Psychoactive substance consumption after the Fund ão dam mine tailing disaster in Minas Gerais State, Brazil
Cad Saude Publica. 2024 Mar 11;40(3):e00237022. doi: 10.1590/0102-311XEN237022. eCollection 2024.ABSTRACTDisasters cause changes in morbidity, mortality, and medicine use. Brazil is one of the main producers of mineral ores at great environmental cost. Mine tailings are stored in dams and ruptures have led to major disasters. We investigated the consumption of psychoactive medicines in the municipalities affected by the Fundão dam disaster in Minas Gerais State. An ecological study was carried out on drug consumption, estimated using public purchases in Minas Gerais and dispensing data from private retail pharmacies. Cons...
Source: Cadernos de Saude Publica - March 13, 2024 Category: International Medicine & Public Health Authors: Elaine Silva Miranda Marcelo Dell'Aringa Everaldo Alves da Costa Thais Piazza Francesco Della Corte Luca Ragazzoni Francesco Barone-Adesi Carla Louren ço Tavares de Andrade Claudia Garcia Serpa Osorio-de-Castro Source Type: research
Psychoactive substance consumption after the Fund ão dam mine tailing disaster in Minas Gerais State, Brazil
Cad Saude Publica. 2024 Mar 11;40(3):e00237022. doi: 10.1590/0102-311XEN237022. eCollection 2024.ABSTRACTDisasters cause changes in morbidity, mortality, and medicine use. Brazil is one of the main producers of mineral ores at great environmental cost. Mine tailings are stored in dams and ruptures have led to major disasters. We investigated the consumption of psychoactive medicines in the municipalities affected by the Fundão dam disaster in Minas Gerais State. An ecological study was carried out on drug consumption, estimated using public purchases in Minas Gerais and dispensing data from private retail pharmacies. Cons...
Source: Cadernos de Saude Publica - March 13, 2024 Category: International Medicine & Public Health Authors: Elaine Silva Miranda Marcelo Dell'Aringa Everaldo Alves da Costa Thais Piazza Francesco Della Corte Luca Ragazzoni Francesco Barone-Adesi Carla Louren ço Tavares de Andrade Claudia Garcia Serpa Osorio-de-Castro Source Type: research
Psychoactive substance consumption after the Fund ão dam mine tailing disaster in Minas Gerais State, Brazil
Cad Saude Publica. 2024 Mar 11;40(3):e00237022. doi: 10.1590/0102-311XEN237022. eCollection 2024.ABSTRACTDisasters cause changes in morbidity, mortality, and medicine use. Brazil is one of the main producers of mineral ores at great environmental cost. Mine tailings are stored in dams and ruptures have led to major disasters. We investigated the consumption of psychoactive medicines in the municipalities affected by the Fundão dam disaster in Minas Gerais State. An ecological study was carried out on drug consumption, estimated using public purchases in Minas Gerais and dispensing data from private retail pharmacies. Cons...
Source: Cadernos de Saude Publica - March 13, 2024 Category: International Medicine & Public Health Authors: Elaine Silva Miranda Marcelo Dell'Aringa Everaldo Alves da Costa Thais Piazza Francesco Della Corte Luca Ragazzoni Francesco Barone-Adesi Carla Louren ço Tavares de Andrade Claudia Garcia Serpa Osorio-de-Castro Source Type: research
Psychoactive substance consumption after the Fund ão dam mine tailing disaster in Minas Gerais State, Brazil
Cad Saude Publica. 2024 Mar 11;40(3):e00237022. doi: 10.1590/0102-311XEN237022. eCollection 2024.ABSTRACTDisasters cause changes in morbidity, mortality, and medicine use. Brazil is one of the main producers of mineral ores at great environmental cost. Mine tailings are stored in dams and ruptures have led to major disasters. We investigated the consumption of psychoactive medicines in the municipalities affected by the Fundão dam disaster in Minas Gerais State. An ecological study was carried out on drug consumption, estimated using public purchases in Minas Gerais and dispensing data from private retail pharmacies. Cons...
Source: Cadernos de Saude Publica - March 13, 2024 Category: International Medicine & Public Health Authors: Elaine Silva Miranda Marcelo Dell'Aringa Everaldo Alves da Costa Thais Piazza Francesco Della Corte Luca Ragazzoni Francesco Barone-Adesi Carla Louren ço Tavares de Andrade Claudia Garcia Serpa Osorio-de-Castro Source Type: research
Psychoactive substance consumption after the Fund ão dam mine tailing disaster in Minas Gerais State, Brazil
Cad Saude Publica. 2024 Mar 11;40(3):e00237022. doi: 10.1590/0102-311XEN237022. eCollection 2024.ABSTRACTDisasters cause changes in morbidity, mortality, and medicine use. Brazil is one of the main producers of mineral ores at great environmental cost. Mine tailings are stored in dams and ruptures have led to major disasters. We investigated the consumption of psychoactive medicines in the municipalities affected by the Fundão dam disaster in Minas Gerais State. An ecological study was carried out on drug consumption, estimated using public purchases in Minas Gerais and dispensing data from private retail pharmacies. Cons...
