Evaluating the safety and efficacy of cryopreserved ovarian tissue transplantation in leukemia patients with different bone marrow remission status using xenotransplantation
ConclusionFor leukemia patients having ovarian tissue preserved in the first and only centralized human ovarian tissue cryobank in China, immunodeficient mice xenotransplantation can be a method to evaluate the safety and efficacy of OTT; the risk of malignant cell reimplantation due to OTT is higher in leukemia patients with MRD-positive status than those with MRD-negative status before OTC. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 25, 2024 Category: Endocrinology Source Type: research
Cortical lipid metabolic pathway alteration of early Alzheimer ’s disease and candidate drugs screen
ConclusionsAD cortical lipid metabolism disorder was associated with the dysregulation of the PPAR signaling pathway, glycerophospholipid metabolism, adipocytokine signaling pathway, fatty acid biosynthesis, fatty acid degradation, ferroptosis, biosynthesis of unsaturated fatty acids, and fatty acid elongation. Candidate drugs including bisphenol A, benzo(a)pyrene, ethinyl estradiol, and active compounds including adenosine phosphate, oxidized Photinus luciferin, and BMS-488043 have potential therapeutic effects on cortical lipid metabolism disorder of early AD. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - March 25, 2024 Category: Research Source Type: research
Qixian granule inhibits ferroptosis in vascular endothelial cells by modulating TRPML1 in the lysosome to prevent postmenopausal atherosclerosis
CONCLUSION: QXG inhibited GPX4 and FTH1-mediated ferroptosis in vascular endothelial cells through up-regulating GPER/TRPML1 signaling, providing a potential therapeutic option for postmenopausal females seeking a safe and effective medication to prevent atherosclerosis. The study highlights QXG's estrogenic properties and its promising role in combating postmenopausal atherosclerosis.PMID:38521431 | DOI:10.1016/j.jep.2024.118076 (Source: Atherosclerosis)
Source: Atherosclerosis - March 23, 2024 Category: Cardiology Authors: Meng Zhang Chenhan Mao Yang Dai Xiaojin Xu Xindong Wang Source Type: research
Does extreme psychological burden (Hamas terrorist attack on October 7th, 2023) affect in vitro fertilization outcome?
ConclusionsIn the present study, we are witness to the effect of acute emotional and psychological trauma on IVF outcome, as reflected by its detrimental effect on sperm and embryo quality. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - March 23, 2024 Category: Reproduction Medicine Source Type: research
Liraglutide improved the reproductive function of obese mice by upregulating the testicular AC3/cAMP/PKA pathway
CONCLUSIONS: Liraglutide can improve the sex hormone levels and semen quality of obese male mice. In addition to its weight loss effect, liraglutide can improve the reproductive function of obese male mice, which may also be related to the upregulation of AC3/cAMP/PKA pathway in the testis. This work lays the groundwork for future clinical studies.PMID:38509558 | DOI:10.1186/s12958-024-01202-0 (Source: Reproductive Biology)
Source: Reproductive Biology - March 21, 2024 Category: Reproduction Medicine Authors: Ruibing Qi Yuzhen Liang Jinming Yu Bing Chen Jiaqin Jiang Xingye Wu Wensheng Lu Zhengming Li Source Type: research
XinJiaCongRongTuSiZiWan protects triptolide-induced rats from oxidative stress injury via mitophagy mediated PINK1/Parkin signaling pathway
CONCLUSIONS: XJCRTSZW protects TP-induced rats from oxidative stress injury via the mitophagy-mediated PINK1/Parkin pathway.PMID:38511762 | DOI:10.1590/acb391424 (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - March 21, 2024 Category: Surgery Authors: Yan Jin Deng Di-Si Wu Ke-Ming Source Type: research
Health risks of Bisphenol-A exposure: From Wnt signaling perspective
Environ Res. 2024 Mar 19:118752. doi: 10.1016/j.envres.2024.118752. Online ahead of print.ABSTRACTHuman beings are routinely exposed to chronic and low dose of Bisphenols (BPs) due to their widely pervasiveness in the environment. BPs hold similar chemical structures to 17β-estradiol (E2) and thyroid hormone, thus posing threats to human health by rendering the endocrine system dysfunctional. Among BPs, Bisphenol-A (BPA) is the best-known and extensively studied endocrine disrupting compound (EDC). BPA possesses multisystem toxicity, including reproductive toxicity, neurotoxicity, hepatoxicity and nephrotoxicity. Particul...
Source: Environmental Research - March 21, 2024 Category: Environmental Health Authors: Zhi-Hua Liu Yanzhou Xia Shu Ai Hui-Li Wang Source Type: research
