Cardiac MRI may not detect myocardial ischemia and fibrosis in dogs with cardiomegaly secondary to myxomatous mitral valve disease
Am J Vet Res. 2022 Aug 2;83(10):ajvr.22.05.0076. doi: 10.2460/ajvr.22.05.0076.ABSTRACTOBJECTIVE: To assess whether cardiac MRI or various biomarkers can be used to detect myocardial ischemia and fibrosis in dogs with cardiomegaly secondary to myxomatous mitral valve disease (MMVD).ANIMALS: 6 dogs with cardiomegaly secondary to naturally occurring stage B2 MMVD being treated only with pimobendan with or without enalapril and 6 control dogs with no cardiac disease. All dogs were ≥ 5 years old with no systemic illness.PROCEDURES: Serum cardiac troponin I and concentrations were measured, and dogs were anesthetized for cardi...
Source: American Journal of Veterinary Research - July 29, 2022 Category: Veterinary Research Authors: William A Clark Randolph L Winter Turi K Aarnes Eric M Green Katarzyna Mikrut Patrick Ruz Daniel Addison Jaylyn D Rhinehart Karsten E Schober Harry T Friel Source Type: research
Impact of Salt Intake and RAAS blockade on lung SARS CoV-2 Host Factors
CONCLUSIONS: These findings offer biological support regarding the safety of these drugs that are often prescribed to COVID-19 patients with cardiovascular co-morbidity. High salt intake on the other hand might adversely affect COVID-19 outcome. Our preclinical data should stimulate clinical studies addressing this point of concern.PMID:35878596 | DOI:10.1159/000525368 (Source: Cell Research)
Source: Cell Research - July 25, 2022 Category: Cytology Authors: Xiaoli Zhang Liping Liu Mohamed M S Gaballa Ahmed A Hasan Yingquan Xiong Li Xie Thomas Klein Denis Delic Burkhard Kleuser Bernhard K Kr ämer Jian Li Berthold Hocher Source Type: research
Impact of Salt Intake and RAAS blockade on lung SARS CoV-2 Host Factors
Conclusions: These findings offer biological support regarding the safety of these drugs that are often prescribed to COVID-19 patients with cardiovascular co-morbidity. High salt intake on the other hand might adversely affect COVID-19 outcome. Our preclinical data should stimulate clinical studies addressing this point of concern. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - July 25, 2022 Category: Urology & Nephrology Source Type: research
Impact of Salt Intake and Renin-Angiotensin-Aldosterone System Blockade on Lung Severe Acute Respiratory Syndrome Coronavirus 2 Host Factors
Conclusions: These findings offer biological support regarding the safety of these drugs that are often prescribed to COVID-19 patients with cardiovascular comorbidity. High salt intake, on the other hand, might adversely affect COVID-19 outcome. Our preclinical data should stimulate clinical studies addressing this point of concern. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - July 25, 2022 Category: Urology & Nephrology Source Type: research
Effect of Costus pictus per se and in combination with Metformin and Enalapril in streptozotocin induced diabetic nephropathy in rats
ConclusionsThe results indicate that combination therapy of metformin, enalapril, and MECP has beneficial effects in management of diabetic nephropathy. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - July 18, 2022 Category: Endocrinology Source Type: research
Within trial comparison of survival time projections from short ‐term follow‐up with long‐term follow‐up findings
ConclusionsAge-based survival projections using within-trial data generally provided concordant results with the actual survival measured in long-term follow-up extension studies. Our findings suggest that age-based lifetime projections may be used as means to assess the long-term treatment effects. (Source: ESC Heart Failure)
Source: ESC Heart Failure - July 7, 2022 Category: Cardiology Authors: Jo ão Pedro Ferreira,
Brian L. Claggett,
Kieran F. Docherty,
Pardeep S. Jhund,
Faiez Zannad,
Scott D. Solomon,
John J.V. McMurray Tags: Short Communication Source Type: research
Brief Early Life Angiotensin-Converting Enzyme Inhibition Offers Renoprotection in Sheep with a Solitary Functioning Kidney at 8 Months of Age
Conclusions
Brief and early ACEi in SFK is associated with reduced glomerular hyperfiltration–mediated kidney disease up to 8 months of age in a sheep model. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - June 30, 2022 Category: Urology & Nephrology Authors: McArdle, Z., Singh, R. R., Bielefeldt-Ohmann, H., Moritz, K. M., Schreuder, M. F., Denton, K. M. Tags: Hypertension Source Type: research
