Prevalence and molecular heterogeneity of glucose-6-phosphate dehydrogenase (G6PD) deficiency in the Senoi Malaysian Orang Asli population
This study aimed to elucidate the G6PD molecular heterogeneity in this subethnic group which is important for malaria elimination. A total of 662 blood samples (369 males and 293 females) from the Senoi subethnic group were screened for G6PD deficiency using a quantitative G6PD assay, OSMMR2000-D kit with Hb normalization. After excluding the family members, the overall prevalence of G6PD deficiency in the studied population was 15.2% (95% CI: 11 –19%; 56 of 369), with males (30 of 172; 17.4%) outnumbering females (26 of 197; 13.2%). The adjusted male median (AMM), defined as 100% G6PD activity, was 11.8 IU/gHb. A total ...
Source: PLoS One - December 12, 2023 Category: Biomedical Science Authors: Danny Xuan-Rong Koh Source Type: research
Mandatory role of endoplasmic reticulum and its pentose phosphate shunt in the myocardial defense mechanisms against the redox stress induced by anthracyclines
Mol Cell Biochem. 2023 Dec 12. doi: 10.1007/s11010-023-04903-z. Online ahead of print.ABSTRACTAnthracyclines' cardiotoxicity involves an accelerated generation of reactive oxygen species. This oxidative damage has been found to accelerate the expression of hexose-6P-dehydrogenase (H6PD), that channels glucose-6-phosphate (G6P) through the pentose phosphate pathway (PPP) confined within the endoplasmic/sarcoplasmic reticulum (SR). To verify the role of SR-PPP in the defense mechanisms activated by doxorubicin (DXR) in cardiomyocytes, we tested the effect of this drug in H6PD knockout mice (H6PD-/-). Twenty-eight wildtype (W...
Source: Molecular and Cellular Biochemistry - December 11, 2023 Category: Biochemistry Authors: Gianmario Sambuceti Vanessa Cossu Francesca Vitale Eva Bianconi Sonia Carta Consuelo Venturi Sabrina Chiesa Francesco Lanfranchi Laura Emionite Sebastiano Carlone Luca Sofia Francesca D'Amico Tania Di Raimondo Silvia Chiola Anna Maria Orengo Silvia Morbel Source Type: research
Mandatory role of endoplasmic reticulum and its pentose phosphate shunt in the myocardial defense mechanisms against the redox stress induced by anthracyclines
Mol Cell Biochem. 2023 Dec 12. doi: 10.1007/s11010-023-04903-z. Online ahead of print.ABSTRACTAnthracyclines' cardiotoxicity involves an accelerated generation of reactive oxygen species. This oxidative damage has been found to accelerate the expression of hexose-6P-dehydrogenase (H6PD), that channels glucose-6-phosphate (G6P) through the pentose phosphate pathway (PPP) confined within the endoplasmic/sarcoplasmic reticulum (SR). To verify the role of SR-PPP in the defense mechanisms activated by doxorubicin (DXR) in cardiomyocytes, we tested the effect of this drug in H6PD knockout mice (H6PD-/-). Twenty-eight wildtype (W...
Source: Molecular and Cellular Biochemistry - December 11, 2023 Category: Biochemistry Authors: Gianmario Sambuceti Vanessa Cossu Francesca Vitale Eva Bianconi Sonia Carta Consuelo Venturi Sabrina Chiesa Francesco Lanfranchi Laura Emionite Sebastiano Carlone Luca Sofia Francesca D'Amico Tania Di Raimondo Silvia Chiola Anna Maria Orengo Silvia Morbel Source Type: research
Mandatory role of endoplasmic reticulum and its pentose phosphate shunt in the myocardial defense mechanisms against the redox stress induced by anthracyclines
Mol Cell Biochem. 2023 Dec 12. doi: 10.1007/s11010-023-04903-z. Online ahead of print.ABSTRACTAnthracyclines' cardiotoxicity involves an accelerated generation of reactive oxygen species. This oxidative damage has been found to accelerate the expression of hexose-6P-dehydrogenase (H6PD), that channels glucose-6-phosphate (G6P) through the pentose phosphate pathway (PPP) confined within the endoplasmic/sarcoplasmic reticulum (SR). To verify the role of SR-PPP in the defense mechanisms activated by doxorubicin (DXR) in cardiomyocytes, we tested the effect of this drug in H6PD knockout mice (H6PD-/-). Twenty-eight wildtype (W...
