Association of Commonly Prescribed Antepartum Medications and Incidence of Orofacial Clefting
CONCLUSION: New associations between commonly prescribed antepartum medications and orofacial clefting were found. These findings should be confirmed as causality is not assessed in this report. Practitioners should be aware of the potential increased risk associated with these medications.PMID:38449319 | DOI:10.1177/10556656241237679 (Source: The Cleft Palate-Craniofacial Journal)
Source: The Cleft Palate-Craniofacial Journal - March 7, 2024 Category: ENT & OMF Authors: Matteo Laspro Hilliard T Brydges Alexandra N Verzella Jill Schechter Andre Alcon Ashley S Roman Roberto L Flores Source Type: research
Association of Commonly Prescribed Antepartum Medications and Incidence of Orofacial Clefting
CONCLUSION: New associations between commonly prescribed antepartum medications and orofacial clefting were found. These findings should be confirmed as causality is not assessed in this report. Practitioners should be aware of the potential increased risk associated with these medications.PMID:38449319 | DOI:10.1177/10556656241237679 (Source: The Cleft Palate-Craniofacial Journal)
Source: The Cleft Palate-Craniofacial Journal - March 7, 2024 Category: ENT & OMF Authors: Matteo Laspro Hilliard T Brydges Alexandra N Verzella Jill Schechter Andre Alcon Ashley S Roman Roberto L Flores Source Type: research
Serotonergic neurotransmission mediated cognitive dysfunction in two mouse models of sepsis-associated encephalopathy
CONCLUSIONS: Our study demonstrated that serotonergic neurotransmission plays a significant role in mechanisms underlying cognitive impairment in SAE. These findings contribute to identification of novel targets to prevent and arrest cognitive impairment in SAE.PMID:38433019 | DOI:10.1111/cns.14655 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 3, 2024 Category: Neuroscience Authors: Chen Zhang Fafa Tian Jing Peng Xia Wang Jingchen Li Lina Zhang Zheren Tan Source Type: research
Quercetin attenuates brain apoptosis in mice with chronic unpredictable mild stress-induced depression
CONCLUSION: QUE could attenuate brain apoptosis in mice with CUMS-induced depression, and the mechanism may be related to the ERK/Nrf2 pathway, indicating that QUE could be a potential treatment for depression.PMID:38432303 | DOI:10.1016/j.bbr.2024.114934 (Source: Brain Research)
Source: Brain Research - March 3, 2024 Category: Neurology Authors: Chenjie Ge Shiliang Wang Xuqi Wu Lilei Lei Source Type: research
Quercetin attenuates brain apoptosis in mice with chronic unpredictable mild stress-induced depression
CONCLUSION: QUE could attenuate brain apoptosis in mice with CUMS-induced depression, and the mechanism may be related to the ERK/Nrf2 pathway, indicating that QUE could be a potential treatment for depression.PMID:38432303 | DOI:10.1016/j.bbr.2024.114934 (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - March 3, 2024 Category: Neurology Authors: Chenjie Ge Shiliang Wang Xuqi Wu Lilei Lei Source Type: research
Serotonergic neurotransmission mediated cognitive dysfunction in two mouse models of sepsis-associated encephalopathy
CONCLUSIONS: Our study demonstrated that serotonergic neurotransmission plays a significant role in mechanisms underlying cognitive impairment in SAE. These findings contribute to identification of novel targets to prevent and arrest cognitive impairment in SAE.PMID:38433019 | DOI:10.1111/cns.14655 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 3, 2024 Category: Neuroscience Authors: Chen Zhang Fafa Tian Jing Peng Xia Wang Jingchen Li Lina Zhang Zheren Tan Source Type: research
Case Report: Life-Threatening Fluoxetine-Linked Postoperative Bleeding Informed by Pharmacogenetic Evaluation
ConclusionSSRI-induced bleeding is dose-related and strongly influenced by individual variations in drug metabolizing enzymes and transporters.Video abstractSupplementary file1 (MP4 8441 KB) (Source: Drugs in R&D)
Source: Drugs in R&D - February 28, 2024 Category: Drugs & Pharmacology Source Type: research
Azathioprine and hydroxychloroquine overdose in Sj ögren’s syndrome patient with hypocalcemia: a case report
ConclusionHydroxychloroquine and azathioprine toxicity are considered rare, but it is likely to increase in frequency given the prevalence and increase in autoimmune diseases and the increasing usage of these drugs in treating such diseases. We found hypocalcemia as the presentation to this patient, which needs further investigation into the probable mechanism. Clinicians need to consider the unique effects of hydroxychloroquine and azathioprine poisoning and initiate appropriate emergency interventions to improve the outcomes in similar patients. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - February 27, 2024 Category: General Medicine Source Type: research
Safety Profile of Selective Serotonin Reuptake Inhibitors in Real-World Settings: A Pharmacovigilance Study Based on FDA Adverse Event Reporting System
