Prognostic Usefulness of Myocardial Work in Patients with Heart Failure and Reduced Ejection Fraction Treated by Sacubitril/Valsartan
Heart failure (HF) is a major public health problem due to its high prevalence, major morbidity and mortality1. Sacubitril/Valsartan, an inhibitor of the angiotensin receptor-neprilysin2, has demonstrated a 20% relative reduction in cardiovascular death and a 16% relative risk reduction in all-cause mortality, when compared with Enalapril. This prognostic effect is associated with a striking improvement in left ventricular (LV) function and reverse remodelling3, which could be attributed to the afterload reduction induced by this treatment4. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - April 2, 2020 Category: Cardiology Authors: Yanis Bouali, Erwan Donal, Alban Gallard, Cl ément Laurin, Arnaud Hubert, Auriane Bidaut, Christophe Leclercq, Elena Galli Source Type: research

Real-World Analysis of Diuretic Requirements in Patients with Heart Failure with Reduced Ejection Fraction after Initiation of Sacubitril/Valsartan
This study hypothesizes that maintenance on sacubitril/valsartan leads to lower diuretic dose requirements. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2020 Category: Transplant Surgery Authors: A. Miah, U. Ahmed, P. Pirlamarla, G. Reeves, C. Abbas, M. Shah, R. Alvarez, S. Cozzi, C. Demastus, A. Ervin, I. Danelich Tags: (359) Source Type: research

Impact of Sacubitril/Valsartan in Cardiac Reverse Remodeling in Ischemic vs. Nonischemic Cardiomyopathy
Guideline directed medical therapy with beta blockers, ACEi/ARBs, and aldosterone antagonists with the goal of affecting cardiac reverse remodeling (CRR) has previously been the cornerstone of management of patients with heart failure with reduced ejection fraction (HFrEF). More recently, PARADIGM-HF demonstrated the superiority of sacubitril-valsartan to enalapril in reducing HF hospitalizations as well as cardiac and all-cause mortality. Other studies demonstrated that ARNI therapy may enhance CRR to a greater degree than ACEI or ARB therapy alone. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2020 Category: Transplant Surgery Authors: O. Safdar, A. Ervin, S. Cozzi, I. Danelich, M. Shah, A. Vishnevsky, R. Alvarez, P. Pirlamarla Tags: (580) Source Type: research

Outcomes on the Waiting List for Candidates Receiving an Angiotensin Receptor-Neprilysin Inhibitor at Listing
This study aimed to assess the outcomes of heart transplant candidates receiving SV at listing. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2020 Category: Transplant Surgery Authors: C. Jasseron, R. Dorent, O. Bastien, C. Legeai Tags: (579) Source Type: research

Facts and reflections on COVID-19 and anti-hypertensives drugs.
Authors: Marin GH Abstract Based on some publications that associate SARS-CoV-2 infection with the use of anti-hypertensive drug groups such as angiotensin-converting-enzyme inhibitors (e.g. enalapril) or angiotensin II receptor blockers (e.g. losartan), many patients from South America, Central America or Spain, have stopped or intend to interrupt their treatments with these drugs. Hence, it may exist ominous consequences due to this drop out. For this reason, it is necessary to quickly warn about this situation and the risks associated with it. PMID: 32213760 [PubMed - as supplied by publisher] (Source: Drug ...
Source: Drug Discoveries and Therapeutics - March 29, 2020 Category: Drugs & Pharmacology Tags: Drug Discov Ther Source Type: research

Pre-analytical variables evaluation in laboratory tests of patients attended at the Vitória da Conquista Central laboratory, Bahia, Brazil
Conclusion: The findings indic ate that pre-analytical variables remain an important focus for attention to the clinical laboratory. The correct data collection of patients ’ conditions is critical to support the post-analytical phase with useful information for the production of reliable exams and serve as a useful interpretation to diagnosis.RESUMEN Introducci ón: Las pruebas de laboratorio tienen como objetivo proporcionar información necesaria a la aclaración de diagnósticos o situaciones específicas que no se pueden esclarecer por otros modos. Los análisis de laboratorio...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - March 17, 2020 Category: Pathology Source Type: research

