Replacing the Name of NAFLD With a Metabolic or Another Forename as Indicator of the Era of Stagnation in NASH Studies
No abstract available (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - June 10, 2021 Category: Gastroenterology Tags: Letter to the Editor Source Type: research

Predictors and Management of Failed Fecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection
Background and Goals: Clostridioides difficile infection (CDI) recurs in 10% to 15% after fecal microbiota transplantation (FMT). We identify predictors, and describe management and outcome of patients with recurrent CDI after FMT in a predominantly outpatient cohort. Methods: A nested case-control study of patients undergoing FMT for recurrent CDI from August 2012 to January 2017 was performed. FMT failure was defined as recurrent diarrhea with positive C. difficile stool test during follow-up (≥2 mo). Controls (patients without FMT failures) were matched to cases 1:1 for sex and timing of FMT±...
Source: Journal of Clinical Gastroenterology - June 10, 2021 Category: Gastroenterology Tags: Alimentary Tract: Original Articles Source Type: research

Incidence Rates, Treatment, and Survival of Rectal Cancer Among Young Patients: A Nationwide Cohort Study
Background: The incidence of colorectal cancer is increasing among young adults in the United States. We aim to investigate the incidence rate, the effect of multimodal therapy, and survival outcomes of rectal cancer in patients under 45 years of age. Patients and Methods: Data on young-onset (under 45 y) rectal cancer between 2000 and 2016 was extracted from the Surveillance, Epidemiology, and End Results Registry (SEER). Results: A total of 10,375 patients with young-onset rectal cancer were identified where 54.7% were male. The median age at diagnosis was 40±5.7 years. The overall age-adj...
Source: Journal of Clinical Gastroenterology - June 10, 2021 Category: Gastroenterology Tags: Alimentary Tract: Original Articles Source Type: research

Impact of Knowledge and Risk Perceptions on Older Adults’ Intention for Surveillance Colonoscopy
Conclusions: In this survey of older adults with a history of polyps, many had a falsely elevated perception of polyps’ potential for cancer that was associated with a higher intention for future colonoscopy. Ensuring older adults have an understanding of the risks of polyps is an essential step toward improving decision making around surveillance colonoscopy. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - June 10, 2021 Category: Gastroenterology Tags: Alimentary Tract: Original Articles Source Type: research

Do Water-aided Techniques Improve Serrated Polyp Detection Rate During Colonoscopy?: A Systematic Review With Meta-Analysis
Background and Study Aims: The utility of water-aided techniques (WT): water exchange (WE) and water immersion (WI) have been studied extensively in the literature for improving colonoscopy outcome metrics such as adenoma detection rate. Serrated polyps owing to their location and appearance have a high miss rate. The authors performed a systematic review and meta-analysis of studies comparing WT with the standard gas-assisted (GA) method to determine if there was any impact on serrated polyp detection rate (SPDR) and sessile serrated polyp detection rate. Methods: The following databases were queried for this s...
Source: Journal of Clinical Gastroenterology - June 10, 2021 Category: Gastroenterology Tags: Alimentary Tract: Original Articles Source Type: research

Effects of Lubiprostone, an Intestinal Secretagogue, on Electrolyte Homeostasis in Chronic Idiopathic and Opioid-induced Constipation
Conclusions: Lubiprostone did not cause clinically meaningful electrolyte imbalances or affect markers of renal function in either the short-term or long-term treatment of CIC or OIC. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - June 10, 2021 Category: Gastroenterology Tags: Alimentary Tract: Original Articles Source Type: research

Peroral Endoscopic Myotomy Is Safe and Highly Effective Treatment for Advanced Achalasia With Sigmoid Esophagus
Background and Aims: In advanced achalasia patients with sigmoid esophagus, peroral endoscopic myotomy (POEM) might be technically challenging and its outcomes are not well known in western population. Hence, our study aims were to assess and compare the safety and efficacy of POEM in achalasia patients with and without sigmoid esophagus. Materials and Methods: Medical records of achalasia patients who had POEM at our institution between April 2014 and December 2019 were reviewed. Patients who underwent work-up comprising timed barium esophagram (TBE) and high-resolution esophageal manometry (HREM) before POEM a...
Source: Journal of Clinical Gastroenterology - June 10, 2021 Category: Gastroenterology Tags: Alimentary Tract: Original Articles Source Type: research

