Combined Arterial Hypertension and Ischemic Stroke Exaggerate Anesthesia-Related Hypotension and Cerebral Oxygenation Deficits: A Preclinical Study
CONCLUSIONS: Our findings are the first demonstration that ischemic stroke per se increases the severity of IOH, particularly when combined with a prior history of hypertension; this combination appears to compromise penumbral perfusion.PMID:36730724 | DOI:10.1213/ANE.0000000000006263 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - February 2, 2023 Category: Anesthesiology Authors: Tracy Zhang Pratik Thakkar Tonja W Emans Debra Fong Suma Thampi Igor S A Felippe Carolyn J Barrett Robyn Billing Douglas Campbell Fiona D McBryde Source Type: research
Combined Arterial Hypertension and Ischemic Stroke Exaggerate Anesthesia-Related Hypotension and Cerebral Oxygenation Deficits: A Preclinical Study
CONCLUSIONS: Our findings are the first demonstration that ischemic stroke per se increases the severity of IOH, particularly when combined with a prior history of hypertension; this combination appears to compromise penumbral perfusion.PMID:36730724 | DOI:10.1213/ANE.0000000000006263 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - February 2, 2023 Category: Anesthesiology Authors: Tracy Zhang Pratik Thakkar Tonja W Emans Debra Fong Suma Thampi Igor S A Felippe Carolyn J Barrett Robyn Billing Douglas Campbell Fiona D McBryde Source Type: research
Combined Arterial Hypertension and Ischemic Stroke Exaggerate Anesthesia-Related Hypotension and Cerebral Oxygenation Deficits: A Preclinical Study
CONCLUSIONS: Our findings are the first demonstration that ischemic stroke per se increases the severity of IOH, particularly when combined with a prior history of hypertension; this combination appears to compromise penumbral perfusion.PMID:36730724 | DOI:10.1213/ANE.0000000000006263 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - February 2, 2023 Category: Anesthesiology Authors: Tracy Zhang Pratik Thakkar Tonja W Emans Debra Fong Suma Thampi Igor S A Felippe Carolyn J Barrett Robyn Billing Douglas Campbell Fiona D McBryde Source Type: research
Novel strategies to reverse chemoresistance in colorectal cancer
Chemoresistance is the major cause of treatment failure and disease relapse in colorectal cancer (CRC). In addition to some common reversal measures, some novel strategies have sprouted in recent years, including drug repurposing, gene therapy, protein inhibitor, natural herbal compounds, new drug delivery system, and combination therapy, which promise to improve the treatment of CRC. AbstractColorectal cancer (CRC) is a common gastrointestinal malignancy with high morbidity and fatality. Chemotherapy, as traditional therapy for CRC, has exerted well antitumor effect and greatly improved the survival of CRC patients. Never...
Source: Cancer Medicine - January 16, 2023 Category: Cancer & Oncology Authors: Shu ‐Chang Ma,
Jia‐Qi Zhang,
Tian‐Hua Yan,
Ming‐Xing Miao,
Ye‐Min Cao,
Yong‐Bing Cao,
Li‐Chao Zhang,
Ling Li Tags: REVIEW Source Type: research
Sustainable Synthesis of α-Hydroxycarboxylic Acids by Manganese Catalyzed Acceptorless Dehydrogenative Coupling of Ethylene Glycol and Primary Alcohols
Angew Chem Int Ed Engl. 2023 Jan 11. doi: 10.1002/anie.202218329. Online ahead of print.ABSTRACTHerein, we report a straightforward synthesis of valuable α-hydroxycarboxylic acid molecules via an acceptorless dehydrogenative coupling of ethylene glycol and primary alcohols. A bench-stable manganese complex catalyzed the reaction, which is scalable, with the product being isolated with high yields and selectivities under mild conditions. The protocol is environmentally benign, producing water and hydrogen gas as the only byproducts. Methanol can also be used as a C1 source for producing the platform molecule lactic acid, w...
Source: Angewandte Chemie - January 11, 2023 Category: Chemistry Authors: Satyadeep Waiba Kakoli Maji Mamata Maiti Biplab Maji Source Type: research
Preventing cardiotoxicity in patients with breast cancer and lymphoma: protocol for a multicentre randomised controlled trial (PROACT)
BMJ Open. 2022 Dec 30;12(12):e066252. doi: 10.1136/bmjopen-2022-066252.ABSTRACTINTRODUCTION: Anthracyclines are included in chemotherapy regimens to treat several different types of cancer and are extremely effective. However, it is recognised that a significant side effect is cardiotoxicity; anthracyclines can cause irreversible damage to cardiac cells and ultimately impaired cardiac function and heart failure, which may only be evident years after exposure. The PROACT trial will establish the effectiveness of the ACE inhibitor enalapril maleate (enalapril) in preventing cardiotoxicity in patients with breast cancer and n...
