Clonal evolution of leukemia from G6PD studies
Haematologica. 2023 Dec 1;108(12):3191-3192. doi: 10.3324/haematol.2023.284215.NO ABSTRACTPMID:38037797 | PMC:PMC10690888 | DOI:10.3324/haematol.2023.284215 (Source: Haematologica)
Source: Haematologica - December 1, 2023 Category: Hematology Authors: Tal Bacharach Liran I Shlush Source Type: research
Pharmacological and genetic increases in liver NADPH levels ameliorate NASH progression in female mice
Free Radic Biol Med. 2023 Nov 28:S0891-5849(23)01120-6. doi: 10.1016/j.freeradbiomed.2023.11.019. Online ahead of print.ABSTRACTNon-alcoholic steatohepatitis (NASH) is one of the fastest growing liver diseases worldwide, and oxidative stress is one of NASH main key drivers. Nicotinamide adenine dinucleotide phosphate (NADPH) is the ultimate donor of reductive power to a number of antioxidant defences. Here, we explored the potential of increasing NADPH levels to prevent NASH progression. We used nicotinamide riboside (NR) supplementation or a G6PD-tg mouse line harbouring an additional copy of the human G6PD gene. Both too...
Source: Free Radical Biology and Medicine - November 30, 2023 Category: Biology Authors: Ildefonso Rodriguez-Ramiro Andr és Pastor-Fernández Jos é Luis López-Aceituno Esther Garcia-Dominguez Aranzazu Sierra-Ramirez Angela M Valverde B árbara Martinez-Pastor Alejo Efeyan Mari Carmen Gomez-Cabrera Jos é Viña Pablo J Fernandez-Marcos Source Type: research
Pharmacological and genetic increases in liver NADPH levels ameliorate NASH progression in female mice
Free Radic Biol Med. 2023 Nov 28:S0891-5849(23)01120-6. doi: 10.1016/j.freeradbiomed.2023.11.019. Online ahead of print.ABSTRACTNon-alcoholic steatohepatitis (NASH) is one of the fastest growing liver diseases worldwide, and oxidative stress is one of NASH main key drivers. Nicotinamide adenine dinucleotide phosphate (NADPH) is the ultimate donor of reductive power to a number of antioxidant defences. Here, we explored the potential of increasing NADPH levels to prevent NASH progression. We used nicotinamide riboside (NR) supplementation or a G6PD-tg mouse line harbouring an additional copy of the human G6PD gene. Both too...
Source: Free Radical Biology and Medicine - November 30, 2023 Category: Biology Authors: Ildefonso Rodriguez-Ramiro Andr és Pastor-Fernández Jos é Luis López-Aceituno Esther Garcia-Dominguez Aranzazu Sierra-Ramirez Angela M Valverde B árbara Martinez-Pastor Alejo Efeyan Mari Carmen Gomez-Cabrera Jos é Viña Pablo J Fernandez-Marcos Source Type: research
Identification of a venetoclax-resistance prognostic signature base on 6-senescence genes and its clinical significance for acute myeloid leukemia
ConclusionsThe 6-senescence genes prognostic model has significant meaning for the prediction of VEN-resistance, guiding personalized molecularly targeted therapies, and improving AML prognosis. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - November 30, 2023 Category: Cancer & Oncology Source Type: research
Hemolytic anemia in a two-year-old child: A case of multiple red blood cell abnormalities
Ann Biol Clin (Paris). 2023 Nov 29;81(5). doi: 10.1684/abc.2023.1843. Online ahead of print.ABSTRACTThe discovery of hemolytic anemia requires a meticulous investigation to determine its etiology. Among patients of African origin, it is not uncommon to find multiple constitutional red blood cell abnormalities, which can complicate diagnosis. We herein describe the case of a two-year-old child presenting with acute hemolytic anemia. A G6PD deficiency, hereditary spherocytosis, and a sickle cell trait A/S were simultaneously identified, all within the context of a primary infection with Parvovirus B19. This virus commonly tr...
Source: Annales de Biologie Clinique - November 29, 2023 Category: Biochemistry Authors: Romain Ravel-Chapuis L éo Mottin Ma ïssa Souissi Agn ès Lahary Victor Bob ée Source Type: research
Hemolytic anemia in a two-year-old child: A case of multiple red blood cell abnormalities
Ann Biol Clin (Paris). 2023 Nov 29;81(5). doi: 10.1684/abc.2023.1843. Online ahead of print.ABSTRACTThe discovery of hemolytic anemia requires a meticulous investigation to determine its etiology. Among patients of African origin, it is not uncommon to find multiple constitutional red blood cell abnormalities, which can complicate diagnosis. We herein describe the case of a two-year-old child presenting with acute hemolytic anemia. A G6PD deficiency, hereditary spherocytosis, and a sickle cell trait A/S were simultaneously identified, all within the context of a primary infection with Parvovirus B19. This virus commonly tr...