Coexisting Abnormal Esophageal Body Motility Predicts Clinical Symptoms and Bolus Transit in Patients With Esophagogastric Junction Outflow Obstruction (EGJOO)
Conclusion: Coexisting abnormal EBM is associated with esophageal symptoms and bolus transit in patients with EGJOO. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - June 10, 2021 Category: Gastroenterology Tags: Alimentary Tract: Original Articles Source Type: research

Efficacy of Hemospray (TC-325) in the Treatment of Gastrointestinal Bleeding: An Updated Systematic Review and Meta-analysis
Conclusions: The addition of Hemospray to conventional therapy appears to increase immediate hemostasis but does not decrease rebleeding or mortality. As such, the use of Hemospray will likely be limited to clinical situations requiring urgent, but temporary, hemostasis to bridge to more definitive therapy. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - June 10, 2021 Category: Gastroenterology Tags: Clinical Reviews Source Type: research

Safety and Efficacy of Biological Therapy in Chronic Antibiotic Refractory Pouchitis: A Systematic Review With Meta-analysis
Conclusion: Biologic therapy is safe and effective in the treatment of CARP. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - June 10, 2021 Category: Gastroenterology Tags: Clinical Reviews Source Type: research

Probiotics for the Prevention of Antibiotic-associated Diarrhea in Adults: A Meta-Analysis of Randomized Placebo-Controlled Trials
Conclusions: This updated meta-analysis suggested that using probiotics as early as possible during antibiotic therapy has a positive and safe effect on preventing AAD in adults. Further studies should focus on the optimal dosage and duration of probiotics to develop a specific recommendation. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - June 10, 2021 Category: Gastroenterology Tags: Clinical Reviews Source Type: research

Understanding the GERD Barrier
Gastroesophageal reflux disease (GERD) is steadily increasing in incidence and now affects 18% to 28% of the population in the United States. A thorough understanding of the pathophysiology underlying this disease is necessary to improve the current standard of care. Most GERD pathophysiology models focus on the lower esophageal sphincter (LES) as the key element which prevents esophageal reflux. More recent research has highlighted the crural diaphragm (CD) as an additional critical component of the GERD barrier. We now know that the CD actively relaxes when the distal esophagus is distended and contracts when the stomach...
Source: Journal of Clinical Gastroenterology - June 10, 2021 Category: Gastroenterology Tags: Clinical Reviews Source Type: research

The Efficacy of Simethicone With Polyethylene Glycol for Bowel Preparation: A Systematic Review and Meta-Analysis
Background: Simethicone (SIM) is a commonly used antifoaming agent in the clinic. However, it has not been clarified whether SIM can improve the quality of intestinal preparation and the detection rates of adenomas (ADR) and polyps (PDR). This systematic review and meta-analysis were carried out to mainly evaluate the effect of SIM in bowel preparation for colonoscopy. Materials and Methods: An electronic and a manual search of the literature for studies was conducted in PubMed, EMBASE, and Web of Science in all published data before February 1, 2020. The primary outcomes were the quality of bowel preparation an...
Source: Journal of Clinical Gastroenterology - June 10, 2021 Category: Gastroenterology Tags: Online Article: Clinical Review Source Type: research

World Gastroenterology Organisation (WGO) News and Events
No abstract available (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - June 10, 2021 Category: Gastroenterology Tags: WGO News Source Type: research

Liver Stiffness Measured by Either Magnetic Resonance or Transient Elastography Is Associated With Liver Fibrosis and Is an Independent Predictor of Outcomes Among Patients With Primary Biliary Cholangitis
Conclusion: LS measurement with either TE or MRE can accurately detect advanced fibrosis and offers additional prognostic value beyond existing serologic predictive tools. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - April 16, 2021 Category: Gastroenterology Tags: Liver, Pancreas & Biliary Tract: Original Articles Source Type: research

Disparities in Liver Cancer Surveillance Among People With Disabilities: A National Database Study in Korea
Conclusions: Despite the availability of a national liver cancer surveillance program, a marked disparity was found in liver cancer surveillance participation, especially among people with severe disabilities, renal disease, or brain-related or mental disabilities. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - April 16, 2021 Category: Gastroenterology Tags: Liver, Pancreas & Biliary Tract: Original Articles Source Type: research

