Urgent Versus Standard Colonscopy for Management of Acute Lower Gastrointestinal Bleeding
No abstract available (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - June 6, 2020 Category: Gastroenterology Tags: LETTER TO THE EDITOR Source Type: research

Hepatitis B Surface Antigen Levels Are Related to Spontaneous Hepatitis B Surface Antigen Seroconversion in Inactive Hepatitis B Carriers
The objective of this study is to identify predictors of spontaneous HBsAg seroconversion from community practice. Methods: We performed a matched analysis of patients who HBsAg seroconverted (cases) and patients who did not HBsAg seroconvert (control) in a 1:5 ratio according to date of clinic visit between 2014 and 2019 in a large community practice situated in Los Angeles area. Baseline laboratory and clinical data were collected. Univariate analysis and 2-sided t tests were performed, χ2 test for proportions, and logistic regression. Results: We identified 14 cases and 70 controls. The mean (±SD) ages ...
Source: Journal of Clinical Gastroenterology - June 6, 2020 Category: Gastroenterology Tags: LIVER, PANCREAS & BILIARY TRACT: Original Articles Source Type: research

EUS-Directed Transgastric Endoscopic Retrograde Cholangiopancreatography (EDGE): The First Learning Curve
Introduction: Endoscopic ultrasound (EUS)-directed transgastric endoscopic retrograde cholangiopancreatography (EDGE) is a minimally invasive option for pancreaticobiliary access in patients with Roux-en-Y anatomy. The procedure involves creating a fistulous tract between the remnant stomach or jejunum and the bypassed stomach with the deployment of a lumen-apposing metal stent (LAMS), followed by the advancement of an endoscope through the LAMS to perform an ERCP or EUS. It is a technically challenging procedure, requiring skills in EUS, fluoroscopy, and LAMS deployment. The aim of this study was to determine the learni...
Source: Journal of Clinical Gastroenterology - June 6, 2020 Category: Gastroenterology Tags: LIVER, PANCREAS & BILIARY TRACT: Original Articles Source Type: research

Carvedilol Combined With Ivabradine Improves Left Ventricular Diastolic Dysfunction, Clinical Progression, and Survival in Cirrhosis
Background: Left ventricular diastolic dysfunction (LVDD) refers to impaired cardiac diastolic relaxation and may be improved by targeted heart rate reduction (THR). The authors evaluated whether a combination of carvedilol and ivabradine, an If channel blocker that reduces heart rate without affecting blood pressure, could improve LVDD and outcomes in cirrhosis. Patients and Methods: THR was defined as heart rate reduction to 55 to 65 beats per minute. Of 260 patients with cirrhosis, 189 (72%) with LVDD were randomized to THR [group (Gr.)A; n=94; carvedilol±ivabradine)] or standard care (Gr.B; n=95; no β-...
Source: Journal of Clinical Gastroenterology - June 6, 2020 Category: Gastroenterology Tags: LIVER, PANCREAS & BILIARY TRACT: Original Articles Source Type: research

Impact of Tilt-Down Positioning Compared With Left Lateral Positioning on Ease of Colonoscope Insertion During Colonoscopy
Goals: The aim of this study was to evaluate the efficacy of tilt-down (TD) versus left lateral (LL) positioning in speed and ease of colonoscope insertion in women with risk factors for difficult colonoscopy. Background: Risk factors for difficult colonoscopy in women include pelvic surgery, diverticulosis, and thin body habitus. Study: Female patients with body mass index (BMI) under 25, diverticulosis and history of pelvic surgery were randomized to TD or LL positioning. Five colonoscopists performed all studies at a single center. Time to splenic flexure and cecum, type and amount of medication administered, Bo...
Source: Journal of Clinical Gastroenterology - June 6, 2020 Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research

Effectiveness of a Deep-learning Polyp Detection System in Prospectively Collected Colonoscopy Videos With Variable Bowel Preparation Quality
Conclusions: A deep-learning algorithm can function effectively to detect polyps in a prospectively collected series of colonoscopies, even in the setting of variable preparation quality. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - June 6, 2020 Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research

