Fight Aging! Newsletter, January 8th 2024
This study examined whether the local injection of the supernatant of activated PRP (saPRP) into the salivary gland (SG) could help prevent aging-induced SG dysfunction and explored the mechanisms responsible for the protective effects on the SG hypofunction.
Human salivary gland epithelial cells (hSGEC) were treated with saPRP or PRP after senescence through irradiation. The significant proliferation of hSGEC was observed in saPRP treated group compared to irradiation only group and irradiation + PRP group. Cellular senescence, apoptosis, and inflammation were significantly reduced in the saPRP group.
Th...
Source: Fight Aging! - January 7, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Sirtuin 2 Overexpression Fails to Extend Life in Mice
One long-lasting result of the hype engineered over sirtuin 1 overexpression as a possible avenue to modestly slow aging is a continued focus on other sirtuins in the context of aging. Sirtuin 1 overexpression turned out to be entirely unimpressive, a dead end. Sirtuin 6, however, is more interesting, and overexpression in mice does modestly extend life span, possibly by improving DNA repair efficiency. It may also be the case that sirtuin 3 overexpression can improve mitochondrial function to a great enough degree to also be interesting.
On the whole, however, this sort of approach to manipulating metabolism has y...
Source: Fight Aging! - January 4, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
FINDER Device for Bedside G6PD Deficiency Testing Cleared in EU
Baebies, a company out of Durham, North Carolina, just announced receiving the CE Mark for its FINDER device, clearing the way for it to be introduced in Europe. The device can help spot Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency, the most common enzyme deficiency out there, a condition that can lead to bilirubinemia, jaundice, and hemolysis, the breakup of red blood cells. The device uses only a small blood sample (50 μL) and provides results within fifteen minutes, making it easy to closely monitor newborns with the condition.
Currently, newborn blood has to be sent to the lab for analysis, but the FINDER sy...
Source: Medgadget - December 19, 2019 Category: Medical Devices Authors: Medgadget Editors Tags: Medicine Pediatrics Source Type: blogs
23andMe ’s Pharmacogenetic Test Approved by FDA
The FDA has just approved 23andMe’s Personal Genomic Service (PGS) Pharmacogenetic Reports. This marks the first direct-to-consumer test for pharmacogenetics of enzyme variants that may affect the way patients break down medications. Consumers collect their saliva into 23andMe’s testing kit, mail it to the company’s labs, and then receive the results via an online portal. The approved pharmacogenetic assessment system looks for 33 variants of common enzymes that affect medication metabolism, including CYP2C19, CYP2C9, CYP3A5, UGT1A1, DPYD, TPMT, SLCO1B1, and CYP2D6. The full list of variants can be found ...
Source: Medgadget - November 1, 2018 Category: Medical Devices Authors: Ben Ouyang Tags: Diagnostics Genetics News Source Type: blogs
Funtabulously Frivolous Friday Five 255
Just when you thought your brain could unwind on a Friday, you realise that it would rather be challenged with some good old fashioned medical trivia… Read more → (Source: Life in the Fast Lane)
Source: Life in the Fast Lane - October 12, 2018 Category: Emergency Medicine Authors: Dr Mark Corden Tags: FFFF Anton Chekhov Chinese Hamster Ovary CHO cell Fava beans fracture blister G6PD G6PD deficiency Mel Herbert Seidel's test Source Type: blogs
Funtabulously Frivolous Friday Five 255
Just when you thought your brain could unwind on a Friday, you realise that it would rather be challenged with some good old fashioned medical trivia FFFF…introducing Funtabulously Frivolous Friday Five 255 Question 1 What is the Seidel Test? Reveal the funtabulous answerTest to detect ocular leaks from the corneal, sclera or conjunctiva following surgery ...
The post Funtabulously Frivolous Friday Five 255 appeared first on Life in the Fast Lane. (Source: Life in the Fast Lane)
Source: Life in the Fast Lane - October 12, 2018 Category: Emergency Medicine Authors: Dr Mark Corden Tags: FFFF Anton Chekhov Chinese Hamster Ovary CHO cell Fava beans fracture blister G6PD G6PD deficiency Mel Herbert Seidel's test Source Type: blogs
Tropical Travel Trouble 007 Mega Malaria Extravaganza
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog
aka Tropical Travel Trouble 007
When you think tropical medicine, malaria has to be near the top. It can be fairly complex and fortunately treatment has become a lot simpler. This post is designed to walk you through the basic principals with links to more in depth teaching if your niche is travel medicine, laboratory diagnostics or management of severe or cerebral malaria. If you stubbled on this post while drinking a cup of tea or sitting on the throne and want a few basi...
Source: Life in the Fast Lane - April 5, 2018 Category: Emergency Medicine Authors: Neil Long Tags: Clinical Cases Tropical Medicine malaria Plasmodium plasmodium falciparum plasmodium knowles plasmodium malariae plasmodium ovale plasmodium vivax Source Type: blogs
Infections Develop Via a Sequence of Biological Steps
A prior post listed 7 assertions regarding the role of infectious organisms on the human genome. In the next few blogs we ' ll look at each assertion, in excerpts fromPrecision Medicine and the Reinvention of Human Disease. Here ' s the seventh:By dissecting the biological steps involved in the pathogenesis of infectious disease, it is possible to develop new treatments, other than antibiotics, that will be effective against a range of related organisms. Nature, by interfering with the different steps in the development of infectious diseases, has a variety of protective mechanisms against organisms. For example, to defend...