Source: Molecular and Cellular Biochemistry - December 11, 2023 Category: Biochemistry Authors: Gianmario Sambuceti Vanessa Cossu Francesca Vitale Eva Bianconi Sonia Carta Consuelo Venturi Sabrina Chiesa Francesco Lanfranchi Laura Emionite Sebastiano Carlone Luca Sofia Francesca D'Amico Tania Di Raimondo Silvia Chiola Anna Maria Orengo Silvia Morbel Source Type: research
Mandatory role of endoplasmic reticulum and its pentose phosphate shunt in the myocardial defense mechanisms against the redox stress induced by anthracyclines
Mol Cell Biochem. 2023 Dec 12. doi: 10.1007/s11010-023-04903-z. Online ahead of print.ABSTRACTAnthracyclines' cardiotoxicity involves an accelerated generation of reactive oxygen species. This oxidative damage has been found to accelerate the expression of hexose-6P-dehydrogenase (H6PD), that channels glucose-6-phosphate (G6P) through the pentose phosphate pathway (PPP) confined within the endoplasmic/sarcoplasmic reticulum (SR). To verify the role of SR-PPP in the defense mechanisms activated by doxorubicin (DXR) in cardiomyocytes, we tested the effect of this drug in H6PD knockout mice (H6PD-/-). Twenty-eight wildtype (W...
Source: Molecular and Cellular Biochemistry - December 11, 2023 Category: Biochemistry Authors: Gianmario Sambuceti Vanessa Cossu Francesca Vitale Eva Bianconi Sonia Carta Consuelo Venturi Sabrina Chiesa Francesco Lanfranchi Laura Emionite Sebastiano Carlone Luca Sofia Francesca D'Amico Tania Di Raimondo Silvia Chiola Anna Maria Orengo Silvia Morbel Source Type: research
Mandatory role of endoplasmic reticulum and its pentose phosphate shunt in the myocardial defense mechanisms against the redox stress induced by anthracyclines
Mol Cell Biochem. 2023 Dec 12. doi: 10.1007/s11010-023-04903-z. Online ahead of print.ABSTRACTAnthracyclines' cardiotoxicity involves an accelerated generation of reactive oxygen species. This oxidative damage has been found to accelerate the expression of hexose-6P-dehydrogenase (H6PD), that channels glucose-6-phosphate (G6P) through the pentose phosphate pathway (PPP) confined within the endoplasmic/sarcoplasmic reticulum (SR). To verify the role of SR-PPP in the defense mechanisms activated by doxorubicin (DXR) in cardiomyocytes, we tested the effect of this drug in H6PD knockout mice (H6PD-/-). Twenty-eight wildtype (W...
Source: Molecular and Cellular Biochemistry - December 11, 2023 Category: Biochemistry Authors: Gianmario Sambuceti Vanessa Cossu Francesca Vitale Eva Bianconi Sonia Carta Consuelo Venturi Sabrina Chiesa Francesco Lanfranchi Laura Emionite Sebastiano Carlone Luca Sofia Francesca D'Amico Tania Di Raimondo Silvia Chiola Anna Maria Orengo Silvia Morbel Source Type: research
Mandatory role of endoplasmic reticulum and its pentose phosphate shunt in the myocardial defense mechanisms against the redox stress induced by anthracyclines
Mol Cell Biochem. 2023 Dec 12. doi: 10.1007/s11010-023-04903-z. Online ahead of print.ABSTRACTAnthracyclines' cardiotoxicity involves an accelerated generation of reactive oxygen species. This oxidative damage has been found to accelerate the expression of hexose-6P-dehydrogenase (H6PD), that channels glucose-6-phosphate (G6P) through the pentose phosphate pathway (PPP) confined within the endoplasmic/sarcoplasmic reticulum (SR). To verify the role of SR-PPP in the defense mechanisms activated by doxorubicin (DXR) in cardiomyocytes, we tested the effect of this drug in H6PD knockout mice (H6PD-/-). Twenty-eight wildtype (W...
