Cost-effectiveness of folic acid therapy for primary prevention of stroke in patients with hypertension
For hypertensive patients without a history of stroke or myocardial infarction (MI), the China Stroke Primary Prevention Trial (CSPPT) demonstrated that treatment with enalapril-folic acid reduced the risk of ... (Source: BMC Medicine)
Source: BMC Medicine - October 25, 2022 Category: Internal Medicine Authors: Tiantian Zhang, Zhuoru Liang, Tengfei Lin, David J. Cohen, Alejandro Arrieta, Xiaobin Wang, Xianhui Qin, Binyan Wang, Yong Huo, Gordon G. Liu, Jie Jiang and Zugui Zhang Tags: Research article Source Type: research
Robust arm and leg muscle adaptation to training despite ACE inhibition: a randomized placebo-controlled trial
ConclusionEight weeks of high-intensity whole-body exercise training improves markers of skeletal muscle mitochondrial oxidative capacity, glycolytic capacity and angiogenesis, with no overall effect of pharmacological ACE inhibition in healthy adults. (Source: European Journal of Applied Physiology)
Source: European Journal of Applied Physiology - October 22, 2022 Category: Physiology Source Type: research
Acute kidney injury and long-term renal effects of alectinib in anaplastic lymphoma kinase-positive non-small cell lung carcinoma: a case report
ConclusionsOur data suggest direct or indirect toxic (proximal) tubulopathy due to alectinib with a good prognosis after cessation. Adverse acute renal effects of alectinib may be prevented by avoiding other medication influencing renal hemodynamics, in particular nonsteroidal anti-inflammatory drugs. Without these co-medications, alectinib could be reintroduced in our patient. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - September 29, 2022 Category: General Medicine Source Type: research
The Relationship between Angiotensin-Neprilysin Treatment, Echocardiographic Parameters, and NT-proBNP Levels in HFpEF Patients with Acute Decompensated Heart Failure
CONCLUSION: Sacubitril-valsartan treatment, which lowered NT-proBNP levels and improved cardiac function, was more effective in HFpEF patients with acute decompensated heart failure than enalapril.PMID:36132549 | PMC:PMC9484936 | DOI:10.1155/2022/4298644 (Source: Computational and Mathematical Methods in Medicine)
Source: Computational and Mathematical Methods in Medicine - September 22, 2022 Category: Statistics Authors: Xiaoliang Zhang Song Yang Zhonglin Xu Source Type: research
Heart Failure Duration and Mechanistic Efficacy of Sacubitril/Valsartan in Heart Failure with Reduced Ejection Fraction
Modulation of the renin-angiotensin system is one of the cornerstones for treatment of heart failure with reduced ejection fraction (HFrEF) (1). In the Prospective Comparison of Angiotensin Receptor –Neprilysin Inhibitor (ARNI) with Angiotensin Converting Enzyme (ACE) Inhibitor to Determine Impact on Global Mortality and Morbidity in Heart Failure Trial (PARADIGM-HF) (2), treatment with the angiotensin receptor/neprilysin inhibitor (ARNI) sacubitril/valsartan (Sac/Val) significantly reduced c ardiovascular (CV) mortality and HF hospitalization compared to the ACE inhibitor enalapril; treatment with Sac/Val also reduced c...
Source: Journal of Cardiac Failure - September 16, 2022 Category: Cardiology Authors: Reza Mohebi, Yuxi Liu, G. Michael Felker, Margaret F. Prescott, Jonathan H. Ward, Ileana L. Pi ña, Javed Butler, Scott D. Solomon, James L. Januzzi Source Type: research
Intravital imaging of hemodynamic glomerular effects of enalapril or/and empagliflozin in STZ-diabetic mice
Conclusion: SGLT2 inhibition, besides ACE inhibition, is an essential hemodynamic regulator of glomerular filtration during diabetes mellitus. Nevertheless, additional mechanisms—independent from hemodynamic regulation—are involved in the nephroprotective effects especially of the combination therapy and should be further explored in future studies. (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - September 12, 2022 Category: Physiology Source Type: research
Huangqi decoction attenuates renal interstitial fibrosis transforming growth factor- β1/mitogen-activated protein kinase signaling pathways in 5/6 nephrectomy mice
CONCLUSIONS: The protective effect of Huangqi decoction for renal interstitial fibrosis in 5/6 nep-hrectomized mice the inhibition of Epithelial-Mesenchymal Transitions and downregulating the TGF-β1/ MAPK signaling pathway.PMID:36083479 | DOI:10.19852/j.cnki.jtcm.2022.05.006 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - September 9, 2022 Category: Complementary Medicine Authors: Zhao Jie Wang Li Cao Ai-Li Wang Yun-Man Chi Yang-Feng Wang Yi Wang Hao Peng Wen Source Type: research
AA amyloidosis presenting with acute kidney injury, curable or not?