Source: Cadernos de Saude Publica - March 13, 2024 Category: International Medicine & Public Health Authors: Elaine Silva Miranda Marcelo Dell'Aringa Everaldo Alves da Costa Thais Piazza Francesco Della Corte Luca Ragazzoni Francesco Barone-Adesi Carla Louren ço Tavares de Andrade Claudia Garcia Serpa Osorio-de-Castro Source Type: research
Elucidation of escitalopram oxalate and related antidepressants as putative inhibitors of PTP4A3/PRL-3 protein in hepatocellular carcinoma: A multi-computational investigation
Comput Biol Chem. 2024 Feb 29;110:108039. doi: 10.1016/j.compbiolchem.2024.108039. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) persists to be one of the most devastating and deadliest malignancies globally. Recent research into the molecular signaling networks entailed in many malignancies has given some prominent insights that can be leveraged to create molecular therapeutics for combating HCC. Therefore, in the current communication, an in-silico drug repurposing approach has been employed to target the function of PTP4A3/PRL-3 protein in HCC using antidepressants: Fluoxetine hydrochloride, Citalopram, A...
Source: Computational Biology and Chemistry - March 12, 2024 Category: Bioinformatics Authors: Ishfaq Hassan Mir Kankipati Teja Shyam Susmida Seni Balakrishnan Muthuvel Suresh Kumar Thiyagarajan Ramesh Chinnasamy Thirunavukkarasu Source Type: research
Elucidation of escitalopram oxalate and related antidepressants as putative inhibitors of PTP4A3/PRL-3 protein in hepatocellular carcinoma: A multi-computational investigation
Comput Biol Chem. 2024 Feb 29;110:108039. doi: 10.1016/j.compbiolchem.2024.108039. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) persists to be one of the most devastating and deadliest malignancies globally. Recent research into the molecular signaling networks entailed in many malignancies has given some prominent insights that can be leveraged to create molecular therapeutics for combating HCC. Therefore, in the current communication, an in-silico drug repurposing approach has been employed to target the function of PTP4A3/PRL-3 protein in HCC using antidepressants: Fluoxetine hydrochloride, Citalopram, A...
Source: Computational Biology and Chemistry - March 12, 2024 Category: Bioinformatics Authors: Ishfaq Hassan Mir Kankipati Teja Shyam Susmida Seni Balakrishnan Muthuvel Suresh Kumar Thiyagarajan Ramesh Chinnasamy Thirunavukkarasu Source Type: research
Elucidation of escitalopram oxalate and related antidepressants as putative inhibitors of PTP4A3/PRL-3 protein in hepatocellular carcinoma: A multi-computational investigation
Comput Biol Chem. 2024 Feb 29;110:108039. doi: 10.1016/j.compbiolchem.2024.108039. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) persists to be one of the most devastating and deadliest malignancies globally. Recent research into the molecular signaling networks entailed in many malignancies has given some prominent insights that can be leveraged to create molecular therapeutics for combating HCC. Therefore, in the current communication, an in-silico drug repurposing approach has been employed to target the function of PTP4A3/PRL-3 protein in HCC using antidepressants: Fluoxetine hydrochloride, Citalopram, A...
Source: Computational Biology and Chemistry - March 12, 2024 Category: Bioinformatics Authors: Ishfaq Hassan Mir Kankipati Teja Shyam Susmida Seni Balakrishnan Muthuvel Suresh Kumar Thiyagarajan Ramesh Chinnasamy Thirunavukkarasu Source Type: research
Antidepressant fluoxetine alleviates colitis by reshaping intestinal microenvironment
The impact of antidepressants on Inflammatory bowel diseases (IBD) has been extensively studied. However, the biological effects and molecular mechanisms of antidepressants in alleviating colitis remain unclear. (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - March 12, 2024 Category: Molecular Biology Authors: Shuo Teng, Yi Yang, Wanru Zhang, Xiangji Li, Wenkun Li, Zilu Cui, Li Min and Jing Wu Tags: Research Source Type: research
Neonatal hypoxia impairs serotonin release and cognitive functions in adult mice
Neurobiol Dis. 2024 Mar 7:106465. doi: 10.1016/j.nbd.2024.106465. Online ahead of print.ABSTRACTChildren who experienced moderate perinatal asphyxia (MPA) are at risk of developing long lasting subtle cognitive and behavioral deficits, including learning disabilities and emotional problems. The prefrontal cortex (PFC) regulates cognitive flexibility and emotional behavior. Neurons that release serotonin (5-HT) project to the PFC, and compounds modulating 5-HT activity influence emotion and cognition. Whether 5-HT dysregulations contribute to MPA-induced cognitive problems is unknown. We established a MPA mouse model, which...
