Development of social recognition ability in female rats: Effect of pubertal ovarian hormones
Horm Behav. 2023 Mar 24;151:105347. doi: 10.1016/j.yhbeh.2023.105347. Online ahead of print.ABSTRACTThe ability to recognize previously encountered conspecifics is crucial for social interaction. This social recognition ability is well characterized in adult rodents of both sexes but remains largely unexplored in juveniles. Using the social discrimination test of social recognition with short intervals (30 min and 1 h), we first found that juvenile female rats do not display a difference in investigation directed toward a novel vs. familiar stimulus rat. Using the social discrimination test with a 30-minute interval, we th...
Source: Hormones and Behavior - March 26, 2023 Category: Endocrinology Authors: Katie E Yoest Morgen G Henry Haley A Velisek Alexa H Veenema Source Type: research
Prediction of oocyte maturation rate in the GnRH antagonist flexible IVF protocol using a novel machine learning algorithm - A retrospective study
Eur J Obstet Gynecol Reprod Biol. 2023 Mar 21;284:100-104. doi: 10.1016/j.ejogrb.2023.03.022. Online ahead of print.ABSTRACTOocyte maturation is affected by various patient and cycle parameters and has a key effect on treatment outcome. A prediction model for oocyte maturation rate formulated by using machine learning and neural network algorithms has not yet been described. A retrospective cohort study that included all women aged ≤ 38 years who underwent their first IVF treatment using a flexible GnRH antagonist protocol in a single tertiary hospital between 2010 and 2015. 462 patients met the inclusion criteria. Media...
Source: Reproductive Biology - March 25, 2023 Category: Reproduction Medicine Authors: Ohad Houri Yotam Gil Shir Danieli-Gruber Yoel Shufaro Onit Sapir Alyssa Hochberg Avi Ben-Haroush Avital Wertheimer Source Type: research
Effects of two protocols of ovulation synchronization on corpus luteum size and blood flow, progesterone concentration, and pregnancy rate in beef heifers
The objective of this study was to evaluate the effect of 7-day estradiol-progesterone-based [Treat(C)] and 5-day Co-Synch plus progesterone [Treat(Co-Sy)] protocols on ovulation time, pre-ovulatory follicle diameter, corpus luteum (CL) size and blood flow, progesterone (P4) concentration and pregnancy rate (PR) in beef heifers. In Experiment 1, a crossover design was applied (n = 9). For Treat(C), a progesterone intravaginal (PI) device was inserted, plus 2 mg of estradiol benzoate (day 0). On day 7, 500 µg of cloprostenol plus 0.5 mg of estradiol cypionate were administered, and PI was removed. For Treat(Co-Sy), on day ...
Source: Animal Reproduction Science - March 25, 2023 Category: Zoology Authors: Pablo Sebasti án Reineri Sergio Daniel Rold án Bernhard Santiago Alberto Principi Gustavo Daniel Gerlero Juan Florencio Aller Source Type: research
Estrogen receptors regulate galectin ‑3 in androgen‑independent DU‑145 prostate cancer cells
Oncol Rep. 2023 May;49(5):93. doi: 10.3892/or.2023.8530. Epub 2023 Mar 24.ABSTRACTThe aim of the present study was to investigate the role of estrogen receptor (ER)α and ERβ, and galectin‑3 (GAL‑3) in migration and invasion of androgen‑independent DU‑145 prostate cancer cells, and to examine the regulation of the expression of GAL‑3 by the activation of these receptors. Wound healing and cell invasion assays were performed using the control (basal level of cellular function) and treated DU‑145 cells. At 24 h of treatment, 17β‑estradiol (E2), the ERα‑selective agonist, 4,4',4"‑(4‑propyl‑(1H)‑pyra...
Source: Cancer Control - March 24, 2023 Category: Cancer & Oncology Authors: Deborah S Souza Carla Macheroni Carolina M Vicente Renan P Cavalheiro Vanessa L Campo Catarina S Porto Source Type: research
Reproductive and metabolic toxic effects of polystyrene microplastics in adult female Wistar rats: a mechanistic study
Environ Sci Pollut Res Int. 2023 Mar 24. doi: 10.1007/s11356-023-26565-6. Online ahead of print.ABSTRACTMicroplastics, such as polystyrene microplastics (PS-MPs), have become an emerging environmental hazard for animals and humans. Long-term exposure to PS-MPs has led to neurotoxicity, reproductive dysfunction, and carcinogenesis. The goal of this study was to evaluate the effect of sub-chronic exposure of PS-MPs on metabolic and reproductive functions in female rats. The PS-MPs were prepared by cryogenic technique. The PS-MPs were given orally to female Wistar rats for 45 days at 2.5, 5, and 10 mg/kg/day. The average PS-M...
