Risk factors of dementia in patients with cerebral vascular diseases based on Taiwan National Health Insurance data
CONCLUSION: Depression, osteoporosis and the use of enalapril were associated with a higher risk of dementia, while nitroglycerin might be a protecting factor for dementia, in subjects with cerebrovascular diseases without mention of cerebral infarction.PMID:36948166 | DOI:10.1159/000530102 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - March 22, 2023 Category: Psychiatry Authors: Bin Zhou Cheng-Li Lin Shinsuke Kojima Masanori Fukushima Chung Y Hsu Source Type: research
Risk factors of dementia in patients with cerebral vascular diseases based on Taiwan National Health Insurance data
CONCLUSION: Depression, osteoporosis and the use of enalapril were associated with a higher risk of dementia, while nitroglycerin might be a protecting factor for dementia, in subjects with cerebrovascular diseases without mention of cerebral infarction.PMID:36948166 | DOI:10.1159/000530102 (Source: Atherosclerosis)
Source: Atherosclerosis - March 22, 2023 Category: Cardiology Authors: Bin Zhou Cheng-Li Lin Shinsuke Kojima Masanori Fukushima Chung Y Hsu Source Type: research
Risk factors of dementia in patients with cerebral vascular diseases based on Taiwan National Health Insurance data
CONCLUSION: Depression, osteoporosis and the use of enalapril were associated with a higher risk of dementia, while nitroglycerin might be a protecting factor for dementia, in subjects with cerebrovascular diseases without mention of cerebral infarction.PMID:36948166 | DOI:10.1159/000530102 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - March 22, 2023 Category: Psychiatry Authors: Bin Zhou Cheng-Li Lin Shinsuke Kojima Masanori Fukushima Chung Y Hsu Source Type: research
Sacubitril –valsartan versus enalapril for the treatment of acute decompensated heart failure in Chinese settings: A cost-effectiveness analysis
Conclusion: Early initiation of sacubitril–valsartan after stabilization of ADHF is highly cost-effective compared with the use of enalapril; late initiation of sacubitril–valsartan after stabilization of HF is still cost-effective but not as cost-effective as early initiation of sacubitril–valsartan in ADHF. For Chinese ADHF patients, the time to initiate sacubitril–valsartan should be when the patient is stabilized from ADHF rather than when stabilized from HF, from the perspective of economic evaluation. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 2, 2023 Category: Drugs & Pharmacology Source Type: research
Efficacy and safety of cardioprotective drugs in chemotherapy-induced cardiotoxicity: an updated systematic review & amp; network meta-analysis
CONCLUSION: Our analysis reaffirmed that statins, MRAs, ACEIs, and beta-blockers can significantly attenuate chemotherapy-induced cardiotoxicity, while ARBs showed no significant effects. Spironolactone showed the most robust improvement of LVEF, which best supports its use among this population. Our analysis warrants future clinical studies examining the cardioprotective effects of cardiac remodeling therapy in cancer patients treated with chemotherapeutic agents.PMID:36804940 | DOI:10.1186/s40959-023-00159-0 (Source: Cancer Control)
Source: Cancer Control - February 22, 2023 Category: Cancer & Oncology Authors: Ali Mir Yasra Badi Seif Bugazia Anas Zakarya Nourelden Ahmed Hashem Fathallah Khaled Mohamed Ragab Mohammed Alsillak Sarah Makram Elsayed Abdulrahman Ibrahim Hagrass Sawyer Bawek Mohamad Kalot Zachary L Brumberger Source Type: research
Prophylactic Agents for Preventing Cardiotoxicity Induced Following Anticancer Agents: A Systematic Review and Meta-Analysis of Clinical Trials
CONCLUSION: This meta-analysis showed that prophylactic treatment with cardio-protective drugs, including dexrazoxane, beta blocker, and ACEI drugs in patients undergoing chemotherapy with anthracycline, have a protective effect on LVEF and prevent EF drop.PMID:36803186 | DOI:10.2174/1574887118666230118102252 (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - February 21, 2023 Category: Cancer & Oncology Authors: Ehsan Keshavarzian Tella Sadighpour Seyed Mohammadreza Mortazavizadeh Mohammadhossein Soltani Amir Farzin Motevalipoor Shahriyar Shahbazi Khamas Mohammad Moazen Mohamad Kogani Seyed Mohammad Amin Hashemipour Hamid Hosseinpour Rohollah Valizadeh Source Type: research
Prophylactic Agents for Preventing Cardiotoxicity Induced Following Anticancer Agents: A Systematic Review and Meta-Analysis of Clinical Trials
CONCLUSION: This meta-analysis showed that prophylactic treatment with cardio-protective drugs, including dexrazoxane, beta blocker, and ACEI drugs in patients undergoing chemotherapy with anthracycline, have a protective effect on LVEF and prevent EF drop.PMID:36803186 | DOI:10.2174/1574887118666230118102252 (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - February 21, 2023 Category: Cancer & Oncology Authors: Ehsan Keshavarzian Tella Sadighpour Seyed Mohammadreza Mortazavizadeh Mohammadhossein Soltani Amir Farzin Motevalipoor Shahriyar Shahbazi Khamas Mohammad Moazen Mohamad Kogani Seyed Mohammad Amin Hashemipour Hamid Hosseinpour Rohollah Valizadeh Source Type: research
Cost-effectiveness in unstable economies: the case of sacubitril/valsartan in heart failure with reduced ejection fraction in Argentina
ConclusionSacubitril/valsartan is a cost-effective treatment in HFrEF using local inputs that considered the financial instability. For both payers considered the cost per QALY gained are under the cost-effectiveness threshold considered. (Source: Health Economics Review)
Source: Health Economics Review - February 18, 2023 Category: International Medicine & Public Health Source Type: research
AST-120 to target protein-bound uremic toxins improves cardiac output and kidney oxygenation in experimental chronic kidney disease.
In this study, we investigated the effect of reducing plasma levels of protein bound uremic toxins in a rat model of CKD, challenged with high salt intake and compared the effects to that of conventional treatment using an angiotensin converting enzyme inhibitor (ACEI).
Methods
In rats, the right kidney and 2/3 of the left kidney were surgically removed (5/6 nephrectomy). Animals were fed a normal salt diet and randomized to either no treatment (control) or chronic treatment with either the oral absorbent AST-120 to reduce plasma levels of protein bound uremic to xins; or the ACEI enalapril to inhibit angiotensin II sign...
Source: Kidney and Blood Pressure Research - February 15, 2023 Category: Urology & Nephrology Source Type: research
Radiation-Induced Pulmonary Fibrosis: Roles of Therapy-Induced Senescence and microRNAs
CONCLUSION: Our analysis of the published literature in the last decade on RIPF, miRNA, and TIS identifies TIS as a mechanism in the onset and progression of RIPF, which is regulated through several miRNAs. This work may lead to the discovery and development of the next generation of miRNA therapeutics and/or the repurposing of approved pharmaceutical agents and the development of early biomarker panels to predict RIPF.PMID:36763093 | DOI:10.1080/09553002.2023.2177768 (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - February 10, 2023 Category: Radiology Authors: Pataje G S Prasanna Molykutty Aryankalayil Deborah E Citrin C Norman Coleman Source Type: research
