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Metabolic Activities Catalyzed by Human Cytochrome P450 (CYP) 2D6 and CYP3A Subfamily Members and Effect of Various Compounds, Including Endogenous Steroid Hormones, on These Activities
Yakugaku Zasshi. 2024;144(2):197-202. doi: 10.1248/yakushi.23-00174.ABSTRACTMy research focused on the effects of various drugs on (1) dopamine formation from p-tyramine catalyzed by polymorphic cytochrome P450 (CYP or P450) 2D6 variants and (2) endogenous steroid hormone hydroxylation catalyzed by CYP3A subfamily members (CYP3A4, CYP3A5, CYP3A7). The activation (cooperativity) of metabolic reactions catalyzed by P450s was especially emphasized. The effects of various psychotropic agents on dopamine formation from p-tyramine, catalyzed by wild-type CYP2D6.1 and CYP2D6 variants, including CYP2D6.2 (Arg296Cys;Ser486Thr), CYP...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 31, 2024 Category: Drugs & Pharmacology Authors: Toshiro Niwa Source Type: research

Molecules, Vol. 29, Pages 676: Direct Immersion & ndash;Solid Phase Microextraction for Therapeutic Drug Monitoring of Patients with Mood Disorders
This article discusses a new method for monitoring drug concentrations in blood samples from patients with mood disorders. The method uses solid-phase microextraction to extract analytes directly from blood samples. It has been adapted to identify the most commonly used drugs in mood disorders, including amitriptyline, citalopram, fluoxetine, paroxetine, sertraline, trazodone, duloxetine, venlafaxine, lamotrigine, quetiapine, olanzapine, and mirtazapine. The analysis is carried out using high-performance liquid chromatography coupled with mass spectroscopy. The proposed DI-SPME/LC-MS method allows for a simple and quick sc...
Source: Molecules - January 31, 2024 Category: Chemistry Authors: Magdalena Świądro-Piętoń Dominika Dudek Renata Wietecha-Pos łuszny Tags: Article Source Type: research

Repetitive transcranial magnetic stimulation and fluoxetine attenuate astroglial activation and benefit behaviours in a chronic unpredictable mild stress mouse model of depression
Volume 25, Issue 2, February 2024, Page 82-94 . (Source: World Journal of Biological Psychiatry)
Source: World Journal of Biological Psychiatry - January 31, 2024 Category: Psychiatry Authors: Qianfa YuanYuying LeiKai YuJunnan WuZhizhong XuChunyan WenYanlong LiuWenqiang WangJue Hea Fujian Psychiatric Center, Fujian Clinical Research Center for Mental Disorders, Xiamen Xian Yue Hospital, Xian Yue Hospital Affiliated with Xiamen Medical College, Source Type: research

The Practice of Prescribing Antidepressants During Pregnancy and Breastfeeding Among Mental Health Practitioners in Tertiary Care Centers in Oman
CONCLUSIONS: There was inconsistency among mental health practitioners in making prescription decisions and in their prescribing patterns.PMID:38264515 | PMC:PMC10801695 | DOI:10.5001/omj.2023.123 (Source: Oman Medical Journal)
Source: Oman Medical Journal - January 24, 2024 Category: Middle East Health Authors: Salim Al Kasbi Yousif Obaid Samir Al Adawi Sanjay Jaju Source Type: research

The effect of drug holidays on sexual dysfunction in men treated with selective serotonin reuptake inhibitors (SSRIs) other than fluoxetine: an 8-week open-label randomized clinical trial
Selective serotonin reuptake inhibitors (SSRIs) are widely used for the treatment of various mental disorders. Sexual dysfunction is one of the most common side effects of SSRIs, and often leads to poor adhere... (Source: BMC Psychiatry)
Source: BMC Psychiatry - January 23, 2024 Category: Psychiatry Authors: Arman Alipour-Kivi, Negin Eissazade, Seyed Vahid Shariat, Razieh Salehian, Shiva Soraya, Sanaz Askari and Mohammadreza Shalbafan Tags: Research Source Type: research