Source: Specified Life - February 14, 2018 Category: Information Technology Tags: biological steps infections disease pathogenesis precision medicine Source Type: blogs
Intermountain Precision Genomics to Develop Hereditary Cancer Gene Panels
The emerging healthcare model which is dominated by a small number of very large health systems will be characterized, in part, by in-house, sophisticated genomic and molecular lab testing by these systems. This is because these large health systems will have the capital to invest in their own"laboratories of excellence" within their system. Such is the case withIntermountain Healthcare which has its own in-house genomics laboratory called Intermountain Precision Genomics. Intermountain Health is one of the giant health systems with 37,000 employees, 22 hospitals, and more than 185 clinics. Here is the miss...
Source: Lab Soft News - February 13, 2018 Category: Laboratory Medicine Authors: Bruce Friedman Tags: Clinical Lab Industry News Clinical Lab Testing Genomic Testing Healthcare Business Healthcare Innovations Lab Industry Trends Lab Processes and Procedures Medical Consumerism Pathology Informatics Reference Laboratories Test Kits and Source Type: blogs
Funtabulously Frivolous Friday Five 156
Just when you thought your brain could unwind on a Friday, you realise that it would rather be challenged with some good old fashioned medical trivia FFFF…introducing Funtabulously Frivolous Friday Five 155
Question 1
What is the story behind the Cochrane logo?
+ Reveal the Funtabulous Answer
expand(document.getElementById('ddet1929929766'));expand(document.getElementById('ddetlink1929929766'))
The forest plot within the logo shows one of the first meta analyses done by Cochrane. It was showing the benefit of corticosteroids given to women who are about to give birth prematurely.
Despite several trials showing the...
Source: Life in the Fast Lane - August 26, 2016 Category: Emergency Medicine Authors: Neil Long Tags: Frivolous Friday Five cochrane logo fava beans G6PD deficiency Hannibal methaemoglobinaemia scabies scrivener's palsy seven year itch writers palsy Source Type: blogs
Increased NADPH Levels Extend Life in Female Mice Only
Researchers here report on one of many attempts to slow aging via manipulation of antioxidant levels in cells, finding that the results are gender-specific. Over the past decade there have been mixed results from animal studies that use gene therapy and other methods to increase antioxidant levels in various parts of the cell. The idea is to reduce oxidative damage associated with aging, but it is not at all obvious that this is the mechanism by which aging is slowed in those approaches that do modestly extend life. The reactive oxidant molecules that cause damage are also signals, so changing the levels of these signals c...
Source: Fight Aging! - March 16, 2016 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Don't Be Blue
A 21-year-old woman presented with a sore throat, low-grade fever, body aches, swollen glands, and generalized malaise for three days. The patient said her symptoms had worsened over the past day. She denied any difficulty breathing but endorsed pain and difficulty swallowing.
Her initial vital signs were blood pressure 132/84 mm Hg, heart rate 113 bpm, respiratory rate 22 bpm, temperature 100.4°F, and pulse oximetry 100% on room air. She was diagnosed with a peritonsillar abscess, and the EP applied a topical anesthetic to the area prior to draining it. During the procedure, the patient’s pulse oximetry dropped to...
Source: The Tox Cave - November 2, 2015 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
Don't Be Blue
A 21-year-old woman presented with a sore throat, low-grade fever, body aches, swollen glands, and generalized malaise for three days. The patient said her symptoms had worsened over the past day. She denied any difficulty breathing but endorsed pain and difficulty swallowing.
Her initial vital signs were blood pressure 132/84 mm Hg, heart rate 113 bpm, respiratory rate 22 bpm, temperature 100.4°F, and pulse oximetry 100% on room air. She was diagnosed with a peritonsillar abscess, and the EP applied a topical anesthetic to the area prior to draining it. During the procedure, the patient’s pulse oximetry dropped to 8...
Source: The Tox Cave - November 2, 2015 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
Sugar Surprises!
By Amy Campbell
’Tis the season for visions of sugarplums dancing in your head…and lurking in your food, too. The holidays are certainly a time for all sorts of treats and goodies, many which are loaded with sugar in one form or another. It's virtually impossible — and unnecessary, I might add — to completely avoid sugar. We all know that it's OK for people with diabetes to eat sugar in moderation. However, too much of a good thing isn't all that good, diabetes or not.
Sugar bombs
Americans love their sweets. But becoming too sweet on sugar has its downfalls. Dietary guidelines advise us to get no m...
Source: Diabetes Self-Management - December 23, 2013 Category: Diabetes Authors: Amy Campbell Source Type: blogs
MedlinePlus Health Topic: G6PD Deficiency
MedlinePlus has a new Health Topic page for G6PD Deficiency, a genetic condition which can cause anemia, jaundice and other health problems. The condition affects mainly males of African, Mediterranean and Middle Eastern descent, including 1 in 10 African American males.
Access resources at the Health Topic page: http://1.usa.gov/19YW5KH (Source: BHIC)
Source: BHIC - August 12, 2013 Category: Databases & Libraries Authors: Kate Flewelling Tags: Minority Health Concerns National Library of Medicine News Source Type: blogs