Sacubitril/valsartan in patients with heart failure with reduced ejection fraction with end ‐stage of renal disease
AbstractAimsSacubitril/valsartan (SV) reduced heart failure hospitalization and cardiovascular mortality compared with enalapril in the Prospective Comparison of ARNI with ACE ‐I to Determine Impact on Global Mortality and Morbidity in Heart Failure trial. However, this trial excluded patients with end stage of renal disease (ESRD); thus, the efficacy and safety of SV in heart failure with reduced ejection fraction (HFrEF) with ESRD remains uncertain.Methods and resultsWe retrospectively analysed the clinical and laboratory data of 501 HFrEF patients who administered with SV from March 2017 to April 2019 in a single tert...
Source: ESC Heart Failure - March 10, 2020 Category: Cardiology Authors: Seonhwa Lee, Jaewon Oh, Hyoeun Kim, Jaehyung Ha, Kyeong ‐hyeon Chun, Chan Joo Lee, Sungha Park, Sang‐Hak Lee, Seok‐Min Kang Tags: Short Communication Source Type: research

Angiotensin-converting enzyme inhibitor treatment early after myocardial infarction attenuates acute cardiac and neuroinflammation without effect on chronic neuroinflammation
AbstractPurposeMyocardial infarction (MI) triggers a local inflammatory response which orchestrates cardiac repair and contributes to concurrent neuroinflammation. Angiotensin-converting enzyme (ACE) inhibitor therapy not only attenuates cardiac remodeling by interfering with the neurohumoral system, but also influences acute leukocyte mobilization from hematopoietic reservoirs. Here, we seek to dissect the anti-inflammatory and anti-remodeling contributions of ACE inhibitors to the benefit of heart and brain outcomes after MI.MethodsC57BL/6 mice underwent permanent coronary artery ligation (n = 41) or sham s...
Source: European Journal of Nuclear Medicine and Molecular Imaging - March 3, 2020 Category: Nuclear Medicine Source Type: research

Lower Hospitalization and Total Healthcare Costs Among Patients with Heart Failure When Treated with Sacubitril/Valsartan Versus Angiotensin-Converting Enzyme Inhibitor or Angiotensin-Receptor Blocker: A Retrospective Study of Managed Care Claims
In the PARADIGM-HF trial, sacubitril/valsartan (SAC/VAL) was superior to enalapril in reducing risks of cardiovascular death and heart failure (HF) hospitalization in patients with HF and reduced ejection fraction (HFrEF); however, there is limited knowledge of the impact of SAC/VAL on real-world clinical outcomes and costs compared to angiotensin-converting enzyme inhibitor (ACEI) or angiotensin-receptor blocker (ARB). (Source: Heart and Lung)
Source: Heart and Lung - March 1, 2020 Category: Intensive Care Authors: Nancy Albert, Erin Buysman, Chunlan Chang, Jason Swindle Source Type: research

Effect of the baseline pulse wave velocity on short term and long term blood pressure control in primary hypertension
Arterial stiffness may affect antihypertensive response to antihypertensive treatment. However, sufficient clinical evidence is lacking. This longitudinal study aimed to evaluate the effect of baseline arterial stiffness measured by the brachial-ankle pulse wave velocity (baPWV) on response to short-term and long-term enalapril-based treatment in 3310 hypertensive adults from the China Stroke Primary Prevention Trial (CSPPT). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 24, 2020 Category: Cardiology Authors: Y. Fan, W. Gao, J. Li, F. Fan, X. Qin, L. Liu, X. Cheng, X. Xu, X. Wang, B. Wang, Y. Huo Source Type: research

HUANGKUISIWUFANG inhibits pyruvate dehydrogenase to improve glomerular injury in anti-Thy1 nephritis model
ConclusionChinese herbal preparation HKSWF has remarkable curative effects on glomerulonephritis animals. HKSWF attenuates pyruvate dehydrogenase to improve glomerular injury.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - February 21, 2020 Category: Drugs & Pharmacology Source Type: research

A validated LC–MS/MS method for the quantification of amlodipine, bisoprolol, enalapril and enalaprilat—Application to pharmacokinetic study in healthy volunteers
Publication date: June 2020Source: Microchemical Journal, Volume 155Author(s): Liliya Logoyda, Sergiy Kovalenk, Moustafa Gaafar, Ahmed M. Abdel-Megied, Fawzy A. ElbarbryAbstractIn this work, a highly sensitive and rapid liquid chromatography-tandem mass spectrometry (LC–MS/MS) method for the simultaneous determination of amlodipine (AML), bisoprolol (BIS) and enalapril maleate (ENA) in the presence of its metabolite enalaprilat (ENT) in real human plasma was developed and validated using felodipine, propranolol, ramipril, and captopril, as internal standards (IS), respectively. The prepared samples were chromatograph...
Source: Microchemical Journal - February 14, 2020 Category: Chemistry Source Type: research

