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XinJiaCongRongTuSiZiWan protects triptolide-induced rats from oxidative stress injury via mitophagy mediated PINK1/Parkin signaling pathway
CONCLUSIONS: XJCRTSZW protects TP-induced rats from oxidative stress injury via the mitophagy-mediated PINK1/Parkin pathway.PMID:38511762 | PMC:PMC10953615 | DOI:10.1590/acb391424 (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - March 21, 2024 Category: Surgery Authors: Yan Jin Deng Di-Si Wu Ke-Ming Source Type: research

The estrogen receptor alpha regulates the sex-dependent expression and pronociceptive role of bestrophin-1 in neuropathic rats
This study investigated if 17 β-estradiol and estrogen receptor alpha (ERα) activation regulate bestrophin-1 activity and expression in neuropathic rats. Neuropathic pain was induced by L5-spinal nerve transection (SNT). Intrathecal administration of CaCCinh-A01 (0.1-1 µg), a CaCC blocker, reversed tactile allodynia induced b y SNT in female but not male rats. (Source: The Journal of Pain)
Source: The Journal of Pain - March 21, 2024 Category: Materials Science Authors: Diana Laura Calvillo-Montoya, Carlos Javier Mart ínez-Magaña, Norma Oviedo, Janet Murbartián Tags: Original Reports Source Type: research

Protective effect of thyroid and restores of ovarian function of Buzhong Yiqi granule on experimental autoimmune thyroiditis in female rats
CONCLUSIONS: BZYQ granule could regulate the thyroid function of EAT rats, reduce thyroid antibody titers, then act on the ovarian function, regulate hormone disorders, and alleviate the pathological damage of rat's ovarian tissues. The effect of high dose Buzhong Yiqi granule is the best.PMID:38504537 | DOI:10.19852/j.cnki.jtcm.20240203.008 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - March 20, 2024 Category: Complementary Medicine Authors: Wang Yuezhu Zhang Yuyang Qiao Jiajun L U Yuyuan Xia Zhongyuan Source Type: research

Developing liver-targeted naringenin nanoparticles for breast cancer endocrine therapy by promoting estrogen metabolism
J Nanobiotechnology. 2024 Mar 19;22(1):122. doi: 10.1186/s12951-024-02356-0.ABSTRACTEndocrine therapy is standard for hormone receptor-positive (HR+) breast cancer treatment. However, current strategies targeting estrogen signaling pay little attention to estradiol metabolism in the liver and is usually challenged by treatment failure. In a previous study, we demonstrated that the natural compound naringenin (NAR) inhibited HR+ breast cancer growth by activating estrogen sulfotransferase (EST) expression in the liver. Nevertheless, the poor water solubility, low bio-barrier permeability, and non-specific distribution limit...
Source: Cancer Control - March 20, 2024 Category: Cancer & Oncology Authors: Yuying Zhao Hanxu Tan Juping Zhang Dandan Zhan Bowen Yang Shicui Hong Bo Pan Neng Wang Tongkai Chen Yafei Shi Zhiyu Wang Source Type: research

Endocrine disrupting effects of parabens in zebrafish (Danio rerio): New insights from transcriptomics, metabolomics, and molecular dynamics simulation
This study assessed the endocrine hormone interference effects of four typical PBs, namely methylparaben (MeP), ethylparaben (EtP), propylparaben (PrP), and butylparaben (BuP), in zebrafish and elucidated the probable underlying mechanisms. Transcriptomic and metabolomic analyses showed that the differentially expressed genes and metabolites were associated with the tyrosine metabolism, arachidonate metabolism, and glycerophospholipid metabolism, indicating they were essential precursors of steroid hormone biosynthesis and metabolism. Histopathological analysis revealed impaired gonad development in the zebrafish exposed t...
Source: Chemosphere - March 20, 2024 Category: Chemistry Authors: Fang Wei Huifeng Yue Binjie Wang Hefa Cheng Nan Sang Source Type: research