A self-powered electrochemical aptasensor for the detection of 17 β-estradiol based on carbon nanocages/gold nanoparticles and DNA bioconjugate mediated biofuel cells
Analyst, 2024, Advance Article DOI: 10.1039/D4AN00085D, PaperYongju Wu, Dan Luo, Jinfei Yi, Rong Li, Dan Yang, Pengfei Pang, Hongbin Wang, Wenrong Yang, Yanli Zhang A BFC-based electrochemical aptasensor for E2 detection based on CNCs/AuNPs and PMNPs@aptamer DNA bioconjugate. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - March 28, 2024 Category: Chemistry Authors: Yongju Wu Source Type: research

PFAS Modulate Osmotic Signaling Independent of Gravimetric Changes in the Rat Uterus
This study screened multiple PFAS in the rat uterotrophic assay to determine potential estrogenic effects on the uterus with PFAS exposure. This study also explored PFAS-dependent uterine signaling with an osmotic stress mRNA gene expression array. Briefly, Sprague-Dawley rats (26-39 days old) were ovariectomized, and uterine tissue was allowed to regress for a 3-week period of recovery. Animals were then exposed daily via oral gavage to PFAS for 4 days, and then uterine weight was determined. In contrast to the positive control estrogens, the PFAS tested (4:2, 6:2, and 8:2FTOH; perfluorooctanesulfonamide (PFOSA), perfluor...
Source: Cancer Control - March 27, 2024 Category: Cancer & Oncology Authors: Aaron Dixon Evelyn G Rowan Allison N Yackley Erin P Hines Source Type: research

Effects of Follicle Stimulating Hormone on Energy Balance and Tissue Metabolic Health After Loss of Ovarian Function
Am J Physiol Endocrinol Metab. 2024 Mar 27. doi: 10.1152/ajpendo.00400.2023. Online ahead of print.ABSTRACTLoss of ovarian function imparts increased susceptibility to obesity and metabolic disease. These effects are largely attributed to decreased estradiol (E2), but the role of increased follicle stimulating hormone (FSH) in modulating energy balance has not been fully investigated. Previous work that blocked FSH binding to its receptor in mice suggested this hormone may play a part in modulating body weight and energy expenditure after ovariectomy. We used an alternate approach to isolate the individual and combined con...
Source: Am J Physiol Endocri... - March 27, 2024 Category: Endocrinology Authors: Andrew E Libby Claudia Solt Matthew Jackman Vanessa Sherk Rebecca M Foright Ginger C Johnson Thi-Tina Nguyen Matthew Breit Nicholas Hulett Michael Rudolph Paul A Roberson Elizabeth Wellberg Purevsuren Jambal Rebecca L Scalzo Janine Higgins T Rajendra Kuma Source Type: research

Effects of Follicle Stimulating Hormone on Energy Balance and Tissue Metabolic Health After Loss of Ovarian Function
Am J Physiol Endocrinol Metab. 2024 Mar 27. doi: 10.1152/ajpendo.00400.2023. Online ahead of print.ABSTRACTLoss of ovarian function imparts increased susceptibility to obesity and metabolic disease. These effects are largely attributed to decreased estradiol (E2), but the role of increased follicle stimulating hormone (FSH) in modulating energy balance has not been fully investigated. Previous work that blocked FSH binding to its receptor in mice suggested this hormone may play a part in modulating body weight and energy expenditure after ovariectomy. We used an alternate approach to isolate the individual and combined con...
Source: American Journal of Physiology. Endocrinology and Metabolism - March 27, 2024 Category: Physiology Authors: Andrew E Libby Claudia Solt Matthew Jackman Vanessa Sherk Rebecca M Foright Ginger C Johnson Thi-Tina Nguyen Matthew Breit Nicholas Hulett Michael Rudolph Paul A Roberson Elizabeth Wellberg Purevsuren Jambal Rebecca L Scalzo Janine Higgins T Rajendra Kuma Source Type: research

Bioinformatics and system biology approach to identify the influences among COVID-19, influenza, and HIV on the regulation of gene expression
ConclusionThis research provides valuable insights into shared molecular targets, signaling pathways, drug chemicals, and potential biomarkers for individuals facing the complex intersection of COVID-19, influenza, and HIV. These findings hold promise for enhancing the precision of diagnosis and treatment for individuals with HIV co-infected with COVID-19 and influenza. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - March 27, 2024 Category: Allergy & Immunology Source Type: research

A Phase 0/1 Pharmacokinetic and Pharmacodynamics and Safety and Tolerability Study of Letrozole in Combination with Standard Therapy in Recurrent High-Grade Gliomas
CONCLUSION: Based on safety, brain tumoral PK, and mechanistic data, 15 mg daily is identified as the RP2D for future trials.PMID:38530160 | DOI:10.1158/1078-0432.CCR-23-3341 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - March 26, 2024 Category: Cancer & Oncology Authors: Pankaj B Desai Aniruddha Karve Misam Zawit Priyanka Arora Nimita Dave Joy Awosika Ningjing Li Bethany Fuhrman Mario Medvedovic Larry Sallans Ady Kendler Biplab DasGupta David Plas Richard Curry Mario Zuccarello Rekha Chaudhary Soma Sengupta Trisha M Wise- Source Type: research