CONCLUSIONS AND RELEVANCE: Most of our findings are consistent with those reported previously, but some AEs were not previously identified. However, AEs attributed to SSRIs remain ambiguous, warranting further validation. Applying data-mining methods to the FAERS database can provide additional insights that can assist in appropriately utilizing SSRIs.PMID:38407147 | DOI:10.1177/10600280241231116 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 26, 2024 Category: Drugs & Pharmacology Authors: Yi Zhao Yuzhou Zhang Lin Yang Kanghuai Zhang Sha Li Source Type: research
Safety Profile of Selective Serotonin Reuptake Inhibitors in Real-World Settings: A Pharmacovigilance Study Based on FDA Adverse Event Reporting System
CONCLUSIONS AND RELEVANCE: Most of our findings are consistent with those reported previously, but some AEs were not previously identified. However, AEs attributed to SSRIs remain ambiguous, warranting further validation. Applying data-mining methods to the FAERS database can provide additional insights that can assist in appropriately utilizing SSRIs.PMID:38407147 | DOI:10.1177/10600280241231116 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 26, 2024 Category: Drugs & Pharmacology Authors: Yi Zhao Yuzhou Zhang Lin Yang Kanghuai Zhang Sha Li Source Type: research
Safety Profile of Selective Serotonin Reuptake Inhibitors in Real-World Settings: A Pharmacovigilance Study Based on FDA Adverse Event Reporting System
CONCLUSIONS AND RELEVANCE: Most of our findings are consistent with those reported previously, but some AEs were not previously identified. However, AEs attributed to SSRIs remain ambiguous, warranting further validation. Applying data-mining methods to the FAERS database can provide additional insights that can assist in appropriately utilizing SSRIs.PMID:38407147 | DOI:10.1177/10600280241231116 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 26, 2024 Category: Drugs & Pharmacology Authors: Yi Zhao Yuzhou Zhang Lin Yang Kanghuai Zhang Sha Li Source Type: research
Safety Profile of Selective Serotonin Reuptake Inhibitors in Real-World Settings: A Pharmacovigilance Study Based on FDA Adverse Event Reporting System
CONCLUSIONS AND RELEVANCE: Most of our findings are consistent with those reported previously, but some AEs were not previously identified. However, AEs attributed to SSRIs remain ambiguous, warranting further validation. Applying data-mining methods to the FAERS database can provide additional insights that can assist in appropriately utilizing SSRIs.PMID:38407147 | DOI:10.1177/10600280241231116 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 26, 2024 Category: Drugs & Pharmacology Authors: Yi Zhao Yuzhou Zhang Lin Yang Kanghuai Zhang Sha Li Source Type: research
Safety Profile of Selective Serotonin Reuptake Inhibitors in Real-World Settings: A Pharmacovigilance Study Based on FDA Adverse Event Reporting System
CONCLUSIONS AND RELEVANCE: Most of our findings are consistent with those reported previously, but some AEs were not previously identified. However, AEs attributed to SSRIs remain ambiguous, warranting further validation. Applying data-mining methods to the FAERS database can provide additional insights that can assist in appropriately utilizing SSRIs.PMID:38407147 | DOI:10.1177/10600280241231116 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 26, 2024 Category: Drugs & Pharmacology Authors: Yi Zhao Yuzhou Zhang Lin Yang Kanghuai Zhang Sha Li Source Type: research
Safety Profile of Selective Serotonin Reuptake Inhibitors in Real-World Settings: A Pharmacovigilance Study Based on FDA Adverse Event Reporting System
CONCLUSIONS AND RELEVANCE: Most of our findings are consistent with those reported previously, but some AEs were not previously identified. However, AEs attributed to SSRIs remain ambiguous, warranting further validation. Applying data-mining methods to the FAERS database can provide additional insights that can assist in appropriately utilizing SSRIs.PMID:38407147 | DOI:10.1177/10600280241231116 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 26, 2024 Category: Drugs & Pharmacology Authors: Yi Zhao Yuzhou Zhang Lin Yang Kanghuai Zhang Sha Li Source Type: research
Safety Profile of Selective Serotonin Reuptake Inhibitors in Real-World Settings: A Pharmacovigilance Study Based on FDA Adverse Event Reporting System
CONCLUSIONS AND RELEVANCE: Most of our findings are consistent with those reported previously, but some AEs were not previously identified. However, AEs attributed to SSRIs remain ambiguous, warranting further validation. Applying data-mining methods to the FAERS database can provide additional insights that can assist in appropriately utilizing SSRIs.PMID:38407147 | DOI:10.1177/10600280241231116 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 26, 2024 Category: Drugs & Pharmacology Authors: Yi Zhao Yuzhou Zhang Lin Yang Kanghuai Zhang Sha Li Source Type: research
