Angiotensin-converting enzyme inhibition prevents L-dopa-induced dyskinesia in a 6-OHDA-induced mouse model of Parkinson's disease
In conclusion, co-treatment with ACEIs and L-dopa, such as perindopril, captopril, and enalapril, may mitigate the severity of L-DOPA-induced dyskinesia in a mouse model of PD.PMID:38642669 | DOI:10.1016/j.ejphar.2024.176573 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 20, 2024 Category: Drugs & Pharmacology Authors: Hye-Yeon Park Ga Seul Lee Jun Go Young-Kyoung Ryu Chul-Ho Lee Jeong Hee Moon Kyoung-Shim Kim Source Type: research
Sacubitril/valsartan compared to equivalent/sub-equivalent dose angiotensin receptor blocker or angiotensin-converting enzyme inhibitor in heart failure with reduced ejection fraction: a meta-analysis of randomized trials
ConclusionWhen compared to equivalent doses of ARB/ACEI, SV is not superior in reducing mortality and worsening heart failure. SV is superior when compared to sub-equivalent doses of ACEI. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - April 10, 2024 Category: Drugs & Pharmacology Source Type: research
Early detection of anthracycline-induced cardiotoxicity using [ < sup > 68 < /sup > Ga]Ga-FAPI-04 imaging
CONCLUSION: [68 Ga]Ga-FAPI PET/CT can be used for the early detection of active myocardial fibrosis in AIC and the evaluation of the efficacy of therapeutic interventions. Early treatment guided by [68 Ga]Ga-FAPI PET/CT may reduce anthracycline-induced myocardial injury and improve heart function.PMID:38491214 | DOI:10.1007/s00259-024-06673-2 (Source: Molecular Medicine)
Source: Molecular Medicine - March 16, 2024 Category: Molecular Biology Authors: Zhuxin Wei Hongchuang Xu Bixi Chen Jiaxin Wang Xing Yang Min-Fu Yang Shihua Zhao Source Type: research
Early detection of anthracycline-induced cardiotoxicity using [ < sup > 68 < /sup > Ga]Ga-FAPI-04 imaging
CONCLUSION: [68 Ga]Ga-FAPI PET/CT can be used for the early detection of active myocardial fibrosis in AIC and the evaluation of the efficacy of therapeutic interventions. Early treatment guided by [68 Ga]Ga-FAPI PET/CT may reduce anthracycline-induced myocardial injury and improve heart function.PMID:38491214 | DOI:10.1007/s00259-024-06673-2 (Source: Cancer Control)
Source: Cancer Control - March 16, 2024 Category: Cancer & Oncology Authors: Zhuxin Wei Hongchuang Xu Bixi Chen Jiaxin Wang Xing Yang Min-Fu Yang Shihua Zhao Source Type: research
Early detection of anthracycline-induced cardiotoxicity using [68 Ga]Ga-FAPI-04 imaging
Conclusion[68 Ga]Ga-FAPI PET/CT can be used for the early detection of active myocardial fibrosis in AIC and the evaluation of the efficacy of therapeutic interventions. Early treatment guided by [68 Ga]Ga-FAPI PET/CT may reduce anthracycline-induced myocardial injury and improve heart function. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - March 16, 2024 Category: Nuclear Medicine Source Type: research
Optimal folic acid dosage in lowering homocysteine: Precision Folic Acid Trial to lower homocysteine (PFAT-Hcy)
ConclusionsThis randomized trial lent further support to the efficacy of FA in lowering tHcy; more importantly, it provided critically needed evidence to inform optimal FA dosage. We found that the efficacy of FA in lowering tHcy reaches a plateau if the daily dosage exceeds 1.2 mg, and only has a small gain by increasing the dosage from 0.8 to 1.2 mg.ClinicalTrials.gov IdentifierNCT03472508 (Registration Date: March 21, 2018). (Source: European Journal of Nutrition)
Source: European Journal of Nutrition - March 13, 2024 Category: Nutrition Source Type: research
Repurposing of Angiotensin-converting-enzyme Inhibitor on Prevention of Post-surgical Tendon Adhesion
CONCLUSION: Our results showed that ACEI is a safe and effective therapeutic candidate with potent immunomodulatory and anti-fibrotic features to alleviate surgery-induced development of fibrotic adhesive tissue. However, its efficacy needs to be further validated in clinical studies.PMID:38468533 | DOI:10.2174/0113816128284671240214080516 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 12, 2024 Category: Drugs & Pharmacology Authors: Hamideh Naimi Majid Khazaei Fariba Sharifnia Sayyed-Hadi Sayyed-Hosseinian Source Type: research
A sustainable activated carbon fiber / TiO < sub > 2 < /sub > cathode for the photoelectro-Fenton treatment of pharmaceutical pollutant enalapril
Chemosphere. 2024 Feb 20:141492. doi: 10.1016/j.chemosphere.2024.141492. Online ahead of print.ABSTRACTIn this work, a TiO2-decorated electrode was fabricated by dip coating activated carbon fibers (ACF) with TiO2, which were then used as a cathode for the photoelectro-Fenton (PEF) treatment of the pharmaceutical enalapril, an angiotensin-converting enzyme inhibitor that has been detected in several waterways. The TiO2 coating was found to principally improve the electrocatalytic properties of ACF for H2O2 production via the 2-e- O2 reduction, in turn increasing enalapril degradation by PEF. The effect of the current densi...