Source: Environmental Science and Pollution Research International - March 24, 2023 Category: Environmental Health Authors: Anam Saeed Muhammad Furqan Akhtar Ammara Saleem Bushra Akhtar Ali Sharif Source Type: research
Estrogen receptors regulate galectin ‑3 in androgen‑independent DU‑145 prostate cancer cells
Oncol Rep. 2023 May;49(5):93. doi: 10.3892/or.2023.8530. Epub 2023 Mar 24.ABSTRACTThe aim of the present study was to investigate the role of estrogen receptor (ER)α and ERβ, and galectin‑3 (GAL‑3) in migration and invasion of androgen‑independent DU‑145 prostate cancer cells, and to examine the regulation of the expression of GAL‑3 by the activation of these receptors. Wound healing and cell invasion assays were performed using the control (basal level of cellular function) and treated DU‑145 cells. At 24 h of treatment, 17β‑estradiol (E2), the ERα‑selective agonist, 4,4',4"‑(4‑propyl‑(1H)‑pyra...
Source: Oncology Reports - March 24, 2023 Category: Cancer & Oncology Authors: Deborah S Souza Carla Macheroni Carolina M Vicente Renan P Cavalheiro Vanessa L Campo Catarina S Porto Source Type: research
Reproductive and metabolic toxic effects of polystyrene microplastics in adult female Wistar rats: a mechanistic study
Environ Sci Pollut Res Int. 2023 Mar 24. doi: 10.1007/s11356-023-26565-6. Online ahead of print.ABSTRACTMicroplastics, such as polystyrene microplastics (PS-MPs), have become an emerging environmental hazard for animals and humans. Long-term exposure to PS-MPs has led to neurotoxicity, reproductive dysfunction, and carcinogenesis. The goal of this study was to evaluate the effect of sub-chronic exposure of PS-MPs on metabolic and reproductive functions in female rats. The PS-MPs were prepared by cryogenic technique. The PS-MPs were given orally to female Wistar rats for 45 days at 2.5, 5, and 10 mg/kg/day. The average PS-M...
Source: Environmental Science and Pollution Research International - March 24, 2023 Category: Environmental Health Authors: Anam Saeed Muhammad Furqan Akhtar Ammara Saleem Bushra Akhtar Ali Sharif Source Type: research
Estrogen receptors regulate galectin ‑3 in androgen‑independent DU‑145 prostate cancer cells
Oncol Rep. 2023 May;49(5):93. doi: 10.3892/or.2023.8530. Epub 2023 Mar 24.ABSTRACTThe aim of the present study was to investigate the role of estrogen receptor (ER)α and ERβ, and galectin‑3 (GAL‑3) in migration and invasion of androgen‑independent DU‑145 prostate cancer cells, and to examine the regulation of the expression of GAL‑3 by the activation of these receptors. Wound healing and cell invasion assays were performed using the control (basal level of cellular function) and treated DU‑145 cells. At 24 h of treatment, 17β‑estradiol (E2), the ERα‑selective agonist, 4,4',4"‑(4‑propyl‑(1H)‑pyra...
Source: Oncology Reports - March 24, 2023 Category: Cancer & Oncology Authors: Deborah S Souza Carla Macheroni Carolina M Vicente Renan P Cavalheiro Vanessa L Campo Catarina S Porto Source Type: research
Ovarian hormones influence immune response to liver ischemia-reperfusion
Braz J Med Biol Res. 2023 Mar 17;56:e12650. doi: 10.1590/1414-431X2023e12650. eCollection 2023.ABSTRACTLiver injury occurs after ischemia and reperfusion (IR), as seen in transplant settings. Sex hormones have been implicated in many pathophysiological mechanisms in females and this could lead to liver protection under inflammatory reperfusion conditions where an excessive immune response occurs. Despite such assumptions, this fact needs to be further investigated. To address this, female and male C57BL/6J mice (8-12 weeks old) were studied. Bilateral ovariectomy (OVX) was performed in females to decrease estradiol levels....