Early experience of Sacubitril –Valsartan in heart failure with reduced ejection fraction in real‐world clinical setting
This study aimed to investigate eligibility, titration, and tolerability for Sac/Val in a real ‐world clinical setting.Methods and resultsThis retrospective cohort study consists of two parts. In Part 1 (eligibility study), all patients discharged from Sahlgrenska University Hospital due to HF were consecutively included during 1 year. Data from the patients' medical records were collected. Patients were adjudicated to be eligible based on European Society of Cardiology (ESC) criteria for angiotensin receptor neprilysin inhibitor (ARNI) with the exception of N ‐terminal (NT)‐proBNP levels. Patients who received
Source: ESC Heart Failure - February 7, 2020 Category: Cardiology Authors: Charlotte Nordberg Backelin, Michael Fu, Charlotta Ljungman Tags: Original Research Article Source Type: research

Cancers, Vol. 12, Pages 327: Treatment with Beta-Blockers and ACE-Inhibitors in Breast Cancer Patients Receiving Adjuvant Trastuzumab-Based Therapy and Developing Mild Cardiac Toxicity: A Prospective Study
Conclusion: Treatment of MCT with ACEis and BB allows faster LVEF recovery from nadir values and should be further studied in this setting. (Source: Cancers)
Source: Cancers - January 31, 2020 Category: Cancer & Oncology Authors: Geuna Lombardi Martinello Garino Bonzano Galizia Nuzzo Berchialla Becco Mangioni Zarlo Montemurro Tags: Article Source Type: research

Highlights in heart failure
This article is aimed to give an update on recent advances in all aspects of this syndrome. Major changes occurred in drug treatment of HF with reduced ejection fraction (HFrEF). Sacubitril/valsartan is indicated as a substitute to ACEi/ARBs after PARADIGM ‐HF (hazard ratio [HR], 0.80; 95% confidence interval [CI], 0.73 to 0.87 for sacubitril/valsartan vs. enalapril for the primary endpoint and Wei, Lin and Weissfeld HR 0.79, 95% CI 0.71–0.89 for recurrent events). Its initiation was then shown as safe and potentially useful in recent studies in p atients hospitalized for acute HF. More recently, dapagliflozin and ...
Source: ESC Heart Failure - January 29, 2020 Category: Cardiology Authors: Daniela Tomasoni, Marianna Adamo, Carlo Mario Lombardi, Marco Metra Tags: Review Source Type: research

Ecotoxicological study of six drugs in Aliivibrio fischeri, Daphnia magna and Raphidocelis subcapitata.
D, Giner B Abstract The presence of drugs in the environment is an emerging issue in the scientific community. It has been shown that these substances are active chemicals that consequently affect aquatic organisms and, finally, humans as end users. To evaluate the toxicity of these compounds and how they affect the environment, it is important to perform systematic ecotoxicological and physicochemical studies. The best way to address this problem is to conduct studies on different aquatic trophic levels. In this work, an ecotoxicological study of six drugs (anhydrous caffeine, diphenhydramine hydrochloride, gent...
Source: Environmental Science and Pollution Research International - January 11, 2020 Category: Environmental Health Authors: Lomba L, Lapeña D, Ros N, Aso E, Cannavò M, Errazquin D, Giner B Tags: Environ Sci Pollut Res Int Source Type: research

PAIT-Survey Follow-Up: Changes in Albuminuria in Hypertensive Diabetic Patients with Mild-Moderate Chronic Kidney Disease
AbstractIntroductionAlbuminuria is an early marker of kidney disease and reduction of albuminuria translates into a decreased occurrence of cardiovascular and renal outcomes.AimsTo evaluate  the changes in the prevalence of albuminuria in diabetic hypertensive patients treated with several combinations of renin-angiotensin aldosterone system with calcium channel blockers.MethodsWe analysed data from  668 unselected patients from the PAIT survey (mean age 60.4 ± 10.2 years, prevalence of males 38%), with and without albuminuria, maintained for 6 months with the previous treatment wit...
Source: High Blood Pressure and Cardiovascular Prevention - January 9, 2020 Category: Cardiology Source Type: research

An uncommon case of arthrogryposis, renal dysfunction, and cholestasis (ARC) syndrome and review of the renal involvement: Questions
AbstractArthrogryposis, renal dysfunction, and cholestasis syndrome is a rare autosomal recessive disorder caused by mutations in the VPS33B and VIPAR genes. Most cases are fatal within the first year of life. Here we describe one of the two oldest patients with arthrogryposis, renal dysfunction, and cholestasis syndrome. This is a 12-year-old Hispanic female, from a non-consanguineous parents, diagnosed with an incomplete phenotype of arthrogryposis, renal dysfunction, and cholestasis syndrome with arthrogryposis and renal tubular dysfunction but without cholestasis. At 11 years of age, she was found to have impaired rena...
Source: Pediatric Nephrology - January 2, 2020 Category: Urology & Nephrology Source Type: research

