Treatment with apoptosis inhibitor restores cognitive impairment in rats with myocardial infarction
In conclusion, treatment with an apoptosis inhibitor reduced cognitive impairment in MI rats via reducing oxidative stress, mitochondrial dysfunction, apoptosis, and restoring dendritic spine density, together with enhancing mitophagy and neurogenesis.PMID:37453581 | DOI:10.1016/j.bbadis.2023.166809 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - July 15, 2023 Category: Biochemistry Authors: Kewarin Jinawong Chanon Piamsiri Nattayaporn Apaijai Chayodom Maneechote Hiranya Pintana Titikorn Chunchai Busarin Arunsak Nipon Chattipakorn Siriporn C Chattipakorn Source Type: research

Analyzing microbial communities and their biodegradation of multiple pharmaceuticals in membrane bioreactors
Appl Microbiol Biotechnol. 2023 Jul 12. doi: 10.1007/s00253-023-12677-z. Online ahead of print.ABSTRACTPharmaceuticals are of concern to our planet and health as they can accumulate in the environment. The impact of these biologically active compounds on ecosystems is hard to predict, and information on their biodegradation is necessary to establish sound risk assessment. Microbial communities are promising candidates for the biodegradation of pharmaceuticals such as ibuprofen, but little is known yet about their degradation capacity of multiple micropollutants at higher concentrations (100 mg/L). In this work, microbial c...
Source: Applied Microbiology and Biotechnology - July 12, 2023 Category: Microbiology Authors: Marcel Suleiman Francesca Demaria Cristina Zimmardi Boris Alexander Kolvenbach Philippe Fran çois-Xavier Corvini Source Type: research

Analyzing microbial communities and their biodegradation of multiple pharmaceuticals in membrane bioreactors
Appl Microbiol Biotechnol. 2023 Jul 12. doi: 10.1007/s00253-023-12677-z. Online ahead of print.ABSTRACTPharmaceuticals are of concern to our planet and health as they can accumulate in the environment. The impact of these biologically active compounds on ecosystems is hard to predict, and information on their biodegradation is necessary to establish sound risk assessment. Microbial communities are promising candidates for the biodegradation of pharmaceuticals such as ibuprofen, but little is known yet about their degradation capacity of multiple micropollutants at higher concentrations (100 mg/L). In this work, microbial c...
Source: Applied Microbiology and Biotechnology - July 12, 2023 Category: Microbiology Authors: Marcel Suleiman Francesca Demaria Cristina Zimmardi Boris Alexander Kolvenbach Philippe Fran çois-Xavier Corvini Source Type: research

Quantification of pharmaceutical compounds in tissue and plasma samples using selective ion accumulation with multiple mass isolation windows
AbstractQuantification of pharmaceutical compounds using matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS) is an alternative to traditional liquid chromatography (LC)-MS techniques. Benefits of MALDI-based approaches include rapid analysis times for liquid samples and imaging mass spectrometry capabilities for tissue samples. As in most quantification experiments, the use of internal standards can compensate for spot-to-spot and shot-to-shot variability associated with MALDI sampling. However, the lack of chromatographic separation in traditional MALDI analyses results in diminished peak capacity d...
Source: Journal of Mass Spectrometry - July 11, 2023 Category: Chemistry Authors: Zhongling Liang, Boone M. Prentice Tags: RESEARCH ARTICLE Source Type: research

Hormetic effects of EGC and EGCG on CES1 activity and its rescue from oxidative stress in rat liver S9
Chem Biol Interact. 2023 Jun 21:110612. doi: 10.1016/j.cbi.2023.110612. Online ahead of print.ABSTRACTCarboxylesterase 1 (CES1) is a hydrolytic enzyme that plays an important role in the activation or deactivation of many therapeutic agents, thus affecting their pharmacokinetic and pharmacodynamic outcomes. Using rat liver S9 as an enzyme source and enalapril as a CES1 substrate, the present study examined effects of a number of flavonoids on the formation of enalaprilat (the active form of enalapril) produced by CES1-mediated hydrolysis. While a majority of flavonoids tested showed inhibition on CES1, an unexpected hormet...
Source: Chemico-Biological Interactions - June 23, 2023 Category: Molecular Biology Authors: Xiaoting Luo Feifei Lu Zhiyue Yin Zhiyun Zhou Zhongmin Wang Hongjian Zhang Source Type: research

Hormetic effects of EGC and EGCG on CES1 activity and its rescue from oxidative stress in rat liver S9
Chem Biol Interact. 2023 Jun 21:110612. doi: 10.1016/j.cbi.2023.110612. Online ahead of print.ABSTRACTCarboxylesterase 1 (CES1) is a hydrolytic enzyme that plays an important role in the activation or deactivation of many therapeutic agents, thus affecting their pharmacokinetic and pharmacodynamic outcomes. Using rat liver S9 as an enzyme source and enalapril as a CES1 substrate, the present study examined effects of a number of flavonoids on the formation of enalaprilat (the active form of enalapril) produced by CES1-mediated hydrolysis. While a majority of flavonoids tested showed inhibition on CES1, an unexpected hormet...
Source: Chemico-Biological Interactions - June 23, 2023 Category: Molecular Biology Authors: Xiaoting Luo Feifei Lu Zhiyue Yin Zhiyun Zhou Zhongmin Wang Hongjian Zhang Source Type: research

