Metabolic Activities Catalyzed by Human Cytochrome P450 (CYP) 2D6 and CYP3A Subfamily Members and Effect of Various Compounds, Including Endogenous Steroid Hormones, on These Activities
Yakugaku Zasshi. 2024;144(2):197-202. doi: 10.1248/yakushi.23-00174.ABSTRACTMy research focused on the effects of various drugs on (1) dopamine formation from p-tyramine catalyzed by polymorphic cytochrome P450 (CYP or P450) 2D6 variants and (2) endogenous steroid hormone hydroxylation catalyzed by CYP3A subfamily members (CYP3A4, CYP3A5, CYP3A7). The activation (cooperativity) of metabolic reactions catalyzed by P450s was especially emphasized. The effects of various psychotropic agents on dopamine formation from p-tyramine, catalyzed by wild-type CYP2D6.1 and CYP2D6 variants, including CYP2D6.2 (Arg296Cys;Ser486Thr), CYP...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 31, 2024 Category: Drugs & Pharmacology Authors: Toshiro Niwa Source Type: research
Metabolic Activities Catalyzed by Human Cytochrome P450 (CYP) 2D6 and CYP3A Subfamily Members and Effect of Various Compounds, Including Endogenous Steroid Hormones, on These Activities
Yakugaku Zasshi. 2024;144(2):197-202. doi: 10.1248/yakushi.23-00174.ABSTRACTMy research focused on the effects of various drugs on (1) dopamine formation from p-tyramine catalyzed by polymorphic cytochrome P450 (CYP or P450) 2D6 variants and (2) endogenous steroid hormone hydroxylation catalyzed by CYP3A subfamily members (CYP3A4, CYP3A5, CYP3A7). The activation (cooperativity) of metabolic reactions catalyzed by P450s was especially emphasized. The effects of various psychotropic agents on dopamine formation from p-tyramine, catalyzed by wild-type CYP2D6.1 and CYP2D6 variants, including CYP2D6.2 (Arg296Cys;Ser486Thr), CYP...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 31, 2024 Category: Drugs & Pharmacology Authors: Toshiro Niwa Source Type: research
Molecules, Vol. 29, Pages 676: Direct Immersion & ndash;Solid Phase Microextraction for Therapeutic Drug Monitoring of Patients with Mood Disorders
This article discusses a new method for monitoring drug concentrations in blood samples from patients with mood disorders. The method uses solid-phase microextraction to extract analytes directly from blood samples. It has been adapted to identify the most commonly used drugs in mood disorders, including amitriptyline, citalopram, fluoxetine, paroxetine, sertraline, trazodone, duloxetine, venlafaxine, lamotrigine, quetiapine, olanzapine, and mirtazapine. The analysis is carried out using high-performance liquid chromatography coupled with mass spectroscopy. The proposed DI-SPME/LC-MS method allows for a simple and quick sc...
Source: Molecules - January 31, 2024 Category: Chemistry Authors: Magdalena Świądro-Piętoń Dominika Dudek Renata Wietecha-Pos łuszny Tags: Article Source Type: research
Repetitive transcranial magnetic stimulation and fluoxetine attenuate astroglial activation and benefit behaviours in a chronic unpredictable mild stress mouse model of depression
Volume 25, Issue 2, February 2024, Page 82-94 . (Source: World Journal of Biological Psychiatry)
Source: World Journal of Biological Psychiatry - January 31, 2024 Category: Psychiatry Authors: Qianfa YuanYuying LeiKai YuJunnan WuZhizhong XuChunyan WenYanlong LiuWenqiang WangJue Hea Fujian Psychiatric Center, Fujian Clinical Research Center for Mental Disorders, Xiamen Xian Yue Hospital, Xian Yue Hospital Affiliated with Xiamen Medical College, Source Type: research
The Practice of Prescribing Antidepressants During Pregnancy and Breastfeeding Among Mental Health Practitioners in Tertiary Care Centers in Oman
CONCLUSIONS: There was inconsistency among mental health practitioners in making prescription decisions and in their prescribing patterns.PMID:38264515 | PMC:PMC10801695 | DOI:10.5001/omj.2023.123 (Source: Oman Medical Journal)
Source: Oman Medical Journal - January 24, 2024 Category: Middle East Health Authors: Salim Al Kasbi Yousif Obaid Samir Al Adawi Sanjay Jaju Source Type: research
The effect of drug holidays on sexual dysfunction in men treated with selective serotonin reuptake inhibitors (SSRIs) other than fluoxetine: an 8-week open-label randomized clinical trial
Selective serotonin reuptake inhibitors (SSRIs) are widely used for the treatment of various mental disorders. Sexual dysfunction is one of the most common side effects of SSRIs, and often leads to poor adhere... (Source: BMC Psychiatry)
Source: BMC Psychiatry - January 23, 2024 Category: Psychiatry Authors: Arman Alipour-Kivi, Negin Eissazade, Seyed Vahid Shariat, Razieh Salehian, Shiva Soraya, Sanaz Askari and Mohammadreza Shalbafan Tags: Research Source Type: research
Neurotoxic pesticides change respiratory parameters in early gill-breathing, but not in skin-breathing life-stages of zebrafish (Danio rerio)
Aquat Toxicol. 2024 Feb;267:106831. doi: 10.1016/j.aquatox.2024.106831. Epub 2024 Jan 8.ABSTRACTNeurotoxic compounds can interfere with active gill ventilation in fish, which might lead to premature death in adult fish, but not in skin-breathing embryos of zebrafish, since these exclusively rely on passive diffusion across the skin. Regarding lethality, this respiratory failure syndrome (RFS) has been discussed as one of the main reasons for the higher sensitivity of adult fish in the acute fish toxicity test (AFT), if compared to embryos in the fish embryo toxicity test (FET). To further elucidate the relationship between...
