Nanoplastics increase < em > in vitro < /em > oestrogenic activity of neurotherapeutic drugs
Arh Hig Rada Toksikol. 2024 Mar 29;75(1):68-75. doi: 10.2478/aiht-2024-75-3818. eCollection 2024 Mar 1.ABSTRACTEnvironmental pollution with plastic nanoparticles (PNPs) has rendered hazard assessment of unintentional human exposure to neurotherapeutic drugs through contaminated water and food ever more complicated. Due to their small size, PNPs can easily enter different cell types and cross different biological barriers, while their high surface-to-volume ratio enables higher adsorption of chemicals. This is how PNPs take the role of a Trojan horse as they enhance bioaccumulation of many different pollutants. One of the h...
Source: Arhiv za Higijenu Rada i Toksikologiju - March 28, 2024 Category: Occupational Health Authors: Lucija Bo žičević Valerije Vr ček Nikolina Perani ć Nikolina Kal čec Ivana Vinkovi ć Vrček Source Type: research
Vilazodone, a Selective Serotonin Reuptake Inhibitor with Diminished Impact on Methylphenidate-Induced Gene Regulation in the Striatum: Role of 5-HT1A Receptor
AbstractSelective serotonin reuptake inhibitors (SSRIs), including fluoxetine, are frequently combined with medical psychostimulants such as methylphenidate (Ritalin), for example, in the treatment of attention-deficit hyperactivity disorder/depression comorbidity. Co-exposure to these medications also occurs with misuse of methylphenidate as a recreational drug by patients on SSRIs. Methylphenidate, a dopamine reuptake blocker, produces moderate addiction-related gene regulation. Findings show that SSRIs such as fluoxetine given in conjunction with methylphenidate potentiate methylphenidate-induced gene regulation in the ...
Source: Molecular Neurobiology - March 27, 2024 Category: Neurology Source Type: research
Involvement of the GABAA Receptor in the Antidepressant-Like Effects Produced by Low and High Doses of the Flavonoid Chrysin in the Rat: A Longitudinal Study
CONCLUSIONS: The differential antidepressant-like effects caused by low and high doses of chrysin are time-dependent. Low dose chrysin produces a rapid antidepressant-like effect, whereas high dose chrysin produces a delayed but sustained the effect, even 48 h after withdrawal. The effect with high dose chrysin was similar to that observed with allopregnanolone and fluoxetine. The mechanism for the antidepressant-like effect of low chrysin appears to be GABAergic, whereas the effect of high dose chrysin may involve other neurotransmission and neuromodulation systems related to the serotonergic system.PMID:38538228 | DOI:10...
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Gabriel Guill én-Ruiz Blandina Bernal-Morales Ana Karen Lim ón-Vázquez Oscar Jer ónimo Olmos-Vázquez Juan Francisco Rodr íguez-Landa Source Type: research
Involvement of the GABAA Receptor in the Antidepressant-Like Effects Produced by Low and High Doses of the Flavonoid Chrysin in the Rat: A Longitudinal Study
CONCLUSIONS: The differential antidepressant-like effects caused by low and high doses of chrysin are time-dependent. Low dose chrysin produces a rapid antidepressant-like effect, whereas high dose chrysin produces a delayed but sustained the effect, even 48 h after withdrawal. The effect with high dose chrysin was similar to that observed with allopregnanolone and fluoxetine. The mechanism for the antidepressant-like effect of low chrysin appears to be GABAergic, whereas the effect of high dose chrysin may involve other neurotransmission and neuromodulation systems related to the serotonergic system.PMID:38538228 | DOI:10...
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Gabriel Guill én-Ruiz Blandina Bernal-Morales Ana Karen Lim ón-Vázquez Oscar Jer ónimo Olmos-Vázquez Juan Francisco Rodr íguez-Landa Source Type: research
Involvement of the GABAA Receptor in the Antidepressant-Like Effects Produced by Low and High Doses of the Flavonoid Chrysin in the Rat: A Longitudinal Study
CONCLUSIONS: The differential antidepressant-like effects caused by low and high doses of chrysin are time-dependent. Low dose chrysin produces a rapid antidepressant-like effect, whereas high dose chrysin produces a delayed but sustained the effect, even 48 h after withdrawal. The effect with high dose chrysin was similar to that observed with allopregnanolone and fluoxetine. The mechanism for the antidepressant-like effect of low chrysin appears to be GABAergic, whereas the effect of high dose chrysin may involve other neurotransmission and neuromodulation systems related to the serotonergic system.PMID:38538228 | DOI:10...
