Adverse drug events associated with nortriptyline compared with paroxetine and alternative medications in an older adult population: a retrospective cohort study in Southern California
Conclusions
Compared with therapeutic alternatives, nortriptyline was found to represent a lower risk for falls, fractures and syncope, versus comparator medications, except for a few instances that had equivalent risk. The risk for these adverse events from paroxetine was comparable to the alternative medications. (Source: BMJ Open)
Source: BMJ Open - December 28, 2023 Category: General Medicine Authors: George, M. M., Deamer, R. L., Do, D. Tags: Open access, Geriatric medicine Source Type: research
Acupuncture alleviates CUMS-induced depression-like behaviors of rats by regulating oxidative stress, neuroinflammation and ferroptosis
CONCLUSION: The study's findings indicate that acupuncture has the potential to mitigate depression-like behaviors in rats induced with CUMS by mitigating OS and reducing neuroinflammation.PMID:38142722 | DOI:10.1016/j.brainres.2023.148715 (Source: Brain Research)
Source: Brain Research - December 24, 2023 Category: Neurology Authors: Junliang Shen Chongyao Hao Siyu Liu Wenjie Chen Tao Tong Yiping Chen Muhammad Shahzad Aslam Simin Yan Jianguo Li Jingyu Zeng Yiwen Chen Yanqin Jiang Peng Li Xianjun Meng Source Type: research
The role of serotonin in modulating social competence in a cooperatively breeding fish
Behav Brain Res. 2023 Dec 21:114819. doi: 10.1016/j.bbr.2023.114819. Online ahead of print.ABSTRACTBehavioural interactions between conspecifics rely on the appreciation of social cues, which is achieved through biochemical switching of pre-existing neurophysiological pathways. Serotonin is one of the major neurotransmitters in the central nervous system responsible for the modulation of physiological and behavioural traits, in particular social behaviour. The relative importance of serotonin in modulating optimal social responses to the available social information (i.e., social competence) is yet unknown. Here we investi...
Source: Brain Research - December 23, 2023 Category: Neurology Authors: Diogo F Antunes Pia R Stettler Taborsky Barbara Source Type: research
The role of serotonin in modulating social competence in a cooperatively breeding fish
Behav Brain Res. 2023 Dec 21:114819. doi: 10.1016/j.bbr.2023.114819. Online ahead of print.ABSTRACTBehavioural interactions between conspecifics rely on the appreciation of social cues, which is achieved through biochemical switching of pre-existing neurophysiological pathways. Serotonin is one of the major neurotransmitters in the central nervous system responsible for the modulation of physiological and behavioural traits, in particular social behaviour. The relative importance of serotonin in modulating optimal social responses to the available social information (i.e., social competence) is yet unknown. Here we investi...
Source: Behavioural Brain Research - December 23, 2023 Category: Neurology Authors: Diogo F Antunes Pia R Stettler Taborsky Barbara Source Type: research
The role of serotonin in modulating social competence in a cooperatively breeding fish
Behav Brain Res. 2023 Dec 21:114819. doi: 10.1016/j.bbr.2023.114819. Online ahead of print.ABSTRACTBehavioural interactions between conspecifics rely on the appreciation of social cues, which is achieved through biochemical switching of pre-existing neurophysiological pathways. Serotonin is one of the major neurotransmitters in the central nervous system responsible for the modulation of physiological and behavioural traits, in particular social behaviour. The relative importance of serotonin in modulating optimal social responses to the available social information (i.e., social competence) is yet unknown. Here we investi...
Source: Brain Research - December 23, 2023 Category: Neurology Authors: Diogo F Antunes Pia R Stettler Taborsky Barbara Source Type: research
The role of serotonin in modulating social competence in a cooperatively breeding fish
Behav Brain Res. 2023 Dec 21:114819. doi: 10.1016/j.bbr.2023.114819. Online ahead of print.ABSTRACTBehavioural interactions between conspecifics rely on the appreciation of social cues, which is achieved through biochemical switching of pre-existing neurophysiological pathways. Serotonin is one of the major neurotransmitters in the central nervous system responsible for the modulation of physiological and behavioural traits, in particular social behaviour. The relative importance of serotonin in modulating optimal social responses to the available social information (i.e., social competence) is yet unknown. Here we investi...
Source: Behavioural Brain Research - December 23, 2023 Category: Neurology Authors: Diogo F Antunes Pia R Stettler Taborsky Barbara Source Type: research
Treatment guesses in the Treatment for Adolescents with Depression Study: Accuracy, unblinding and influence on outcomes
CONCLUSIONS: For Treatment for Adolescents with Depression Study, treatment guesses strongly predicted outcomes and may have led to the exaggeration of drug effectiveness in the absence of actual effects. The integrity of double-blinding in trials should be routinely assessed and reported.PMID:38126083 | DOI:10.1177/00048674231218623 (Source: The Australian and New Zealand Journal of Psychiatry)
Source: The Australian and New Zealand Journal of Psychiatry - December 21, 2023 Category: Psychiatry Authors: Jon Jureidini Joanna Moncrieff Julie Klau Natalie Aboustate Melissa Raven Source Type: research
Treatment guesses in the Treatment for Adolescents with Depression Study: Accuracy, unblinding and influence on outcomes
CONCLUSIONS: For Treatment for Adolescents with Depression Study, treatment guesses strongly predicted outcomes and may have led to the exaggeration of drug effectiveness in the absence of actual effects. The integrity of double-blinding in trials should be routinely assessed and reported.PMID:38126083 | DOI:10.1177/00048674231218623 (Source: The Australian and New Zealand Journal of Psychiatry)
Source: The Australian and New Zealand Journal of Psychiatry - December 21, 2023 Category: Psychiatry Authors: Jon Jureidini Joanna Moncrieff Julie Klau Natalie Aboustate Melissa Raven Source Type: research