Source: Molecular and Cellular Biochemistry - December 11, 2023 Category: Biochemistry Authors: Gianmario Sambuceti Vanessa Cossu Francesca Vitale Eva Bianconi Sonia Carta Consuelo Venturi Sabrina Chiesa Francesco Lanfranchi Laura Emionite Sebastiano Carlone Luca Sofia Francesca D'Amico Tania Di Raimondo Silvia Chiola Anna Maria Orengo Silvia Morbel Source Type: research
Mandatory role of endoplasmic reticulum and its pentose phosphate shunt in the myocardial defense mechanisms against the redox stress induced by anthracyclines
Mol Cell Biochem. 2023 Dec 12. doi: 10.1007/s11010-023-04903-z. Online ahead of print.ABSTRACTAnthracyclines' cardiotoxicity involves an accelerated generation of reactive oxygen species. This oxidative damage has been found to accelerate the expression of hexose-6P-dehydrogenase (H6PD), that channels glucose-6-phosphate (G6P) through the pentose phosphate pathway (PPP) confined within the endoplasmic/sarcoplasmic reticulum (SR). To verify the role of SR-PPP in the defense mechanisms activated by doxorubicin (DXR) in cardiomyocytes, we tested the effect of this drug in H6PD knockout mice (H6PD-/-). Twenty-eight wildtype (W...
Source: Molecular and Cellular Biochemistry - December 11, 2023 Category: Biochemistry Authors: Gianmario Sambuceti Vanessa Cossu Francesca Vitale Eva Bianconi Sonia Carta Consuelo Venturi Sabrina Chiesa Francesco Lanfranchi Laura Emionite Sebastiano Carlone Luca Sofia Francesca D'Amico Tania Di Raimondo Silvia Chiola Anna Maria Orengo Silvia Morbel Source Type: research
Oleic acid as modulator of oxidative stress in European sea bass (Dicentrarchus labrax) juveniles fed high dietary lipid levels
Comp Biochem Physiol B Biochem Mol Biol. 2023 Dec 5:110929. doi: 10.1016/j.cbpb.2023.110929. Online ahead of print.ABSTRACTAlthough the benefits of oleic acid (OA) have been established in mammals, its effects on fish remain understudied. The aim of this study was to evaluate the antioxidant potential of OA in the liver, intestine, and muscle of European sea bass juveniles fed diets containing different lipid levels. For that purpose, six diets with 16 or 22% lipids and 0, 1, and 2% OA were formulated and triplicate groups of European sea bass juveniles (21.4 g) were fed with these experimental diets for 9 weeks. Increasin...
Source: Comparative biochemistry and physiology. Part B, Biochemistry and molecular biology. - December 7, 2023 Category: Biochemistry Authors: Nicole Martins Sara Moutinho Rui Magalh ães Pedro Pous ão-Ferreira Aires Oliva-Teles Helena Peres Carolina Castro Source Type: research
Oleic acid as modulator of oxidative stress in European sea bass (Dicentrarchus labrax) juveniles fed high dietary lipid levels
Comp Biochem Physiol B Biochem Mol Biol. 2023 Dec 5:110929. doi: 10.1016/j.cbpb.2023.110929. Online ahead of print.ABSTRACTAlthough the benefits of oleic acid (OA) have been established in mammals, its effects on fish remain understudied. The aim of this study was to evaluate the antioxidant potential of OA in the liver, intestine, and muscle of European sea bass juveniles fed diets containing different lipid levels. For that purpose, six diets with 16 or 22% lipids and 0, 1, and 2% OA were formulated and triplicate groups of European sea bass juveniles (21.4 g) were fed with these experimental diets for 9 weeks. Increasin...
