The Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for SLCO1B1, ABCG2, and CYP2C9 and statin-associated musculoskeletal symptoms
Clin Pharmacol Ther. 2022 Feb 12. doi: 10.1002/cpt.2557. Online ahead of print.ABSTRACTStatins reduce cholesterol, prevent cardiovascular disease, and are among the most commonly prescribed medications in the world. Statin-associated musculoskeletal symptoms (SAMS) impact statin adherence and ultimately can impede the long-term effectiveness of statin therapy. There are several identified pharmacogenetic variants that impact statin disposition and adverse events during statin therapy. SLCO1B1 encodes a transporter (SLCO1B1; alternative names include OATP1B1 or OATP-C) that facilitates the hepatic uptake of all statins. ABC...
Source: Clinical Pharmacology and Therapeutics - February 13, 2022 Category: Drugs & Pharmacology Authors: Rhonda M Cooper-DeHoff Mikko Niemi Laura B Ramsey Jasmine A Luzum E Katriina Tarkiainen Robert J Straka Li Gong Sony Tuteja Russell A Wilke Mia Wadelius Eric A Larson Dan M Roden Teri E Klein Sook Wah Yee Ronald M Krauss Richard M Turner Latha Palaniappan Source Type: research
Statin Induced Myopathy Among Patients Attending the National Center for Diabetes, endocrinology, & amp; genetics
CONCLUSIONS: The overall incidence of myopathy in patients taking statins was 27.8%. Myopathy was directly related to dose and type of statin used. The use of Fluvastatin XL 80 mg and Rosuvastatin 10 mg showed less incidence of myopathy compared with other statins.PMID:35145672 | PMC:PMC8818528 | DOI:10.1016/j.amsu.2022.103304 (Source: Annals of Medicine)
Source: Annals of Medicine - February 11, 2022 Category: Internal Medicine Authors: Waddah Abed Mousa Abujbara Anwar Batieha Kamel Ajlouni Source Type: research
Shrinking Weibel-Palade bodies prevents high platelet recruitment in assays using thrombotic thrombocytopenic purpura plasma
CONCLUSIONS: This potential approach of ameliorating the endothelial contribution to thrombotic risk by intervening far upstream of hemostasis might prove a useful adjunct to more conventional and direct therapies.PMID:34934893 | PMC:PMC8652131 | DOI:10.1002/rth2.12626 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - December 22, 2021 Category: Hematology Authors: Francesca Patella Chiara Vendramin Oscar Charles Marie A Scully Daniel F Cutler Source Type: research
Shrinking Weibel-Palade bodies prevents high platelet recruitment in assays using thrombotic thrombocytopenic purpura plasma
CONCLUSIONS: This potential approach of ameliorating the endothelial contribution to thrombotic risk by intervening far upstream of hemostasis might prove a useful adjunct to more conventional and direct therapies.PMID:34934893 | PMC:PMC8652131 | DOI:10.1002/rth2.12626 (Source: Cell Research)
Source: Cell Research - December 22, 2021 Category: Cytology Authors: Francesca Patella Chiara Vendramin Oscar Charles Marie A Scully Daniel F Cutler Source Type: research
Fluvastatin enhances IL-33-mediated mast cell IL-6 and TNF production
Cell Immunol. 2021 Nov 24;371:104457. doi: 10.1016/j.cellimm.2021.104457. Online ahead of print.ABSTRACTStatins are HMG-CoA reductase inhibitors prescribed for lowering cholesterol. They can also inhibit inflammatory responses by suppressing isoprenylation of small G proteins. Consistent with this, we previously found that fluvastatin suppresses IgE-mediated mast cell function. However, some studies have found that statins induced pro-inflammatory cytokines in macrophages and NK cells. In contrast to IgE signaling, we show that fluvastatin augments IL-33-induced TNF and IL-6 production by mast cells. This effect required t...
Source: Cellular Immunology - December 9, 2021 Category: Allergy & Immunology Authors: Marcela T Taruselli Elizabeth Motunrayo Kolawole Amina Abdul Qayum Tamara T Haque Heather L Caslin Daniel Abebayehu Sydney A Kee Jordan M Dailey Kaitlyn G Jackson Jason R Burchett Andrew J Spence Neha Pondicherry Brian O Barnstein Gregorio Gomez David B S Source Type: research
Fluvastatin enhances IL-33-mediated mast cell IL-6 and TNF production
Cell Immunol. 2021 Nov 24;371:104457. doi: 10.1016/j.cellimm.2021.104457. Online ahead of print.ABSTRACTStatins are HMG-CoA reductase inhibitors prescribed for lowering cholesterol. They can also inhibit inflammatory responses by suppressing isoprenylation of small G proteins. Consistent with this, we previously found that fluvastatin suppresses IgE-mediated mast cell function. However, some studies have found that statins induced pro-inflammatory cytokines in macrophages and NK cells. In contrast to IgE signaling, we show that fluvastatin augments IL-33-induced TNF and IL-6 production by mast cells. This effect required t...
