Cardiovascular disrupting effects of bisphenols, phthalates, and parabens related to endothelial dysfunction: review of toxicological and pharmacological mechanisms
Environ Toxicol Pharmacol. 2024 Feb 28:104407. doi: 10.1016/j.etap.2024.104407. Online ahead of print.ABSTRACTCardiovascular diseases (CVDs) are the leading cause of death worldwide. CVDs are promoted by the accumulation of lipids and immune cells in the endothelial space resulting in endothelial dysfunction. Endothelial cells are important components of the vascular endothelium, that regulate the vascular flow. The imbalance in the production of vasoactive substances results in the loss of vascular homeostasis, leading the endothelial dysfunction. Thus, endothelial dysfunction plays an essential role in the development of...
Source: Atherosclerosis - March 1, 2024 Category: Cardiology Authors: Cristina Lemini Patricia Silveyra Mariana Segovia-Mendoza Source Type: research
Gynura procumbens and selected metabolites: Amelioration of depressive-like behaviors in mice and risperidone-induced hyperprolactinemia in rats
Biomed Pharmacother. 2024 Feb 29;173:116361. doi: 10.1016/j.biopha.2024.116361. Online ahead of print.ABSTRACTGynura procumbens (Lour.) Merr., utilized in traditional Chinese medicine, is known for its liver-protective, liver-soothing, and depression-alleviating properties. This research examines the antidepressant and anti-hyperprolactinemia potentials of an ethanol extract from G. procumbens stems (EEGS) and specific metabolites. To model depression and hyperprolactinemia, chronic unpredictable mild stress (CUMS) was induced in mice and risperidone was administered to rats, respectively. Treatments involved administering...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 1, 2024 Category: Drugs & Pharmacology Authors: Si-Yu Zhai Hong-Wei Gu Cong Wang Yu-Sang Li He-Bin Tang Source Type: research
Ningxin-Tongyu-Zishen formula alleviates the senescence of granulosa cells on D-galactose-induced premature ovarian insufficiency mice
Aging (Albany NY). 2024 Feb 28;16. doi: 10.18632/aging.205607. Online ahead of print.ABSTRACTNingxin-Tongyu-Zishen formula (NTZF) is a clinical experience formula for the treatment of premature ovarian insufficiency (POI) in traditional Chinese medicine (TCM), and the potential mechanism is unknown. For in vivo experiments, POI mouse models (C57BL/6 mice), were constructed by subcutaneous injection of D-galactose (D-gal, 200 mg/kg). After treatment of NTZF (10.14, 20.27, 40.54 g/kg;) or estradiol valerate (0.15 mg/kg), ovarian function, oxidative stress (OS) and protein expression of Sirt1/p53 were evaluated. For in vitro ...
Source: Aging - March 1, 2024 Category: Biomedical Science Authors: Jia-Wen Ma Zeng-Yan Xiong Xing-Chu Cai Xiang Li Shi-Yan Ren Shuai-Qi An Zai-Yang Zhang Yi-Zhou Zhang Source Type: research
Gynura procumbens and selected metabolites: Amelioration of depressive-like behaviors in mice and risperidone-induced hyperprolactinemia in rats
Biomed Pharmacother. 2024 Feb 29;173:116361. doi: 10.1016/j.biopha.2024.116361. Online ahead of print.ABSTRACTGynura procumbens (Lour.) Merr., utilized in traditional Chinese medicine, is known for its liver-protective, liver-soothing, and depression-alleviating properties. This research examines the antidepressant and anti-hyperprolactinemia potentials of an ethanol extract from G. procumbens stems (EEGS) and specific metabolites. To model depression and hyperprolactinemia, chronic unpredictable mild stress (CUMS) was induced in mice and risperidone was administered to rats, respectively. Treatments involved administering...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 1, 2024 Category: Drugs & Pharmacology Authors: Si-Yu Zhai Hong-Wei Gu Cong Wang Yu-Sang Li He-Bin Tang Source Type: research
The relationship between klotho, testosterone, and sexual health parameters among US adult men
ConclusionOur findings support previous studies suggesting a role for klotho in testosterone levels and sexual function among men. Future studies are warranted to corroborate these findings, determine clinical significance, and elucidate potential mechanisms underlying these associations. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 1, 2024 Category: Endocrinology Source Type: research