A quality control system for ligand-binding assay of plasma renin activity: Proof-of-concept within a pharmacodynamic study
Publication date: Available online 28 December 2019Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Fabian Konstantin Suessenbach, Nina Makowski, Martin Feickert, Tanja Gangnus, Jutta Tins, Bjoern Bengt Burckhardt, on behalf of the LENA consortiumAbstractWhile the role of plasma renin activity (PRA) in heart failure have been widely studied in adults, comprehensive data on pediatric heart failure remain lacking. This drawback is increasingly being addressed by academic research. Nevertheless, such pediatric investigations are commonly conducted only once due to ethical constraints. Therefore, the quality...
Source: Journal of Pharmaceutical and Biomedical Analysis - December 29, 2019 Category: Drugs & Pharmacology Source Type: research

The eligible population of the PARADIGM-HF trial in a real-world outpatient clinic and its cardiovascular risk between 2005 and 2016
Conclusion In a real-world outpatient clinical setting, around 1/3–1/2 of HFrEF were eligible for treatment of Sac/Val except that they are older, sicker, and carry higher risk for all-cause mortality than the PARADIGM-HF trial population. (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - December 27, 2019 Category: Cardiology Tags: Research articles: Heart failure Source Type: research

Egr1/p300/ACE signal mediates postnatal osteopenia in female rat offspring induced by prenatal ethanol exposure.
Abstract Prenatal ethanol exposure induces developmental toxicities of multiple organs in offspring. Here, we investigate the effects of prenatal ethanol exposure on bone mass in postnatal offspring and explore its intrauterine programming mechanism. We found that prenatal ethanol exposure could induce bone dysplasia in fetuses and postnatal osteopenia in female offspring, accompanied by the sustained activation of the local renin-angiotensin systems (RAS) and inhibition of bone formation. Additionally, we also found that histone 3 lysine 9 acetylation (H3K9ac) and H3K27ac levels in the promoter region of angioten...
Source: Food and Chemical Toxicology - December 27, 2019 Category: Food Science Authors: Wu Z, Pan Z, Wen Y, Xiao H, Shangguan Y, Chen L, Wang H Tags: Food Chem Toxicol Source Type: research

Açaí (Euterpe oleracea Mart.) seed extract protects against hepatic steatosis and fibrosis in high-fat diet-fed mice: Role of local renin-angiotensin system, oxidative stress and inflammation
Publication date: Available online 16 December 2019Source: Journal of Functional FoodsAuthor(s): Matheus Henrique Romão, Graziele Freitas de Bem, Izabelle Barcellos Santos, Ricardo de Andrade Soares, Dayane Teixeira Ognibene, Roberto Soares de Moura, Cristiane Aguiar da Costa, Ângela Castro ResendeAbstractThe Euterpe oleracea Mart. (açaí) seed extract (ASE), rich in polyphenols, has been evidenced as a potential regulator of body mass with antioxidant and anti-inflammatory actions. We aimed to assess the effects of ASE and enalapril (ENA) on the hepatic steatosis and fibrosis and related overexpr...
Source: Journal of Functional Foods - December 18, 2019 Category: Nutrition Source Type: research

Comparative Effectiveness of Sacubitril-Valsartan Versus ACE/ARB Therapy in Heart Failure With Reduced Ejection Fraction
Publication date: Available online 11 December 2019Source: JACC: Heart FailureAuthor(s): Nicholas Y. Tan, Lindsey R. Sangaralingham, S. Jeson Sangaralingham, Xiaoxi Yao, Nilay D. Shah, Shannon M. DunlayAbstractObjectivesThis paper aims to compare the effectiveness of sacubitril-valsartan and angiotensin-converting enzyme inhibitor (ACE)/angiotensin receptor blocker (ARB) in systolic heart failure (HF).BackgroundSacubitril-valsartan reduced risks of death and hospitalization for HF versus enalapril in ambulatory patients with HF and reduced ejection fraction in the PARADIGM-HF (Prospective Comparison of Angiotensin II Recep...
Source: JACC: Heart Failure - December 12, 2019 Category: Cardiology Source Type: research

Adjunctive acetazolamide therapy for the treatment of Bartter syndrome
ConclusionOur data define a new physiologic and therapeutic role of acetazolamide for the management of children with Bartter syndrome. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - December 9, 2019 Category: Urology & Nephrology Source Type: research

