Statins potentiate the antibacterial effect of platelets on Staphylococcus aureus.
Authors: Hannachi N, Fournier PE, Martel H, Habib G, Camoin-Jau L
Abstract
Platelets have largely demonstrated their implication in anti-infectious immunity. This effect is ensured by the secreted molecules stored mostly in platelet alpha granules. Previous studies have reported that Staphylococcus aureus showed sensitivity to this antibacterial effect of platelets. Statins, for their part, have shown a modulating effect on platelet activation. Furthermore, several studies have reported a protective effect of statins in staphylococcal endocarditis. The aim of this study was to investigate the influence of ...
Source: Platelets - July 17, 2020 Category: Hematology Tags: Platelets Source Type: research
GSE152327 Fluvastatin-perturbed RNA expression in two t(4;14)-positive multiple myeloma cell lines
Contributors : Joseph Longo ; Petr Smirnov ; Benjamin Haibe-Kains ; Trevor J Pugh ; Linda Z PennSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe goal of this study was to determine the gene expression changes following fluvastatin treatment in t(4;14)-positive multiple myeloma (MM) cell lines. To this end, two cell lines (KMS11 and NCI-H929) were treated with fluvastatin (2 micromolar) or ethanol as a solvent control for 24 hours. RNA was extracted and prepared for high-throughput sequencing in duplicate. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - July 8, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Pitavastatin for lowering lipids.
CONCLUSIONS: Pitavastatin lowers blood total cholesterol, LDL cholesterol and triglyceride in a dose-dependent linear fashion. Based on the effect on LDL cholesterol, pitavastatin is about 6-fold more potent than atorvastatin, 1.7-fold more potent than rosuvastatin, 77-fold more potent than fluvastatin and 3.3-fold less potent than cerivastatin. There were not enough data to determine risk of withdrawal due to adverse effects due to pitavastatin.
PMID: 32557581 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - June 18, 2020 Category: General Medicine Authors: Adams SP, Alaeiilkhchi N, Wright JM Tags: Cochrane Database Syst Rev Source Type: research
Statin Intolerance in Clinical Practice
AbstractPurpose of ReviewIn our pilot study, we aimed to determine how many patients with the statin intolerance history referred to the specialized center for the diagnostics and treatment of lipoprotein metabolism disorders really suffer from a complete statin intolerance. The purpose of the study was to prove that complete statin intolerance is overestimated and overdiagnosed, and with the detailed knowledge of the issue and patient approach, it is possible to find an appropriate statin treatment for the most of patients.Recent FindingsWith the increasing number of statin users worldwide, the issue of statin intolerance...
Source: Current Atherosclerosis Reports - June 2, 2020 Category: Cardiology Source Type: research
Effect of statins on cardiovascular complications in chronic kidney disease patients: A network meta-analysis
Conclusions and implications of key findings:
Pravastatin 40 mg demonstrated the best effect on all-cause mortality, and was observed to be effective with high ranking in cardiac events. We anticipate that the data of this study will assist physicians in making informed decisions when selecting statins, such as pravastatin, as a treatment option for CKD patients. (Source: Medicine)
Source: Medicine - May 29, 2020 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research
Encapsulation of Starch Hydrogel and Doping Nanomagnetite onto Metal-Organic Frameworks for Efficient Removal of Fluvastatin Antibiotic from Water
Publication date: Available online 26 May 2020Source: Carbohydrate PolymersAuthor(s): Asmaa K. Mohamed, Mohamed E. Mahmoud (Source: Carbohydrate Polymers)
Source: Carbohydrate Polymers - May 27, 2020 Category: Biomedical Science Source Type: research
Statins and the COVID-19 main protease: in silico evidence on direct interaction.
Conclusions: These results indicate, based upon the binding energy of pitavastatin, rosuvastatin, lovastatin, and fluvastatin, that statins could be efficient SARS-CoV-2 Mpro inhibitors. This is supported by the fact that the effects of some statins, especially pitavastatin, have a binding energy that is even greater than that of protease or polymerase inhibitors. However, further research is necessary to investigate their potential use as drugs for COVID-19.
PMID: 32399094 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - May 15, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research
Fluvastatin prevents the development of arthritis in env-pX rats via up- regulation of Rho GTPase-activating protein 12.
This study aimed to determine the efficacy of statins on rheumatoid arthritis (RA) and clarify how statins affect its pathogenesis. Fluvastatin (500 μg/kg/day) or vehicle was given per os to env-pX rats, which carry the human T-cell leukemia virus type I env-pX gene and spontaneously develop destructive arthritis mimicking RA, for 30 days. Blood sampling and ultrasonography (US) of the ankle joints were conducted on days 0, 10, 20, and 30. On day 30, all rats were euthanized, and the ankle joints were subjected to histological analysis. To clarify how fluvastatin affects the pathogenesis of RA, comprehensive serum exo...
Source: Experimental and Molecular Pathology - May 14, 2020 Category: Pathology Authors: Tanimura S, Nishida M, Horie T, Kamishima T, Matsumoto H, Morimura Y, Nishibata Y, Masuda S, Nakazawa D, Tomaru U, Atsumi T, Ishizu A Tags: Exp Mol Pathol Source Type: research
GSE113546 Transcriptomic analysis reveals a statin-induced core molecular signature in human iPSC-CMs
We report a comprehensive transcriptomic analysis of iPSC-CMs derived from four healthy donors and different differentiation batches following treatment with fluvastatin, simvastatin, atorvastatin, and lovastatin. Our data display dynamic transcriptional networks and reveal a statin-induced molecular signature in iPSC-CMs independent of genetic background and technical variability. Finally, in-depth pathway enrichment analysis uncovers that all statins affect mainly metabolic properties of iPSC-CMs and particularly the regulation of cholesterol biosynthesis and fatty acid metabolism. Our study provides a global insight int...
