A High-Cholesterol Diet Increases Toll-like Receptors and Other Harmful Factors in the Rabbit Myocardium: The Beneficial Effect of Statins
CONCLUSIONS: HCD increases the levels of TLRs; inflammatory, fibrotic and apoptotic factors; and BNP in the rabbit myocardium. Atherogenic diets adversely affect the myocardium at a molecular level and are reversed by statins.PMID:34449561 | DOI:10.3390/cimb43020059 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - August 27, 2021 Category: Molecular Biology Authors: Alkistis Kapelouzou Michalis Katsimpoulas Christos Kontogiannis Irene Lidoriki Georgios Georgiopoulos Christos Kourek Christos Papageorgiou Konstantinos S Mylonas Spyridon Dritsas Alexandros Charalabopoulos Dennis V Cokkinos Source Type: research
A High-Cholesterol Diet Increases Toll-like Receptors and Other Harmful Factors in the Rabbit Myocardium: The Beneficial Effect of Statins
CONCLUSIONS: HCD increases the levels of TLRs; inflammatory, fibrotic and apoptotic factors; and BNP in the rabbit myocardium. Atherogenic diets adversely affect the myocardium at a molecular level and are reversed by statins.PMID:34449561 | DOI:10.3390/cimb43020059 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - August 27, 2021 Category: Molecular Biology Authors: Alkistis Kapelouzou Michalis Katsimpoulas Christos Kontogiannis Irene Lidoriki Georgios Georgiopoulos Christos Kourek Christos Papageorgiou Konstantinos S Mylonas Spyridon Dritsas Alexandros Charalabopoulos Dennis V Cokkinos Source Type: research
A High-Cholesterol Diet Increases Toll-like Receptors and Other Harmful Factors in the Rabbit Myocardium: The Beneficial Effect of Statins
CONCLUSIONS: HCD increases the levels of TLRs; inflammatory, fibrotic and apoptotic factors; and BNP in the rabbit myocardium. Atherogenic diets adversely affect the myocardium at a molecular level and are reversed by statins.PMID:34449561 | DOI:10.3390/cimb43020059 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - August 27, 2021 Category: Molecular Biology Authors: Alkistis Kapelouzou Michalis Katsimpoulas Christos Kontogiannis Irene Lidoriki Georgios Georgiopoulos Christos Kourek Christos Papageorgiou Konstantinos S Mylonas Spyridon Dritsas Alexandros Charalabopoulos Dennis V Cokkinos Source Type: research
A High-Cholesterol Diet Increases Toll-like Receptors and Other Harmful Factors in the Rabbit Myocardium: The Beneficial Effect of Statins
CONCLUSIONS: HCD increases the levels of TLRs; inflammatory, fibrotic and apoptotic factors; and BNP in the rabbit myocardium. Atherogenic diets adversely affect the myocardium at a molecular level and are reversed by statins.PMID:34449561 | DOI:10.3390/cimb43020059 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - August 27, 2021 Category: Molecular Biology Authors: Alkistis Kapelouzou Michalis Katsimpoulas Christos Kontogiannis Irene Lidoriki Georgios Georgiopoulos Christos Kourek Christos Papageorgiou Konstantinos S Mylonas Spyridon Dritsas Alexandros Charalabopoulos Dennis V Cokkinos Source Type: research
A High-Cholesterol Diet Increases Toll-like Receptors and Other Harmful Factors in the Rabbit Myocardium: The Beneficial Effect of Statins
CONCLUSIONS: HCD increases the levels of TLRs; inflammatory, fibrotic and apoptotic factors; and BNP in the rabbit myocardium. Atherogenic diets adversely affect the myocardium at a molecular level and are reversed by statins.PMID:34449561 | DOI:10.3390/cimb43020059 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - August 27, 2021 Category: Molecular Biology Authors: Alkistis Kapelouzou Michalis Katsimpoulas Christos Kontogiannis Irene Lidoriki Georgios Georgiopoulos Christos Kourek Christos Papageorgiou Konstantinos S Mylonas Spyridon Dritsas Alexandros Charalabopoulos Dennis V Cokkinos Source Type: research
A High-Cholesterol Diet Increases Toll-like Receptors and Other Harmful Factors in the Rabbit Myocardium: The Beneficial Effect of Statins
CONCLUSIONS: HCD increases the levels of TLRs; inflammatory, fibrotic and apoptotic factors; and BNP in the rabbit myocardium. Atherogenic diets adversely affect the myocardium at a molecular level and are reversed by statins.PMID:34449561 | DOI:10.3390/cimb43020059 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - August 27, 2021 Category: Molecular Biology Authors: Alkistis Kapelouzou Michalis Katsimpoulas Christos Kontogiannis Irene Lidoriki Georgios Georgiopoulos Christos Kourek Christos Papageorgiou Konstantinos S Mylonas Spyridon Dritsas Alexandros Charalabopoulos Dennis V Cokkinos Source Type: research
