The hippocampal Salt-Inducible Kinase 2-CREB-Regulated Transcription Co-activator 1 system mediates the antidepressant actions of paroxetine in mice
Behav Brain Res. 2024 Mar 27:114972. doi: 10.1016/j.bbr.2024.114972. Online ahead of print.ABSTRACTThe hippocampal salt-inducible kinase 2 (SIK2)-CREB-regulated transcription co-activator 1 (CRTC1) system has been demonstrated to participate in not only the pathogenesis of depression but also the antidepressant mechanisms of several antidepressant medications including fluoxetine, paroxetine, and mirtazapine. Like fluoxetine, paroxetine is also a widely used selective serotonin (5-HT) reuptake inhibitor (SSRI). Recent studies have indicated that paroxetine also modulates several pharmacological targets other than the 5-HT ...
Source: Behavioural Brain Research - March 29, 2024 Category: Neurology Authors: Xiang-Ming Cai Xiao-Yu Sun Rui Li Pei-Juan Wang Jian-Cheng Qi Yu-Xin Ge Lei Yang Source Type: research
The hippocampal Salt-Inducible Kinase 2-CREB-Regulated Transcription Co-activator 1 system mediates the antidepressant actions of paroxetine in mice
Behav Brain Res. 2024 Mar 27:114972. doi: 10.1016/j.bbr.2024.114972. Online ahead of print.ABSTRACTThe hippocampal salt-inducible kinase 2 (SIK2)-CREB-regulated transcription co-activator 1 (CRTC1) system has been demonstrated to participate in not only the pathogenesis of depression but also the antidepressant mechanisms of several antidepressant medications including fluoxetine, paroxetine, and mirtazapine. Like fluoxetine, paroxetine is also a widely used selective serotonin (5-HT) reuptake inhibitor (SSRI). Recent studies have indicated that paroxetine also modulates several pharmacological targets other than the 5-HT ...
Source: Brain Research - March 29, 2024 Category: Neurology Authors: Xiang-Ming Cai Xiao-Yu Sun Rui Li Pei-Juan Wang Jian-Cheng Qi Yu-Xin Ge Lei Yang Source Type: research
Nanoplastics increase < em > in vitro < /em > oestrogenic activity of neurotherapeutic drugs
Arh Hig Rada Toksikol. 2024 Mar 29;75(1):68-75. doi: 10.2478/aiht-2024-75-3818. eCollection 2024 Mar 1.ABSTRACTEnvironmental pollution with plastic nanoparticles (PNPs) has rendered hazard assessment of unintentional human exposure to neurotherapeutic drugs through contaminated water and food ever more complicated. Due to their small size, PNPs can easily enter different cell types and cross different biological barriers, while their high surface-to-volume ratio enables higher adsorption of chemicals. This is how PNPs take the role of a Trojan horse as they enhance bioaccumulation of many different pollutants. One of the h...
Source: Arhiv za Higijenu Rada i Toksikologiju - March 28, 2024 Category: Occupational Health Authors: Lucija Bo žičević Valerije Vr ček Nikolina Perani ć Nikolina Kal čec Ivana Vinkovi ć Vrček Source Type: research
Nanoplastics increase < em > in vitro < /em > oestrogenic activity of neurotherapeutic drugs
Arh Hig Rada Toksikol. 2024 Mar 29;75(1):68-75. doi: 10.2478/aiht-2024-75-3818. eCollection 2024 Mar 1.ABSTRACTEnvironmental pollution with plastic nanoparticles (PNPs) has rendered hazard assessment of unintentional human exposure to neurotherapeutic drugs through contaminated water and food ever more complicated. Due to their small size, PNPs can easily enter different cell types and cross different biological barriers, while their high surface-to-volume ratio enables higher adsorption of chemicals. This is how PNPs take the role of a Trojan horse as they enhance bioaccumulation of many different pollutants. One of the h...
Source: Arhiv za Higijenu Rada i Toksikologiju - March 28, 2024 Category: Occupational Health Authors: Lucija Bo žičević Valerije Vr ček Nikolina Perani ć Nikolina Kal čec Ivana Vinkovi ć Vrček Source Type: research
Nanoplastics increase < em > in vitro < /em > oestrogenic activity of neurotherapeutic drugs
Arh Hig Rada Toksikol. 2024 Mar 29;75(1):68-75. doi: 10.2478/aiht-2024-75-3818. eCollection 2024 Mar 1.ABSTRACTEnvironmental pollution with plastic nanoparticles (PNPs) has rendered hazard assessment of unintentional human exposure to neurotherapeutic drugs through contaminated water and food ever more complicated. Due to their small size, PNPs can easily enter different cell types and cross different biological barriers, while their high surface-to-volume ratio enables higher adsorption of chemicals. This is how PNPs take the role of a Trojan horse as they enhance bioaccumulation of many different pollutants. One of the h...
