Molecular epidemiological investigation of G6PD deficiency in Yangjiang region, western Guangdong province
Conclusion: This investigation into G6PD deficiency in this area is expected to significantly improve our understanding of the prevalence and molecular characterization of this condition. (Source: Frontiers in Genetics)
Source: Frontiers in Genetics - January 9, 2024 Category: Genetics & Stem Cells Source Type: research
Tafenoquine following G6PD screening versus primaquine for the treatment of vivax malaria in Brazil: A cost-effectiveness analysis using a transmission model
ConclusionsIn our modelling study that incorporated impact on transmission, tafenoquine prescribed after a semiquantitative G6PD testing was highly likely to be cost-effective in Brazil. These results demonstrate the potential health and economic importance of ensuring safe and effective radical cure. (Source: PLoS Medicine)
Source: PLoS Medicine - January 9, 2024 Category: Internal Medicine Authors: David J. Price Source Type: research
ROR α inhibits gastric cancer proliferation through attenuating G6PD and PFKFB3 induced glycolytic activity
Glycolysis is critical for harvesting abundant energy to maintain the tumor microenvironment in malignant tumors. Retinoic acid-related orphan receptor α (RORα) has been identified as a circadian gene. However... (Source: Cancer Cell International)
Source: Cancer Cell International - January 6, 2024 Category: Cancer & Oncology Authors: Xiaoshan Wang, Junyi Zhang, Yuwei Wu, Yuqing Zhang, Siyuan Zhang, Angqing Li, Jian Wang and Zhengguang Wang Tags: Research Source Type: research
The solute carrier SLC25A17 sustains peroxisomal redox homeostasis in diverse mammalian cell lines
In this study, we sought to assess potential associations between the cellular redox landscape and the human peroxisomal solute carrier SLC25A17, also known as PMP34. This carrier has been reported to function as a counter-exchanger of adenine-containing cofactors such as coenzyme A (CoA), dephospho-CoA, flavin adenine dinucleotide, nicotinamide adenine dinucleotide (NAD+), adenosine 3',5'-diphosphate, flavin mononucleotide, and adenosine monophosphate. We found that inactivation of SLC25A17 resulted in a shift toward a more reductive state in the glutathione redox couple (GSSG/GSH) across HEK-293 cells, HeLa cells, and SV...
Source: Free Radical Biology and Medicine - December 30, 2023 Category: Biology Authors: Cl áudio F Costa Celien Lismont Serhii Chornyi Janet Koster Hongli Li Mohamed A F Hussein Paul P Van Veldhoven Hans R Waterham Marc Fransen Source Type: research
A positive correlation between mutated gene of sickle cell anemia and glucose-6-phosphate dehydrogenase among gond tribes of Chhattisgarh, India
CONCLUSION: A high degree of correlation between SCA and G6PD was reported among Gond tribes of Chhattisgarh, India with a high degree of mutated GSTP1, GSTP1a, Mahidol, and Union variants. The study makes it possible to take specific preventive measures concerning the medication of anti-oxidizing drugs.PMID:38134753 | DOI:10.1016/j.mrfmmm.2023.111849 (Source: Cell Research)
Source: Cell Research - December 22, 2023 Category: Cytology Authors: Ekta Singh Lohit Raj Shivwanshi Anil Kumar Source Type: research
A positive correlation between mutated gene of sickle cell anemia and glucose-6-phosphate dehydrogenase among gond tribes of Chhattisgarh, India
CONCLUSION: A high degree of correlation between SCA and G6PD was reported among Gond tribes of Chhattisgarh, India with a high degree of mutated GSTP1, GSTP1a, Mahidol, and Union variants. The study makes it possible to take specific preventive measures concerning the medication of anti-oxidizing drugs.PMID:38134753 | DOI:10.1016/j.mrfmmm.2023.111849 (Source: Cell Research)
Source: Cell Research - December 22, 2023 Category: Cytology Authors: Ekta Singh Lohit Raj Shivwanshi Anil Kumar Source Type: research
A rare adverse effects of COVID-19 vaccine in a patient with a latent tumor: A case report and literature review
This article may complement a rare mechanism of vaccine side effects and chemotherapy-related side effects.PMID:38115902 | PMC:PMC10728639 | DOI:10.3389/fonc.2023.1269735 (Source: Cancer Control)
Source: Cancer Control - December 20, 2023 Category: Cancer & Oncology Authors: Wenjing Xu Weiqi Nian Source Type: research
Development of a plasma maltose assay method as a screening test for upper gastrointestinal disorders
DISCUSSION: This method has a high sensitivity and a high precision and can be used for high-speed analysis on an automatic analyzer. It has the potential to be used as a screening test for gastric mucosal damage.PMID:38111970 | DOI:10.1177/00045632231224218 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - December 19, 2023 Category: Biochemistry Authors: Tetuya Komene Kotoko Kai Kiyoko Kinpara Tomoaki Sato Eisaku Hokazono Tatsuo Shimosawa Susumu Osawa Masanori Seimiya Source Type: research