Ethyl Rosmarinate Prevents the Impairment of Vascular Function and Morphological Changes in L-NAME-Induced Hypertensive Rats.
Conclusions: Ethyl rosmarinate is an interesting candidate as an alternative treatment for hypertension due to its ability to improve vascular function and to increase the expression of eNOS similar to enalapril which is a drug commonly used in hypertension. PMID: 31817916 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - December 7, 2019 Category: Universities & Medical Training Authors: Pantan R, Tocharus J, Nakaew A, Suksamrarn A, Tocharus C Tags: Medicina (Kaunas) Source Type: research

Role of Cardioprotective Agents on Chemotherapy-induced Heart Failure: A Systematic Review and Network Meta-analysis of Randomized Controlled Trials
ConclusionWhen classified according to drug type, aldosterone antagonists, ACEIs, statins, and beta-blockers could substantially improve the LV systolic function. In the analysis classified by single drug or drug combination, spironolactone, enalapril, and statin have a significant cardioprotective effect. However, ARBs have no cardioprotective effect and fail to improve the LVEF.Graphical Abstract (Source: Pharmacological Research)
Source: Pharmacological Research - November 30, 2019 Category: Drugs & Pharmacology Source Type: research

Pharmacotherapy problems in cardiology patients 30 days post discharge from a tertiary hospital in Brazil: a randomized controlled trial
OBJECTIVES: This is a randomized controlled trial that aims to evaluate the impact of pharmacist-led discharge counseling on reducing pharmacotherapy problems in the 30-day postdischarge period of cardiology patients from a tertiary hospital in Brazil. METHODS: At discharge, two cardiovascular pharmacy residents performed a medication counseling session with the intervention group, and the follow-up was performed by telephone (3 and 15 days after discharge). The number of pharmacotherapy problems was evaluated during a pharmacist-led ambulatory consultation 30 days after discharge. RESULTS: A total of 66 and 67 patients we...
Source: Clinics - November 26, 2019 Category: General Medicine Source Type: research

Evaluation of drug utilization in cardiovascular disease at a teaching and referral hospital in Northern Telangana
CONCLUSION: Polypharmacy and least use of generic name were observed in the study which may affect the rationality. The use of antiplatelets, statins, and angiotensin-converting enzyme-inhibitors was appropriate, but furosemide overuse is of major concern. Therefore, appropriate prescription writing improvises treatment compliance in the patients, which results in rationality. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - November 26, 2019 Category: Drugs & Pharmacology Authors: Chandana Naliganti Chandrasekhar Valupadas Raghuram Rao Akkinepally Shivarani Eesam Source Type: research

Angiotensin receptor/neprilysin inhibitor —a breakthrough in chronic heart failure therapy: summary of subanalysis on PARADIGM-HF trial findings
This article includes also recently announced findings on the TRANSITION study which revealed that HFrEF therapy with ARNI might be safely initiated after an acute decompensated heart failure episode, including patients with heart failure de novo and ACEI/ARB na ïve, both hospitalised or shortly after discharge, in contrary to the PARADIGM-HF trial, where patients had to be administered a stable dose of an ACEI/ARB equivalent to enalapril 10 mg a day for at least 4 weeks before the screening. (Source: Heart Failure Reviews)
Source: Heart Failure Reviews - November 12, 2019 Category: Cardiology Source Type: research

New orodispersible mini-tablets for paediatric use – A comparison of isomalt with a mannitol based co-processed excipient
Publication date: Available online 31 October 2019Source: International Journal of PharmaceuticsAuthor(s): Ard Lura, Oliver Luhn, Javier Suarez Gonzales, Jörg BreitkreutzAbstractThe development of orodispersible mini-tablets (ODMTs) for paediatric use has gained importance within recent years as European authorities set up regulations for developing suitable and palatable dosage forms for paediatric patients. Polyols like mannitol and isomalt are frequently used in the manufacture of tablets where sensory properties have to be taken into account. In literature, ODTMs based on a commercialized co-processed excipient ba...
Source: International Journal of Pharmaceutics - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Effects of Sacubitril-valsartan Compared with Enalapril on Arterial Hemodynamics, Cardiac Remodeling, and Quality of Life in Patients with Heart Failure and Reduced Ejection Fraction
Compared to angiotensin-converting enzyme inhibition alone, angiotensin receptor-neprilysin inhibition reduces cardiovascular mortality and heart failure (HF) hospitalization in patients with HF and reduced ejection fraction (HFrEF). The pathophysiologic mechanisms responsible for these clinical benefits remain unclear but may be related to effects on central hemodynamics and cardiac structure and function. We sought to determine whether treatment of HFrEF with sacubitril/valsartan improves central aortic stiffness, cardiac remodeling, biomarkers of wall stress and injury, and quality of life compared with enalapril. (Sour...
Source: Journal of Cardiac Failure - November 1, 2019 Category: Cardiology Authors: Akshay S. Desai, Scott D. Solomon, Amil M. Shah, Brian L. Claggett, James C. Fang, Joseph Izzo, Cheryl A. Abbas, Ricardo A. Rocha, Gary F. Mitchell Source Type: research