Source: Brazilian Journal of Medical and Biological Research - March 22, 2023 Category: Research Authors: T H C de Oliveira G K N Gon çalves Source Type: research
Ovarian hormones influence immune response to liver ischemia-reperfusion
Braz J Med Biol Res. 2023 Mar 17;56:e12650. doi: 10.1590/1414-431X2023e12650. eCollection 2023.ABSTRACTLiver injury occurs after ischemia and reperfusion (IR), as seen in transplant settings. Sex hormones have been implicated in many pathophysiological mechanisms in females and this could lead to liver protection under inflammatory reperfusion conditions where an excessive immune response occurs. Despite such assumptions, this fact needs to be further investigated. To address this, female and male C57BL/6J mice (8-12 weeks old) were studied. Bilateral ovariectomy (OVX) was performed in females to decrease estradiol levels....
Source: Braz J Med Biol Res - March 22, 2023 Category: Research Authors: T H C de Oliveira G K N Gon çalves Source Type: research
< em > Bushen Huoxue Fang < /em > improves recurrent miscarriage in mice by down-regulating the JAK2/STAT3 pathway
CONCLUSION: BSHXF can improve the prethrombotic state and inhibit cell apoptosis by downregulating the JAK2/STAT3 pathway to increase the pregnancy rate in mouse models of RSA.PMID:36946047 | DOI:10.12122/j.issn.1673-4254.2023.02.15 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - March 22, 2023 Category: Universities & Medical Training Authors: J Zhao P Chen G Xu J Sun Y Ruan M Xue Y Wu Source Type: research
Ovarian hormones influence immune response to liver ischemia-reperfusion
Braz J Med Biol Res. 2023 Mar 17;56:e12650. doi: 10.1590/1414-431X2023e12650. eCollection 2023.ABSTRACTLiver injury occurs after ischemia and reperfusion (IR), as seen in transplant settings. Sex hormones have been implicated in many pathophysiological mechanisms in females and this could lead to liver protection under inflammatory reperfusion conditions where an excessive immune response occurs. Despite such assumptions, this fact needs to be further investigated. To address this, female and male C57BL/6J mice (8-12 weeks old) were studied. Bilateral ovariectomy (OVX) was performed in females to decrease estradiol levels....
Source: Brazilian Journal of Medical and Biological Research - March 22, 2023 Category: Research Authors: T H C de Oliveira G K N Gon çalves Source Type: research
Ovarian hormones influence immune response to liver ischemia-reperfusion
Braz J Med Biol Res. 2023 Mar 17;56:e12650. doi: 10.1590/1414-431X2023e12650. eCollection 2023.ABSTRACTLiver injury occurs after ischemia and reperfusion (IR), as seen in transplant settings. Sex hormones have been implicated in many pathophysiological mechanisms in females and this could lead to liver protection under inflammatory reperfusion conditions where an excessive immune response occurs. Despite such assumptions, this fact needs to be further investigated. To address this, female and male C57BL/6J mice (8-12 weeks old) were studied. Bilateral ovariectomy (OVX) was performed in females to decrease estradiol levels....
Source: Braz J Med Biol Res - March 22, 2023 Category: Research Authors: T H C de Oliveira G K N Gon çalves Source Type: research
< em > Bushen Huoxue Fang < /em > improves recurrent miscarriage in mice by down-regulating the JAK2/STAT3 pathway
CONCLUSION: BSHXF can improve the prethrombotic state and inhibit cell apoptosis by downregulating the JAK2/STAT3 pathway to increase the pregnancy rate in mouse models of RSA.PMID:36946047 | PMC:PMC10034533 | DOI:10.12122/j.issn.1673-4254.2023.02.15 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - March 22, 2023 Category: Universities & Medical Training Authors: J Zhao P Chen G Xu J Sun Y Ruan M Xue Y Wu Source Type: research
Ovarian hormones influence immune response to liver ischemia-reperfusion
Braz J Med Biol Res. 2023 Mar 17;56:e12650. doi: 10.1590/1414-431X2023e12650. eCollection 2023.ABSTRACTLiver injury occurs after ischemia and reperfusion (IR), as seen in transplant settings. Sex hormones have been implicated in many pathophysiological mechanisms in females and this could lead to liver protection under inflammatory reperfusion conditions where an excessive immune response occurs. Despite such assumptions, this fact needs to be further investigated. To address this, female and male C57BL/6J mice (8-12 weeks old) were studied. Bilateral ovariectomy (OVX) was performed in females to decrease estradiol levels....
Source: Brazilian Journal of Medical and Biological Research - March 22, 2023 Category: Research Authors: T H C de Oliveira G K N Gon çalves Source Type: research
