A Comparative Analysis of the Clinical Efficacy of Sacubitril Valsartan Sodium and Enalapril in Patients with Non-Valvular Ejection Fraction Reduction in Heart Failure
CONCLUSION: The main findings of the study showed that Sacubitril valsartan sodium showed better clinical efficacy than enalapril in patients with heart failure and non-valvular reduced ejection fraction. Specifically, the drug significantly improved patients' kidney function, reduced cardiovascular marker levels, and reduced the incidence of adverse cardiovascular events. These findings have important clinical implications for guiding treatment selection in patients with heart failure.PMID:38330576 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - February 8, 2024 Category: Complementary Medicine Authors: Qinqqing Zhang Jiao Wang Yingxiao Da Xin Li Lei Pan Source Type: research
A Comparative Analysis of the Clinical Efficacy of Sacubitril Valsartan Sodium and Enalapril in Patients with Non-Valvular Ejection Fraction Reduction in Heart Failure
CONCLUSION: The main findings of the study showed that Sacubitril valsartan sodium showed better clinical efficacy than enalapril in patients with heart failure and non-valvular reduced ejection fraction. Specifically, the drug significantly improved patients' kidney function, reduced cardiovascular marker levels, and reduced the incidence of adverse cardiovascular events. These findings have important clinical implications for guiding treatment selection in patients with heart failure.PMID:38330576 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - February 8, 2024 Category: Complementary Medicine Authors: Qinqqing Zhang Jiao Wang Yingxiao Da Xin Li Lei Pan Source Type: research
A Comparative Analysis of the Clinical Efficacy of Sacubitril Valsartan Sodium and Enalapril in Patients with Non-Valvular Ejection Fraction Reduction in Heart Failure
CONCLUSION: The main findings of the study showed that Sacubitril valsartan sodium showed better clinical efficacy than enalapril in patients with heart failure and non-valvular reduced ejection fraction. Specifically, the drug significantly improved patients' kidney function, reduced cardiovascular marker levels, and reduced the incidence of adverse cardiovascular events. These findings have important clinical implications for guiding treatment selection in patients with heart failure.PMID:38330576 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - February 8, 2024 Category: Complementary Medicine Authors: Qinqqing Zhang Jiao Wang Yingxiao Da Xin Li Lei Pan Source Type: research
A Comparative Analysis of the Clinical Efficacy of Sacubitril Valsartan Sodium and Enalapril in Patients with Non-Valvular Ejection Fraction Reduction in Heart Failure
CONCLUSION: The main findings of the study showed that Sacubitril valsartan sodium showed better clinical efficacy than enalapril in patients with heart failure and non-valvular reduced ejection fraction. Specifically, the drug significantly improved patients' kidney function, reduced cardiovascular marker levels, and reduced the incidence of adverse cardiovascular events. These findings have important clinical implications for guiding treatment selection in patients with heart failure.PMID:38330576 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - February 8, 2024 Category: Complementary Medicine Authors: Qinqqing Zhang Jiao Wang Yingxiao Da Xin Li Lei Pan Source Type: research
A Comparative Analysis of the Clinical Efficacy of Sacubitril Valsartan Sodium and Enalapril in Patients with Non-Valvular Ejection Fraction Reduction in Heart Failure
CONCLUSION: The main findings of the study showed that Sacubitril valsartan sodium showed better clinical efficacy than enalapril in patients with heart failure and non-valvular reduced ejection fraction. Specifically, the drug significantly improved patients' kidney function, reduced cardiovascular marker levels, and reduced the incidence of adverse cardiovascular events. These findings have important clinical implications for guiding treatment selection in patients with heart failure.PMID:38330576 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - February 8, 2024 Category: Complementary Medicine Authors: Qinqqing Zhang Jiao Wang Yingxiao Da Xin Li Lei Pan Source Type: research