Fecal Lactoferrin for Assessment of Inflammatory Bowel Disease Activity: A Systematic Review and Meta-Analysis
Conclusion: Our meta-analysis has found that FL is an inexpensive, simple, stable, and useful screening marker with high sensitivity and modest specificity for assessing IBD activity, appearing to have greater ability to evaluate UC rather than CD. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - June 6, 2020 Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research

Transcutaneous Neuromodulation at ST36 (Zusanli) is More Effective than Transcutaneous Tibial Nerve Stimulation in Treating Constipation
This study was designed to compare the effectiveness of TN between these 2 points. Materials and Methods: Eighteen functional constipation patients (M/F: 9/9) were recruited to participate in a cross-over study with a 2-week TN at ST36 and a 2-week TN at PTN. A bowel movement diary, and the questionnaires of Patient Assessment of Constipation Symptom (PAC-SYM) and Constipation Quality of Life (PAC-QoL) were completed; anorectal manometry and spectral analysis of heart rate variability for assessing the autonomic function were performed. Results: (1) Both TN at ST36 and TN at PTN improved constipation-related symptoms...
Source: Journal of Clinical Gastroenterology - June 6, 2020 Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research

Induction of Meal-related Symptoms as a Novel Mechanism of Action of the Duodenal-Jejunal Bypass Sleeve
Background: Treatment with a duodenal-jejunal bypass sleeve (DJBS) induces clinically significant weight loss, but little is known about the mechanisms of action of this device. Aim: The aim of this study was to characterize the mechanisms of action of the DJBS and determine the durability of weight loss and metabolic improvements. Materials and Methods: We studied a cohort of 19 subjects with severe obesity and type 2 diabetes (baseline body mass index: 43.7±5.3 kg/m2). Anthropometry, body composition, blood pressure, biochemical measures, and dietary intake were monitored for 48 weeks after DJBS imp...
Source: Journal of Clinical Gastroenterology - June 6, 2020 Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research

10-Day Versus 14-Day Quadruple Concomitant Nonbismuth Therapy for the Treatment of Helicobacter pylori Infection: Results From a Randomized Prospective Study in a High Clarithromycin Resistance Country
Conclusion: In Greece, the 10-day concomitant nonbismuth quadruple regimen for first-line treatment remains the most efficient strategy for H. pylori eradication. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - June 6, 2020 Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research

Increased Acid Exposure on Pretransplant Impedance-pH Testing Is Associated With Chronic Rejection After Lung Transplantation
Conclusion: Increased acid exposure on pretransplant reflux testing was associated with the development of BOS and CLAD, both measures of chronic allograft rejection, after lung transplantation, and may provide clinically relevant information to improve lung allograft survival through aggressive reflux management. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - June 6, 2020 Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research

Comparison of Short-Term Efficacy Between Endoscopic Submucosal Tunnel Dissection and Endoscopic Submucosal Dissection in Treatment of Wide Esophageal Squamous Cell Carcinoma of Early Stage
Conclusion: Both ESTD and ESD are safe and effective therapies for early-stage esophageal cancer wider than or equal to one half the esophageal circumference. The dissection speed of ESTD is faster than that of ESD. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - June 6, 2020 Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research

Treatment Options for Thrombocytopenia in Patients With Chronic Liver Disease Undergoing a Scheduled Procedure
Thrombocytopenia is a consequence of portal hypertension and is the most common hematological manifestation of chronic liver disease (CLD) (ie, cirrhosis). Data indicates the rates of CLD are increasing and, as a result, so will the incidence of this complication. Although bleeding risks are only relevant when elective procedures are performed, this is a frequent concern as these procedures are commonly part of the spectrum of care for patients with cirrhosis. As such, thrombocytopenia remains a pertinent issue. Fortunately, we now have effective and accurate treatment modalities to raise platelet counts before scheduled p...
Source: Journal of Clinical Gastroenterology - June 6, 2020 Category: Gastroenterology Tags: CLINICAL REVIEWS Source Type: research