Source: Annales de Biologie Clinique - November 29, 2023 Category: Biochemistry Authors: Romain Ravel-Chapuis L éo Mottin Ma ïssa Souissi Agn ès Lahary Victor Bob ée Source Type: research
Hemolytic anemia in a two-year-old child: A case of multiple red blood cell abnormalities
Ann Biol Clin (Paris). 2023 Nov 29;81(5). doi: 10.1684/abc.2023.1843. Online ahead of print.ABSTRACTThe discovery of hemolytic anemia requires a meticulous investigation to determine its etiology. Among patients of African origin, it is not uncommon to find multiple constitutional red blood cell abnormalities, which can complicate diagnosis. We herein describe the case of a two-year-old child presenting with acute hemolytic anemia. A G6PD deficiency, hereditary spherocytosis, and a sickle cell trait A/S were simultaneously identified, all within the context of a primary infection with Parvovirus B19. This virus commonly tr...
Source: Annales de Biologie Clinique - November 29, 2023 Category: Biochemistry Authors: Romain Ravel-Chapuis L éo Mottin Ma ïssa Souissi Agn ès Lahary Victor Bob ée Source Type: research
Hemolytic anemia in a two-year-old child: A case of multiple red blood cell abnormalities
Ann Biol Clin (Paris). 2023 Nov 29;81(5). doi: 10.1684/abc.2023.1843. Online ahead of print.ABSTRACTThe discovery of hemolytic anemia requires a meticulous investigation to determine its etiology. Among patients of African origin, it is not uncommon to find multiple constitutional red blood cell abnormalities, which can complicate diagnosis. We herein describe the case of a two-year-old child presenting with acute hemolytic anemia. A G6PD deficiency, hereditary spherocytosis, and a sickle cell trait A/S were simultaneously identified, all within the context of a primary infection with Parvovirus B19. This virus commonly tr...
Source: Annales de Biologie Clinique - November 29, 2023 Category: Biochemistry Authors: Romain Ravel-Chapuis L éo Mottin Ma ïssa Souissi Agn ès Lahary Victor Bob ée Source Type: research
Hemolytic anemia in a two-year-old child: A case of multiple red blood cell abnormalities
Ann Biol Clin (Paris). 2023 Nov 29;81(5). doi: 10.1684/abc.2023.1843. Online ahead of print.ABSTRACTThe discovery of hemolytic anemia requires a meticulous investigation to determine its etiology. Among patients of African origin, it is not uncommon to find multiple constitutional red blood cell abnormalities, which can complicate diagnosis. We herein describe the case of a two-year-old child presenting with acute hemolytic anemia. A G6PD deficiency, hereditary spherocytosis, and a sickle cell trait A/S were simultaneously identified, all within the context of a primary infection with Parvovirus B19. This virus commonly tr...
Source: Annales de Biologie Clinique - November 29, 2023 Category: Biochemistry Authors: Romain Ravel-Chapuis L éo Mottin Ma ïssa Souissi Agn ès Lahary Victor Bob ée Source Type: research
Hemolytic anemia in a two-year-old child: A case of multiple red blood cell abnormalities
Ann Biol Clin (Paris). 2023 Nov 29;81(5). doi: 10.1684/abc.2023.1843. Online ahead of print.ABSTRACTThe discovery of hemolytic anemia requires a meticulous investigation to determine its etiology. Among patients of African origin, it is not uncommon to find multiple constitutional red blood cell abnormalities, which can complicate diagnosis. We herein describe the case of a two-year-old child presenting with acute hemolytic anemia. A G6PD deficiency, hereditary spherocytosis, and a sickle cell trait A/S were simultaneously identified, all within the context of a primary infection with Parvovirus B19. This virus commonly tr...