Source: GEO: Gene Expression Omnibus - April 29, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Source Type: research
Independent and Joint Use of Statins and Metformin by Elderly Patients With Diabetes and Overall Survival Following HCC Diagnosis
Conclusions:
Prediagnosis use of metformin dose ≤1500 mg/d is associated with longer overall survival of elderly diabetic HCC patients. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - April 10, 2020 Category: Gastroenterology Tags: LIVER, PANCREAS & BILIARY TRACT: Original Articles Source Type: research
Bempedoic Acid (Nexletol) for Lowering LDL-Cholesterol
Date: April 6, 2020
Issue #:
1595Summary:
The FDA has approved the oral adenosine triphosphate-citrate
lyase (ACL) inhibitor bempedoic acid for
use alone (Nexletol– Esperion) and in a fixed-dose
combination with the cholesterol absorption inhibitor
ezetimibe(Nexlizet) as an adjunct to diet and maximally
tolerated statin therapy in adults with heterozygous
familial hypercholesterolemia (HeFH) or established
atherosclerotic cardiovascular disease (ASCVD) who
require additional lowering of LDL-cholesterol (LDL-C).
Bempedoic acid is the first ACL inhibitor to be approved
in the US....
Source: The Medical Letter - March 4, 2020 Category: Drugs & Pharmacology Authors: admin Tags: alirocumab Altoprev Atorvastatin bempedoic acid Cholesterol Cholestyramine Colesevelam Colestid Colestipol Crestor evolocumab Ezetimibe Ezetrol Fenofibrate Flolipid Fluvastatin Gemfibrozil icosapent ethyl Lescol Lipit Source Type: research
[Evaluation of statin use on LDL cholesterol levels in Turkey: A systematic review].
CONCLUSION: In Turkey, only 15% of the patients who had received statin therapy had a LDL cholesterol level of <70 mg/dL. Revision of the current treatment should be considered to reach the target levels recommended in the guidelines, especially for patients with high cardiovascular risk.
PMID: 32147651 [PubMed - in process] (Source: Turk Kardiyoloji Dernegi arsivi)
Source: Turk Kardiyoloji Dernegi arsivi - February 29, 2020 Category: Cardiology Authors: Kızılırmak P, Öngen Z, Kayıkçıoğlu M, Tokgözoğlu L Tags: Turk Kardiyol Dern Ars Source Type: research
Fluvastatin protects myocardial cells in mice with acute myocardial infarction through inhibiting RhoA/ROCK pathway.
Authors: Yi Z, Ke J, Wang Y, Cai K
Abstract
Protective effect of fluvastatin (Flu) on myocardial cells in mice with acute myocardial infarction (AMI) and the mechanism were explored. Forty C57B/L6 mice in similar physiological status were selected and randomly divided into sham operation (Sham) group (n=10), AMI group (n=10), Flu group (n=10) and Flu + Angiotensin II (Ang II) (Ang II) group (n=10). The pathological changes in heart tissues were detected via hematoxylin and eosin (H&E) staining, and apoptosis of myocardial cells was detected via terminal deoxynucleotidyl transferase-mediated dUTP nick e...
Source: Experimental and Therapeutic Medicine - February 29, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research
Statin mediated cholesterol depletion exerts coordinated effects on the alterations in rat vascular smooth muscle cell biomechanics and migration.
This study demonstrates and evaluates the changes in rat vascular smooth muscle cell biomechanics following statin mediated cholesterol depletion. Evidence is presented to show correlated changes in migration and adhesion of vascular smooth muscle cells to extracellular matrix proteins fibronectin and collagen. Concurrently, integrin α5 expression was enhanced but not integrin α2. Atomic force microscopy analysis provides compelling evidence of coordinated reduction in vascular smooth muscle cell stiffness and actin cytoskeletal orientation in response to statin mediated cholesterol depletion. Proof is provided that stat...
Source: The Journal of Physiology - February 20, 2020 Category: Physiology Authors: Sanyour HJ, Li N, Rickel AP, Torres HM, Anderson RH, Miles MR, Childs JD, Francis KR, Tao J, Hong Z Tags: J Physiol Source Type: research
Rheumatoid arthritis downregulates the drug transporter OATP1B1: fluvastatin as a probe.
CONCLUSION: The lower values of CL/F and V/F for both fluvastatin enantiomers in RA patients suggest that the inflammatory disease downregulates the sinusoidal drug transporter OATP1B1, the rate-determining step in the hepatic clearance of fluvastatin.
PMID: 32058056 [PubMed - as supplied by publisher] (Source: European Journal of Pharmaceutical Sciences)
Source: European Journal of Pharmaceutical Sciences - February 10, 2020 Category: Drugs & Pharmacology Authors: Caris JA, Benzi JRL, de Souza FFL, de Oliveira RDR, Donadi EA, Lanchote VL Tags: Eur J Pharm Sci Source Type: research