Fluorofenidone inhibits apoptosis of renal tubular epithelial cells in rats with renal interstitial fibrosis.
In conclusion, AKF-PD improved renal interstitial fibrosis by inhibiting apoptosis of renal tubular epithelial cells in rats with UUO. PMID: 31664306 [PubMed - in process] (Source: Brazilian Journal of Medical and Biological Research)
Source: Brazilian Journal of Medical and Biological Research - October 31, 2019 Category: Research Tags: Braz J Med Biol Res Source Type: research

Activity sensors to evaluate the effect of sacubitril/valsartan on quality ‐of‐life in heart failure: rationale and design of the AWAKE‐HF study
ConclusionsThis will be the first study to assess the effects of sacubitril/valsartan on objective measures of sleep and activity in individuals with HFrEF within the context of their daily lives. Wearable accelerometer devices will be used to gain insight into how the medication affects physical activity and sleep. (Source: ESC Heart Failure)
Source: ESC Heart Failure - October 22, 2019 Category: Cardiology Authors: Raj M. Khandwalla, Kade Birkeland, J. Thomas Heywood, Steven Steinhubl, Kevin McCague, Emmanuel Fombu, Daniel Grant, Jerome B. Riebman, Robert L. Owens Tags: Study Design Source Type: research

Postoperative angioedema induced by angiotensin-converting enzyme inhibitor: case report
ConclusionAngioedema is a potentially fatal condition when it affects the airway, and should be recognized by anesthesiologists and physicians working in the emergency departments.ResumoJustificativa e objetivosO angioedema é uma condição potencialmente fatal que pode surgir em qualquer momento no perioperatório. Pode decorrer da liberação de histamina, em uma reação de hipersensibilidade a drogas, ou ser desencadeado pela bradicinina, em reações não alérgicas, de etiologia hereditária ou adquirida. O objetivo desserelato é de...
Source: Brazilian Journal of Anesthesiology - October 21, 2019 Category: Anesthesiology Source Type: research

Continuous Flow Synthesis of ACE Inhibitors From N-Substituted l-Alanine Derivatives.
Abstract A strategy for the continuous flow synthesis of angiotensin converting enzyme (ACE) inhibitors is described. An optimization effort guided by in situ IR analysis resulted in a general amide coupling approach facilitated by N-carboxyanhydride (NCA) activation that was further characterized by reaction kinetics analysis in batch. The three-step continuous process was demonstrated by synthesizing 8 different ACE inhibitors in up to 88 % yield with throughputs in the range of ≈0.5 g h-1 , all while avoiding both isolation of reactive intermediates and process intensive reaction conditi...
Source: Chemistry - October 18, 2019 Category: Chemistry Authors: Breen CP, Jamison TF Tags: Chemistry Source Type: research

Effect of Vitamin B12 Levels on the Association Between Folic Acid Treatment and CKD Progression: A Post Hoc Analysis of a Folic Acid Interventional Trial
Publication date: Available online 16 October 2019Source: American Journal of Kidney DiseasesAuthor(s): Youbao Li, J. David Spence, Xiaobin Wang, Yong Huo, Xiping Xu, Xianhui QinRationale & ObjectiveIn populations with folic acid fortification or supplementation, the main nutritional determinant of total homocysteine levels is vitamin B12 (B12) status. We aimed to evaluate the modifying effect of B12 levels on the association between folic acid treatment and chronic kidney disease (CKD) progression.Study DesignA post hoc analysis of an interventional trial.Setting & ParticipantsThis is a post hoc analysis of 1,374 ...
Source: American Journal of Kidney Diseases - October 17, 2019 Category: Urology & Nephrology Source Type: research