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Gabriel Guill én-Ruiz Blandina Bernal-Morales Ana Karen Lim ón-Vázquez Oscar Jer ónimo Olmos-Vázquez Juan Francisco Rodr íguez-Landa Source Type: research
Involvement of the GABAA Receptor in the Antidepressant-Like Effects Produced by Low and High Doses of the Flavonoid Chrysin in the Rat: A Longitudinal Study
CONCLUSIONS: The differential antidepressant-like effects caused by low and high doses of chrysin are time-dependent. Low dose chrysin produces a rapid antidepressant-like effect, whereas high dose chrysin produces a delayed but sustained the effect, even 48 h after withdrawal. The effect with high dose chrysin was similar to that observed with allopregnanolone and fluoxetine. The mechanism for the antidepressant-like effect of low chrysin appears to be GABAergic, whereas the effect of high dose chrysin may involve other neurotransmission and neuromodulation systems related to the serotonergic system.PMID:38538228 | DOI:10...
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Gabriel Guill én-Ruiz Blandina Bernal-Morales Ana Karen Lim ón-Vázquez Oscar Jer ónimo Olmos-Vázquez Juan Francisco Rodr íguez-Landa Source Type: research
Involvement of the GABAA Receptor in the Antidepressant-Like Effects Produced by Low and High Doses of the Flavonoid Chrysin in the Rat: A Longitudinal Study
CONCLUSIONS: The differential antidepressant-like effects caused by low and high doses of chrysin are time-dependent. Low dose chrysin produces a rapid antidepressant-like effect, whereas high dose chrysin produces a delayed but sustained the effect, even 48 h after withdrawal. The effect with high dose chrysin was similar to that observed with allopregnanolone and fluoxetine. The mechanism for the antidepressant-like effect of low chrysin appears to be GABAergic, whereas the effect of high dose chrysin may involve other neurotransmission and neuromodulation systems related to the serotonergic system.PMID:38538228 | DOI:10...
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Gabriel Guill én-Ruiz Blandina Bernal-Morales Ana Karen Lim ón-Vázquez Oscar Jer ónimo Olmos-Vázquez Juan Francisco Rodr íguez-Landa Source Type: research
Involvement of the GABAA Receptor in the Antidepressant-Like Effects Produced by Low and High Doses of the Flavonoid Chrysin in the Rat: A Longitudinal Study
CONCLUSIONS: The differential antidepressant-like effects caused by low and high doses of chrysin are time-dependent. Low dose chrysin produces a rapid antidepressant-like effect, whereas high dose chrysin produces a delayed but sustained the effect, even 48 h after withdrawal. The effect with high dose chrysin was similar to that observed with allopregnanolone and fluoxetine. The mechanism for the antidepressant-like effect of low chrysin appears to be GABAergic, whereas the effect of high dose chrysin may involve other neurotransmission and neuromodulation systems related to the serotonergic system.PMID:38538228 | DOI:10...
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Gabriel Guill én-Ruiz Blandina Bernal-Morales Ana Karen Lim ón-Vázquez Oscar Jer ónimo Olmos-Vázquez Juan Francisco Rodr íguez-Landa Source Type: research
Involvement of the GABAA Receptor in the Antidepressant-Like Effects Produced by Low and High Doses of the Flavonoid Chrysin in the Rat: A Longitudinal Study
CONCLUSIONS: The differential antidepressant-like effects caused by low and high doses of chrysin are time-dependent. Low dose chrysin produces a rapid antidepressant-like effect, whereas high dose chrysin produces a delayed but sustained the effect, even 48 h after withdrawal. The effect with high dose chrysin was similar to that observed with allopregnanolone and fluoxetine. The mechanism for the antidepressant-like effect of low chrysin appears to be GABAergic, whereas the effect of high dose chrysin may involve other neurotransmission and neuromodulation systems related to the serotonergic system.PMID:38538228 | DOI:10...
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Gabriel Guill én-Ruiz Blandina Bernal-Morales Ana Karen Lim ón-Vázquez Oscar Jer ónimo Olmos-Vázquez Juan Francisco Rodr íguez-Landa Source Type: research
Involvement of the GABAA Receptor in the Antidepressant-Like Effects Produced by Low and High Doses of the Flavonoid Chrysin in the Rat: A Longitudinal Study
CONCLUSIONS: The differential antidepressant-like effects caused by low and high doses of chrysin are time-dependent. Low dose chrysin produces a rapid antidepressant-like effect, whereas high dose chrysin produces a delayed but sustained the effect, even 48 h after withdrawal. The effect with high dose chrysin was similar to that observed with allopregnanolone and fluoxetine. The mechanism for the antidepressant-like effect of low chrysin appears to be GABAergic, whereas the effect of high dose chrysin may involve other neurotransmission and neuromodulation systems related to the serotonergic system.PMID:38538228 | DOI:10...