Pre ‐diagnostic free androgen and estradiol levels influence heart failure risk in both women and men: A prospective cohort study in the UK Biobank
ConclusionsSex hormones potentially influence HF pathogenesis and may offer pathways for interventions. (Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - March 26, 2024 Category: Cardiology Authors: Jungeun Lim, Maryam Hashemian, Batel Blechter, V éronique L. Roger, Jason Y.Y. Wong Tags: Research Article Source Type: research

Effects of injectable contraception with depot medroxyprogesterone acetate or norethisterone enanthate on estradiol levels and menstrual, psychological and behavioral measures relevant to HIV risk: The WHICH randomized trial
by Mandisa Singata-Madliki, Jenni Smit, Mags Beksinska, Yusentha Balakrishna, Chanel Avenant, Ivana Beesham, Ishen Seocharan, Joanne Batting, Janet P. Hapgood, G. Justus Hofmeyr BackgroundObservational data suggest lower HIV risk with norethisterone enanthate (NET-EN) than with depo-medroxyprogesterone acetate intramuscular (DMPA-IM) injectable contraceptives. If confirmed, a switch between these similar injectable methods would be programmatically feasible and could impact the trajectory of the HIV epidemic. We aimed in this paper to investigate the effects of DMPA-IM and NET-EN on estradiol levels, measures of depression...
Source: PLoS One - March 26, 2024 Category: Biomedical Science Authors: Mandisa Singata-Madliki Source Type: research

COVID-19 (SARS-CoV-2) mRNA vaccination does not affect basal sex hormone levels (follicle-stimulating hormone, luteinizing hormone, estradiol) in reproductive-age women
CONCLUSION: This study showed no significant differences in basal hormone levels (FSH, LH, and estradiol) before and after SARS-CoV-2 mRNA vaccination.PMID:38525522 | DOI:10.5653/cerm.2023.06107 (Source: Clinical and Experimental Reproductive Medicine)
Source: Clinical and Experimental Reproductive Medicine - March 25, 2024 Category: Reproduction Medicine Authors: Haeng Jun Jeon Woo Sik Lee Ji Eun Park Ji Young Hwang Ji Won Kim Source Type: research

Evaluating the safety and efficacy of cryopreserved ovarian tissue transplantation in leukemia patients with different bone marrow remission status using xenotransplantation
ConclusionFor leukemia patients having ovarian tissue preserved in the first and only centralized human ovarian tissue cryobank in China, immunodeficient mice xenotransplantation can be a method to evaluate the safety and efficacy of OTT; the risk of malignant cell reimplantation due to OTT is higher in leukemia patients with MRD-positive status than those with MRD-negative status before OTC. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 25, 2024 Category: Endocrinology Source Type: research

Cortical lipid metabolic pathway alteration of early Alzheimer ’s disease and candidate drugs screen
ConclusionsAD cortical lipid metabolism disorder was associated with the dysregulation of the PPAR signaling pathway, glycerophospholipid metabolism, adipocytokine signaling pathway, fatty acid biosynthesis, fatty acid degradation, ferroptosis, biosynthesis of unsaturated fatty acids, and fatty acid elongation. Candidate drugs including bisphenol A, benzo(a)pyrene, ethinyl estradiol, and active compounds including adenosine phosphate, oxidized Photinus luciferin, and BMS-488043 have potential therapeutic effects on cortical lipid metabolism disorder of early AD. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - March 25, 2024 Category: Research Source Type: research

Qixian granule inhibits ferroptosis in vascular endothelial cells by modulating TRPML1 in the lysosome to prevent postmenopausal atherosclerosis
CONCLUSION: QXG inhibited GPX4 and FTH1-mediated ferroptosis in vascular endothelial cells through up-regulating GPER/TRPML1 signaling, providing a potential therapeutic option for postmenopausal females seeking a safe and effective medication to prevent atherosclerosis. The study highlights QXG's estrogenic properties and its promising role in combating postmenopausal atherosclerosis.PMID:38521431 | DOI:10.1016/j.jep.2024.118076 (Source: Atherosclerosis)
Source: Atherosclerosis - March 23, 2024 Category: Cardiology Authors: Meng Zhang Chenhan Mao Yang Dai Xiaojin Xu Xindong Wang Source Type: research

Does extreme psychological burden (Hamas terrorist attack on October 7th, 2023) affect in vitro fertilization outcome?
ConclusionsIn the present study, we are witness to the effect of acute emotional and psychological trauma on IVF outcome, as reflected by its detrimental effect on sperm and embryo quality. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - March 23, 2024 Category: Reproduction Medicine Source Type: research