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Comparative effects of pravastatin and rosuvastatin on carbohydrate metabolism in an experimental diabetic rat model
Acta Pharm. 2024 Mar 30;74(1):117-130. doi: 10.2478/acph-2024-0001. Print 2024 Mar 1.ABSTRACTStatin treatment may increase the risk of diabetes; there is insufficient data on how statins affect glucose regulation and glycemic control and the effects of statins on liver enzymes related to carbohydrate metabolism have not been fully studied. Therefore, we aimed to compare the effects of the statin derivatives, pravastatin, and rosuvastatin, on carbohydrate metabolism in an experimental diabetic rat model. Female Wistar albino rats were used and diabetes was induced by intraperitoneal injection of streptozotocin. Thereafter, ...
Source: Acta Pharmaceutica - March 30, 2024 Category: Drugs & Pharmacology Authors: Hacer Kayhan Kaya Berjan Demirtas Beran Yokus Dilek Ayg ün Kesim Ezel Tasdemir Abdurrahman Sermet Source Type: research

A nanochitosan-D-galactose formulation increases the accumulation of primaquine in the liver
Antimicrob Agents Chemother. 2024 Mar 22:e0091523. doi: 10.1128/aac.00915-23. Online ahead of print.ABSTRACTPrimaquine is the mainstream antimalarial drug to prevent Plasmodium vivax relapses. However, this drug can induce hemolysis in patients with glucose-6-phosphate dehydrogenase deficiency. Nanostructure formulations of primaquine loaded with D-galactose were used as a strategy to target the drug to the liver and decrease the hemolytic risks. Nanoemulsion (NE-Pq) and nanochitosan (NQ-Pq) formulations of primaquine diphosphate containing D-galactose were prepared and characterized by their physicochemistry properties. P...
Source: Antimicrobial Agents and Chemotherapy - March 22, 2024 Category: Microbiology Authors: F Gomes A C Ribeiro G S Sanches H S Borges L A U Takahashi C T Daniel-Ribeiro A C Tedesco J W L Nascimento L J M Carvalho Source Type: research

Metabolic pathways for glucose and fructose: I synthesis and metabolism of fructose by ovine conceptuses
This study characterized key enzymes involved in fructose synthesis and metabolism by ovine conceptuses throughout pregnancy. Day 17 conceptuses expressed mRNAs for the polyol pathway (SORD and AKR1B1) and glucose and fructose metabolism (HK1, HK2, G6PD, OGT, and FBP), but not those required for gluconeogenesis (G6Pase or PCK). Ovine placentomes also expressed mRNAs for SORD, AKR1B1, HK1, and OGT. Fructose can be metabolized via the ketohexokinase (KHK) pathway and isoforms, KHK-A and KHK-C, were expressed in ovine conceptuses from Day 16 of pregnancy and placentomes during pregnancy in a cell specific manner: KHK-A protei...
Source: Biology of Reproduction - March 19, 2024 Category: Reproduction Medicine Authors: Robyn M Moses Claire Stenhouse Katherine M Halloran Nirvay Sah Emily C Hoskins Shannon E Washburn Gregory A Johnson Guoyao Wu Fuller W Bazer Source Type: research

Metabolic pathways for glucose and fructose: I synthesis and metabolism of fructose by ovine conceptuses
This study characterized key enzymes involved in fructose synthesis and metabolism by ovine conceptuses throughout pregnancy. Day 17 conceptuses expressed mRNAs for the polyol pathway (SORD and AKR1B1) and glucose and fructose metabolism (HK1, HK2, G6PD, OGT, and FBP), but not those required for gluconeogenesis (G6Pase or PCK). Ovine placentomes also expressed mRNAs for SORD, AKR1B1, HK1, and OGT. Fructose can be metabolized via the ketohexokinase (KHK) pathway and isoforms, KHK-A and KHK-C, were expressed in ovine conceptuses from Day 16 of pregnancy and placentomes during pregnancy in a cell specific manner: KHK-A protei...
Source: Reproductive Biology - March 19, 2024 Category: Reproduction Medicine Authors: Robyn M Moses Claire Stenhouse Katherine M Halloran Nirvay Sah Emily C Hoskins Shannon E Washburn Gregory A Johnson Guoyao Wu Fuller W Bazer Source Type: research