Metabolic pathways for glucose and fructose: I synthesis and metabolism of fructose by ovine conceptuses
This study characterized key enzymes involved in fructose synthesis and metabolism by ovine conceptuses throughout pregnancy. Day 17 conceptuses expressed mRNAs for the polyol pathway (SORD and AKR1B1) and glucose and fructose metabolism (HK1, HK2, G6PD, OGT, and FBP), but not those required for gluconeogenesis (G6Pase or PCK). Ovine placentomes also expressed mRNAs for SORD, AKR1B1, HK1, and OGT. Fructose can be metabolized via the ketohexokinase (KHK) pathway and isoforms, KHK-A and KHK-C, were expressed in ovine conceptuses from Day 16 of pregnancy and placentomes during pregnancy in a cell specific manner: KHK-A protei...
Source: Biology of Reproduction - March 19, 2024 Category: Reproduction Medicine Authors: Robyn M Moses Claire Stenhouse Katherine M Halloran Nirvay Sah Emily C Hoskins Shannon E Washburn Gregory A Johnson Guoyao Wu Fuller W Bazer Source Type: research
Acalypha indica induced acute oxidative haemolysis and methaemoglobinaemia: two case reports
ConclusionsThis case highlights the potential hemolytic and methaemoglobinaemic effects of ingesting oxidant herbal products and the importance of considering such exposures in patients presenting with hemolysis and multiorgan involvement, particularly in communities where herbal product intake is popular. Healthcare providers should be aware of the risks associated with traditional remedies and maintain a high index of suspicion to ensure prompt recognition and appropriate management. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - March 19, 2024 Category: General Medicine Source Type: research
Glucose-6-phosphate dehydrogenase deficiency and neonatal indirect hyperbilirubinemia: a retrospective cohort study among 40,305 consecutively born babies
Journal of Perinatology, Published online: 13 March 2024; doi:10.1038/s41372-024-01927-1Glucose-6-phosphate dehydrogenase deficiency and neonatal indirect hyperbilirubinemia: a retrospective cohort study among 40,305 consecutively born babies (Source: Journal of Perinatology)
Source: Journal of Perinatology - March 13, 2024 Category: Perinatology & Neonatology Authors: Rajai Rofail Raja Al-Bedaywi Khalil Mohd Khalil Salameh Sarfrazul Abedin Brijroy Viswanathan Abedalkhalik Ahmad Khedr Lina Hussain M. Habboub Source Type: research
Enabling High Activation of Glucose-6-phosphate Dehydrogenase Activity Trough Liquid Condensate Formation and Compression
Chemistry. 2024 Mar 12:e202400690. doi: 10.1002/chem.202400690. Online ahead of print.ABSTRACTDroplet formation via liquid-liquid phase separation is thought to be involved in the regulation of various biological processes, including enzymatic reactions. We investigated a glycolytic enzymatic reaction, the conversion of glucose-6-phosphate to 6-phospho-D-glucono-1,3-lactone with concomitant reduction of NADP+ to NADPH both in the absence and presence of dynamically controlled liquid droplet formation. Here, the nucleotide serves as substrate as well as the scaffold required for the formation of liquid droplets. To further ...
Source: Chemistry - March 12, 2024 Category: Chemistry Authors: Michel W Jaworek Rosario Oliva Roland Winter Source Type: research
Enabling High Activation of Glucose-6-phosphate Dehydrogenase Activity Trough Liquid Condensate Formation and Compression
Chemistry. 2024 Mar 12:e202400690. doi: 10.1002/chem.202400690. Online ahead of print.ABSTRACTDroplet formation via liquid-liquid phase separation is thought to be involved in the regulation of various biological processes, including enzymatic reactions. We investigated a glycolytic enzymatic reaction, the conversion of glucose-6-phosphate to 6-phospho-D-glucono-1,3-lactone with concomitant reduction of NADP+ to NADPH both in the absence and presence of dynamically controlled liquid droplet formation. Here, the nucleotide serves as substrate as well as the scaffold required for the formation of liquid droplets. To further ...