Influence of Weight and Body Size on the Pharmacokinetics of Heart Failure Pharmacotherapy: A Systematic Review
CONCLUSION: Considering the significant impact of WT on most HF drugs in this review, it may be important to further investigate it in the context of personalized therapy, particularly in patients presenting extreme WTs.PMID:37338205 | DOI:10.1177/10600280231179484 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - June 20, 2023 Category: Drugs & Pharmacology Authors: Jessica Hindi Myriam Fr échette-Le Bel Jean Lucien Rouleau Simon de Denus Source Type: research

Influence of Weight and Body Size on the Pharmacokinetics of Heart Failure Pharmacotherapy: A Systematic Review
CONCLUSION: Considering the significant impact of WT on most HF drugs in this review, it may be important to further investigate it in the context of personalized therapy, particularly in patients presenting extreme WTs.PMID:37338205 | DOI:10.1177/10600280231179484 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - June 20, 2023 Category: Drugs & Pharmacology Authors: Jessica Hindi Myriam Fr échette-Le Bel Jean Lucien Rouleau Simon de Denus Source Type: research

Comparing Renin-Angiotensin-Aldosterone Blockade Regimens for Long-Term Chemotherapy-Related Cardiac Dysfunction: A Network Meta-Analysis
ConclusionNineteen studies reported the effects of 13 interventions (N = 1905 patients). Only enalapril (RR 0.05, 95% CI 0.00 –0.20) was associated with reduced risk of patients developing significant decline in LVEF relative to placebo. Subgroup analysis showed that the beneficial effect of enalapril was driven by protection against anthracycline-associated toxicity. In addition, no RAAS-inhibiting agents showed efficac y in protection against treatment with both anthracycline and trastuzumab. The use of RAAS inhibition therapy did not conclusively impact on other markers of cardiac function, including left ventricular ...
Source: Cardiovascular Drugs and Therapy - June 14, 2023 Category: Cardiology Source Type: research

EE552 Importance of Half Cycle Correction for Cost-Effectiveness Analysis: Case Study of Sacubitril/Valsartan Vs in Enalapril Heart Failure with Reduced Ejection Fraction
For products indicated for chronic heart failure with reduced ejective fraction (HFrEF) half-cycle correction might be of increased importance to capture effect of survival gains and reduction in hospitalizations. To understand the importance and effect of half-cycle correction in cost-effectiveness analysis for Sacubitril/Valsartan vs Enalapril in HFrEF. (Source: Value in Health)
Source: Value in Health - June 1, 2023 Category: International Medicine & Public Health Authors: S. Aggarwal, S. Kumar, O. Topaloglu Source Type: research

Aerobic Physical Exercise is Essential for Cardiac Autonomic Regulation in Hypertensive Patients Undergoing Chronic Treatment with Renin-Angiotensin System Inhibitors
CONCLUSION: Long-term treatment with enalapril and losartan may harm the autonomic modulation of HRV and BRS. Aerobic physical training is essential to promote positive adjustments in the autonomic modulation of HRV and BRS in hypertensive patients treated with RASi, especially with enalapril.PMID:37218203 | DOI:10.2174/1570161121666230522105458 (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - May 23, 2023 Category: Drugs & Pharmacology Authors: T ábata de Paula Facioli Stella Vieira Philbois Jens Tank Ada Clarice Gastaldi Bruno Augusto Aguilar Ana Catarine da Veiga Oliveira Lucas Dalvit Ferreira Hugo Celso Dutra de Souza Source Type: research

Aerobic Physical Exercise is Essential for Cardiac Autonomic Regulation in Hypertensive Patients Undergoing Chronic Treatment with Renin-Angiotensin System Inhibitors
CONCLUSION: Long-term treatment with enalapril and losartan may harm the autonomic modulation of HRV and BRS. Aerobic physical training is essential to promote positive adjustments in the autonomic modulation of HRV and BRS in hypertensive patients treated with RASi, especially with enalapril.PMID:37218203 | DOI:10.2174/1570161121666230522105458 (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - May 23, 2023 Category: Drugs & Pharmacology Authors: T ábata de Paula Facioli Stella Vieira Philbois Jens Tank Ada Clarice Gastaldi Bruno Augusto Aguilar Ana Catarine da Veiga Oliveira Lucas Dalvit Ferreira Hugo Celso Dutra de Souza Source Type: research

Aerobic Physical Exercise is Essential for Cardiac Autonomic Regulation in Hypertensive Patients Undergoing Chronic Treatment with Renin-Angiotensin System Inhibitors
CONCLUSION: Long-term treatment with enalapril and losartan may harm the autonomic modulation of HRV and BRS. Aerobic physical training is essential to promote positive adjustments in the autonomic modulation of HRV and BRS in hypertensive patients treated with RASi, especially with enalapril.PMID:37218203 | DOI:10.2174/1570161121666230522105458 (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - May 23, 2023 Category: Drugs & Pharmacology Authors: T ábata de Paula Facioli Stella Vieira Philbois Jens Tank Ada Clarice Gastaldi Bruno Augusto Aguilar Ana Catarine da Veiga Oliveira Lucas Dalvit Ferreira Hugo Celso Dutra de Souza Source Type: research

23 Plasma renin activity in young children with heart failure: influence of age, disease and ACE inhibitor treatment
Conclusions Very young children had higher endogenous PRA levels compared to adults. Heart failure at this age was associated with even higher PRA levels and ACEi treatment further increased PRA levels. These results indicate that patients appear to respond to ACEi treatment but question the value of PRA levels as prognostic marker in this population. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - May 18, 2023 Category: Pediatrics Authors: Steichert, M., Cawello, W., Breur, J. M., Male, C., de Wildt, S. N., Läer, S. Tags: General abstracts Source Type: research