Synergistic neuroprotective action of prolactin and 17 β-estradiol on kainic acid-induced hippocampal injury and long-term memory deficit in ovariectomized rats
CONCLUSION: Taken together, these results point to a synergic effect of E2 and PRL in the hippocampus to produce their behavioral, proliferative, and neuroprotective effects.PMID:38625627 | DOI:10.1007/s42000-024-00551-0 (Source: Hormones)
Source: Hormones - April 16, 2024 Category: Endocrinology Authors: Karen De la Torre Marco Antonio Cerb ón Gladys Molina-Salinas Jos é Eduardo Suárez-Santiago Jean-Pascal Morin Gabriel Rold án-Roldán Ofir Picazo Source Type: research
Functional analysis, diversity, and distribution of the < em > ean < /em > cluster responsible for 17 < em > β < /em > -estradiol degradation in sphingomonads
In this study, the newly isolated Sphingomonas colocasiae C3-2 could degrade E2 through both the 4,5-seco pathway and the 9,10-seco pathway. The novel gene cluster ean (including eanA, eanB1, eanC, and eanD) responsible for E2 degradation by the 4,5-seco pathway was identified; the novel two-component monooxygenase EanE1E2 can open ring B of 4-OH-E1 through the 9,10-seco pathway. The TetR family transcriptional regulator EanR acts as a transcriptional repressor of the ean cluster. The cluster ean was also found to be present in other reported E2-degrading sphingomonads, indicating the ubiquity of the E2 metabolism in the e...
Source: Applied and Environmental Microbiology - April 15, 2024 Category: Microbiology Authors: Mingliang Zhang Siyuan Gao Kaihua Pan Hongfei Liu Qian Li Xuekun Bai Qian Zhu Zeyou Chen Xin Yan Qing Hong Source Type: research
Mechanism of resveratrol in protecting ovary in poor ovarian response mice by regulating Hippo signaling pathway
In conclusion, Res effectively inhibits ovarian cell apoptosis in mice and improves ovarian responsiveness. Its mechanism may be related to the regulation of key molecules in the Hippo pathway.PMID:38621878 | DOI:10.19540/j.cnki.cjcmm.20230915.401 (Source: Cell Research)
Source: Cell Research - April 15, 2024 Category: Cytology Authors: Jian-Heng Hao Bo-Ya Chang Jia Ren Hai-Jun Wang Lai-Xi Ji Source Type: research
Functional analysis, diversity, and distribution of the < em > ean < /em > cluster responsible for 17 < em > β < /em > -estradiol degradation in sphingomonads
In this study, the newly isolated Sphingomonas colocasiae C3-2 could degrade E2 through both the 4,5-seco pathway and the 9,10-seco pathway. The novel gene cluster ean (including eanA, eanB1, eanC, and eanD) responsible for E2 degradation by the 4,5-seco pathway was identified; the novel two-component monooxygenase EanE1E2 can open ring B of 4-OH-E1 through the 9,10-seco pathway. The TetR family transcriptional regulator EanR acts as a transcriptional repressor of the ean cluster. The cluster ean was also found to be present in other reported E2-degrading sphingomonads, indicating the ubiquity of the E2 metabolism in the e...
Source: Applied and Environmental Microbiology - April 15, 2024 Category: Microbiology Authors: Mingliang Zhang Siyuan Gao Kaihua Pan Hongfei Liu Qian Li Xuekun Bai Qian Zhu Zeyou Chen Xin Yan Qing Hong Source Type: research
Low Estradiol Level and Endometrial Thickness on the Day of Endometrial Transformation Influence Clinical Pregnancy After Intrauterine Insemination
(Source: International Journal of General Medicine)
Source: International Journal of General Medicine - April 15, 2024 Category: General Medicine Tags: International Journal of General Medicine Source Type: research
Laparoscopic sleeve gastrectomy for premenstrual syndrome symptoms in patients with obesity
ConclusionLSG can improve the management of obesity in patients with PMS to some extent. Changes in BMI, testosterone, and E2 may be indicative of improvement in patients with obesity and PMS. (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - April 15, 2024 Category: Surgery Source Type: research
Description of Solvent-Extractable Chemicals in Thermal Receipts and Toxicological Assessment of Bisphenol S and Diphenyl Sulfone
Bull Environ Contam Toxicol. 2024 Apr 14;112(4):63. doi: 10.1007/s00128-024-03871-4.ABSTRACTResearch on thermal receipts has previously focused on the toxic effects of dermal exposure from the most publicized developers (e.g., bisphenol A (BPA) and bisphenol S (BPS)), while no studies have reported on the other solvent-extractable compounds therein. Diphenyl sulfone (DPS) is a sensitizer added to thermal receipts, but little is known about DPS concentrations in receipts or potential toxicity. Here, we quantified BPA, BPS, and DPS concentrations and tentatively identified the solvent-extractable compounds of thermal receipt...