Psoriasis After Exposure to Angiotensin-Converting Enzyme Inhibitors: French Pharmacovigilance Data and Review of the Literature
AbstractIntroductionAngiotensin-converting enzyme inhibitors (ACEIs) can induce or aggravate psoriasis. This risk is not specified in the Summary of Product Characteristics (SmPC) of some drugs of this class, such as captopril or enalapril. We aimed to investigate the association between psoriasis and ACEI exposure.MethodsWe analyzed spontaneous reports recorded in the French national Pharmacovigilance Database (FPVD) from 1985 to 31 December 2018. The association between psoriasis and ACEI exposure was assessed using the case/non-case method. We also reviewed literature reports.ResultsOne hundred reports of psoriasis afte...
Source: Drug Safety - October 9, 2019 Category: Drugs & Pharmacology Source Type: research

Effect of GLP-1 Receptor Agonists in the Cardiometabolic Complications in a Rat Model of Postmenopausal PCOS.
Abstract Polycystic Ovary Syndrome (PCOS) is characterized by hyperandrogenism and ovulatory dysfunction. PCOS women have elevated prevalence of cardiometabolic risk factors that worsen after menopause. Liraglutide (Lira), a glucagon-like peptide-1 receptor agonist, have shown beneficial metabolic effects in small clinic trials in reproductive-age PCOS women. We have shown that chronic hyperandrogenemia in an experimental model of postmenopausal PCOS (PCOS) is associated with an adverse cardiometabolic profile and upregulation of the intrarenal renin angiotensin system (RAS). We analyzed the effect of Lira in the ...
Source: Endocrinology - October 8, 2019 Category: Endocrinology Authors: Torres Fernandez ED, Huffman AM, Syed M, Romero DG, Yanes Cardozo LL Tags: Endocrinology Source Type: research

354PAnti-HER-2 therapies and left ventricular dysfunction the renaissance study
ConclusionsWhile the LVD related with AH2 therapies is a real problem in HER2+ breast cancer patients ’ care, a timely diagnosis and t. with therapies for HF can allow LVEF recovery and specific oncological therapy continuance.Legal entity responsible for the studyThe authors.FundingHas not received any funding.DisclosureAll authors have declared no conflicts of interest. (Source: Annals of Oncology)
Source: Annals of Oncology - October 1, 2019 Category: Cancer & Oncology Source Type: research

YangXue QingNao Wan, a Compound Chinese Medicine, Attenuates Cerebrovascular Hyperpermeability and Neuron Injury in Spontaneously Hypertensive Rat: Effect and Mechanism
ConclusionThe overall result shows the potential of YXQNW to attenuate blood–brain barrier (BBB) breakdown in SHR, which involves regulation of energy metabolism and Src/MLCK/MLC signaling. This result provides evidence supporting the application of YXQNW as an adjuvant management for hypertensive patients to prevent hypertensive encephalopathy. (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - October 1, 2019 Category: Physiology Source Type: research

Outcome of HIV Related Kidney Diseases Treated with Combined Antiretroviral Therapy (cART).
Conclusion: Treatment with combined ART and ACEIs slows the progression of HIV-associated kidney disease, decreases proteinuria and improves the GFR. PMID: 31561682 [PubMed - in process] (Source: Journal of the Association of Physicians of India)
Source: Journal of the Association of Physicians of India - September 30, 2019 Category: General Medicine Tags: J Assoc Physicians India Source Type: research

Blockade of Renin Angiotensin System Ameliorates the Cardiac Arrythmias and Sympathetic Neural Remodeling in Hearts of Type 2 DM Rat Model.
CONCLUSIONS: RAS have a role in the cardiac sympathetic nerve sprouting and cardiac arrhythmias induced by type 2 DM and its blockade might have a cardioprotective effect via attenuation of sympathetic nerve fibres remodelling, myocardial norepinephrine contents and oxidative stress. PMID: 31544705 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 24, 2019 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

[Postoperative angioedema induced by angiotensin-converting enzyme inhibitor: case report].
CONCLUSION: Angioedema is a potentially fatal condition when it affects the airway, and should be recognized by anesthesiologists and physicians working in the emergency departments. PMID: 31526514 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Anestesiologia)
Source: Revista Brasileira de Anestesiologia - September 20, 2019 Category: Anesthesiology Tags: Rev Bras Anestesiol Source Type: research

ARNIs: balancing “the good and the bad” of neuroendocrine response to HF
ConclusionsThe beneficial effects of ARNI are related, in part at least, to a positive modulation of the neuroendocrine response to the disease, resulting in an increase of physiological diuresis and dilatation. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - September 17, 2019 Category: Cardiology Source Type: research

