Rheumatoid arthritis downregulates the drug transporter OATP1B1: fluvastatin as a probe.

CONCLUSION: The lower values of CL/F and V/F for both fluvastatin enantiomers in RA patients suggest that the inflammatory disease downregulates the sinusoidal drug transporter OATP1B1, the rate-determining step in the hepatic clearance of fluvastatin. PMID: 32058056 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32058056?dopt=Abstract

Source: European Journal of Pharmaceutical Sciences - February 10, 2020 Category: Drugs & Pharmacology Authors: Caris JA, Benzi JRL, de Souza FFL, de Oliveira RDR, Donadi EA, Lanchote VL Tags: Eur J Pharm Sci Source Type: research