Renal Failure is Associated With Increased Mortality and Hospital Utilization in Patients Admitted With Nonalcoholic Steatohepatitis
Conclusions: The prevalence of renal failure in NASH hospitalizations is associated with markedly increased mortality, hospital costs, and length of stay. As a result, clinicians should be vigilant in treating kidney failure in this population. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - April 16, 2021 Category: Gastroenterology Tags: Liver, Pancreas & Biliary Tract: Original Articles Source Type: research

Use of Small Bowel Ultrasound to Predict Response to Infliximab Induction in Pediatric Crohn’s Disease
Goal: The goal of this study was to explore the utility of small bowel ultrasound (SBUS) as a noninvasive tool to assess induction response to infliximab (IFX) in pediatric Crohn’s disease (CD). Background: Inflammatory bowel disease management has shifted to a treat-to-target and tight control strategy utilizing noninvasive serum and fecal markers to monitor disease activity in response to therapy. Bowel wall changes as seen on cross-sectional imaging may be a more accurate marker of treatment success. Materials and Methods: Pediatric patients with CD with small bowel involvement initiating IFX wer...
Source: Journal of Clinical Gastroenterology - April 16, 2021 Category: Gastroenterology Tags: Alimentary Tract: Original Articles Source Type: research

Associations of Abdominal Pain and Psychosocial Distress Measures With Health-Related Quality-of-Life in Pediatric Healthy Controls and Irritable Bowel Syndrome
Conclusions: Multiple psychosocial distress measures, including somatization, were associated with HRQOL in children with IBS; HRQOL in HC was driven consistently by somatization, to the exclusion of other psychosocial concerns. The associations of somatization and functional disability with HRQOL are distinctly different between HC and IBS. This knowledge supports utilization of psychosocial interventions to improve overall well-being for children with IBS. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - April 16, 2021 Category: Gastroenterology Tags: Alimentary Tract: Original Articles Source Type: research

IBS Patients’ Treatment Expectancy and Motivation Impacts Quality of the Therapeutic Alliance With Provider: Results of the IBS Outcome Study
Conclusion: When managing IBS, a focus on dynamic factors of treatment motivation, social support, and treatment expectancy may be useful in improving the quality of the therapeutic alliance between patient and clinical gastroenterologist. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - April 16, 2021 Category: Gastroenterology Tags: Alimentary Tract: Original Articles Source Type: research

A Network Meta-Analysis of Randomized Controlled Trials on the Treatment of Eosinophilic Esophagitis in Adults and Children
Conclusions: This meta-analysis showed that budesonide 1 mg orodispersible tablet twice daily was the best treatment for EoE, as it was the most effective. This treatment remained the optimal approach in adult patients, whereas fluticasone was the best treatment in pediatric patients. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - April 16, 2021 Category: Gastroenterology Tags: Alimentary Tract: Original Articles Source Type: research

Hepatitis B Reactivation: A Review of Clinical Guidelines
Hepatitis B virus reactivation (HBVr) can occur spontaneously, but more often occurs when a patient is in an immunocompromised state or on immunosuppressive therapy. HBVr can lead to clinical hepatitis, acute liver failure, and even death. HBVr is preventable with screening of at-risk patients and initiation of prophylactic antiviral therapy for appropriate candidates. Screening for hepatitis B virus is recommended for all patients who plan to initiate immunosuppressive therapy. An individual’s serological profile, underlying disease, and planned type of immunosuppression contribute to their risk of HBVr. This review...
Source: Journal of Clinical Gastroenterology - April 16, 2021 Category: Gastroenterology Tags: Clinical Reviews Source Type: research

Association Between Helicobacter pylori Colonization and Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis
Conclusions: In this meta-analysis, all statistical data support the theory that H. pylori has a protective role in IBD. However, more primary studies using proper methodology are needed to confirm this association. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - April 16, 2021 Category: Gastroenterology Tags: Clinical Reviews Source Type: research

Jackhammer Esophagus: Current Concepts and Dilemmas
Jackhammer esophagus (JE) is a recently recognized esophageal motility disorder that is characterized by hypercontractile peristalsis. More than 500 cases have been reported in the literature. Among patients referred for esophageal motility disorders, the prevalence of JE ranges from 0.42% to 9%, with most series describing a prevalence of 2% to 4%. Most cases are women (60.5%). The mean reported age of patients with JE is 65.2 years, and patients commonly have dysphagia (62.8%). Reflux symptoms occur in ∼40% of patients, and chest pain affects more than one-third of patients (36.4%). JE is a heterogenous disorder that...
Source: Journal of Clinical Gastroenterology - April 16, 2021 Category: Gastroenterology Tags: Clinical Reviews Source Type: research