Source: Aquatic Toxicology - January 20, 2024 Category: Toxicology Authors: Nadine K ämmer Tanja Reimann Thomas Braunbeck Source Type: research
Medicating the coast in a metropolitan city: Enantiomeric profiles and joint probabilistic risk assessment of antidepressants and antihistamines
Environ Int. 2024 Jan 9;184:108434. doi: 10.1016/j.envint.2024.108434. Online ahead of print.ABSTRACTPharmaceuticals are receiving increasing attention as emerging contaminants in the aquatic environment. Herein, we investigated the occurrence of 11 antidepressants, 6 antihistamines and 4 metabolites in treated wastewater effluents, rivers, stormwater, and seawater in Hong Kong, with special focus on chirality. The average levels of ∑pharmaceuticals ranged from 0.525 to 1070 ng/L in all samples and the total annual mass load of target pharmaceuticals in the marine environment of Hong Kong was 756 kg/y. Antihistamines acc...
Source: Environment International - January 18, 2024 Category: Environmental Health Authors: Rongben Wu Esther Yan-Yin Sin Kai Zhang Shaopeng Xu Yuefei Ruan Yim Ling Mak Ying-Kit Yung Sunny Wai-Choi Sun Rong Yang Paul K S Lam Source Type: research
Niuhuang Qingxin Wan ameliorates depressive-like behaviors and improves hippocampal neurogenesis through modulating TrkB/ERK/CREB signaling pathway in chronic restraint stress or corticosterone challenge mice
Discussion: Taken together, NHQXW could be a promising TCM formula to attenuate depressive- and anxiety-like behaviors against chronic stress and depression. The underlying anti-depressant mechanisms could be correlated with its neurogenic activities by stimulating the TrkB/ERK/CREB signaling pathway. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - January 11, 2024 Category: Drugs & Pharmacology Source Type: research
Fluoxetine alters rat's milk properties causing impact on offspring's development
Toxicol Appl Pharmacol. 2024 Jan 6:116805. doi: 10.1016/j.taap.2024.116805. Online ahead of print.ABSTRACTFluoxetine is an antidepressant used to treat several conditions including postpartum depression. This disease causes cognitive, emotional, behavioral and physical changes, negatively affecting the mother, child and family life. However, fluoxetine is excreted in breast milk, causing short and long-term effects on children who were exposed to the drug during lactation, so studies that seek to uncover the consequences of these effects are needed. Thus, the aim of this study was to evaluate the effects of fluoxetine on t...
Source: Toxicology and Applied Pharmacology - January 8, 2024 Category: Toxicology Authors: Gabriel R Abreu Julia Zaccarelli-Magalh ães La ís S Féba Emily Y Penna Julia P Silva Mariana V Teixeira Marianna Manes Guilherme A Vergara Leonardo M A Rodrigues Andr é R Fukushima Esther L Ricci Helenice S Spinosa Source Type: research
Fluoxetine alters rat's milk properties causing impact on offspring's development
Toxicol Appl Pharmacol. 2024 Feb;483:116805. doi: 10.1016/j.taap.2024.116805. Epub 2024 Jan 6.ABSTRACTFluoxetine is an antidepressant used to treat several conditions including postpartum depression. This disease causes cognitive, emotional, behavioral and physical changes, negatively affecting the mother, child and family life. However, fluoxetine is excreted in breast milk, causing short and long-term effects on children who were exposed to the drug during lactation, so studies that seek to uncover the consequences of these effects are needed. Thus, the aim of this study was to evaluate the effects of fluoxetine on the n...