The Prevalence of Adverse Drug Reactions and Adverse Drug Events from Heart Failure Medications in Frail Older Adults: A Systematic Review
ConclusionThe potential harms from heart failure medications in frail older people are poorly studied and understood. Clinical trials and pharmacovigilance studies should include frailty as a covariate to inform medication optimisation for this vulnerable and growing population.RegistrationProspero registration number: CRD 42021253762.Graphical Abstract (Source: Drugs and Aging)
Source: Drugs and Aging - June 28, 2022 Category: Geriatrics Source Type: research
Effects of sacubitril/valsartan on glycemia in patients with diabetes and heart failure: the PARAGON-HF and PARADIGM-HF trials
Compared with enalapril, sacubitril/valsartan lowered HbA1c and reduced new insulin therapy in patients with heart failure with reduced ejection fraction (HFrEF) and diabetes in the PARADIGM-HF trial. We sough... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 18, 2022 Category: Cardiology Authors: Magnus O. Wijkman, Brian Claggett, Muthiah Vaduganathan, Jonathan W. Cunningham, Rasmus R ørth, Alice Jackson, Milton Packer, Michael Zile, Jean Rouleau, Karl Swedberg, Martin Lefkowitz, Sanjiv J. Shah, Marc A. Pfeffer, John J. V. McMurray and Scott D. S Tags: Research Source Type: research
Predictors of sacubitril/valsartan high dose tolerability in a real world population with HFrEF
ConclusionsOur study is the first to analyse the potential role of echocardiography and, in particular, of RV dysfunction, measured by TAPSE, in predicting Sac/Val maximum dose tolerability. Therefore, patients with RV dysfunction (baseline TAPSE<16 mm, in our cohort) might benefit from a different strategy to titrate Sac/Val, such as starting from the lowest dose and/or waiting for a more extended period of observation before attempting with the higher doses. (Source: ESC Heart Failure)
Source: ESC Heart Failure - June 15, 2022 Category: Cardiology Authors: Valeria Visco,
Ilaria Radano,
Alfonso Campanile,
Amelia Ravera,
Angelo Silverio,
Daniele Masarone,
Giuseppe Pacileo,
Michele Correale,
Pietro Mazzeo,
Giuseppe Dattilo,
Francesco Giallauria,
Alessandra Cuomo,
Valentina Mercurio,
Carlo Gabriele Tags: Original Article Source Type: research
Enalapril ‐induced angioedema: A forgotten adverse event
We describe a case of a patient who was prescribed with enalapril and presented with symptoms suggestive of angioedema. (Source: Clinical Case Reports)
Source: Clinical Case Reports - June 2, 2022 Category: General Medicine Authors: Mar ía Carolina Manzur‐Barbur,
Ana Milena Mejia‐Sanjuanelo,
María Cristina Martínez‐Ávila,
Fernando Manzur‐Jattin,
Juan Camilo García‐Dominguez,
Beatriz Orozco‐Sebá Tags: CASE IMAGE Source Type: research
Integrated Bioinformatics and Clinical Correlation Analysis of Key Genes, Pathways, and Potential Therapeutic Agents Related to Diabetic Nephropathy
CONCLUSIONS: VEGFA, NPHS1, WT1, CTGF, SYNPO, and PODXL are promising biomarkers for diagnosing and evaluating the progression of DN. The drug-gene interaction analyses provide a list of candidate drugs for the precise treatment of DN.PMID:35637650 | PMC:PMC9148260 | DOI:10.1155/2022/9204201 (Source: Disease Markers)
Source: Disease Markers - May 31, 2022 Category: Laboratory Medicine Authors: Shengnan Chen Lei Chen Hongli Jiang Source Type: research
A Rare Case of Unilateral Tongue Edema with Angiotensin Converting Enzyme Inhibitors
We report a case of a 55-year-old man, with a history of hypertension, on enalapril for three years, who presented to the hospital with unilateral tongue swelling, without airway compromise. Other causes were excluded and the diagnosis of angioedema due to enalapril was established. The patient was discharged with discontinuation of ACEi with total resolution of symptoms and without relapse after several months. Although very rare, unilateral tongue swelling should be considered in the presentation of angioedema associated with ACEi. Tight surveillance is important to prevent fatal complications such as airway obstruction....
Source: Acta Medica Portuguesa - May 25, 2022 Category: General Medicine Authors: Beatriz Gil Braga M árcia Cravo Pedro Neves Filipe Pinto Catarina Mendon ça Source Type: research