Urgent Versus Standard Colonoscopy for Management of Acute Lower Gastrointestinal Bleeding: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Conclusions: Timing of colonoscopy in acute LGIB may not significantly affect patient outcomes. Timing should therefore be decided on a case-by-case basis. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - June 6, 2020 Category: Gastroenterology Tags: CLINICAL REVIEWS Source Type: research

Esophageal Function Abnormalities in Patients With Barrett’s Esophagus
Various esophageal functional abnormalities have been described in patients with Barrett’s esophagus (BE). A significantly higher esophageal acid exposure especially in the supine position has been documented in BE, as compared with the other gastroesophageal reflux disease phenotypes. In addition, weakly acidic reflux and duodenogastroesophageal reflux are more common in BE patients. The presence of Barrett’s mucosa reduces esophageal mucosal impedance, occasionally to a level that prevents detection of reflux episodes. Reduced amplitude contractions and lower esophageal sphincter basal pressure are more commo...
Source: Journal of Clinical Gastroenterology - June 6, 2020 Category: Gastroenterology Tags: CLINICAL REVIEWS Source Type: research

Manometric Esophageal Length to Height (MELH) Ratio Predicts Hiatal Hernia Recurrence
Introduction: The shortened esophagus is poorly defined and is determined intraoperatively, as there exists no objective test to identify a shortened esophagus before surgical hiatal hernia repair. We devised a unique manometric esophageal length to height (MELH) ratio to define the presence of a shortened esophagus and examined the role of esophageal length in hiatal hernia recurrence. Patients and Methods: A retrospective review identified 254 patients with hiatal hernia who underwent preoperative esophageal manometry and either an open hernia repair with Collis gastroplasty and fundoplication (with Collis) or lapar...
Source: Journal of Clinical Gastroenterology - June 6, 2020 Category: Gastroenterology Tags: ONLINE ARTICLE: Original Articles Source Type: research

Genetic Variations at rs3129891 and rs77005575 are Associated With Reduced Expression of Enteric α-defensins in IBD Patients
Conclusions: As enteric α-defensins play critical roles in the mucosal antimicrobial barrier, their reduced expression may partly explain the microbial-induced mucosal inflammation in colonic IBD patients, especially in patients carrying rs3129891 and rs77005575 mutant genotypes. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - June 6, 2020 Category: Gastroenterology Tags: ONLINE ARTICLE: Original Articles Source Type: research

World Gastroenterology Organisation (WGO) News and Events
No abstract available (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - June 6, 2020 Category: Gastroenterology Tags: WGO NEWS Source Type: research

Adverse Events After Inpatient Colonoscopy in Octogenarians: Patient Selection Key for Colonoscopies
No abstract available (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - April 10, 2020 Category: Gastroenterology Tags: LETTER TO THE EDITOR Source Type: research

Thirty-Day Readmission After Esophageal Variceal Hemorrhage and its Impact on Outcomes in the United States
Aims: The authors sought to determine the 30-day readmission rate of patients with esophageal variceal hemorrhage (EVH) and its impact on mortality, morbidity, and health care utilization. Background: EVH is a common complication of cirrhosis and leads to substantial morbidity and mortality. Study: The 2014 National Readmission Database was used to examine adult patients with urgent/emergent admissions and a principal diagnosis of EVH. The primary outcome was 30-day readmission. Secondary outcomes were in-hospital and 30-day mortality rate, most common reasons for readmission, readmission mortality rate, morbidity,...
Source: Journal of Clinical Gastroenterology - April 10, 2020 Category: Gastroenterology Tags: LIVER, PANCREAS & BILIARY TRACT: Original Articles Source Type: research

Independent and Joint Use of Statins and Metformin by Elderly Patients With Diabetes and Overall Survival Following HCC Diagnosis
Conclusions: Prediagnosis use of metformin dose ≤1500 mg/d is associated with longer overall survival of elderly diabetic HCC patients. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - April 10, 2020 Category: Gastroenterology Tags: LIVER, PANCREAS & BILIARY TRACT: Original Articles Source Type: research