A High-Cholesterol Diet Increases Toll-like Receptors and Other Harmful Factors in the Rabbit Myocardium: The Beneficial Effect of Statins
CONCLUSIONS: HCD increases the levels of TLRs; inflammatory, fibrotic and apoptotic factors; and BNP in the rabbit myocardium. Atherogenic diets adversely affect the myocardium at a molecular level and are reversed by statins.PMID:34449561 | DOI:10.3390/cimb43020059 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - August 27, 2021 Category: Molecular Biology Authors: Alkistis Kapelouzou Michalis Katsimpoulas Christos Kontogiannis Irene Lidoriki Georgios Georgiopoulos Christos Kourek Christos Papageorgiou Konstantinos S Mylonas Spyridon Dritsas Alexandros Charalabopoulos Dennis V Cokkinos Source Type: research
A High-Cholesterol Diet Increases Toll-like Receptors and Other Harmful Factors in the Rabbit Myocardium: The Beneficial Effect of Statins
CONCLUSIONS: HCD increases the levels of TLRs; inflammatory, fibrotic and apoptotic factors; and BNP in the rabbit myocardium. Atherogenic diets adversely affect the myocardium at a molecular level and are reversed by statins.PMID:34449561 | DOI:10.3390/cimb43020059 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - August 27, 2021 Category: Molecular Biology Authors: Alkistis Kapelouzou Michalis Katsimpoulas Christos Kontogiannis Irene Lidoriki Georgios Georgiopoulos Christos Kourek Christos Papageorgiou Konstantinos S Mylonas Spyridon Dritsas Alexandros Charalabopoulos Dennis V Cokkinos Source Type: research
A High-Cholesterol Diet Increases Toll-like Receptors and Other Harmful Factors in the Rabbit Myocardium: The Beneficial Effect of Statins
CONCLUSIONS: HCD increases the levels of TLRs; inflammatory, fibrotic and apoptotic factors; and BNP in the rabbit myocardium. Atherogenic diets adversely affect the myocardium at a molecular level and are reversed by statins.PMID:34449561 | DOI:10.3390/cimb43020059 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - August 27, 2021 Category: Molecular Biology Authors: Alkistis Kapelouzou Michalis Katsimpoulas Christos Kontogiannis Irene Lidoriki Georgios Georgiopoulos Christos Kourek Christos Papageorgiou Konstantinos S Mylonas Spyridon Dritsas Alexandros Charalabopoulos Dennis V Cokkinos Source Type: research
Viruses, Vol. 13, Pages 1437: Inhibition of Orbivirus Replication by Fluvastatin and Identification of the Key Elements of the Mevalonate Pathway Involved
am Attoui
Statin derivatives can inhibit the replication of a range of viruses, including hepatitis C virus (HCV, Hepacivirus), dengue virus (Flavivirus), African swine fever virus (Asfarviridae) and poliovirus (Picornaviridae). We assess the antiviral effect of fluvastatin in cells infected with orbiviruses (bluetongue virus (BTV) and Great Island virus (GIV)). The synthesis of orbivirus outer-capsid protein VP2 (detected by confocal immunofluorescence imaging) was used to assess levels of virus replication, showing a reduction in fluvastatin-treated cells. A reduction in virus titres of ~1.7 log (98%) in fluvastatin-...
Source: Viruses - July 23, 2021 Category: Virology Authors: Fauziah Mohd Jaafar Baptiste Monsion Mourad Belhouchet Peter P. C. Mertens Houssam Attoui Tags: Article Source Type: research
Fluvastatin-Loaded Emulsomes Exhibit Improved Cytotoxic and Apoptosis in Prostate Cancer Cells
AAPS PharmSciTech. 2021 Jun 14;22(5):177. doi: 10.1208/s12249-021-02021-x.ABSTRACTFluvastatin (FLV) is known to inhibit the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA), which is over-expressed in various cancers. FLV has been reported to decrease cancer development and metastasis. However, because of low bioavailability, extensive first-pass metabolism and short half-life of FLV (1.2 h), it is not appropriate for clinical application. Therefore, FLV-loaded emulsomes were formulated and optimized using Box-Behnken experimental design to achieve higher efficiency of formulation. Antitumor activity of optimized FLV-loaded...