Source: Comparative biochemistry and physiology. Part B, Biochemistry and molecular biology. - December 7, 2023 Category: Biochemistry Authors: Nicole Martins Sara Moutinho Rui Magalh ães Pedro Pous ão-Ferreira Aires Oliva-Teles Helena Peres Carolina Castro Source Type: research
Prevalence of G6PD deficiency and submicroscopic malaria parasites carriage in malaria hotspot area in Northwest, Tanzania
The use of primaquine for mass drug administration (MDA) is being considered as a key strategy for malaria elimination. In addition to being the only drug active against the dormant and relapsing forms of Plasmod... (Source: Malaria Journal)
Source: Malaria Journal - December 7, 2023 Category: Infectious Diseases Authors: Alphaxard Manjurano, Eric Lyimo, Coleman Kishamawe, Justin Omolo, Jacklin Mosha, Miyaye Donald, Paul Kazyoba, Saidi Kapiga and John Changalucha Tags: Research Source Type: research
Fucoidan from Cladosiphon okamuranus enhances antioxidant activity and prevents reproductive dysfunction in polystyrene microplastic-induced male rats
This study aimed to investigate the effects of fucoidan extracted from Cladosiphon okamuranus on the polystyrene microplastic-induced oxidative stress of the Leydig (LC540) cells and reproductive damage in male rats. The oxidative stress of the LC540 cells and reproductive damage in the rats were induced by PS-MP. The fucoidan treatment reduces nitric oxide (NO) and reactive oxygen species generation in the LC540 cells. In the animal study, fucoidan treatment enhanced enzymatic antioxidant activities (glutathione peroxidase, superoxide dismutase, glucose-6-phosphate dehydrogenase, and glutathione reductase) and reduced mal...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 6, 2023 Category: Drugs & Pharmacology Authors: Yi-Yuh Hwang Sabri Sudirman En-Yu Wei Zwe-Ling Kong Deng-Fwu Hwang Source Type: research
Fucoidan from Cladosiphon okamuranus enhances antioxidant activity and prevents reproductive dysfunction in polystyrene microplastic-induced male rats
This study aimed to investigate the effects of fucoidan extracted from Cladosiphon okamuranus on the polystyrene microplastic-induced oxidative stress of the Leydig (LC540) cells and reproductive damage in male rats. The oxidative stress of the LC540 cells and reproductive damage in the rats were induced by PS-MP. The fucoidan treatment reduces nitric oxide (NO) and reactive oxygen species generation in the LC540 cells. In the animal study, fucoidan treatment enhanced enzymatic antioxidant activities (glutathione peroxidase, superoxide dismutase, glucose-6-phosphate dehydrogenase, and glutathione reductase) and reduced mal...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 6, 2023 Category: Drugs & Pharmacology Authors: Yi-Yuh Hwang Sabri Sudirman En-Yu Wei Zwe-Ling Kong Deng-Fwu Hwang Source Type: research
A rare adverse effects of COVID-19 vaccine in a patient with a latent tumor: A case report and literature review
This article may complement a rare mechanism of vaccine side effects and chemotherapy-related side effects. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - December 5, 2023 Category: Cancer & Oncology Source Type: research
Glucose-6-Phosphate Dehydrogenase Deficiency and Psychotic Disorders: A Systematic Review
Conclusions Based on the information available there was no clear association between G6PD deficiency and psychotic illness or treatment resistance, although paucity of studies and risk of bias limit strong conclusions.PMID:38044502 | DOI:10.1080/15622975.2023.2290563 (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - December 4, 2023 Category: Psychiatry Authors: Christopher Gandar James G Scott Nicola Warren Source Type: research