Source: Arhiv za Higijenu Rada i Toksikologiju - March 28, 2024 Category: Occupational Health Authors: Lucija Bo žičević Valerije Vr ček Nikolina Perani ć Nikolina Kal čec Ivana Vinkovi ć Vrček Source Type: research
Nanoplastics increase < em > in vitro < /em > oestrogenic activity of neurotherapeutic drugs
Arh Hig Rada Toksikol. 2024 Mar 29;75(1):68-75. doi: 10.2478/aiht-2024-75-3818. eCollection 2024 Mar 1.ABSTRACTEnvironmental pollution with plastic nanoparticles (PNPs) has rendered hazard assessment of unintentional human exposure to neurotherapeutic drugs through contaminated water and food ever more complicated. Due to their small size, PNPs can easily enter different cell types and cross different biological barriers, while their high surface-to-volume ratio enables higher adsorption of chemicals. This is how PNPs take the role of a Trojan horse as they enhance bioaccumulation of many different pollutants. One of the h...
Source: Arhiv za Higijenu Rada i Toksikologiju - March 28, 2024 Category: Occupational Health Authors: Lucija Bo žičević Valerije Vr ček Nikolina Perani ć Nikolina Kal čec Ivana Vinkovi ć Vrček Source Type: research
Nanoplastics increase < em > in vitro < /em > oestrogenic activity of neurotherapeutic drugs
Arh Hig Rada Toksikol. 2024 Mar 29;75(1):68-75. doi: 10.2478/aiht-2024-75-3818. eCollection 2024 Mar 1.ABSTRACTEnvironmental pollution with plastic nanoparticles (PNPs) has rendered hazard assessment of unintentional human exposure to neurotherapeutic drugs through contaminated water and food ever more complicated. Due to their small size, PNPs can easily enter different cell types and cross different biological barriers, while their high surface-to-volume ratio enables higher adsorption of chemicals. This is how PNPs take the role of a Trojan horse as they enhance bioaccumulation of many different pollutants. One of the h...
Source: Arhiv za Higijenu Rada i Toksikologiju - March 28, 2024 Category: Occupational Health Authors: Lucija Bo žičević Valerije Vr ček Nikolina Perani ć Nikolina Kal čec Ivana Vinkovi ć Vrček Source Type: research
Nanoplastics increase < em > in vitro < /em > oestrogenic activity of neurotherapeutic drugs
Arh Hig Rada Toksikol. 2024 Mar 29;75(1):68-75. doi: 10.2478/aiht-2024-75-3818. eCollection 2024 Mar 1.ABSTRACTEnvironmental pollution with plastic nanoparticles (PNPs) has rendered hazard assessment of unintentional human exposure to neurotherapeutic drugs through contaminated water and food ever more complicated. Due to their small size, PNPs can easily enter different cell types and cross different biological barriers, while their high surface-to-volume ratio enables higher adsorption of chemicals. This is how PNPs take the role of a Trojan horse as they enhance bioaccumulation of many different pollutants. One of the h...
Source: Arhiv za Higijenu Rada i Toksikologiju - March 28, 2024 Category: Occupational Health Authors: Lucija Bo žičević Valerije Vr ček Nikolina Perani ć Nikolina Kal čec Ivana Vinkovi ć Vrček Source Type: research
Nanoplastics increase < em > in vitro < /em > oestrogenic activity of neurotherapeutic drugs
Arh Hig Rada Toksikol. 2024 Mar 29;75(1):68-75. doi: 10.2478/aiht-2024-75-3818. eCollection 2024 Mar 1.ABSTRACTEnvironmental pollution with plastic nanoparticles (PNPs) has rendered hazard assessment of unintentional human exposure to neurotherapeutic drugs through contaminated water and food ever more complicated. Due to their small size, PNPs can easily enter different cell types and cross different biological barriers, while their high surface-to-volume ratio enables higher adsorption of chemicals. This is how PNPs take the role of a Trojan horse as they enhance bioaccumulation of many different pollutants. One of the h...
Source: Arhiv za Higijenu Rada i Toksikologiju - March 28, 2024 Category: Occupational Health Authors: Lucija Bo žičević Valerije Vr ček Nikolina Perani ć Nikolina Kal čec Ivana Vinkovi ć Vrček Source Type: research
Nanoplastics increase < em > in vitro < /em > oestrogenic activity of neurotherapeutic drugs
Arh Hig Rada Toksikol. 2024 Mar 29;75(1):68-75. doi: 10.2478/aiht-2024-75-3818. eCollection 2024 Mar 1.ABSTRACTEnvironmental pollution with plastic nanoparticles (PNPs) has rendered hazard assessment of unintentional human exposure to neurotherapeutic drugs through contaminated water and food ever more complicated. Due to their small size, PNPs can easily enter different cell types and cross different biological barriers, while their high surface-to-volume ratio enables higher adsorption of chemicals. This is how PNPs take the role of a Trojan horse as they enhance bioaccumulation of many different pollutants. One of the h...