The Efficacy and Safety of Hemospray for the Management of Gastrointestinal Bleeding: A Systematic Review and Meta-Analysis
Conclusions: Hemospray is highly effective in achieving immediate hemostasis in gastrointestinal bleeding. However, due to significantly high rebleeding rates, Hemospray is not suited for definitive long-term therapy. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - April 16, 2021 Category: Gastroenterology Tags: Online Article: Original Article Source Type: research

World Gastroenterology Organisation (WGO) News and Events
No abstract available (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - April 16, 2021 Category: Gastroenterology Tags: WGO News Source Type: research

COVID-19 and Novel Coronavirus Cholecystitis
No abstract available (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - March 11, 2021 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Disease-related Knowledge of People With Older-onset Inflammatory Bowel Disease
No abstract available (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - March 11, 2021 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Repeated Negative Urine Trypsinogen-2 Dipstick Test Rules Out Diagnosis of Post-ERCP Pancreatitis
Conclusions: A positive dipstick seems to identify PEP cases and a negative test excludes PEP with high accuracy. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - March 11, 2021 Category: Gastroenterology Tags: Liver, Pancreas & Biliary Tract: Original Articles Source Type: research

Risk Factors Associated With Postendoscopic Mucosal Resection Bleeding in Patients With Cirrhosis: A Retrospective Multicenter Cohort Study
Conclusions: EMR in cirrhotics has an acceptable bleeding risk. Age above 65 years, right colon polyp, polyp size>15 mm, and use of antiplatelets within 5 days are independent risk factors for bleeding. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - March 11, 2021 Category: Gastroenterology Tags: Liver, Pancreas & Biliary Tract: Original Articles Source Type: research

Patients With Inflammatory Bowel Diseases Are at Higher Risk for Meningitis
Conclusions: Although the overall rate of meningitis is low, IBD patients are at an increased risk compared with non-IBD comparators. Comorbidities are a risk factor for meningitis in IBD patients. Pneumococcal and meningococcal vaccinations should be discussed. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - March 11, 2021 Category: Gastroenterology Tags: Alimentary Tract: Original Articles Source Type: research

≥3 Nonadvanced Adenomas are More Common in the Era of Contemporary Colonoscopy and Not Associated With Metachronous Advanced Neoplasia
Introduction: Data from standard definition colonoscopy era demonstrate patients with an advanced adenoma (≥10 mm, villous features or high-grade dysplasia) or ≥3 nonadvanced adenomas are considered high-risk for metachronous advanced neoplasia (MAN). Low-risk adenoma (LRA) patients are those with 1 to 2, (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - March 11, 2021 Category: Gastroenterology Tags: Alimentary Tract: Original Articles Source Type: research

Increased Sessile Serrated Adenoma Detection Rate With Mechanical New Technology Devices: A Systematic Review and Meta-Analysis
Conclusion: Mechanical NTDs, notably Endocuff, are a safe and effective tool to increase the SSADR. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - March 11, 2021 Category: Gastroenterology Tags: Alimentary Tract: Original Articles Source Type: research

Estimating the Impact of Verification Bias on Celiac Disease Testing
Conclusions: The CER may have largely overestimated the sensitivity of IgA tTG due to a failure to account for verification bias. These findings suggest caution in the interpretation of a negative IgA tTG to rule out celiac disease in clinical practice. More broadly, they highlight the impact of verification bias on diagnostic accuracy estimates and suggest that studies at risk for this bias be excluded from systematic reviews. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - March 11, 2021 Category: Gastroenterology Tags: Alimentary Tract: Original Articles Source Type: research

Low Risk of Progression of Barrett’s Esophagus to Neoplasia in Women
Background and Aims: Men are at a higher risk for Barrett’s esophagus (BE) and esophageal adenocarcinoma (EAC), but little is known about BE progression to dysplasia and EAC in women. We performed a retrospective, multicenter cohort study to assess risk of BE progression to dysplasia and EAC in women compared with men. We also investigated comorbidities, medication use, and endoscopic features that contribute to sex differences in risk of BE progression. Methods: We collected data from large cohort of patients with BE seen at 6 centers in the United States and Europe, followed for a median 5.7 years. We ob...
Source: Journal of Clinical Gastroenterology - March 11, 2021 Category: Gastroenterology Tags: Alimentary Tract: Original Articles Source Type: research

