Long Term Metabolic Effects of Sacubitril/Valsartan in Non-Diabetic and Diabetic Patients With Heart Failure Reduced Ejection Fraction: A Real Life Study
Sacubitril/Valsartan (sac/val) has improved clinical prognosis in patients affected by heart failure (HF) with reduced ejection fraction (HFrEF). HF and type 2 diabetes mellitus (T2DM) frequently coexist, with a prevalence of T2DM of 35%–40% in patients with HF. T2DM is the third co-morbidities in patients with HF and a strong independent risk factor for the progression of HF. In a post hoc analysis of PARADIGM-HF, improved glycemic control was shown in patients with T2DM and HFrEF receiving sac/val compared to enalapril at 12 months of follow-up. The aim of the present study was to evaluate, in a series of repeated obs...
Source: Frontiers in Physiology - May 25, 2022 Category: Physiology Source Type: research
Ethnopharmacological investigation of Croton urucurana Baill. against metabolic-associated fatty liver disease in rats
Conclusion: C. urucurana extract exerted promising hepatoprotective and lipid-lowering effects in a preclinical rat model of MAFLD. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - May 20, 2022 Category: Drugs & Pharmacology Source Type: research
Changes in Cardiac Biomarkers in Association with Alterations in Cardiac Structure and Function, and Health Status in HFrEF: The EVALUATE ‐HF Trial
ConclusionIn HFrEF, serial changes in NT-proBNP correlate with changes in several key measures of cardiac structure and health status. cTnT changes correlate with changes in LV mass and sST2 with changes in health status. These data highlight possible complementary pathophysiologic implications of changes NT-proBNP, cTnT and sST2. (Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - May 13, 2022 Category: Cardiology Authors: Peder L. Myhre,
Brian L. Claggett,
Amil M. Shah,
Margaret F. Prescott,
Jonathan H. Ward,
James C. Fang,
Gary F. Mitchell,
Scott D. Solomon,
Akshay S. Desai Tags: Research Article Source Type: research
Joint Association of Low Vitamin K1 and D Status With First Stroke in General Hypertensive Adults: Results From the China Stroke Primary Prevention Trial (CSPPT)
ConclusionLow concentrations of both vitamin K1 and 25(OH)D were associated with increased risk of stroke. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - May 12, 2022 Category: Neurology Source Type: research
Hf-567-02 sacubitril-valsartan and burden of ventricular arrhythmia: a meta-analysis
PARADIGM-HF showed a reduction in sudden cardiac death with Sacubitril-Valsartan (SV) use compared to enalapril in patients with heart failure with reduced ejection fraction (HFrEF). However, it is not clear if there is significant reduction in ventricular arrhythmias due to SV. (Source: Heart Rhythm)
Source: Heart Rhythm - April 29, 2022 Category: Cardiology Authors: Ritesh Shrestha, Raj Dangol, Suresh Paudel, Vijaywant Brar, Paari Dominic Source Type: research
Safety and Efficacy of ARNI (valsartan/sacubitril) Vs ACEI (enalapril) in Acute Heart Failure - A Prospective Observational Study
CONCLUSION: The ARNI study group showed better safety and efficacy outcomes at the end of 6 months follow-up compared to ACEI group.PMID:35483448 | DOI:10.1016/j.ihj.2022.04.003 (Source: Indian Heart J)
Source: Indian Heart J - April 28, 2022 Category: Cardiology Authors: Tahir Saleem Bhat Imran Hafeez Sobia Fatima Tak Asif Mattoo Aamir Rashid Patigaroo Abad Khan Ajaz Ahmad Lone Jahangir Rashid Beig Source Type: research
Safety and Efficacy of ARNI (valsartan/sacubitril) Vs ACEI (enalapril) in Acute Heart Failure - A Prospective Observational Study
CONCLUSION: The ARNI study group showed better safety and efficacy outcomes at the end of 6 months follow-up compared to ACEI group.PMID:35483448 | DOI:10.1016/j.ihj.2022.04.003 (Source: Indian Heart J)
Source: Indian Heart J - April 28, 2022 Category: Cardiology Authors: Tahir Saleem Bhat Imran Hafeez Sobia Fatima Tak Asif Mattoo Aamir Rashid Patigaroo Abad Khan Ajaz Ahmad Lone Jahangir Rashid Beig Source Type: research
Safety and Efficacy of ARNI (valsartan/sacubitril) Vs ACEI (enalapril) in Acute Heart Failure - A Prospective Observational Study
CONCLUSION: The ARNI study group showed better safety and efficacy outcomes at the end of 6 months follow-up compared to ACEI group.PMID:35483448 | DOI:10.1016/j.ihj.2022.04.003 (Source: Indian Heart J)
Source: Indian Heart J - April 28, 2022 Category: Cardiology Authors: Tahir Saleem Bhat Imran Hafeez Sobia Fatima Tak Asif Mattoo Aamir Rashid Patigaroo Abad Khan Ajaz Ahmad Lone Jahangir Rashid Beig Source Type: research
Renin-angiotensin-aldosterone system inhibition in patients affected by heart failure: efficacy, mechanistic effects and practical use of sacubitril/valsartan. Position Paper of the Italian Society of Cardiology
Eur J Intern Med. 2022 Apr 22:S0953-6205(22)00142-X. doi: 10.1016/j.ejim.2022.04.006. Online ahead of print.ABSTRACTRenin-angiotensin-aldosterone system (RAAS) inhibition is a mainstay of the pharmacological treatment of heart failure with reduced ejection fraction (HFrEF). In the last years RAAS blockade has been improved by the introduction of the Angiotensin Receptor-Neprilysin Inhibitor (ARNI) sacubitril/valsartan, that combines RAAS inhibition with the block of neprilysin, boosting the positive effects of natriuretic peptides. The PARADIGM-HF trial demonstrated a significant advantage of sacubitril/valsartan over enal...