Source: Arhiv za Higijenu Rada i Toksikologiju - March 28, 2024 Category: Occupational Health Authors: Lucija Bo žičević Valerije Vr ček Nikolina Perani ć Nikolina Kal čec Ivana Vinkovi ć Vrček Source Type: research
Nanoplastics increase < em > in vitro < /em > oestrogenic activity of neurotherapeutic drugs
Arh Hig Rada Toksikol. 2024 Mar 29;75(1):68-75. doi: 10.2478/aiht-2024-75-3818. eCollection 2024 Mar 1.ABSTRACTEnvironmental pollution with plastic nanoparticles (PNPs) has rendered hazard assessment of unintentional human exposure to neurotherapeutic drugs through contaminated water and food ever more complicated. Due to their small size, PNPs can easily enter different cell types and cross different biological barriers, while their high surface-to-volume ratio enables higher adsorption of chemicals. This is how PNPs take the role of a Trojan horse as they enhance bioaccumulation of many different pollutants. One of the h...
Source: Arhiv za Higijenu Rada i Toksikologiju - March 28, 2024 Category: Occupational Health Authors: Lucija Bo žičević Valerije Vr ček Nikolina Perani ć Nikolina Kal čec Ivana Vinkovi ć Vrček Source Type: research
Nanoplastics increase < em > in vitro < /em > oestrogenic activity of neurotherapeutic drugs
Arh Hig Rada Toksikol. 2024 Mar 29;75(1):68-75. doi: 10.2478/aiht-2024-75-3818. eCollection 2024 Mar 1.ABSTRACTEnvironmental pollution with plastic nanoparticles (PNPs) has rendered hazard assessment of unintentional human exposure to neurotherapeutic drugs through contaminated water and food ever more complicated. Due to their small size, PNPs can easily enter different cell types and cross different biological barriers, while their high surface-to-volume ratio enables higher adsorption of chemicals. This is how PNPs take the role of a Trojan horse as they enhance bioaccumulation of many different pollutants. One of the h...
Source: Arhiv za Higijenu Rada i Toksikologiju - March 28, 2024 Category: Occupational Health Authors: Lucija Bo žičević Valerije Vr ček Nikolina Perani ć Nikolina Kal čec Ivana Vinkovi ć Vrček Source Type: research
Nanoplastics increase < em > in vitro < /em > oestrogenic activity of neurotherapeutic drugs
Arh Hig Rada Toksikol. 2024 Mar 29;75(1):68-75. doi: 10.2478/aiht-2024-75-3818. eCollection 2024 Mar 1.ABSTRACTEnvironmental pollution with plastic nanoparticles (PNPs) has rendered hazard assessment of unintentional human exposure to neurotherapeutic drugs through contaminated water and food ever more complicated. Due to their small size, PNPs can easily enter different cell types and cross different biological barriers, while their high surface-to-volume ratio enables higher adsorption of chemicals. This is how PNPs take the role of a Trojan horse as they enhance bioaccumulation of many different pollutants. One of the h...
Source: Arhiv za Higijenu Rada i Toksikologiju - March 28, 2024 Category: Occupational Health Authors: Lucija Bo žičević Valerije Vr ček Nikolina Perani ć Nikolina Kal čec Ivana Vinkovi ć Vrček Source Type: research
Nanoplastics increase < em > in vitro < /em > oestrogenic activity of neurotherapeutic drugs
Arh Hig Rada Toksikol. 2024 Mar 29;75(1):68-75. doi: 10.2478/aiht-2024-75-3818. eCollection 2024 Mar 1.ABSTRACTEnvironmental pollution with plastic nanoparticles (PNPs) has rendered hazard assessment of unintentional human exposure to neurotherapeutic drugs through contaminated water and food ever more complicated. Due to their small size, PNPs can easily enter different cell types and cross different biological barriers, while their high surface-to-volume ratio enables higher adsorption of chemicals. This is how PNPs take the role of a Trojan horse as they enhance bioaccumulation of many different pollutants. One of the h...
Source: Arhiv za Higijenu Rada i Toksikologiju - March 28, 2024 Category: Occupational Health Authors: Lucija Bo žičević Valerije Vr ček Nikolina Perani ć Nikolina Kal čec Ivana Vinkovi ć Vrček Source Type: research
Nanoplastics increase < em > in vitro < /em > oestrogenic activity of neurotherapeutic drugs
Arh Hig Rada Toksikol. 2024 Mar 29;75(1):68-75. doi: 10.2478/aiht-2024-75-3818. eCollection 2024 Mar 1.ABSTRACTEnvironmental pollution with plastic nanoparticles (PNPs) has rendered hazard assessment of unintentional human exposure to neurotherapeutic drugs through contaminated water and food ever more complicated. Due to their small size, PNPs can easily enter different cell types and cross different biological barriers, while their high surface-to-volume ratio enables higher adsorption of chemicals. This is how PNPs take the role of a Trojan horse as they enhance bioaccumulation of many different pollutants. One of the h...
Source: Arhiv za Higijenu Rada i Toksikologiju - March 28, 2024 Category: Occupational Health Authors: Lucija Bo žičević Valerije Vr ček Nikolina Perani ć Nikolina Kal čec Ivana Vinkovi ć Vrček Source Type: research