Source: Neurobiology of Disease - March 9, 2024 Category: Neurology Authors: Karen K Y Lee Bidisha Chattopadhyaya Ant ônia Samia Fernandes do Nascimento Luc Moquin Pedro Rosa-Neto B énédicte Amilhon Graziella Di Cristo Source Type: research
Neonatal hypoxia impairs serotonin release and cognitive functions in adult mice
Neurobiol Dis. 2024 Mar 7:106465. doi: 10.1016/j.nbd.2024.106465. Online ahead of print.ABSTRACTChildren who experienced moderate perinatal asphyxia (MPA) are at risk of developing long lasting subtle cognitive and behavioral deficits, including learning disabilities and emotional problems. The prefrontal cortex (PFC) regulates cognitive flexibility and emotional behavior. Neurons that release serotonin (5-HT) project to the PFC, and compounds modulating 5-HT activity influence emotion and cognition. Whether 5-HT dysregulations contribute to MPA-induced cognitive problems is unknown. We established a MPA mouse model, which...
Source: Neurobiology of Disease - March 9, 2024 Category: Neurology Authors: Karen K Y Lee Bidisha Chattopadhyaya Ant ônia Samia Fernandes do Nascimento Luc Moquin Pedro Rosa-Neto B énédicte Amilhon Graziella Di Cristo Source Type: research
Association of Commonly Prescribed Antepartum Medications and Incidence of Orofacial Clefting
CONCLUSION: New associations between commonly prescribed antepartum medications and orofacial clefting were found. These findings should be confirmed as causality is not assessed in this report. Practitioners should be aware of the potential increased risk associated with these medications.PMID:38449319 | DOI:10.1177/10556656241237679 (Source: The Cleft Palate-Craniofacial Journal)
Source: The Cleft Palate-Craniofacial Journal - March 7, 2024 Category: ENT & OMF Authors: Matteo Laspro Hilliard T Brydges Alexandra N Verzella Jill Schechter Andre Alcon Ashley S Roman Roberto L Flores Source Type: research
Association of Commonly Prescribed Antepartum Medications and Incidence of Orofacial Clefting
CONCLUSION: New associations between commonly prescribed antepartum medications and orofacial clefting were found. These findings should be confirmed as causality is not assessed in this report. Practitioners should be aware of the potential increased risk associated with these medications.PMID:38449319 | DOI:10.1177/10556656241237679 (Source: The Cleft Palate-Craniofacial Journal)
Source: The Cleft Palate-Craniofacial Journal - March 7, 2024 Category: ENT & OMF Authors: Matteo Laspro Hilliard T Brydges Alexandra N Verzella Jill Schechter Andre Alcon Ashley S Roman Roberto L Flores Source Type: research
Association of Commonly Prescribed Antepartum Medications and Incidence of Orofacial Clefting
CONCLUSION: New associations between commonly prescribed antepartum medications and orofacial clefting were found. These findings should be confirmed as causality is not assessed in this report. Practitioners should be aware of the potential increased risk associated with these medications.PMID:38449319 | DOI:10.1177/10556656241237679 (Source: The Cleft Palate-Craniofacial Journal)
Source: The Cleft Palate-Craniofacial Journal - March 7, 2024 Category: ENT & OMF Authors: Matteo Laspro Hilliard T Brydges Alexandra N Verzella Jill Schechter Andre Alcon Ashley S Roman Roberto L Flores Source Type: research
Association of Commonly Prescribed Antepartum Medications and Incidence of Orofacial Clefting
CONCLUSION: New associations between commonly prescribed antepartum medications and orofacial clefting were found. These findings should be confirmed as causality is not assessed in this report. Practitioners should be aware of the potential increased risk associated with these medications.PMID:38449319 | DOI:10.1177/10556656241237679 (Source: The Cleft Palate-Craniofacial Journal)
Source: The Cleft Palate-Craniofacial Journal - March 7, 2024 Category: ENT & OMF Authors: Matteo Laspro Hilliard T Brydges Alexandra N Verzella Jill Schechter Andre Alcon Ashley S Roman Roberto L Flores Source Type: research