Source: European Journal of Internal Medicine - April 26, 2022 Category: Internal Medicine Authors: Pasquale Perrone-Filardi Stefania Paolillo Piergiuseppe Agostoni Christian Basile Cristina Basso Francesco Barill à Michele Correale Antonio Curcio Massimo Mancone Marco Merlo Marco Metra Saverio Muscoli Savina Nodari Alberto Palazzuoli Roberto Pedrinell Source Type: research
Renin-angiotensin-aldosterone system inhibition in patients affected by heart failure: efficacy, mechanistic effects and practical use of sacubitril/valsartan. Position Paper of the Italian Society of Cardiology
Eur J Intern Med. 2022 Apr 22:S0953-6205(22)00142-X. doi: 10.1016/j.ejim.2022.04.006. Online ahead of print.ABSTRACTRenin-angiotensin-aldosterone system (RAAS) inhibition is a mainstay of the pharmacological treatment of heart failure with reduced ejection fraction (HFrEF). In the last years RAAS blockade has been improved by the introduction of the Angiotensin Receptor-Neprilysin Inhibitor (ARNI) sacubitril/valsartan, that combines RAAS inhibition with the block of neprilysin, boosting the positive effects of natriuretic peptides. The PARADIGM-HF trial demonstrated a significant advantage of sacubitril/valsartan over enal...
Source: European Journal of Internal Medicine - April 26, 2022 Category: Internal Medicine Authors: Pasquale Perrone-Filardi Stefania Paolillo Piergiuseppe Agostoni Christian Basile Cristina Basso Francesco Barill à Michele Correale Antonio Curcio Massimo Mancone Marco Merlo Marco Metra Saverio Muscoli Savina Nodari Alberto Palazzuoli Roberto Pedrinell Source Type: research
Antihypertensive effect of Mali-Nil surin rice bran hydrolysate and its mechanisms related to the EDHF-mediated vasorelaxation and L-type Ca < sup > 2+ < /sup > channel-mediated vasoconstriction in L-NAME hypertensive rats
This study investigated an antihypertensive effect of MRH and evaluated the mechanisms mediating this action in Nω-nitro-L-arginine-methyl ester (L-NAME)-induced hypertensive rats. Antihypertensive activity was determined in male rats orally administered with MRH (100 or 300 mg/kg) or enalapril (15 mg/kg) daily together with L-NAME (50 mg/kg/day) in drinking water, for 21 days. Concurrent oral treatment with MRH lowered the high blood pressure in the L-NAME-induced hypertensive rats. MRH treatment improved endothelial function and increased the endothelium-derived hyperpolarizing factor-mediated vasorelaxation in L-NAME h...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 24, 2022 Category: Drugs & Pharmacology Authors: Patchareewan Pannangpetch Panot Tangsucharit Ratthipha Thanaruksa Tunvaraporn Proongkhong Supawadee Srisuwan Direk Aekthammarat Source Type: research
Antihypertensive effect of Mali-Nil surin rice bran hydrolysate and its mechanisms related to the EDHF-mediated vasorelaxation and L-type Ca < sup > 2+ < /sup > channel-mediated vasoconstriction in L-NAME hypertensive rats
This study investigated an antihypertensive effect of MRH and evaluated the mechanisms mediating this action in Nω-nitro-L-arginine-methyl ester (L-NAME)-induced hypertensive rats. Antihypertensive activity was determined in male rats orally administered with MRH (100 or 300 mg/kg) or enalapril (15 mg/kg) daily together with L-NAME (50 mg/kg/day) in drinking water, for 21 days. Concurrent oral treatment with MRH lowered the high blood pressure in the L-NAME-induced hypertensive rats. MRH treatment improved endothelial function and increased the endothelium-derived hyperpolarizing factor-mediated vasorelaxation in L-NAME h...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 24, 2022 Category: Drugs & Pharmacology Authors: Patchareewan Pannangpetch Panot Tangsucharit Ratthipha Thanaruksa Tunvaraporn Proongkhong Supawadee Srisuwan Direk Aekthammarat Source Type: research
GSE188349 Transcriptomic response in the heart and kidney to different types of antihypertensive drug administration [kidney]
Contributors : Fumihiko Takeuchi ; Norihiro KatoSeries Type : Expression profiling by arrayOrganism : Rattus norvegicusTo unravel antihypertensive drug-induced gene expression changes that are potentially related to the amelioration of end-organ damages, we performed in vivo phenotypic evaluation and transcriptomic analysis on the heart and the kidney, with administration of antihypertensive drugs to two inbred strains of (i.e., hypertensive and normotensive) rats. We chose to use six antihypertensive classes: enalapril (angiotensin converting enzyme inhibitor), candesartan (angiotensin receptor blocker), hydrochlorothia...
Source: GEO: Gene Expression Omnibus - April 15, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by array Rattus norvegicus Source Type: research