Source: Bulletin of Environmental Contamination and Toxicology - April 14, 2024 Category: Environmental Health Authors: Tasnia Sharin Lucas J Leinen David Schreiber Vaille A Swenson Sarah A Emsley E Jamie Trammell Patrick Videau Doug Crump Michael O Gaylor Source Type: research
Description of Solvent-Extractable Chemicals in Thermal Receipts and Toxicological Assessment of Bisphenol S and Diphenyl Sulfone
Bull Environ Contam Toxicol. 2024 Apr 14;112(4):63. doi: 10.1007/s00128-024-03871-4.ABSTRACTResearch on thermal receipts has previously focused on the toxic effects of dermal exposure from the most publicized developers (e.g., bisphenol A (BPA) and bisphenol S (BPS)), while no studies have reported on the other solvent-extractable compounds therein. Diphenyl sulfone (DPS) is a sensitizer added to thermal receipts, but little is known about DPS concentrations in receipts or potential toxicity. Here, we quantified BPA, BPS, and DPS concentrations and tentatively identified the solvent-extractable compounds of thermal receipt...
Source: Bulletin of Environmental Contamination and Toxicology - April 14, 2024 Category: Environmental Health Authors: Tasnia Sharin Lucas J Leinen David Schreiber Vaille A Swenson Sarah A Emsley E Jamie Trammell Patrick Videau Doug Crump Michael O Gaylor Source Type: research
The combined effects of preservative chemicals in consumer products: an analysis using embryonic and adult zebrafish
In this study, zebrafish embryos were exposed to BIT, PP, and mixtures of both for 96 h to investigate the effects on growth hormone (GH), insulin-like growth factor-1 (IGF-1), and the transcription of 19 genes related to the GH/IGFs axis. Concentrations of BIT and PP were measured in the whole body of larvae. Zebrafish pairs were also exposed to BIT, PP, and mixtures for 21 d to evaluate the effects on sex hormones, histology in gonad, and transcription of 22 genes related to the hypothalamus-pituitary-gonad axis and vitellogenin. The mixtures had potentiation effects on development, reproduction, hormones, and gene trans...
Source: Chemosphere - April 13, 2024 Category: Chemistry Authors: Chaeun Park Hyeri Jeon Younglim Kho Kyunghee Ji Source Type: research
The combined effects of preservative chemicals in consumer products: an analysis using embryonic and adult zebrafish
In this study, zebrafish embryos were exposed to BIT, PP, and mixtures of both for 96 h to investigate the effects on growth hormone (GH), insulin-like growth factor-1 (IGF-1), and the transcription of 19 genes related to the GH/IGFs axis. Concentrations of BIT and PP were measured in the whole body of larvae. Zebrafish pairs were also exposed to BIT, PP, and mixtures for 21 d to evaluate the effects on sex hormones, histology in gonad, and transcription of 22 genes related to the hypothalamus-pituitary-gonad axis and vitellogenin. The mixtures had potentiation effects on development, reproduction, hormones, and gene trans...