Source: AAPS PharmSciTech - June 15, 2021 Category: Drugs & Pharmacology Authors: Nabil A Alhakamy Shaimaa M Badr-Eldin Hibah M Aldawsari Anas Alfarsi Thikryat Neamatallah Solomon Z Okbazghi Usama A Fahmy Osama A A Ahmad Basma G Eid Wael Ali Mahdi Adel F Alghaith Sultan Alshehri Shadab Md Source Type: research
Fluvastatin attenuated ischemia/reperfusion-induced autophagy and apoptosis in cardiomyocytes through down-regulation HMGB1/TLR4 signaling pathway
This study aims to evaluate whether the cardioprotective role of fluvastatin in I/R is mediated by high-mobility group box 1 (HMGB1)/toll-like receptor 4 (TLR4) pathway via anti-apoptotic and anti-autophagic functions. Sprague-Dawley rats were anesthetized, artificially ventilated and subjected to 30 min of coronary occlusion, followed by 4 h of reperfusion. The animals were randomized into four groups: (i) Sham operation; (ii) I/R; (iii) I/R + low-dosage fluvastatin (10 mg/kg); and (iv) I/R + high-dosage fluvastatin (20 mg/kg). After reperfusion, the hemodynamic parameters, myocardial infarct size, structural alteration o...
Source: Molecular Biology Reports - May 25, 2021 Category: Molecular Biology Authors: Hua-Sheng Ding Jun Yang Jian Yang Xin Guo Yan-Hong Tang Yan Huang Zhen Chen Zhi-Xing Fan Cong-Xin Huang Source Type: research
In silico interactions of statins with cell death-inducing DNA fragmentation factor-like effector A (CIDEA)
Chem Biol Interact. 2021 May 19:109528. doi: 10.1016/j.cbi.2021.109528. Online ahead of print.ABSTRACTStatins are the low-density lipoproteins (LDL)-cholesterol-lowering drugs of first choice and are used to prevent the increased risk of cardiovascular and cerebrovascular diseases. Although some of their effects are well known, little is known about their ability to regulate other lipid-related proteins which control apoptotic mechanisms. The aim of this study was to explore whether statins can bind to cell death-inducing DNA fragmentation factor-like effector A (CIDEA), which might be a possible pleiotropic mechanism of a...
Source: Mol Biol Cell - May 22, 2021 Category: Molecular Biology Authors: George E Barreto Janneth Gonzalez Željko Reiner Tannaz Jamialahmadi Valentina Echeverria Ghulam Md Ashraf Amirhossein Sahebkar Source Type: research
In silico interactions of statins with cell death-inducing DNA fragmentation factor-like effector A (CIDEA)
Chem Biol Interact. 2021 May 19:109528. doi: 10.1016/j.cbi.2021.109528. Online ahead of print.ABSTRACTStatins are the low-density lipoproteins (LDL)-cholesterol-lowering drugs of first choice and are used to prevent the increased risk of cardiovascular and cerebrovascular diseases. Although some of their effects are well known, little is known about their ability to regulate other lipid-related proteins which control apoptotic mechanisms. The aim of this study was to explore whether statins can bind to cell death-inducing DNA fragmentation factor-like effector A (CIDEA), which might be a possible pleiotropic mechanism of a...
Source: Chemico-Biological Interactions - May 22, 2021 Category: Molecular Biology Authors: George E Barreto Janneth Gonzalez Željko Reiner Tannaz Jamialahmadi Valentina Echeverria Ghulam Md Ashraf Amirhossein Sahebkar Source Type: research
Statins repress needle-like carbon nanotube- or cholesterol crystal-stimulated IL-1 β production by inhibiting the uptake of crystals by macrophages
In this study, we evaluated the effect of statins on crystal-induced IL-1β production in macrophages. We found that various statins, including pitavastatin, atorvastatin, fluvastatin, and lovastatin, but not squalene synthase inhibitor, repressed IL-1β release upon MWCNT stimulation. In addition, IL-1β production induced by cholesterol crystals and MSU crystals, but not by ATP or nigericin, was diminished. MWCNT-stimulated IL-1β release was dependent on the expression of NLRP3, but not AIM2, NLRC4, or MEFV. Statin-induced repression was accompanied by reduced levels of mature caspase-1 and decreased uptake of MWCNT int...
Source: Biochemical Pharmacology - April 30, 2021 Category: Drugs & Pharmacology Authors: Hongyan Cui Keisuke Soga Norimasa Tamehiro Reiko Adachi Akiko Hachisuka Akihiko Hirose Kazunari Kondo Tomoko Nishimaki-Mogami Source Type: research
