Comparing Renin-Angiotensin-Aldosterone Blockade Regimens for Long-Term Chemotherapy-Related Cardiac Dysfunction: A Network Meta-Analysis
ConclusionNineteen studies reported the effects of 13 interventions (N = 1905 patients). Only enalapril (RR 0.05, 95% CI 0.00 –0.20) was associated with reduced risk of patients developing significant decline in LVEF relative to placebo. Subgroup analysis showed that the beneficial effect of enalapril was driven by protection against anthracycline-associated toxicity. In addition, no RAAS-inhibiting agents showed efficac y in protection against treatment with both anthracycline and trastuzumab. The use of RAAS inhibition therapy did not conclusively impact on other markers of cardiac function, including left ventricular ...
Source: Cardiovascular Drugs and Therapy - June 14, 2023 Category: Cardiology Source Type: research

EE552 Importance of Half Cycle Correction for Cost-Effectiveness Analysis: Case Study of Sacubitril/Valsartan Vs in Enalapril Heart Failure with Reduced Ejection Fraction
For products indicated for chronic heart failure with reduced ejective fraction (HFrEF) half-cycle correction might be of increased importance to capture effect of survival gains and reduction in hospitalizations. To understand the importance and effect of half-cycle correction in cost-effectiveness analysis for Sacubitril/Valsartan vs Enalapril in HFrEF. (Source: Value in Health)
Source: Value in Health - June 1, 2023 Category: International Medicine & Public Health Authors: S. Aggarwal, S. Kumar, O. Topaloglu Source Type: research

Aerobic Physical Exercise is Essential for Cardiac Autonomic Regulation in Hypertensive Patients Undergoing Chronic Treatment with Renin-Angiotensin System Inhibitors
CONCLUSION: Long-term treatment with enalapril and losartan may harm the autonomic modulation of HRV and BRS. Aerobic physical training is essential to promote positive adjustments in the autonomic modulation of HRV and BRS in hypertensive patients treated with RASi, especially with enalapril.PMID:37218203 | DOI:10.2174/1570161121666230522105458 (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - May 23, 2023 Category: Drugs & Pharmacology Authors: T ábata de Paula Facioli Stella Vieira Philbois Jens Tank Ada Clarice Gastaldi Bruno Augusto Aguilar Ana Catarine da Veiga Oliveira Lucas Dalvit Ferreira Hugo Celso Dutra de Souza Source Type: research

Aerobic Physical Exercise is Essential for Cardiac Autonomic Regulation in Hypertensive Patients Undergoing Chronic Treatment with Renin-Angiotensin System Inhibitors
CONCLUSION: Long-term treatment with enalapril and losartan may harm the autonomic modulation of HRV and BRS. Aerobic physical training is essential to promote positive adjustments in the autonomic modulation of HRV and BRS in hypertensive patients treated with RASi, especially with enalapril.PMID:37218203 | DOI:10.2174/1570161121666230522105458 (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - May 23, 2023 Category: Drugs & Pharmacology Authors: T ábata de Paula Facioli Stella Vieira Philbois Jens Tank Ada Clarice Gastaldi Bruno Augusto Aguilar Ana Catarine da Veiga Oliveira Lucas Dalvit Ferreira Hugo Celso Dutra de Souza Source Type: research

Aerobic Physical Exercise is Essential for Cardiac Autonomic Regulation in Hypertensive Patients Undergoing Chronic Treatment with Renin-Angiotensin System Inhibitors
CONCLUSION: Long-term treatment with enalapril and losartan may harm the autonomic modulation of HRV and BRS. Aerobic physical training is essential to promote positive adjustments in the autonomic modulation of HRV and BRS in hypertensive patients treated with RASi, especially with enalapril.PMID:37218203 | DOI:10.2174/1570161121666230522105458 (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - May 23, 2023 Category: Drugs & Pharmacology Authors: T ábata de Paula Facioli Stella Vieira Philbois Jens Tank Ada Clarice Gastaldi Bruno Augusto Aguilar Ana Catarine da Veiga Oliveira Lucas Dalvit Ferreira Hugo Celso Dutra de Souza Source Type: research

23 Plasma renin activity in young children with heart failure: influence of age, disease and ACE inhibitor treatment
Conclusions Very young children had higher endogenous PRA levels compared to adults. Heart failure at this age was associated with even higher PRA levels and ACEi treatment further increased PRA levels. These results indicate that patients appear to respond to ACEi treatment but question the value of PRA levels as prognostic marker in this population. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - May 18, 2023 Category: Pediatrics Authors: Steichert, M., Cawello, W., Breur, J. M., Male, C., de Wildt, S. N., Läer, S. Tags: General abstracts Source Type: research

Effects of Sacubitril/Valsartan on Exercise Capacity in Patients with Heart Failure with Reduced Ejection Fraction and the Role of Percentage of Delayed Enhancement Measured by Cardiac Magnetic Resonance in Predicting Therapeutic Response: A Multicentre S
Sacubitril/valsartan (S/V) therapy in patients with heart failure (HF) with reduced ejection fraction (HFrEF) has been shown to be superior to enalapril in reducing the risk of death and hospitalisation for HF.1 Cardiopulmo... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - May 15, 2023 Category: Cardiology Authors: dbarot525787 Source Type: research

