Atorvastatin does not ameliorate nephrogenic diabetes insipidus induced by lithium or potassium depletion in mice
In conclusion, atorvastatin does not appear to be able to prevent or rescue Li-NDI or to prevent hypokalemic-ind uced NDI. (Source: Physiological Reports)
Source: Physiological Reports - November 11, 2021 Category: Physiology Authors: Maria L. Thomsen,
Camilla Gr ønkjær,
Anna Iervolino,
Soham Rej,
Francesco Trepiccione,
Birgitte M. Christensen Tags: ORIGINAL ARTICLE Source Type: research
Fluvastatin Reduces Glucose Tolerance in Healthy Young Individuals Independently of Cold Induced BAT Activity
ConclusionsTreatment with fluvastatin for two weeks reduced serum lipid levels but increased glucose AUC in young, healthy men, indicating reduced glucose tolerance. This was not associated with changes in cold-induced BAT activity. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - November 10, 2021 Category: Endocrinology Source Type: research
A Cell Cycle Progression-Derived Gene Signature to Predict Prognosis and Therapeutic Response in Hepatocellular Carcinoma
CONCLUSION: Collectively, CCP-derived gene signature was a promising marker in prediction of survival outcomes and therapeutic responses for HCC patients.PMID:34721731 | PMC:PMC8553501 | DOI:10.1155/2021/1986159 (Source: Disease Markers)
Source: Disease Markers - November 1, 2021 Category: Laboratory Medicine Authors: Yongfeng Hui Junzhi Leng Dong Jin Di Liu Genwang Wang Qi Wang Yanyang Wang Source Type: research
The pleotropic effects of fluvastatin on complement-mediated T-cell activation in hypercholesterolemia
Biomed Pharmacother. 2021 Nov;143:112224. doi: 10.1016/j.biopha.2021.112224. Epub 2021 Sep 24.ABSTRACTT-cells orchestrate the inflammatory responses in atherosclerosis, and their function is modified by the lipoprotein milieu and complement activity. We investigated the effects of fluvastatin on the expression of complement decay-accelerating factor (DAF/CD55) antigen, and the levels of transcription factors in circulating T-cells in hypercholesterolemia. The hypercholesterolemic state was associated with the upregulation of DAF expression on circulating T-cells and increased levels nuclear factor kappa B (NF-kB) and inter...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 15, 2021 Category: Drugs & Pharmacology Authors: Tawanda Maurice Nyambuya Phiwayinkosi Vusi Dludla Vuyolwethu Mxinwa Bongani Brian Nkambule Source Type: research
The pleotropic effects of fluvastatin on complement-mediated T-cell activation in hypercholesterolemia
Biomed Pharmacother. 2021 Nov;143:112224. doi: 10.1016/j.biopha.2021.112224. Epub 2021 Sep 24.ABSTRACTT-cells orchestrate the inflammatory responses in atherosclerosis, and their function is modified by the lipoprotein milieu and complement activity. We investigated the effects of fluvastatin on the expression of complement decay-accelerating factor (DAF/CD55) antigen, and the levels of transcription factors in circulating T-cells in hypercholesterolemia. The hypercholesterolemic state was associated with the upregulation of DAF expression on circulating T-cells and increased levels nuclear factor kappa B (NF-kB) and inter...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 15, 2021 Category: Drugs & Pharmacology Authors: Tawanda Maurice Nyambuya Phiwayinkosi Vusi Dludla Vuyolwethu Mxinwa Bongani Brian Nkambule Source Type: research
Novel function of fluvastatin in attenuating oxidized low-density lipoprotein-induced endothelial cell ferroptosis in a glutathione peroxidase4- and cystine-glutamate antiporter-dependent manner
Exp Ther Med. 2021 Nov;22(5):1275. doi: 10.3892/etm.2021.10710. Epub 2021 Sep 8.ABSTRACTOxidized low-density lipoprotein (ox-LDL) induces endothelial cell apoptosis and dysfunction. Statins are drugs that are clinically used to lower serum cholesterol levels, and they have been shown to exert vascular protective effects. In the present study, human umbilical vein endothelial cells were transfected with scramble control siRNA or siRNA specific for glutathione peroxidase (GPx)4 or cystine-glutamate antiporter (xCT). MTT, Matrigel and Transwell assays were used to evaluate cell proliferation, tube formation and migration, res...