Source: Chemosphere - February 22, 2024 Category: Chemistry Authors: Hugo Olvera-Vargas Suthan Selvam Rishikesh Veer Orlando Garc ía-Rodríguez Srikanth Mutnuri Olivier Lefebvre Source Type: research
A sustainable activated carbon fiber / TiO < sub > 2 < /sub > cathode for the photoelectro-Fenton treatment of pharmaceutical pollutant enalapril
Chemosphere. 2024 Feb 20:141492. doi: 10.1016/j.chemosphere.2024.141492. Online ahead of print.ABSTRACTIn this work, a TiO2-decorated electrode was fabricated by dip coating activated carbon fibers (ACF) with TiO2, which were then used as a cathode for the photoelectro-Fenton (PEF) treatment of the pharmaceutical enalapril, an angiotensin-converting enzyme inhibitor that has been detected in several waterways. The TiO2 coating was found to principally improve the electrocatalytic properties of ACF for H2O2 production via the 2-e- O2 reduction, in turn increasing enalapril degradation by PEF. The effect of the current densi...
Source: Chemosphere - February 22, 2024 Category: Chemistry Authors: Hugo Olvera-Vargas Suthan Selvam Rishikesh Veer Orlando Garc ía-Rodríguez Srikanth Mutnuri Olivier Lefebvre Source Type: research
A sustainable activated carbon fiber / TiO < sub > 2 < /sub > cathode for the photoelectro-Fenton treatment of pharmaceutical pollutant enalapril
Chemosphere. 2024 Feb 20:141492. doi: 10.1016/j.chemosphere.2024.141492. Online ahead of print.ABSTRACTIn this work, a TiO2-decorated electrode was fabricated by dip coating activated carbon fibers (ACF) with TiO2, which were then used as a cathode for the photoelectro-Fenton (PEF) treatment of the pharmaceutical enalapril, an angiotensin-converting enzyme inhibitor that has been detected in several waterways. The TiO2 coating was found to principally improve the electrocatalytic properties of ACF for H2O2 production via the 2-e- O2 reduction, in turn increasing enalapril degradation by PEF. The effect of the current densi...
Source: Chemosphere - February 22, 2024 Category: Chemistry Authors: Hugo Olvera-Vargas Suthan Selvam Rishikesh Veer Orlando Garc ía-Rodríguez Srikanth Mutnuri Olivier Lefebvre Source Type: research
A sustainable activated carbon fiber / TiO < sub > 2 < /sub > cathode for the photoelectro-Fenton treatment of pharmaceutical pollutant enalapril
Chemosphere. 2024 Feb 20:141492. doi: 10.1016/j.chemosphere.2024.141492. Online ahead of print.ABSTRACTIn this work, a TiO2-decorated electrode was fabricated by dip coating activated carbon fibers (ACF) with TiO2, which were then used as a cathode for the photoelectro-Fenton (PEF) treatment of the pharmaceutical enalapril, an angiotensin-converting enzyme inhibitor that has been detected in several waterways. The TiO2 coating was found to principally improve the electrocatalytic properties of ACF for H2O2 production via the 2-e- O2 reduction, in turn increasing enalapril degradation by PEF. The effect of the current densi...
Source: Chemosphere - February 22, 2024 Category: Chemistry Authors: Hugo Olvera-Vargas Suthan Selvam Rishikesh Veer Orlando Garc ía-Rodríguez Srikanth Mutnuri Olivier Lefebvre Source Type: research
Modulating Mitochondrial Dynamics Mitigates Cognitive Impairment in Rats with Myocardial Infarction
Conclusion: Mitochondrial dynamics modulators improved cognitive function in MI rats through a reduction of systemic oxidative stress and brain mitochondrial dysfunction and the enhancement of mitochondrial metabolism. In addition, this mitochondrial fission inhibitor increased mitochondrial fusion in MI rats.PMID:38362882 | DOI:10.2174/1570159X22666240131114913 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - February 16, 2024 Category: Drugs & Pharmacology Authors: Kewarin Jinawong Chanon Piamsiri Nattayaporn Apaijai Chayodom Maneechote Busarin Arunsak Wichwara Nawara Chanisa Thonusin Hiranya Pintana Nipon Chattipakorn Siriporn C Chattipakorn Source Type: research
Modulating Mitochondrial Dynamics Mitigates Cognitive Impairment in Rats with Myocardial Infarction
Conclusion: Mitochondrial dynamics modulators improved cognitive function in MI rats through a reduction of systemic oxidative stress and brain mitochondrial dysfunction and the enhancement of mitochondrial metabolism. In addition, this mitochondrial fission inhibitor increased mitochondrial fusion in MI rats.PMID:38362882 | DOI:10.2174/1570159X22666240131114913 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - February 16, 2024 Category: Drugs & Pharmacology Authors: Kewarin Jinawong Chanon Piamsiri Nattayaporn Apaijai Chayodom Maneechote Busarin Arunsak Wichwara Nawara Chanisa Thonusin Hiranya Pintana Nipon Chattipakorn Siriporn C Chattipakorn Source Type: research
Modulating Mitochondrial Dynamics Mitigates Cognitive Impairment in Rats with Myocardial Infarction
Conclusion: Mitochondrial dynamics modulators improved cognitive function in MI rats through a reduction of systemic oxidative stress and brain mitochondrial dysfunction and the enhancement of mitochondrial metabolism. In addition, this mitochondrial fission inhibitor increased mitochondrial fusion in MI rats.PMID:38362882 | DOI:10.2174/1570159X22666240131114913 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - February 16, 2024 Category: Drugs & Pharmacology Authors: Kewarin Jinawong Chanon Piamsiri Nattayaporn Apaijai Chayodom Maneechote Busarin Arunsak Wichwara Nawara Chanisa Thonusin Hiranya Pintana Nipon Chattipakorn Siriporn C Chattipakorn Source Type: research