Source: Toxicology and Applied Pharmacology - January 8, 2024 Category: Toxicology Authors: Gabriel R Abreu Julia Zaccarelli-Magalh ães La ís S Féba Emily Y Penna Julia P Silva Mariana V Teixeira Marianna Manes Guilherme A Vergara Leonardo M A Rodrigues Andr é R Fukushima Esther L Ricci Helenice S Spinosa Source Type: research
Polypharmacy and Reversible Drug Induced QT Prolongation in a Patient with Advanced Cancer: Case Report
J Pain Palliat Care Pharmacother. 2024 Jan 5:1-5. doi: 10.1080/15360288.2023.2297218. Online ahead of print.ABSTRACTQT prolongation is related to the development of ventricular arrhythmias such as Torsade de Pointes (TdP) that can lead to sudden cardiac death. Several drugs used in the treatment of patients with advanced cancer may induce QT prolongation due to their interference with cardiac ion channels. Some patients may be at higher risk if predisposing factors are present. Herein we present the case of a patient with advanced cancer under anti-tumor treatment with radical intention that developed a reversible drug-ind...
Source: Journal of Pain and Palliative Care Pharmacotherapy - January 5, 2024 Category: Palliative Care Authors: Gabriela Cerd à Joaquim Juli à-Torras Jes ús González-Barboteo Margarita Romeo Agn ès Calsina-Berna Source Type: research
Is cognitive behavioral therapy more effective than pharmacotherapy for binge spectrum disorders? A systematic review and meta-analysis
CONCLUSIONS: Data are scarce, comparisons underpowered and, considering the inherent methodological limitations of psychotherapy trials, questions arise regarding the presumed superiority of cognitive behavioral therapy. Further research is needed.PMID:38179705 | DOI:10.1177/00048674231219593 (Source: The Australian and New Zealand Journal of Psychiatry)
Source: The Australian and New Zealand Journal of Psychiatry - January 5, 2024 Category: Psychiatry Authors: Myrto T Samara Niki Michou Andreas S Lappas Aikaterini Argyrou Elissavet Mathioudaki Dimitra Rafailia Bakaloudi Eirini Tsekitsidi Zoi A Polyzopoulou Nikos Christodoulou Georgios Papazisis Michail Chourdakis Source Type: research
Polypharmacy and Reversible Drug Induced QT Prolongation in a Patient with Advanced Cancer: Case Report
J Pain Palliat Care Pharmacother. 2024 Jan 5:1-5. doi: 10.1080/15360288.2023.2297218. Online ahead of print.ABSTRACTQT prolongation is related to the development of ventricular arrhythmias such as Torsade de Pointes (TdP) that can lead to sudden cardiac death. Several drugs used in the treatment of patients with advanced cancer may induce QT prolongation due to their interference with cardiac ion channels. Some patients may be at higher risk if predisposing factors are present. Herein we present the case of a patient with advanced cancer under anti-tumor treatment with radical intention that developed a reversible drug-ind...
Source: Journal of Pain and Palliative Care Pharmacotherapy - January 5, 2024 Category: Palliative Care Authors: Gabriela Cerd à Joaquim Juli à-Torras Jes ús González-Barboteo Margarita Romeo Agn ès Calsina-Berna Source Type: research
Is cognitive behavioral therapy more effective than pharmacotherapy for binge spectrum disorders? A systematic review and meta-analysis
CONCLUSIONS: Data are scarce, comparisons underpowered and, considering the inherent methodological limitations of psychotherapy trials, questions arise regarding the presumed superiority of cognitive behavioral therapy. Further research is needed.PMID:38179705 | DOI:10.1177/00048674231219593 (Source: The Australian and New Zealand Journal of Psychiatry)
Source: The Australian and New Zealand Journal of Psychiatry - January 5, 2024 Category: Psychiatry Authors: Myrto T Samara Niki Michou Andreas S Lappas Aikaterini Argyrou Elissavet Mathioudaki Dimitra Rafailia Bakaloudi Eirini Tsekitsidi Zoi A Polyzopoulou Nikos Christodoulou Georgios Papazisis Michail Chourdakis Source Type: research