Association Between Sacubitril/Valsartan Initiation and Health Status Outcomes in Heart Failure With Reduced Ejection Fraction
This study sought to describe the short-term health status benefits of angiotensin-neprilysin inhibitor (ARNI) therapy in patients with heart failure and reduced ejection fraction (HFrEF).BackgroundAlthough therapy with sacubitril/valsartan, a neprilysin inhibitor, improved patients’ health status (compared with enalapril) at 8 months in the PARADIGM-HF (Prospective Comparison of ARNI with ACE inhibitor to Determine Impact on Global Mortality and Morbidity in Heart Failure) study, the early impact of ARNI on patients’ symptoms, functions, and quality of life is unknown.MethodsHealth status was assesse...
Source: JACC: Heart Failure - September 12, 2019 Category: Cardiology Source Type: research

Efficacy of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers in the Preventative Treatment of Episodic Migraine in Adults
AbstractPurpose of ReviewSystematic review of angiotensin-converting enzyme inhibitors (ACE inhibitors) and angiotensin receptor blockers (ARB) in the prophylactic treatment of adults with migraine. To identify gaps in research and provide guidance for future clinical trials.Recent FindingsA search was completed using PubMed, MEDLINE, Embase, and the Cochrane Library January 1, 1990 through December 31, 2017. The following are keywords used in the search: migraine, migraine prophylaxis/prevention, renin-angiotensin-aldosterone system, RAAS, ACE inhibitors, angiotensin-converting enzyme inhibitors: quinapril, perindopril, r...
Source: Current Pain and Headache Reports - September 12, 2019 Category: Neurology Source Type: research

Prognostic Implications of Congestion on Physical Examination Among Contemporary Patients with Heart Failure and Reduced Ejection Fraction:PARADIGM-HF.
We examined the association of the number of signs of congestion (jugular venous distention, edema, rales, and S3) with the primary outcome (cardiovascular death or HF hospitalization), its individual components, and all-cause mortality using time-updated, multivariable-adjusted Cox regression. We further evaluated whether sacubitril/valsartan reduced congestion during follow-up, and whether improvement in congestion is related to changes in clinical outcomes and QoL, assessed by Kansas City Cardiomyopathy Questionnaire clinical summary scores (KCCQ-OSS). Results: Among 8380 participants, 0, 1, 2, and 3+ signs of congestio...
Source: Circulation - September 12, 2019 Category: Cardiology Authors: Selvaraj S, Claggett B, Pozzi A, McMurray JJV, Jhund PS, Packer M, Desai AS, Lewis EF, Vaduganathan M, Lefkowitz MP, Rouleau JL, Shi VC, Zile MR, Swedberg K, Solomon SD Tags: Circulation Source Type: research

PIONEER-HF: a new frontier in the role of neprilysin inhibition in the management of heart failure with reduced ejection fraction
The addition of a neprilysin inhibitor to a renin –angiotensin system (RAS) antagonist, using the combination of sacubitril and valsartan, was shown to reduce morbidity and mortality in outpatients with chronic heart failure and reduced ejection fraction (HFrEF).1 In PARADIGM-HF (Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure trial), sacubitril/valsartan reduced the risk of cardiovascular death or heart failure (HF) hospitalization by 20%, compared with a RAS blocker alone [the gold-standard angiotensin-converting enzyme (ACE)-inhibitor enalapril]. Cons...
Source: Cardiovascular Research - September 8, 2019 Category: Cardiology Source Type: research

Dipeptidyl peptidase-4 inhibitors can inhibit angiotensin converting enzyme.
Abstract Angiotensin-1 converting enzyme inhibitors (ACEIs) improve insulin sensitivity. Inhibitors of dipeptidyl peptidase-4 (DPP-4) are anti-diabetic drugs with several cardio-renal effects. Both ACE and DPP-4 share common features and so we tested if they could be inhibited by one inhibitor. First, in silico screening was used to investigate the ability of different DPP-4 inhibitors or ACEIs to interact with DPP-4 and ACE. The results of screening were then extrapolated into animal study. Fifty Sprague Dawley rat were randomly assigned into 5 groups treated with vehicle, captopril, enalapril, linagliptin or sit...
Source: European Journal of Pharmacology - September 3, 2019 Category: Drugs & Pharmacology Authors: Abouelkheir M, El-Metwally TH Tags: Eur J Pharmacol Source Type: research

Effect of Sacubitril-Valsartan vs Enalapril on Aortic Stiffness in Heart Failure and Reduced Ejection Fraction
This randomized trial compares the effects of sacubitril-valsartan vs enalapril on central aortic stiffness and other physiologic indexes in patients with heart failure and reduced ejection fraction. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - September 2, 2019 Category: General Medicine Source Type: research