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Gabriel Guill én-Ruiz Blandina Bernal-Morales Ana Karen Lim ón-Vázquez Oscar Jer ónimo Olmos-Vázquez Juan Francisco Rodr íguez-Landa Source Type: research
Involvement of the GABAA Receptor in the Antidepressant-Like Effects Produced by Low and High Doses of the Flavonoid Chrysin in the Rat: A Longitudinal Study
CONCLUSIONS: The differential antidepressant-like effects caused by low and high doses of chrysin are time-dependent. Low dose chrysin produces a rapid antidepressant-like effect, whereas high dose chrysin produces a delayed but sustained the effect, even 48 h after withdrawal. The effect with high dose chrysin was similar to that observed with allopregnanolone and fluoxetine. The mechanism for the antidepressant-like effect of low chrysin appears to be GABAergic, whereas the effect of high dose chrysin may involve other neurotransmission and neuromodulation systems related to the serotonergic system.PMID:38538228 | DOI:10...
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Gabriel Guill én-Ruiz Blandina Bernal-Morales Ana Karen Lim ón-Vázquez Oscar Jer ónimo Olmos-Vázquez Juan Francisco Rodr íguez-Landa Source Type: research
Involvement of the GABAA Receptor in the Antidepressant-Like Effects Produced by Low and High Doses of the Flavonoid Chrysin in the Rat: A Longitudinal Study
CONCLUSIONS: The differential antidepressant-like effects caused by low and high doses of chrysin are time-dependent. Low dose chrysin produces a rapid antidepressant-like effect, whereas high dose chrysin produces a delayed but sustained the effect, even 48 h after withdrawal. The effect with high dose chrysin was similar to that observed with allopregnanolone and fluoxetine. The mechanism for the antidepressant-like effect of low chrysin appears to be GABAergic, whereas the effect of high dose chrysin may involve other neurotransmission and neuromodulation systems related to the serotonergic system.PMID:38538228 | DOI:10...
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Gabriel Guill én-Ruiz Blandina Bernal-Morales Ana Karen Lim ón-Vázquez Oscar Jer ónimo Olmos-Vázquez Juan Francisco Rodr íguez-Landa Source Type: research
Involvement of the GABAA Receptor in the Antidepressant-Like Effects Produced by Low and High Doses of the Flavonoid Chrysin in the Rat: A Longitudinal Study
CONCLUSIONS: The differential antidepressant-like effects caused by low and high doses of chrysin are time-dependent. Low dose chrysin produces a rapid antidepressant-like effect, whereas high dose chrysin produces a delayed but sustained the effect, even 48 h after withdrawal. The effect with high dose chrysin was similar to that observed with allopregnanolone and fluoxetine. The mechanism for the antidepressant-like effect of low chrysin appears to be GABAergic, whereas the effect of high dose chrysin may involve other neurotransmission and neuromodulation systems related to the serotonergic system.PMID:38538228 | DOI:10...
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Gabriel Guill én-Ruiz Blandina Bernal-Morales Ana Karen Lim ón-Vázquez Oscar Jer ónimo Olmos-Vázquez Juan Francisco Rodr íguez-Landa Source Type: research
Involvement of the GABAA Receptor in the Antidepressant-Like Effects Produced by Low and High Doses of the Flavonoid Chrysin in the Rat: A Longitudinal Study
CONCLUSIONS: The differential antidepressant-like effects caused by low and high doses of chrysin are time-dependent. Low dose chrysin produces a rapid antidepressant-like effect, whereas high dose chrysin produces a delayed but sustained the effect, even 48 h after withdrawal. The effect with high dose chrysin was similar to that observed with allopregnanolone and fluoxetine. The mechanism for the antidepressant-like effect of low chrysin appears to be GABAergic, whereas the effect of high dose chrysin may involve other neurotransmission and neuromodulation systems related to the serotonergic system.PMID:38538228 | DOI:10...
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Gabriel Guill én-Ruiz Blandina Bernal-Morales Ana Karen Lim ón-Vázquez Oscar Jer ónimo Olmos-Vázquez Juan Francisco Rodr íguez-Landa Source Type: research
Involvement of the GABAA Receptor in the Antidepressant-Like Effects Produced by Low and High Doses of the Flavonoid Chrysin in the Rat: A Longitudinal Study
CONCLUSIONS: The differential antidepressant-like effects caused by low and high doses of chrysin are time-dependent. Low dose chrysin produces a rapid antidepressant-like effect, whereas high dose chrysin produces a delayed but sustained the effect, even 48 h after withdrawal. The effect with high dose chrysin was similar to that observed with allopregnanolone and fluoxetine. The mechanism for the antidepressant-like effect of low chrysin appears to be GABAergic, whereas the effect of high dose chrysin may involve other neurotransmission and neuromodulation systems related to the serotonergic system.PMID:38538228 | DOI:10...
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Gabriel Guill én-Ruiz Blandina Bernal-Morales Ana Karen Lim ón-Vázquez Oscar Jer ónimo Olmos-Vázquez Juan Francisco Rodr íguez-Landa Source Type: research