Source: Cellular Immunology - December 9, 2021 Category: Allergy & Immunology Authors: Marcela T Taruselli Elizabeth Motunrayo Kolawole Amina Abdul Qayum Tamara T Haque Heather L Caslin Daniel Abebayehu Sydney A Kee Jordan M Dailey Kaitlyn G Jackson Jason R Burchett Andrew J Spence Neha Pondicherry Brian O Barnstein Gregorio Gomez David B S Source Type: research
Fluvastatin enhances IL-33-mediated mast cell IL-6 and TNF production
Cell Immunol. 2021 Nov 24;371:104457. doi: 10.1016/j.cellimm.2021.104457. Online ahead of print.ABSTRACTStatins are HMG-CoA reductase inhibitors prescribed for lowering cholesterol. They can also inhibit inflammatory responses by suppressing isoprenylation of small G proteins. Consistent with this, we previously found that fluvastatin suppresses IgE-mediated mast cell function. However, some studies have found that statins induced pro-inflammatory cytokines in macrophages and NK cells. In contrast to IgE signaling, we show that fluvastatin augments IL-33-induced TNF and IL-6 production by mast cells. This effect required t...
Source: Cellular Immunology - December 9, 2021 Category: Allergy & Immunology Authors: Marcela T Taruselli Elizabeth Motunrayo Kolawole Amina Abdul Qayum Tamara T Haque Heather L Caslin Daniel Abebayehu Sydney A Kee Jordan M Dailey Kaitlyn G Jackson Jason R Burchett Andrew J Spence Neha Pondicherry Brian O Barnstein Gregorio Gomez David B S Source Type: research
Fluvastatin enhances IL-33-mediated mast cell IL-6 and TNF production
Cell Immunol. 2021 Nov 24;371:104457. doi: 10.1016/j.cellimm.2021.104457. Online ahead of print.ABSTRACTStatins are HMG-CoA reductase inhibitors prescribed for lowering cholesterol. They can also inhibit inflammatory responses by suppressing isoprenylation of small G proteins. Consistent with this, we previously found that fluvastatin suppresses IgE-mediated mast cell function. However, some studies have found that statins induced pro-inflammatory cytokines in macrophages and NK cells. In contrast to IgE signaling, we show that fluvastatin augments IL-33-induced TNF and IL-6 production by mast cells. This effect required t...
Source: Cellular Immunology - December 9, 2021 Category: Allergy & Immunology Authors: Marcela T Taruselli Elizabeth Motunrayo Kolawole Amina Abdul Qayum Tamara T Haque Heather L Caslin Daniel Abebayehu Sydney A Kee Jordan M Dailey Kaitlyn G Jackson Jason R Burchett Andrew J Spence Neha Pondicherry Brian O Barnstein Gregorio Gomez David B S Source Type: research
Development of Sustained Release Eudragit Based Matrix Tablet of Fluvastatin Sodium Microspheres
Neha Kanojia, S. Singh and Neelam Sharma* (Source: Indian Journal of Pharmaceutical Sciences)
Source: Indian Journal of Pharmaceutical Sciences - December 6, 2021 Category: Drugs & Pharmacology Source Type: research
GSE161536 Expression data from ASPC1-GFP PDAC cells treated with fluvastatin
Contributors : Barbara M Gr üner ; Madeleine DorschSeries Type : Expression profiling by arrayOrganism : Homo sapiensDrug treatments often result in dramatic changes in gene expression.Thus, we used microarray to uncover gene expression effects of fluvastatin treatment on ASPC1-GFP PDAC cells. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - November 23, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Fluvastatin sensitizes pancreatic cancer cells toward radiation therapy and suppresses radiation- and/or TGF- β-induced tumor-associated fibrosis
In this study, we aimed to evaluate the radiosensitizing and anti-RIF potential of fluvastatin in PC. Short-term viability and clonogenic survival assays were used to evaluate the radiosensitizing potential of fluvastatin in multiple human and murine PC cell lines. The expression of different proteins was analyzed to understand the mechanisms of fluvastatin-mediated radiosensitization of PC cells and its anti-RIF effects in both mouse and human pancreatic stellate cells (PSCs). Finally, these effects of fluvastatin and/or radiation were assessed in an immune-competent syngeneic murine model of PC. Fluvastatin radiosensitiz...
Source: Cell Research - November 13, 2021 Category: Cytology Authors: Debasish Mohapatra Biswajit Das Voddu Suresh Deepti Parida Aliva Prity Minz Usharani Nayak Amlan Priyadarshee Mohapatra Rajeeb K Swain Shantibhusan Senapati Source Type: research
Atorvastatin does not ameliorate nephrogenic diabetes insipidus induced by lithium or potassium depletion in mice
In conclusion, atorvastatin does not appear to be able to prevent or rescue Li-NDI or to prevent hypokalemic-ind uced NDI. (Source: Physiological Reports)
Source: Physiological Reports - November 11, 2021 Category: Physiology Authors: Maria L. Thomsen,
Camilla Gr ønkjær,
Anna Iervolino,
Soham Rej,
Francesco Trepiccione,
Birgitte M. Christensen Tags: ORIGINAL ARTICLE Source Type: research