Development of a plasma maltose assay method as a screening test for upper gastrointestinal disorders
DISCUSSION: This method has a high sensitivity and a high precision and can be used for high-speed analysis on an automatic analyzer. It has the potential to be used as a screening test for gastric mucosal damage.PMID:38111970 | DOI:10.1177/00045632231224218 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - December 19, 2023 Category: Biochemistry Authors: Tetuya Komene Kotoko Kai Kiyoko Kinpara Tomoaki Sato Eisaku Hokazono Tatsuo Shimosawa Susumu Osawa Masanori Seimiya Source Type: research
Development of a plasma maltose assay method as a screening test for upper gastrointestinal disorders
DISCUSSION: This method has a high sensitivity and a high precision and can be used for high-speed analysis on an automatic analyzer. It has the potential to be used as a screening test for gastric mucosal damage.PMID:38111970 | DOI:10.1177/00045632231224218 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - December 19, 2023 Category: Biochemistry Authors: Tetuya Komene Kotoko Kai Kiyoko Kinpara Tomoaki Sato Eisaku Hokazono Tatsuo Shimosawa Susumu Osawa Masanori Seimiya Source Type: research
Development of a plasma maltose assay method as a screening test for upper gastrointestinal disorders
DISCUSSION: This method has a high sensitivity and a high precision and can be used for high-speed analysis on an automatic analyzer. It has the potential to be used as a screening test for gastric mucosal damage.PMID:38111970 | DOI:10.1177/00045632231224218 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - December 19, 2023 Category: Biochemistry Authors: Tetuya Komene Kotoko Kai Kiyoko Kinpara Tomoaki Sato Eisaku Hokazono Tatsuo Shimosawa Susumu Osawa Masanori Seimiya Source Type: research
The dynamic relationship between inorganic polyphosphate and adenosine triphosphate in human non-small cell lung cancer H1299 cells
In this study, we explored the interplay between polyP and ATP in cellular energy metabolism. Treatment with polyP did not affect cell proliferation of human non-small cell lung cancer H1299 and human glioblastoma T98G cell lines as compared to their respective control cells until 72 h post-treatment. The mitochondrial membrane potential (MMP) in polyP-treated cells was low, contrasting with the time-dependent increase observed in control cells. While the ATP content increased over time in untreated and Na-phosphate-treated control cells, it remained unchanged in polyP-treated cells. Furthermore, the addition of cyclospori...
Source: Cancer Control - December 18, 2023 Category: Cancer & Oncology Authors: Kaori Tsutsumi Thititip Tippayamontri Mari Hayashi Nobuto Matsuda Yusaku Goto Source Type: research
A feedback loop of PPP and PI3K/AKT signal pathway drives regorafenib-resistance in HCC
ConclusionTaken together, a feedback loop of PPP and PI3K/AKT signal pathway drives regorafenib-resistance in HCC and targeting the feedback loop could be a promising approach to overcome drug resistance. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - December 18, 2023 Category: Cancer & Oncology Source Type: research
Cyclosporine A alleviates colitis by inhibiting the formation of neutrophil extracellular traps via the regulating pentose phosphate pathway
CONCLUSION: Our results indicated CsA could alleviate the severity of colitis by decreasing the formation of NETs in vivo. In vitro, CsA reduced ROS-dependent NETs release via downregulating PPP and cellular ROS levels by decreasing G6PD activity directly by activating the P53 protein.PMID:38093197 | DOI:10.1186/s10020-023-00758-8 (Source: Molecular Medicine)
Source: Molecular Medicine - December 13, 2023 Category: Molecular Biology Authors: Chenjing Xu Ziping Ye Wenyu Jiang Shu Wang Hongjie Zhang Source Type: research
Cyclosporine A alleviates colitis by inhibiting the formation of neutrophil extracellular traps via the regulating pentose phosphate pathway
CONCLUSION: Our results indicated CsA could alleviate the severity of colitis by decreasing the formation of NETs in vivo. In vitro, CsA reduced ROS-dependent NETs release via downregulating PPP and cellular ROS levels by decreasing G6PD activity directly by activating the P53 protein.PMID:38093197 | PMC:PMC10720086 | DOI:10.1186/s10020-023-00758-8 (Source: Molecular Medicine)
Source: Molecular Medicine - December 13, 2023 Category: Molecular Biology Authors: Chenjing Xu Ziping Ye Wenyu Jiang Shu Wang Hongjie Zhang Source Type: research