A Comparative Analysis of the Clinical Efficacy of Sacubitril Valsartan Sodium and Enalapril in Patients with Non-Valvular Ejection Fraction Reduction in Heart Failure
CONCLUSION: The main findings of the study showed that Sacubitril valsartan sodium showed better clinical efficacy than enalapril in patients with heart failure and non-valvular reduced ejection fraction. Specifically, the drug significantly improved patients' kidney function, reduced cardiovascular marker levels, and reduced the incidence of adverse cardiovascular events. These findings have important clinical implications for guiding treatment selection in patients with heart failure.PMID:38330576 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - February 8, 2024 Category: Complementary Medicine Authors: Qinqqing Zhang Jiao Wang Yingxiao Da Xin Li Lei Pan Source Type: research
ER stress improvement by aerobic training or enalapril differently ameliorates pathological cardiac remodeling in obese mice
Mol Cell Biochem. 2024 Feb 3. doi: 10.1007/s11010-024-04925-1. Online ahead of print.ABSTRACTOveractivation of the classic arm of the renin-angiotensin system (RAS) is one of the main mechanisms involved in obesity-related cardiac remodeling, and a possible relationship between RAS and ER stress in the cardiovascular system have been described. Thus, the aim of this study is to evaluate if activating the protective arm of the RAS by ACE inhibition or aerobic exercise training could overturn diet-induced pathological cardiac hypertrophy by attenuating ER stress. Male C57BL/6 mice were fed a control (SC) or a high-fat diet (...
Source: Molecular and Cellular Biochemistry - February 3, 2024 Category: Biochemistry Authors: Amanda Concei ção Pimenta Salles Beatriz Alexandre-Santos Thais de Souza Carvalho Ana Beatriz Proen ça Vinicius Sep úlveda-Fragoso Tiago Fernandes Edilamar Menezes Oliveira Antonio Claudio Lucas da N óbrega Eliete Dalla Corte Frantz D'Angelo Carlo Ma Source Type: research
Pharmacogenetic study of CES1 gene and enalapril efficacy
J Appl Genet. 2024 Jan 23. doi: 10.1007/s13353-024-00831-w. Online ahead of print.ABSTRACTEnalapril is an orally administered angiotensin-converting enzyme inhibitor which is widely prescribed to treat hypertension, chronic kidney disease, and heart failure. It is an ester prodrug that needs to be activated by carboxylesterase 1 (CES1). CES1 is a hepatic hydrolase that in vivo biotransforms enalapril to its active form enalaprilat in order to produce its desired pharmacological impact. Several single nucleotide polymorphisms in CES1 gene are reported to alter the catalytic activity of CES1 enzyme and influence enalapril me...
Source: J Appl Genet - January 23, 2024 Category: Genetics & Stem Cells Authors: Misbah Hussain Sehrish Basheer Adila Khalil Qurat Ul Ain Haider Hafsa Saeed Muhammad Faizan Source Type: research
Impact of exercise training associated with enalapril treatment on blood pressure variability and renal dysfunctions in an experimental model of arterial hypertension and postmenopause
ConclusionsEnalapril combined with CET attenuated BPV and baroreflex dysfunctions, probably impacting on end-organ damage, as demonstrated by attenuation in the AH-induced renal inflammations, oxidative stress and morphofunctional impairments in postmenopausal rats. (Source: PLoS One)
Source: PLoS One - January 10, 2024 Category: Biomedical Science Authors: Michel Pablo dos Santos Ferreira Silva Source Type: research
Captopril to Lisinopril Conversion in Pediatric Cardiothoracic Surgery Patients Less Than 7 Years of Age (RISE-7)
This study evaluated safety and efficacy of converting from captopril to lisinopril in patients utilizing a pre-defined conversion of 3 mg captopril to 1 mg lisinopril. This was a single center, retrospective study including patients less than 7 years of age admitted for cardi othoracic surgery who received both captopril and lisinopril from 01/01/2017 to 06/01/2022.The primary outcome was mean change in systolic blood pressure (SBP) from baseline for 72 h after conversion of captopril to lisinopril. A total of 99 patients were enrolled. There was a significant decrease in mean SBP (99.12 mmHg vs 94.86 mmHg;p = 0...