Source: Cancer Control - December 30, 2022 Category: Cancer & Oncology Authors: Rebecca H Maier Chris Plummer Adetayo S Kasim Nasima Akhter Emmanuel Ogundimu Jamie Maddox Janine Graham Michael Stewart Andrew Wardley Sophie Haney Sharareh Vahabi Helen Oxenham Alison Humphreys Nicola Cresti Mark Verrill Richard Graham Lisa Chang Helen Source Type: research
Preventing cardiotoxicity in patients with breast cancer and lymphoma: protocol for a multicentre randomised controlled trial (PROACT)
Introduction
Anthracyclines are included in chemotherapy regimens to treat several different types of cancer and are extremely effective. However, it is recognised that a significant side effect is cardiotoxicity; anthracyclines can cause irreversible damage to cardiac cells and ultimately impaired cardiac function and heart failure, which may only be evident years after exposure. The PROACT trial will establish the effectiveness of the ACE inhibitor enalapril maleate (enalapril) in preventing cardiotoxicity in patients with breast cancer and non-Hodgkin’s lymphoma (NHL) receiving anthracycline-based chemotherapy.
M...
Source: BMJ Open - December 30, 2022 Category: General Medicine Authors: Maier, R. H., Plummer, C., Kasim, A. S., Akhter, N., Ogundimu, E., Maddox, J., Graham, J., Stewart, M., Wardley, A., Haney, S., Vahabi, S., Oxenham, H., Humphreys, A., Cresti, N., Verrill, M., Graham, R., Chang, L., Hancock, H. C., Austin, D. Tags: Open access, Cardiovascular medicine Source Type: research
Burden of and factors associated with poor quality antibiotic, antimalarial, antihypertensive and antidiabetic medicines in Malawi
by Francis Kachidza Chiumia, Happy Magwaza Nyirongo, Elizabeth Kampira, Adamson Sinjani Muula, Felix Khuluza
ObjectiveTo assess the prevalence and factors associated with substandard and falsified (SF) medicines among antibiotic, antimalarial, antihypertensive and antidiabetic medicines in Malawi. MethodsWe conducted a cross-sectional study in 23 public, faith-based and private health facilities in Zomba, Machinga and Nsanje districts. We analyzed oral medicine samples of commonly used medicines among antibiotics, antimalarial, antihypertensive and antidiabetics in accordance with Malawi Essential Medicines List and local ...
Source: PLoS One - December 27, 2022 Category: Biomedical Science Authors: Francis Kachidza Chiumia Source Type: research
Mathematical modeling of antihypertensive therapy
This study is a continuation of research on the modular agent-based model of the cardiovascular and renal systems (presented in the previously published article). In the current work, we included in the model equations simulating the response to antihypertensive therapies with different mechanisms of action. For this, we used the pharmacodynamic effects of the angiotensin II receptor blocker losartan, the calcium channel blocker amlodipine, the angiotensin-converting enzyme inhibitor enalapril, the direct renin inhibitor aliskiren, the thiazide diuretic hydrochlorothiazide, and the β-blocker bisoprolol. We fitted therapy ...
Source: Frontiers in Physiology - December 14, 2022 Category: Physiology Source Type: research
Identification of regulatory variants of carboxylesterase 1 (CES1): A proof ‐of‐concept study for the application of the Allele‐Specific Protein Expression (ASPE) assay in identifying cis‐acting regulatory genetic polymorphisms
This study suggests that the ASPE approach is a powerful tool for identifyingcis-regulatory variants. (Source: Proteomics)
Source: Proteomics - December 7, 2022 Category: Biochemistry Authors: Lucy Her,
Jian Shi,
Xinwen Wang,
Bing He,
Logan S. Smith,
Hui Jiang,
Hao ‐Jie Zhu Tags: RESEARCH ARTICLE Source Type: research
Author Correction: Antihypertensive treatment with calcium channel blockers and renal protection: focus on lercanidipine and lercanidipine/enalapril
Eur Rev Med Pharmacol Sci. 2022 Nov;26(22):8204. doi: 10.26355/eurrev_202211_30347.NO ABSTRACTPMID:36459001 | DOI:10.26355/eurrev_202211_30347 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - December 2, 2022 Category: Drugs & Pharmacology Authors: N Ferri A Corsini R Pontremoli Source Type: research
Author Correction: Antihypertensive treatment with calcium channel blockers and renal protection: focus on lercanidipine and lercanidipine/enalapril
Eur Rev Med Pharmacol Sci. 2022 Nov;26(22):8204. doi: 10.26355/eurrev_202211_30347.NO ABSTRACTPMID:36459001 | DOI:10.26355/eurrev_202211_30347 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - December 2, 2022 Category: Drugs & Pharmacology Authors: N Ferri A Corsini R Pontremoli Source Type: research
Author Correction: Antihypertensive treatment with calcium channel blockers and renal protection: focus on lercanidipine and lercanidipine/enalapril
Eur Rev Med Pharmacol Sci. 2022 Nov;26(22):8204. doi: 10.26355/eurrev_202211_30347.NO ABSTRACTPMID:36459001 | DOI:10.26355/eurrev_202211_30347 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - December 2, 2022 Category: Drugs & Pharmacology Authors: N Ferri A Corsini R Pontremoli Source Type: research
Author Correction: Antihypertensive treatment with calcium channel blockers and renal protection: focus on lercanidipine and lercanidipine/enalapril
Eur Rev Med Pharmacol Sci. 2022 Nov;26(22):8204. doi: 10.26355/eurrev_202211_30347.NO ABSTRACTPMID:36459001 | DOI:10.26355/eurrev_202211_30347 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - December 2, 2022 Category: Drugs & Pharmacology Authors: N Ferri A Corsini R Pontremoli Source Type: research