CONCLUSIONS: Amyloidosis should be considered especially in children presenting with proteinuria and with a history of recurrent fever. This report also emphasizes the efficacy of canakinumab to prevent or decelerate chronic renal failure in these patients although it does not reduce tissue deposition in long-term use.PMID:36082654 | DOI:10.24953/turkjped.2020.3900 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - September 9, 2022 Category: Pediatrics Authors: Berfin Uysal Berna Ayta ç Vuruşkan Source Type: research
Huangqi decoction attenuates renal interstitial fibrosis transforming growth factor- β1/mitogen-activated protein kinase signaling pathways in 5/6 nephrectomy mice
CONCLUSIONS: The protective effect of Huangqi decoction for renal interstitial fibrosis in 5/6 nep-hrectomized mice the inhibition of Epithelial-Mesenchymal Transitions and downregulating the TGF-β1/ MAPK signaling pathway.PMID:36083479 | DOI:10.19852/j.cnki.jtcm.2022.05.006 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - September 9, 2022 Category: Complementary Medicine Authors: Zhao Jie Wang Li Cao Ai-Li Wang Yun-Man Chi Yang-Feng Wang Yi Wang Hao Peng Wen Source Type: research
AA amyloidosis presenting with acute kidney injury, curable or not?
CONCLUSIONS: Amyloidosis should be considered especially in children presenting with proteinuria and with a history of recurrent fever. This report also emphasizes the efficacy of canakinumab to prevent or decelerate chronic renal failure in these patients although it does not reduce tissue deposition in long-term use.PMID:36082654 | DOI:10.24953/turkjped.2020.3900 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - September 9, 2022 Category: Pediatrics Authors: Berfin Uysal Berna Ayta ç Vuruşkan Source Type: research
Huangqi decoction attenuates renal interstitial fibrosis transforming growth factor- β1/mitogen-activated protein kinase signaling pathways in 5/6 nephrectomy mice
CONCLUSIONS: The protective effect of Huangqi decoction for renal interstitial fibrosis in 5/6 nep-hrectomized mice the inhibition of Epithelial-Mesenchymal Transitions and downregulating the TGF-β1/ MAPK signaling pathway.PMID:36083479 | DOI:10.19852/j.cnki.jtcm.2022.05.006 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - September 9, 2022 Category: Complementary Medicine Authors: Zhao Jie Wang Li Cao Ai-Li Wang Yun-Man Chi Yang-Feng Wang Yi Wang Hao Peng Wen Source Type: research
AA amyloidosis presenting with acute kidney injury, curable or not?
CONCLUSIONS: Amyloidosis should be considered especially in children presenting with proteinuria and with a history of recurrent fever. This report also emphasizes the efficacy of canakinumab to prevent or decelerate chronic renal failure in these patients although it does not reduce tissue deposition in long-term use.PMID:36082654 | DOI:10.24953/turkjped.2020.3900 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - September 9, 2022 Category: Pediatrics Authors: Berfin Uysal Berna Ayta ç Vuruşkan Source Type: research
Huangqi decoction attenuates renal interstitial fibrosis transforming growth factor- β1/mitogen-activated protein kinase signaling pathways in 5/6 nephrectomy mice
CONCLUSIONS: The protective effect of Huangqi decoction for renal interstitial fibrosis in 5/6 nep-hrectomized mice the inhibition of Epithelial-Mesenchymal Transitions and downregulating the TGF-β1/ MAPK signaling pathway.PMID:36083479 | DOI:10.19852/j.cnki.jtcm.2022.05.006 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - September 9, 2022 Category: Complementary Medicine Authors: Zhao Jie Wang Li Cao Ai-Li Wang Yun-Man Chi Yang-Feng Wang Yi Wang Hao Peng Wen Source Type: research
AA amyloidosis presenting with acute kidney injury, curable or not?
CONCLUSIONS: Amyloidosis should be considered especially in children presenting with proteinuria and with a history of recurrent fever. This report also emphasizes the efficacy of canakinumab to prevent or decelerate chronic renal failure in these patients although it does not reduce tissue deposition in long-term use.PMID:36082654 | DOI:10.24953/turkjped.2020.3900 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - September 9, 2022 Category: Pediatrics Authors: Berfin Uysal Berna Ayta ç Vuruşkan Source Type: research
