lee Tags: Original article Source Type: research

Impact of a single, short morning bright light exposure on tryptophan pathways and visuo- and sensorimotor performance: a crossover study
Bright light (BL) has been shown to be effective in enhancing both cognitive and physical performances. Alterations in nighttime melatonin levels have also been observed. However, evaluations of light-induced ... (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - April 23, 2018 Category: Physiology Authors: Wolfgang Schobersberger, Cornelia Blank, Friedrich Hanser, Andrea Griesmacher, Markus Canazei and Veronika Leichtfried Tags: Original article Source Type: research

Ageing vision and falls: a review
Falls are the leading cause of accidental injury and death among older adults. One of three adults over the age of 65 years falls annually. As the size of elderly population increases, falls become a major con... (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - April 23, 2018 Category: Physiology Authors: Liana Nafisa Saftari and Oh-Sang Kwon Tags: Review Source Type: research

Serotonergic gene polymorphisms (5-HTTLPR, 5HTR1A, 5HTR2A), and population differences in aggression: traditional (Hadza and Datoga) and industrial (Russians) populations compared
Current knowledge on genetic basis of aggressive behavior is still contradictory. This may be due to the fact that the majority of studies targeting associations between candidate genes and aggression are cond... (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - April 16, 2018 Category: Physiology Authors: Marina L. Butovskaya, Polina R. Butovskaya, Vasiliy A. Vasilyev, Jane M. Sukhodolskaya, Dania I. Fekhredtinova, Dmitri V. Karelin, Julia N. Fedenok, Audax Z. P. Mabulla, Alexey P. Ryskov and Oleg E. Lazebny Tags: Original article Source Type: research

Association of EGLN1 genetic polymorphisms with SpO2 responses to acute hypobaric hypoxia in a Japanese cohort
Recent studies have explored various genetic and physiological factors related to high-altitude adaptation in highlander populations. However, the effects of single nucleotide polymorphisms (SNPs), influencing... (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - April 6, 2018 Category: Physiology Authors: Yoshiki Yasukochi, Takayuki Nishimura, Midori Motoi and Shigeki Watanuki Tags: Original article Source Type: research

Enhanced Nogo-P3 amplitudes of mothers compared with non-mother women during an emotional Go/Nogo task
It is known that emotion regulatory responses of humans are changed by the experiences they have, but in particular, they are changed by becoming a mother. A recent study has found how a woman ’s emotion regula... (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - April 2, 2018 Category: Physiology Authors: Sayuri Hayashi, Hiroko Wada, Sung-Phil Kim, Yuki Motomura, Shigekazu Higuchi and Yeon-Kyu Kim Tags: Original article Source Type: research

Sequencing the exons of human glucocorticoid receptor (NR3C1) gene in Han Chinese with high-altitude pulmonary edema
High-altitude pulmonary edema (HAPE) is a serious acute mountain sickness that mainly occurs in non-acclimatized individuals after rapid ascent to high altitude. The precise etiology of HAPE remains unclear. T... (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - March 27, 2018 Category: Physiology Authors: Hui Du, Jing Zhao, Zhanhai Su, Yongnian Liu and Yingzhong Yang Tags: Original article Source Type: research

Seasonal differences in brown adipose tissue density and pulse rate variability in a thermoneutral environment
Brown adipose tissue (BAT) is sympathetically activated and induces thermogenesis during cold exposure, thereby influencing energy expenditure and body fat levels. The very low frequency (VLF) components of pu... (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - February 21, 2018 Category: Physiology Authors: Shinsuke Nirengi, Naoki Sakane, Shiho Amagasa, Sawako Wakui, Toshiyuki Homma, Yuko Kurosawa and Takafumi Hamaoka Tags: Original article Source Type: research

Telomere elongation protects heart and lung tissue cells from fatal damage in rats exposed to severe hypoxia
This study aimed to investigate the change in telomere length of rat heart and lu... (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - February 17, 2018 Category: Physiology Authors: Yaping Wang, Zhen Zhao, Zhiyong Zhu, Pingying Li, Xiaolin Li, Xiaohong Xue, Jie Duo and Yingcai Ma Tags: Original article Source Type: research

Human cerebrovascular function in health and disease: insights from integrative approaches
The marked increase in the size of the brain, and consequently, in neural processing capability, throughout human evolution is the basis of the higher cognitive function in humans. However, greater neural, and... (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - February 17, 2018 Category: Physiology Authors: Erin D. Ozturk and Can Ozan Tan Tags: Review Source Type: research

Black tea aroma inhibited increase of salivary chromogranin-A after arithmetic tasks
In this study, we investigated the alleviating effect of two kin... (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - January 24, 2018 Category: Physiology Authors: Ai Yoto, Natsuki Fukui, Chisa Kaneda, Shoko Torita, Keiichi Goto, Fumio Nanjo and Hidehiko Yokogoshi Tags: Original article Source Type: research

Developmental changes in shortening of pro-saccade reaction time while maintaining neck flexion position
We investigated developmental changes in shortening of pro-saccade reaction time while maintaining neck flexion. (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - January 10, 2018 Category: Physiology Authors: Kenji Kunita, Katsuo Fujiwara, Naoe Kiyota, Chie Yaguchi and Takeo Kiyota Tags: Original article Source Type: research

Timings of attentional switching to perturbation and postural preparation during transient forward or backward floor translation
Relationships between the timings of attentional switching and postural preparation were investigated using a choice-reaction paradigm with transient floor translation (S2), with the direction indicated by a w... (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - January 8, 2018 Category: Physiology Authors: Katsuo Fujiwara, Chie Yaguchi, Maki Maekawa and Naoe Kiyota Tags: Original article Source Type: research

Activation timing of postural muscles of lower legs and prediction of postural disturbance during bilateral arm flexion in older adults
Activation timings of postural muscles of lower legs and prediction of postural disturbance were investigated in young and older adults during bilateral arm flexion in a self-timing task and an oddball task wi... (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - December 22, 2017 Category: Physiology Authors: Chie Yaguchi, Katsuo Fujiwara and Naoe Kiyota Tags: Original article Source Type: research

Muscle co-contraction in elderly people change due to postural stability during single-leg standing
This study primarily aimed to clarify the difference in the effect of a ligh... (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - December 16, 2017 Category: Physiology Authors: Yoshitaka Iwamoto, Makoto Takahashi and Koichi Shinkoda Tags: Original article Source Type: research

Relationship between maximum oxygen uptake and peripheral vasoconstriction in a cold environment
Various individual characteristics affect environmental adaptability of a human. The present study evaluates the relationship between physical fitness and peripheral vasoconstriction in a cold environment. (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - December 6, 2017 Category: Physiology Authors: Takafumi Maeda Tags: Original article Source Type: research

Cathodal transcranial direct-current stimulation over right posterior parietal cortex enhances human temporal discrimination ability
Time perception associated with durations from 1  s to several minutes involves activity in the right posterior parietal cortex (rPPC). It is unclear whether altering the activity of the rPPC affects an individ... (Source: Journal of Physiological Anthropology)
Source: Journal of Physiological Anthropology - December 4, 2017 Category: Physiology Authors: Fuyuki Oyama, Keita Ishibashi and Koichi Iwanaga Tags: Original article Source Type: research