Among Medicare Patients With Hepatocellular Carcinoma, Non–alcoholic Fatty Liver Disease is the Most Common Etiology and Cause of Mortality
Goals: The main purpose of this study was to assess the recent trends in mortality and health care utilization of hepatocellular carcinoma (HCC) among Medicare population in the United States. Background: The incidence of HCC is increasing in the United States. Materials and Methods: Data were obtained for a sample of Medicare beneficiary from 2005 to 2014. Diagnosis of HCC and etiology of liver disease were based on ICD-9 codes. Temporal trends in HCC rates, clinical, demographical and utilization parameters were analyzed by joinpoint regression model. Results: Study cohort included 13,648 Medicare recipients w...
Source: Journal of Clinical Gastroenterology - April 10, 2020 Category: Gastroenterology Tags: LIVER, PANCREAS & BILIARY TRACT: Original Articles Source Type: research

The Use of Capsule Endoscopy For Diagnosis of Iron Deficiency Anemia: A Retrospective Analysis
Conclusion: We report a 33.9% positive yield, with 65.8% of patients undergoing further workup as a result of CE and 12.7% requiring therapeutic intervention. We conclude that CE plays an important role in the investigation of IDA and occult gastrointestinal bleeding and has important implications on further management. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - April 10, 2020 Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research

Stressful Life Events Moderate the Relationship Between Changes in Symptom Severity and Health-related Quality of Life in Patients With Irritable Bowel Syndrome
This study is part of a cohort follow-up study on psychological factors in patients with IBS in tertiary care, and it included 158 patients. In addition to symptom severity and HRQOL, stressful life events were assessed by the Social Readjustment Rating Scale (SRRS). The relationship between symptom severity and HRQOL and the moderating role of stressful life events (in the 12 mo before the follow-up assessment) were analyzed. Results: The majority of participants had moderate levels of stressful life events (41.8%), followed by those who had mild levels (39.2%) and severe levels (19.0%) of stressful life events....
Source: Journal of Clinical Gastroenterology - April 10, 2020 Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research

Association Between Helicobacter pylori Infection and Short-segment/Long-segment Barrett’s Esophagus in a Japanese Population: A Large Cross-Sectional Study
Conclusion: In a Japanese population, H. pylori infection was inversely associated with LSBE but significantly associated with SSBE only in subjects without RE. H. pylori may be a risk factor for SSBE, especially in individuals without RE. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - April 10, 2020 Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research

Reflux Symptoms in Gastroparesis: Correlation With Gastroparesis Symptoms, Gastric Emptying, and Esophageal Function Testing
Goal: The goal of this study was to determine the relationship of reflux with gastroparesis (Gp), looking both at symptoms and objective testing. Background: Gp patients often experience gastroesophageal reflux symptoms. How the severity of reflux correlates with the severity of Gp is not known. Study: Patients referred to our academic center with symptoms of Gp completed the Patient Assessment of Upper Gastrointestinal Symptoms, Hospital Anxiety and Depression Scale, and Patient Health Questionnaire (PHQ)-15. They underwent 4-hour gastric emptying scintigraphy; and, if indicated, high-resolution esophageal manomet...
Source: Journal of Clinical Gastroenterology - April 10, 2020 Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research

Management of Incidental Pancreatic Cystic Lesions: Integrating Novel Diagnostic and Prognostic Factors With Current Clinical Guidelines
Owing to increased detection rates, the diagnosis and management of incidental pancreatic cysts has become a common predicament. Up to 13% of patients undergoing cross-sectional imaging studies for other indications are found to have pancreatic cystic lesions. Although most cystic lesions are benign, the malignant potential of several types of pancreatic cysts makes accurate classification vital to directing therapy. To this end, advances in the last decade led to better characterization of pancreatic cyst morphology and hence enhanced the ability to predict underlying histopathology, and biological behavior. Although accu...
Source: Journal of Clinical Gastroenterology - April 10, 2020 Category: Gastroenterology Tags: CLINICAL REVIEWS Source Type: research