Source: Pediatric Cardiology - December 28, 2023 Category: Cardiology Source Type: research
Genetic Studies in Infants with Congenital Nephrotic Syndrome: A Case Series
Saudi J Kidney Dis Transpl. 2023 Mar 1;34(2):191-195. doi: 10.4103/1319-2442.391899. Epub 2023 Dec 25.ABSTRACTInformation on the genetic profile of congenital nephrotic syndrome (CNS) from India is scarce. The management of CNS is largely supportive of the setting of developing countries, mainly via the administration of intravenous albumin infusions, angiotensin-converting enzyme inhibitors, and levothyroxine. Inadequate infrastructure and management facilities, including genetic analyses, further hamper the outcome. These infants may progress to end-stage renal disease, and mortality is high in infancy. Here, we report a...
Source: Saudi Journal of Kidney Diseases and Transplantation - December 26, 2023 Category: Urology & Nephrology Authors: Pediredla Karunakar Aakash Chandran Chidambaram Sriram Krishnamurthy Palanisamy Sivamurukan Bobbity Deepthi Mamatha Gowda Source Type: research
Genetic Studies in Infants with Congenital Nephrotic Syndrome: A Case Series
Saudi J Kidney Dis Transpl. 2023 Mar 1;34(2):191-195. doi: 10.4103/1319-2442.391899. Epub 2023 Dec 25.ABSTRACTInformation on the genetic profile of congenital nephrotic syndrome (CNS) from India is scarce. The management of CNS is largely supportive of the setting of developing countries, mainly via the administration of intravenous albumin infusions, angiotensin-converting enzyme inhibitors, and levothyroxine. Inadequate infrastructure and management facilities, including genetic analyses, further hamper the outcome. These infants may progress to end-stage renal disease, and mortality is high in infancy. Here, we report a...
Source: Saudi Journal of Kidney Diseases and Transplantation - December 26, 2023 Category: Urology & Nephrology Authors: Pediredla Karunakar Aakash Chandran Chidambaram Sriram Krishnamurthy Palanisamy Sivamurukan Bobbity Deepthi Mamatha Gowda Source Type: research
Genetic Studies in Infants with Congenital Nephrotic Syndrome: A Case Series
Saudi J Kidney Dis Transpl. 2023 Mar 1;34(2):191-195. doi: 10.4103/1319-2442.391899. Epub 2023 Dec 25.ABSTRACTInformation on the genetic profile of congenital nephrotic syndrome (CNS) from India is scarce. The management of CNS is largely supportive of the setting of developing countries, mainly via the administration of intravenous albumin infusions, angiotensin-converting enzyme inhibitors, and levothyroxine. Inadequate infrastructure and management facilities, including genetic analyses, further hamper the outcome. These infants may progress to end-stage renal disease, and mortality is high in infancy. Here, we report a...
Source: Saudi Journal of Kidney Diseases and Transplantation - December 26, 2023 Category: Urology & Nephrology Authors: Pediredla Karunakar Aakash Chandran Chidambaram Sriram Krishnamurthy Palanisamy Sivamurukan Bobbity Deepthi Mamatha Gowda Source Type: research
Genetic Studies in Infants with Congenital Nephrotic Syndrome: A Case Series
Saudi J Kidney Dis Transpl. 2023 Mar 1;34(2):191-195. doi: 10.4103/1319-2442.391899. Epub 2023 Dec 25.ABSTRACTInformation on the genetic profile of congenital nephrotic syndrome (CNS) from India is scarce. The management of CNS is largely supportive of the setting of developing countries, mainly via the administration of intravenous albumin infusions, angiotensin-converting enzyme inhibitors, and levothyroxine. Inadequate infrastructure and management facilities, including genetic analyses, further hamper the outcome. These infants may progress to end-stage renal disease, and mortality is high in infancy. Here, we report a...
Source: Saudi Journal of Kidney Diseases and Transplantation - December 26, 2023 Category: Urology & Nephrology Authors: Pediredla Karunakar Aakash Chandran Chidambaram Sriram Krishnamurthy Palanisamy Sivamurukan Bobbity Deepthi Mamatha Gowda Source Type: research