Short Meal-to-Bed Time Is a Predominant Risk Factor of Gastroesophageal Reflux Disease in Pregnancy
Conclusions: We reported for the first time that short MTBT was a predominant risk factor of GERD in pregnancy. This dieting habit was significantly associated with reflux symptom frequency and reflux-related insomnia. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - March 11, 2021 Category: Gastroenterology Tags: Alimentary Tract: Original Articles Source Type: research

A Review of Endoscopic Full-thickness Resection, Submucosal Tunneling Endoscopic Resection, and Endoscopic Submucosal Dissection for Resection of Subepithelial Lesions
Gastrointestinal subepithelial tumors (SETs) are often found while performing routine endoscopy. Recently, there has been the development of new endoscopic techniques such as endoscopic submucosal dissection, submucosal tunnel endoscopic resection, and endoscopic full-thickness resection, all minimally invasive approaches which have made it possible to resect SETs that were previously resected with surgery. This review discusses the endoscopic treatment of patients with SETs, outcomes for endoscopic treatment, procedure-related complications, and advantages and disadvantages of these endoscopic techniques. (Source: Journal...
Source: Journal of Clinical Gastroenterology - March 11, 2021 Category: Gastroenterology Tags: Clinical Reviews Source Type: research

Oral Fecal Microbiota Transplant Capsules Are Safe and Effective for Recurrent Clostridioides difficile Infection: A Systematic Review and Meta-Analysis
Conclusions: Oral FMT capsules for rCDI are promising because of ease of administration and noninvasive delivery. We found an overall efficacy of 82.1% with a low rate of serious adverse events. Further studies are needed to optimize protocols and outcomes. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - March 11, 2021 Category: Gastroenterology Tags: Clinical Reviews Source Type: research

Nausea and Vomiting in 2021: A Comprehensive Update
Conclusion: On the basis of emerging understandings of the pathophysiology of N/V, improved therapies are becoming available. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - March 11, 2021 Category: Gastroenterology Tags: Clinical Reviews Source Type: research

Efficacy and Safety of Full-thickness Resection Device (FTRD) for Colorectal Lesions Endoscopic Full-thickness Resection: A Systematic Review and Meta-Analysis
Background and Aims: Endoscopic full-thickness resection (eFTR) is a field of increasing interest that offers a minimally invasive resection modality for lesions that are not amenable for resection by conventional methods. Full-thickness resection device (FTRD) is a new device that was developed for a single-step eFTR using an over-the scope-clip. In this meta-analysis, we aim to assess the efficacy and safety of FTRD for eFTR of colorectal lesions. Methods: A Comprehensive literature review of different databases to identify studies reporting FTRD with outcomes of interest was performed. Studies with (Source: J...
Source: Journal of Clinical Gastroenterology - March 11, 2021 Category: Gastroenterology Tags: Online Article: Original Article Source Type: research

World Gastroenterology Organisation (WGO) News and Events
No abstract available (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - March 11, 2021 Category: Gastroenterology Tags: WGO News Source Type: research

Drug Eluting Versus Covered Metal Stents in Malignant Biliary Strictures—Is There a Clinical Benefit?: A Systematic Review and Meta-Analysis
Conclusion: On the basis of this meta-analysis, DES and SEMS seem to demonstrate comparable clinical outcomes in patients with malignant biliary strictures. Reported adverse events and/or complications were comparable as well. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - February 12, 2021 Category: Gastroenterology Tags: LIVER, PANCREAS & BILIARY TRACT: Original Articles Source Type: research

Pancreatic Insufficiency in Patients Under Sorafenib Treatment for Hepatocellular Carcinoma
Conclusions: We validated the association between MA and PI in 10% of sorafenib-treated patients. Pancreatic enzymes supplementation successfully led to symptomatic recovery. Awareness of this adverse event can help in the management of sorafenib irrespective of cancer type and likely, of other tyrosine kinase inhibitors for HCC patients. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - February 12, 2021 Category: Gastroenterology Tags: LIVER, PANCREAS & BILIARY TRACT: Original Articles Source Type: research