Disruption of Circadian Rhythms and Gut Motility: An Overview of Underlying Mechanisms and Associated Pathologies
Circadian rhythms ensure that physiological processes occur at the most biologically meaningful time. The circadian timing in the gastrointestinal tract involves interlocking transcriptional and translational feedback loops that culminate in the rhythmic expression and activity of a set of clock genes and related hormones. The suprachiasmatic nucleus and peripheral core molecular clocks oscillate every 24 hours and are responsible for the periodic activity of various segments and transit along the gastrointestinal tract. Environmental cues may alter or reset these rhythms to align them with new circumstances. Colonic motil...
Source: Journal of Clinical Gastroenterology - April 10, 2020 Category: Gastroenterology Tags: CLINICAL REVIEWS Source Type: research

High Cost for Low Yield: A Systematic Review and Meta-Analysis to Assess Cost of Routine Preoperative Esophagogastroduodenoscopy Before Bariatric Surgery
Routine esophagogastroduodenoscopy (EGD) is an area of continued controversy in the preoperative evaluation for bariatric surgery; more information is needed regarding its impact on surgical management and associated costs. This systematic review and meta-analysis reports rates of abnormalities detected on preoperative EGD that changed operative management or delayed bariatric surgery. Sensitivity analysis examined the impact of controversial findings of hiatal hernia, Helicobacter pylori, gastritis, peptic ulcer disease. Data were used to calculate the cost per surgical alteration made due to abnormalities detected by rou...
Source: Journal of Clinical Gastroenterology - April 10, 2020 Category: Gastroenterology Tags: CLINICAL REVIEWS Source Type: research

Climate Change: Implications for Gastrointestinal Health and Disease
The earth’s atmosphere has warmed by about 1°C compared with preindustrial temperature. This is producing changes in the earth’s climate and weather which have implications for gastrointestinal health and disease. Climate change will exacerbate current challenges with regard to provision of adequate nutrition and access to clean water. An increase in high rainfall events, flooding and droughts will be associated with an increase in enteric infections and hepatitis. Changes in habitat may result in altered distribution of gastrointestinal illness such as Vibrio cholera. Climate change will force migration be...
Source: Journal of Clinical Gastroenterology - April 10, 2020 Category: Gastroenterology Tags: CLINICAL REVIEWS Source Type: research

Serum Levels of Chemerin, Apelin, and Adiponectin in Relation to Clinical Symptoms, Quality of Life, and Psychological Factors in Irritable Bowel Syndrome
Conclusions: Chemerin had significant associations with both the severity of clinical symptoms and psychological factors in IBS; thus, it could be considered as a potential therapeutic target in these patients; however, further studies are needed. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - April 10, 2020 Category: Gastroenterology Tags: ONLINE ARTICLE: Original Article Source Type: research

World Gastroenterology Organisation (WGO) News and Events
No abstract available (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - April 10, 2020 Category: Gastroenterology Tags: WGO NEWS Source Type: research

Interpreting Hemostatic Profiles Assessed With Viscoelastic Tests in Patients With Cirrhosis
No abstract available (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - March 11, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Adverse Events After Inpatient Colonoscopy in Octogenarians: Inferring Procedural Adverse Events From Nonspecific Diagnosis Codes
No abstract available (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - March 11, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

The Prevalence of Lean/Nonobese Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis
Conclusions: The prevalence of NAFLD in the lean/nonobese population is not rare in either the western or eastern regions of the world. This meta-analysis of prevalence assessment and clinical characteristics should enable higher confidence in more specific interventions and health care standards for these patients. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - March 11, 2020 Category: Gastroenterology Tags: Liver, Pancreas & Biliary Tract: Original Articles Source Type: research

The Model to Estimate Survival in Ambulatory Hepatocellular Carcinoma Patients Aids in the Decision for TACE Retreatment
Background/Aims: Transarterial chemoembolization (TACE) is a major therapeutic modality for patients with unresectable hepatocellular carcinoma, which needs repeated treatments. Model to Estimate Survival in Ambulatory Hepatocellular carcinoma patients (MESIAH) was recently developed as a model for predicting survival. We aimed to develop a novel index for TACE retreatment using MESIAH scores. Patients and Methods: From 2005 to 2008, 783 patients with hepatocellular carcinoma who had undergone 1 previous TACE procedure were enrolled. We calculated their pre-TACE and post-TACE-MESIAH and calculated the MESIAH ratio by ...
Source: Journal of Clinical Gastroenterology - March 11, 2020 Category: Gastroenterology Tags: Liver, Pancreas & Biliary Tract: Original Articles Source Type: research