Source: Experimental and Therapeutic Medicine - October 1, 2021 Category: General Medicine Authors: Qing Li Chang Liu Liang Deng Enrui Xie Nishant Yadav Yuanyuan Tie Zheng Cheng Jie Deng Source Type: research
A High-Cholesterol Diet Increases Toll-like Receptors and Other Harmful Factors in the Rabbit Myocardium: The Beneficial Effect of Statins
CONCLUSIONS: HCD increases the levels of TLRs; inflammatory, fibrotic and apoptotic factors; and BNP in the rabbit myocardium. Atherogenic diets adversely affect the myocardium at a molecular level and are reversed by statins.PMID:34449561 | DOI:10.3390/cimb43020059 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - August 27, 2021 Category: Molecular Biology Authors: Alkistis Kapelouzou Michalis Katsimpoulas Christos Kontogiannis Irene Lidoriki Georgios Georgiopoulos Christos Kourek Christos Papageorgiou Konstantinos S Mylonas Spyridon Dritsas Alexandros Charalabopoulos Dennis V Cokkinos Source Type: research
A High-Cholesterol Diet Increases Toll-like Receptors and Other Harmful Factors in the Rabbit Myocardium: The Beneficial Effect of Statins
CONCLUSIONS: HCD increases the levels of TLRs; inflammatory, fibrotic and apoptotic factors; and BNP in the rabbit myocardium. Atherogenic diets adversely affect the myocardium at a molecular level and are reversed by statins.PMID:34449561 | DOI:10.3390/cimb43020059 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - August 27, 2021 Category: Molecular Biology Authors: Alkistis Kapelouzou Michalis Katsimpoulas Christos Kontogiannis Irene Lidoriki Georgios Georgiopoulos Christos Kourek Christos Papageorgiou Konstantinos S Mylonas Spyridon Dritsas Alexandros Charalabopoulos Dennis V Cokkinos Source Type: research
A High-Cholesterol Diet Increases Toll-like Receptors and Other Harmful Factors in the Rabbit Myocardium: The Beneficial Effect of Statins
CONCLUSIONS: HCD increases the levels of TLRs; inflammatory, fibrotic and apoptotic factors; and BNP in the rabbit myocardium. Atherogenic diets adversely affect the myocardium at a molecular level and are reversed by statins.PMID:34449561 | DOI:10.3390/cimb43020059 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - August 27, 2021 Category: Molecular Biology Authors: Alkistis Kapelouzou Michalis Katsimpoulas Christos Kontogiannis Irene Lidoriki Georgios Georgiopoulos Christos Kourek Christos Papageorgiou Konstantinos S Mylonas Spyridon Dritsas Alexandros Charalabopoulos Dennis V Cokkinos Source Type: research
A High-Cholesterol Diet Increases Toll-like Receptors and Other Harmful Factors in the Rabbit Myocardium: The Beneficial Effect of Statins
CONCLUSIONS: HCD increases the levels of TLRs; inflammatory, fibrotic and apoptotic factors; and BNP in the rabbit myocardium. Atherogenic diets adversely affect the myocardium at a molecular level and are reversed by statins.PMID:34449561 | DOI:10.3390/cimb43020059 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - August 27, 2021 Category: Molecular Biology Authors: Alkistis Kapelouzou Michalis Katsimpoulas Christos Kontogiannis Irene Lidoriki Georgios Georgiopoulos Christos Kourek Christos Papageorgiou Konstantinos S Mylonas Spyridon Dritsas Alexandros Charalabopoulos Dennis V Cokkinos Source Type: research
A High-Cholesterol Diet Increases Toll-like Receptors and Other Harmful Factors in the Rabbit Myocardium: The Beneficial Effect of Statins
CONCLUSIONS: HCD increases the levels of TLRs; inflammatory, fibrotic and apoptotic factors; and BNP in the rabbit myocardium. Atherogenic diets adversely affect the myocardium at a molecular level and are reversed by statins.PMID:34449561 | DOI:10.3390/cimb43020059 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - August 27, 2021 Category: Molecular Biology Authors: Alkistis Kapelouzou Michalis Katsimpoulas Christos Kontogiannis Irene Lidoriki Georgios Georgiopoulos Christos Kourek Christos Papageorgiou Konstantinos S Mylonas Spyridon Dritsas Alexandros Charalabopoulos Dennis V Cokkinos Source Type: research