Evaluation of the effectiveness of oxytocin and enalapril in the prevention of epidural fibrosis developed after laminectomy in rats
Epidural fibrosis that develops after spinal surgical interventions may form adhesions around neural structures, causing symptoms similar to those present before surgical treatment, and therefore, further surgical intervention may be required. These surgical re-interventions may lead to serious complications in the patient and leave the patient and the surgeon in a difficult situation [1,2]. To resolve these serious problems and prevent the development of epidural fibrosis, liquid or solid barriers, and systemic and local drugs have all been tried, but an agent providing optimum results has still not been found [3]. (Source: Injury)
Source: Injury - May 12, 2023 Category: Orthopaedics Authors: Mustafa Ilker Karagedik, Ulas Yuksel, Bahar Kartal, Asli Fahriye Ceylan, Mustafa Ogden, Bulent Bakar Source Type: research

Fructose ‐induced salt‐sensitive blood pressure differentially affects sympathetically mediated aortic stiffness in male and female Sprague‐Dawley rats
In male rats, fructose-high salt diet results in elevated blood pressure and increased aortic stiffness. Despite earlier evidence of preserved left ventricular ejection fraction (LVEF), male rats on the fructose high salt diet display a deficit in myocardial function measured as reduced global longitudinal strain. Acute sympathoinhibition, but not RAS antagonism improves blood pressure and aortic stiffness in males. Female rats fed the same fructose-high salt diet maintained normal blood pressure, aortic compliance, and global longitudinal strain comparable to those measured in their  control glucose-fed counterparts. Abs...
Source: Physiological Reports - May 10, 2023 Category: Physiology Authors: Dragana Komnenov, Noreen F. Rossi Tags: ORIGINAL ARTICLE Source Type: research

In silico and in vitro screening for carcinogenic potential of angiotensin-converting enzyme inhibitors and their degradation impurities
Toxicol Appl Pharmacol. 2023 May 4:116541. doi: 10.1016/j.taap.2023.116541. Online ahead of print.ABSTRACTAccording to some clinical observations, the use of angiotensin-converting enzyme inhibitors (ACEI) may be associated with an increased risk of cancer. The aim of the present study was to screen for the potential carcinogenicity, mutagenicity and genotoxicity of these drugs using in silico methodology. Delapril, enalapril, imidapril, lisinopril, moexipril, perindopril, ramipril, trandolapril, spirapril were thereby analyzed. In parallel, the corresponding degradation impurities, the diketopiperazine (DKP) derivatives, ...
Source: Toxicology and Applied Pharmacology - May 6, 2023 Category: Toxicology Authors: Katarzyna Regulska Agnieszka Matera-Witkiewicz Aleksandra Miko łajczyk Beata J Stanisz Source Type: research

P27 The accuracy of tablet splitting to provide appropriate paediatric enalapril doses
Conclusion In general, splitting low-dose tablets of enalapril for paediatric use results in inaccurate dosing. Acceptable dosing was only achieved with the scored 5 mg tablets. Accurate doses below 2.5 mg were not achieved. An age-appropriate dosage formulation of enalapril to provide dosing below 2.5 mg is needed. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - April 19, 2023 Category: Pediatrics Authors: Conquest, A., Ames, M., Shaw, H. Tags: Abstract from the Neonatal and Paediatric Pharmacists Conference 2022 Source Type: research

Angiotensin receptor-neprilysin inhibitors and cardiac remodeling
Braz J Med Biol Res. 2023 Apr 7;56:e12616. doi: 10.1590/1414-431X2023e12616. eCollection 2023.ABSTRACTThe aim of this study was to determine how sacubitril/valsartan compared with valsartan in an outpatient setting affects left ventricular remodeling in heart failure with reduced ejection fraction and functional (or secondary) mitral regurgitation (SMR) due to the effect of dual inhibition of the renin-angiotensin system and neprilysin. The outpatient study included 90 patients with chronic SMR who were followed up for 12 months. They received sacubitril/valsartan or valsartan instead of the more commonly used angiotensin-...
Source: Brazilian Journal of Medical and Biological Research - April 12, 2023 Category: Research Authors: A S Ryazanov E V Shikh M V Makarovskaya A A Kudryavtsev Source Type: research

Angiotensin receptor-neprilysin inhibitors and cardiac remodeling
Braz J Med Biol Res. 2023 Apr 7;56:e12616. doi: 10.1590/1414-431X2023e12616. eCollection 2023.ABSTRACTThe aim of this study was to determine how sacubitril/valsartan compared with valsartan in an outpatient setting affects left ventricular remodeling in heart failure with reduced ejection fraction and functional (or secondary) mitral regurgitation (SMR) due to the effect of dual inhibition of the renin-angiotensin system and neprilysin. The outpatient study included 90 patients with chronic SMR who were followed up for 12 months. They received sacubitril/valsartan or valsartan instead of the more commonly used angiotensin-...
Source: Braz J Med Biol Res - April 12, 2023 Category: Research Authors: A S Ryazanov E V Shikh M V Makarovskaya A A Kudryavtsev Source Type: research

Angiotensin receptor-neprilysin inhibitors and cardiac remodeling
Braz J Med Biol Res. 2023 Apr 7;56:e12616. doi: 10.1590/1414-431X2023e12616. eCollection 2023.ABSTRACTThe aim of this study was to determine how sacubitril/valsartan compared with valsartan in an outpatient setting affects left ventricular remodeling in heart failure with reduced ejection fraction and functional (or secondary) mitral regurgitation (SMR) due to the effect of dual inhibition of the renin-angiotensin system and neprilysin. The outpatient study included 90 patients with chronic SMR who were followed up for 12 months. They received sacubitril/valsartan or valsartan instead of the more commonly used angiotensin-...
Source: Brazilian Journal of Medical and Biological Research - April 12, 2023 Category: Research Authors: A S Ryazanov E V Shikh M V Makarovskaya A A Kudryavtsev Source Type: research