Breath Methane Does Not Correlate With Constipation Severity or Bloating in Patients With Constipation
Goals: We aimed to study (1) if the breath methane level on glucose breath testing (GBT) was associated with constipation severity and (2) compare methane levels between patients with constipation and diarrhea. Background: The breath methane level has been associated with constipation and its severity. However, a few recent studies have questioned these associations. Study: Patients presenting consecutively to a tertiary care gastroenterology motility laboratory for GBT were included. GBT was performed using 75-g glucose load following a standard, institutional protocol. Constipation and irritable bowel syndrome (I...
Source: Journal of Clinical Gastroenterology - March 11, 2020 Category: Gastroenterology Tags: Alimentary Tract: Original Articles Source Type: research

Impact of Colonoscopy Bowel Preparation Quality on Follow-up Interval Recommendations for Average-risk Patients With Normal Screening Colonoscopies: Data From the New Hampshire Colonoscopy Registry
Background and Aims: National guidelines for colonoscopy screening and surveillance assume adequate bowel preparation. We used New Hampshire Colonoscopy Registry (NHCR) data to investigate the influence of bowel preparation quality on endoscopist recommendations for follow-up intervals in average-risk patients following normal screening colonoscopies. Methods: The analysis included 9170 normal screening colonoscopies performed on average risk individuals aged 50 and above between February 2005 and September 2013. The NHCR Procedure Form instructs endoscopists to score based on the worst prepped segment after clearing ...
Source: Journal of Clinical Gastroenterology - March 11, 2020 Category: Gastroenterology Tags: Alimentary Tract: Original Articles Source Type: research

Clostridium difficile Infection in the Emergency Department
Conclusions: Although ED use for CDI increased, rates of hospital admission decreased over 9 years. Identification of predictors of admission and in-hospital mortality will help guide policies and interventions to reduce the burden on health care resources. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - March 11, 2020 Category: Gastroenterology Tags: Alimentary Tract: Original Articles Source Type: research

Usefulness of Full-spectrum Endoscopy for the Upper Gastrointestinal Tract
Goals: We determined whether full-spectrum endoscopy (FUSE) improved the visualization rates of blind spots in a single-center case control study. Background: FUSE provides a 210-degree angle of view with a left side-viewing camera in addition to a forward-viewing camera. FUSE can improve the detectability of blind spots in conventional forward-viewing esophagogastroduodenoscopy (EGD), such as the major duodenal papilla (MDP) and the anal side of the pyloric ring. Study: Between April 2016 and May 2017, successful visualization rates of the whole MDP and anal side of the pyloric ring were compared between 103 parti...
Source: Journal of Clinical Gastroenterology - March 11, 2020 Category: Gastroenterology Tags: Alimentary Tract: Original Articles Source Type: research

Obesity Does Not Impact Outcomes or Rates of Gastroesophageal Reflux After Peroral Endoscopic Myotomy in Achalasia
Conclusions: POEM is an equally safe and effective treatment option for both nonobese and obese patients with achalasia in the short-term. Interestingly, POEM does not lead to higher rates of GERD in obese compared with nonobese patients. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - March 11, 2020 Category: Gastroenterology Tags: Alimentary Tract: Original Articles Source Type: research

Effect of Previous Nitroimidazole Treatment on Helicobacter pylori Eradication Success
Goals: The goal of this study was to examine the impact of prior treatment with a nitroimidazole antibiotic on the success of Helicobacter pylori treatment. Background: Prior nitroimidazole exposure may increase the likelihood of nitroimidazole-resistant H. pylori. Current H. pylori treatment guidelines recommend that, in the absence of susceptibility testing, patients with prior nitroimidazole exposure should not be treated with a nitroimidazole antibiotic. Data to support this recommendation are lacking. Study: We searched the Clalit Health Services database to identify subjects 25 to 60 years old who underwent a...
Source: Journal of Clinical Gastroenterology - March 11, 2020 Category: Gastroenterology Tags: Alimentary Tract: Original Articles Source Type: research