Source: Annales de Biologie Clinique - November 29, 2023 Category: Biochemistry Authors: Romain Ravel-Chapuis L éo Mottin Ma ïssa Souissi Agn ès Lahary Victor Bob ée Source Type: research
Hemolytic anemia in a two-year-old child: A case of multiple red blood cell abnormalities
Ann Biol Clin (Paris). 2023 Nov 29;81(5). doi: 10.1684/abc.2023.1843. Online ahead of print.ABSTRACTThe discovery of hemolytic anemia requires a meticulous investigation to determine its etiology. Among patients of African origin, it is not uncommon to find multiple constitutional red blood cell abnormalities, which can complicate diagnosis. We herein describe the case of a two-year-old child presenting with acute hemolytic anemia. A G6PD deficiency, hereditary spherocytosis, and a sickle cell trait A/S were simultaneously identified, all within the context of a primary infection with Parvovirus B19. This virus commonly tr...
Source: Annales de Biologie Clinique - November 29, 2023 Category: Biochemistry Authors: Romain Ravel-Chapuis L éo Mottin Ma ïssa Souissi Agn ès Lahary Victor Bob ée Source Type: research
Hemolytic anemia in a two-year-old child: A case of multiple red blood cell abnormalities
Ann Biol Clin (Paris). 2023 Nov 29;81(5). doi: 10.1684/abc.2023.1843. Online ahead of print.ABSTRACTThe discovery of hemolytic anemia requires a meticulous investigation to determine its etiology. Among patients of African origin, it is not uncommon to find multiple constitutional red blood cell abnormalities, which can complicate diagnosis. We herein describe the case of a two-year-old child presenting with acute hemolytic anemia. A G6PD deficiency, hereditary spherocytosis, and a sickle cell trait A/S were simultaneously identified, all within the context of a primary infection with Parvovirus B19. This virus commonly tr...
Source: Annales de Biologie Clinique - November 29, 2023 Category: Biochemistry Authors: Romain Ravel-Chapuis L éo Mottin Ma ïssa Souissi Agn ès Lahary Victor Bob ée Source Type: research
Hemolytic anemia in a two-year-old child: A case of multiple red blood cell abnormalities
Ann Biol Clin (Paris). 2023 Nov 29;81(5). doi: 10.1684/abc.2023.1843. Online ahead of print.ABSTRACTThe discovery of hemolytic anemia requires a meticulous investigation to determine its etiology. Among patients of African origin, it is not uncommon to find multiple constitutional red blood cell abnormalities, which can complicate diagnosis. We herein describe the case of a two-year-old child presenting with acute hemolytic anemia. A G6PD deficiency, hereditary spherocytosis, and a sickle cell trait A/S were simultaneously identified, all within the context of a primary infection with Parvovirus B19. This virus commonly tr...
Source: Annales de Biologie Clinique - November 29, 2023 Category: Biochemistry Authors: Romain Ravel-Chapuis L éo Mottin Ma ïssa Souissi Agn ès Lahary Victor Bob ée Source Type: research
Hemolytic anemia in a two-year-old child: A case of multiple red blood cell abnormalities
Ann Biol Clin (Paris). 2023 Nov 29;81(5). doi: 10.1684/abc.2023.1843. Online ahead of print.ABSTRACTThe discovery of hemolytic anemia requires a meticulous investigation to determine its etiology. Among patients of African origin, it is not uncommon to find multiple constitutional red blood cell abnormalities, which can complicate diagnosis. We herein describe the case of a two-year-old child presenting with acute hemolytic anemia. A G6PD deficiency, hereditary spherocytosis, and a sickle cell trait A/S were simultaneously identified, all within the context of a primary infection with Parvovirus B19. This virus commonly tr...
Source: Annales de Biologie Clinique - November 29, 2023 Category: Biochemistry Authors: Romain Ravel-Chapuis L éo Mottin Ma ïssa Souissi Agn ès Lahary Victor Bob ée Source Type: research
Hemolytic anemia in a two-year-old child: A case of multiple red blood cell abnormalities
Ann Biol Clin (Paris). 2023 Nov 29;81(5). doi: 10.1684/abc.2023.1843. Online ahead of print.ABSTRACTThe discovery of hemolytic anemia requires a meticulous investigation to determine its etiology. Among patients of African origin, it is not uncommon to find multiple constitutional red blood cell abnormalities, which can complicate diagnosis. We herein describe the case of a two-year-old child presenting with acute hemolytic anemia. A G6PD deficiency, hereditary spherocytosis, and a sickle cell trait A/S were simultaneously identified, all within the context of a primary infection with Parvovirus B19. This virus commonly tr...
Source: Annales de Biologie Clinique - November 29, 2023 Category: Biochemistry Authors: Romain Ravel-Chapuis L éo Mottin Ma ïssa Souissi Agn ès Lahary Victor Bob ée Source Type: research