National Trends and Outcomes of Nonautoimmune Hemolytic Anemia in Alcoholic Liver Disease: Analysis of the Nationwide Inpatient Sample
Goal: The aim of this study was to determine the burden of nonautoimmune hemolytic anemia (NAHA) in hospitalized patients with coexisting alcoholic liver disease (ALD), identify risk factors for NAHA in ALD and describe the hospitalization outcomes. Background: ALD can result in structural and metabolic alterations in the red-blood cell membrane leading to premature destruction of erythrocytes and hemolytic anemia of varying severity. Study: Hospitalized ALD patients with concomitant NAHA were identified in the Nationwide Inpatient Sample database using International Classification of Diseases-9 codes fro...
Source: Journal of Clinical Gastroenterology - February 12, 2021 Category: Gastroenterology Tags: LIVER, PANCREAS & BILIARY TRACT: Original Articles Source Type: research

Cost-effectiveness of Universal Hepatitis C Screening in Pregnant Women: A Systematic Review
Conclusions: Universally screening pregnant women for HCV was CE in studies that utilized oral DAAs. Most pharmacoeconomic studies failed to incorporate the impact of vertical transmission on infants. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - February 12, 2021 Category: Gastroenterology Tags: LIVER, PANCREAS & BILIARY TRACT: Original Articles Source Type: research

Quantitative Analysis of Intramucosal Mast Cells in Irritable Bowel Syndrome: A Comparison With Inflammatory Bowel Disease in Remission
Conclusions: There is no significant difference in the number of intramucosal mast cells between IBS and IBD that show normal colonic biopsies. In IBS patients, the number of intramucosal mast cell does not correlate with symptoms. The mast cell count (≥20/HPF) is not a reliable criterion for the diagnosis of IBS or for the distinction between patients with IBS and those with IBD in remission. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - February 12, 2021 Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research

Clinical Performance of a Novel LIAISON Fecal Calprotectin Assay for Differentiation of Inflammatory Bowel Disease From Irritable Bowel Syndrome
This study was a multicenter, cross-sectional analysis of prospectively collected stool samples from patients 4 years of age or older who presented with gastrointestinal (GI) symptoms and underwent colonoscopy for diagnostic confirmation. IBD was diagnosed based on clinical, endoscopic, and histologic findings. IBS was diagnosed based on Rome III Criteria and negative colonoscopy. Stool samples were extracted and tested on the DiaSorin LIAISON XL using the LIAISON Calprotectin Assay. Results: A total of 240 patients (67% female) were included in the study. In total, 102 patients had IBD (54% ulcerative colitis), 67 ...
Source: Journal of Clinical Gastroenterology - February 12, 2021 Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research

Comparison of the Efficacy of Polaprezinc Plus Proton Pump Inhibitor and Rebamipide Plus Proton Pump Inhibitor Treatments for Endoscopic Submucosal Dissection-induced Ulcers
Conclusion: The polaprezinc plus PPI treatment showed noninferiority to rebamipide plus PPI treatment in the ulcer healing rate at 4 weeks after ESD. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - February 12, 2021 Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research

Nonbiopsy Approach for Celiac Disease Is Accurate When Using Exact Duodenal Histomorphometry: Prospective Study in 2 Countries
Goals: To test the accuracy of serology-based criteria for diagnosing celiac disease utilizing quantitative histomorphometry. Background: The revised European pediatric guidelines allow noninvasive celiac disease diagnosis for a subgroup of children. However, in some of the studies on this issue, the positive predictive value (PPV) of serology has remained suboptimal, possibly because of challenges of histopathology as the reference standard. Study: Prospectively enrolled children with transglutaminase 2 antibodies (TGA) above the upper limit of normal (ULN) underwent blood sampling and duodenal biopsy in...
Source: Journal of Clinical Gastroenterology - February 12, 2021 Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research

Pancreatic Fungal Infection in Patients With Necrotizing Pancreatitis: A Systematic Review and Meta-analysis
Conclusions: PFI is common in patients with NP and is associated with increased mortality, intensive care unit admission rate, and length of stay. Further prospective studies are needed to better understand the pathophysiology of PFIs and to determine the role for preemptive therapeutic strategies, such as prophylactic antifungal therapy. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - February 12, 2021 Category: Gastroenterology Tags: CLINICAL REVIEWS Source Type: research