A Nonopioid, Nonbenzodiazepine Treatment Approach for Intractable Nausea and Vomiting in the Emergency Department
Conclusion: In this single-center study, the majority of patients presenting with intractable nausea and vomiting reported heavy cannabis use, and symptoms were severe. The combination of chlorpromazine plus ketamine resulted in rapid, definitive cessation of symptoms in most of these patients without the need for opioids or benzodiazepines. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - March 11, 2020 Category: Gastroenterology Tags: Alimentary Tract: Original Articles Source Type: research

Jackhammer Esophagus After Lung Transplantation: Results of a Retrospective Multicenter Study
Conclusions: JE occurs not uncommonly in patients after LT. Older age and COPD pre-LT may be significant risk factors. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - March 11, 2020 Category: Gastroenterology Tags: Alimentary Tract: Original Articles Source Type: research

Evaluation of Renal Disease in Patients With Cirrhosis
Renal dysfunction in cirrhosis is common and is associated with increased mortality. Identifying and treating reversible causes of renal disease can significantly improve outcomes. The etiology, approach, and evaluation of renal disease in this group of patients is similar to the noncirrhosis patient, with a few specific caveats. Renal disease may be unrelated to the cause of cirrhosis (eg, prerenal acute kidney injury, acute tubular necrosis), occur as a manifestation of the same systemic disease responsible for the liver disease (eg, chronic viral hepatitis B and C infection) or as a consequence of cirrhosis (hepatorenal...
Source: Journal of Clinical Gastroenterology - March 11, 2020 Category: Gastroenterology Tags: Clinical Reviews Source Type: research

Rectal Nonsteroidal Anti-Inflammatory Drugs for Endoscopic Retrograde Cholangiopancreatography Postoperative Pancreatitis Prevention: A Network Meta-Analysis
Conclusions: The present study showed that pre-ERCP diclofenac is the optimal prevention method for PEP. However, more high quality head-to-head randomized controlled trials and observational studies are expected in the future. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - March 11, 2020 Category: Gastroenterology Tags: Clinical Reviews Source Type: research

The Psychobiological Etiology of Gastrointestinal Distress in Sport: A Review
Gastrointestinal (GI) disturbances are common during training and competition, especially among endurance athletes. Historically, little attention has been paid to the psychobiological etiology of GI problems in sport. The aim of this review is to: (1) provide a physiological overview of how psychological stress and anxiety impact GI system function; (2) review the literature that has examined the role of stress and anxiety in GI distress in athletes; and (3) provide suggestions for future research. Animal and human studies have documented that psychological stressors reduce gastric motility and delay stomach emptying whil...
Source: Journal of Clinical Gastroenterology - March 11, 2020 Category: Gastroenterology Tags: Clinical Reviews Source Type: research

Efficacy of the Combination of Pinaverium Bromide 100 mg Plus Simethicone 300 mg in Abdominal Pain and Bloating in Irritable Bowel Syndrome: A Randomized, Placebo-controlled Trial
Conclusions: PB+S was superior to placebo in improving abdominal pain and bloating in patients with active IBS. The effect on the frequency of stool consistency was particularly significant in IBS-C and IBS-M. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - March 11, 2020 Category: Gastroenterology Tags: Online Article: Original Article Source Type: research

World Gastroenterology Organisation (WGO) News and Events
No abstract available (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - March 11, 2020 Category: Gastroenterology Tags: WGO News Source Type: research

Bone Mineral Density in Patients With Celiac Disease: A Further Association With Extent of Disease on Capsule Endoscopy
No abstract available (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - February 7, 2020 Category: Gastroenterology Tags: LETTER TO THE EDITOR Source Type: research