Source: Chemistry - March 12, 2024 Category: Chemistry Authors: Michel W Jaworek Rosario Oliva Roland Winter Source Type: research
Talaromycosis from Wuhan: two-case report and literature review
ConclusionTalaromycosis has an insidious onset, long course, atypical clinical symptoms, imaging performance and laboratory results, difficult diagnosis, and high mortality. Therefore, it is important to promptly consider and treat Talaromycosis in immunocompromised patients upon infection in order to reduce mortality. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - March 11, 2024 Category: Microbiology Source Type: research
Study of the antigenic characteristics of red blood cells units and their sickle cell disease recipients and the G6PD activity of transfused red blood cells units
CONCLUSION: The transfusion protocol is established to prevent immunological reactions due to disparities in blood group antigens between donors and SCD recipients. However, the units of African ancestry donors, which allowed the best compatibility, displayed a high rate of G6PD deficiency. The storage and recovery impact of this deficiency must be evaluated.PMID:38462030 | DOI:10.1016/j.tracli.2024.03.002 (Source: Transfusion Clinique et Biologique)
Source: Transfusion Clinique et Biologique - March 10, 2024 Category: Hematology Authors: Morgane Le Gallo St éphane Moutereau M élanie Gentil France Pirenne Source Type: research
Study of the antigenic characteristics of red blood cells units and their sickle cell disease recipients and the G6PD activity of transfused red blood cells units
CONCLUSION: The transfusion protocol is established to prevent immunological reactions due to disparities in blood group antigens between donors and SCD recipients. However, the units of African ancestry donors, which allowed the best compatibility, displayed a high rate of G6PD deficiency. The storage and recovery impact of this deficiency must be evaluated.PMID:38462030 | DOI:10.1016/j.tracli.2024.03.002 (Source: Transfusion Clinique et Biologique)
Source: Transfusion Clinique et Biologique - March 10, 2024 Category: Hematology Authors: Morgane Le Gallo St éphane Moutereau M élanie Gentil France Pirenne Source Type: research
Study of the antigenic characteristics of red blood cells units and their sickle cell disease recipients and the G6PD activity of transfused red blood cells units
CONCLUSION: The transfusion protocol is established to prevent immunological reactions due to disparities in blood group antigens between donors and SCD recipients. However, the units of African ancestry donors, which allowed the best compatibility, displayed a high rate of G6PD deficiency. The storage and recovery impact of this deficiency must be evaluated.PMID:38462030 | DOI:10.1016/j.tracli.2024.03.002 (Source: Transfusion Clinique et Biologique)
Source: Transfusion Clinique et Biologique - March 10, 2024 Category: Hematology Authors: Morgane Le Gallo St éphane Moutereau M élanie Gentil France Pirenne Source Type: research
Study of the antigenic characteristics of red blood cells units and their sickle cell disease recipients and the G6PD activity of transfused red blood cells units
CONCLUSION: The transfusion protocol is established to prevent immunological reactions due to disparities in blood group antigens between donors and SCD recipients. However, the units of African ancestry donors, which allowed the best compatibility, displayed a high rate of G6PD deficiency. The storage and recovery impact of this deficiency must be evaluated.PMID:38462030 | DOI:10.1016/j.tracli.2024.03.002 (Source: Transfusion Clinique et Biologique)
Source: Transfusion Clinique et Biologique - March 10, 2024 Category: Hematology Authors: Morgane Le Gallo St éphane Moutereau M élanie Gentil France Pirenne Source Type: research
Study of the antigenic characteristics of red blood cells units and their sickle cell disease recipients and the G6PD activity of transfused red blood cells units
CONCLUSION: The transfusion protocol is established to prevent immunological reactions due to disparities in blood group antigens between donors and SCD recipients. However, the units of African ancestry donors, which allowed the best compatibility, displayed a high rate of G6PD deficiency. The storage and recovery impact of this deficiency must be evaluated.PMID:38462030 | DOI:10.1016/j.tracli.2024.03.002 (Source: Transfusion Clinique et Biologique)
Source: Transfusion Clinique et Biologique - March 10, 2024 Category: Hematology Authors: Morgane Le Gallo St éphane Moutereau M élanie Gentil France Pirenne Source Type: research
Study of the antigenic characteristics of red blood cells units and their sickle cell disease recipients and the G6PD activity of transfused red blood cells units
CONCLUSION: The transfusion protocol is established to prevent immunological reactions due to disparities in blood group antigens between donors and SCD recipients. However, the units of African ancestry donors, which allowed the best compatibility, displayed a high rate of G6PD deficiency. The storage and recovery impact of this deficiency must be evaluated.PMID:38462030 | DOI:10.1016/j.tracli.2024.03.002 (Source: Transfusion Clinique et Biologique)
Source: Transfusion Clinique et Biologique - March 10, 2024 Category: Hematology Authors: Morgane Le Gallo St éphane Moutereau M élanie Gentil France Pirenne Source Type: research
Study of the antigenic characteristics of red blood cells units and their sickle cell disease recipients and the G6PD activity of transfused red blood cells units
CONCLUSION: The transfusion protocol is established to prevent immunological reactions due to disparities in blood group antigens between donors and SCD recipients. However, the units of African ancestry donors, which allowed the best compatibility, displayed a high rate of G6PD deficiency. The storage and recovery impact of this deficiency must be evaluated.PMID:38462030 | DOI:10.1016/j.tracli.2024.03.002 (Source: Transfusion Clinique et Biologique)
Source: Transfusion Clinique et Biologique - March 10, 2024 Category: Hematology Authors: Morgane Le Gallo St éphane Moutereau M élanie Gentil France Pirenne Source Type: research
Study of the antigenic characteristics of red blood cells units and their sickle cell disease recipients and the G6PD activity of transfused red blood cells units
CONCLUSION: The transfusion protocol is established to prevent immunological reactions due to disparities in blood group antigens between donors and SCD recipients. However, the units of African ancestry donors, which allowed the best compatibility, displayed a high rate of G6PD deficiency. The storage and recovery impact of this deficiency must be evaluated.PMID:38462030 | DOI:10.1016/j.tracli.2024.03.002 (Source: Transfusion Clinique et Biologique)
Source: Transfusion Clinique et Biologique - March 10, 2024 Category: Hematology Authors: Morgane Le Gallo St éphane Moutereau M élanie Gentil France Pirenne Source Type: research
Fed-batch fermentation of Mucor circinelloides reveals significant improvement in biomass and lipid accumulation through performance evaluation, chemical analysis, and expression profiling
This study aimed to improve the lipid and biomass yields of Mucor circinelloides WJ11 by implementing four different fed-batch fermentation strategies, varied in time and glucose concentration (S1-S4). The S1 fermentation strategy yielded the highest biomass, lipid, and fatty acid content (22 ± 0.7 g/L, 53 ± 1.2 %, and 28 ± 1.6 %) after 120 and 144 h, respectively. The γ-linolenic acid titer of 0.75 ± 0.0 g/L was greatest in S3 after 48 h. Quantitative reverse transcription polymerase chain reaction (RT-qPCR) was used to analyze the transcription of key genes involved in lipid accumulation. The glucose-6-phosphate deh...
Source: Bioresource Technology - March 7, 2024 Category: Biotechnology Authors: Hassan Mohamed Tahira Naz Qing Liu Shaoqi Li Xiuwen Wang Yuanda Song Source Type: research