Source: Chemosphere - April 13, 2024 Category: Chemistry Authors: Chaeun Park Hyeri Jeon Younglim Kho Kyunghee Ji Source Type: research
The combined effects of preservative chemicals in consumer products: an analysis using embryonic and adult zebrafish
In this study, zebrafish embryos were exposed to BIT, PP, and mixtures of both for 96 h to investigate the effects on growth hormone (GH), insulin-like growth factor-1 (IGF-1), and the transcription of 19 genes related to the GH/IGFs axis. Concentrations of BIT and PP were measured in the whole body of larvae. Zebrafish pairs were also exposed to BIT, PP, and mixtures for 21 d to evaluate the effects on sex hormones, histology in gonad, and transcription of 22 genes related to the hypothalamus-pituitary-gonad axis and vitellogenin. The mixtures had potentiation effects on development, reproduction, hormones, and gene trans...
Source: Chemosphere - April 13, 2024 Category: Chemistry Authors: Chaeun Park Hyeri Jeon Younglim Kho Kyunghee Ji Source Type: research
Curative effect of motherwort combined with ethinylestradiol-cyproterone acetate on dysfunctional uterine bleeding
CONCLUSION: Thecombination of motherwort and EE/CPA is clinically effective in thetreatment of DUB.PMID:38613836 | DOI:10.1080/17474086.2024.2343878 (Source: Expert Review of Hematology)
Source: Expert Review of Hematology - April 13, 2024 Category: Hematology Authors: Qiaoyun Tang Xueyuan Chen Source Type: research
The effect of tamoxifen on estradiol, SHBG, IGF-1, and CRP in women with breast cancer or at risk of developing breast cancer: a meta-analysis of randomized controlled trials
CONCLUSION: Tamoxifen administration seems to increase estradiol and SHBG levels and reduce CRP and IGF-1 levels in women with breast cancer or at risk of developing breast cancer. Further studies are needed to determine whether these changes have any clinical relevance.PMID:38608792 | DOI:10.1016/j.exger.2024.112431 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 12, 2024 Category: Geriatrics Authors: XingDa Li XueJiao Hou Benjamin Hern ández-Wolters Kousalya Prabahar Hamed Kord-Varkaneh Bo Mei Source Type: research
NADPH OXIDASE-GENERATED REACTIVE OXYGEN SPECIES ARE INVOLVED IN ESTRADIOL 17 ß-d-GLUCURONIDE-INDUCED CHOLESTASIS
Biochimie. 2024 Apr 10:S0300-9084(24)00077-4. doi: 10.1016/j.biochi.2024.04.002. Online ahead of print.ABSTRACTThe endogenous metabolite of estradiol, estradiol 17β-D-glucuronide (E17G), is considered the main responsible of the intrahepatic cholestasis of pregnancy. E17G alters the activity of canalicular transporters through a signaling pathway-dependent cellular internalization, phenomenon that was attributed to oxidative stress in different cholestatic conditions. However, there are no reports involving oxidative stress in E17G-induced cholestasis, representing this the aim of our work. Using polarized hepatocyte cult...
Source: Biochimie - April 12, 2024 Category: Biochemistry Authors: Gimena Salas Alen A Litta Anabela C Medeot Virginia Schuck Romina B Andermatten Gisel S Miszczuk Nadia Ciriaci Ma Valeria Razori Ismael R Barosso Enrique J S ánchez Pozzi Marcelo G Roma Cecilia L Basiglio Fernando A Crocenzi Source Type: research
Estradiol-17 β and bisphenol A affect growth and mineralization in early life stages of seabass
Comp Biochem Physiol C Toxicol Pharmacol. 2024 Apr 10:109921. doi: 10.1016/j.cbpc.2024.109921. Online ahead of print.ABSTRACTNatural and synthetic estrogens are contaminants present in aquatic ecosystems. They can have significant consequences on the estrogen-sensitive functions of organisms, including skeletal development and growth of vertebrate larvae. Synthetic polyphenols represent a group of environmental xenoestrogens capable of binding the receptors for the natural hormone estradiol-17β (E2). To better understand how (xeno-)estrogens can affect the skeleton in fish species with high ecological and commercial inter...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - April 12, 2024 Category: Biochemistry Authors: Camille Martinand-Mari Melanie Debiais-Thibaud Eric Potier Eric Gasset Gilbert Dutto Nicolas Leurs St éphane Lallement Emilie Farcy Source Type: research
