Simplified integration of optimal self-management behaviors is associated with improved HbA1c in patients with type 1 diabetes
ConclusionsSix optimal self-management behaviors, especially CGM usage, were associated with improved glycemic control, emphasizing the feasibility of implementing a simplified version of DSMES in the routine clinical care.Registration number: ClinicalTrials.gov Identifier: NCT03610984 (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 11, 2024 Category: Endocrinology Source Type: research
Bioengineered MSC < sup > Cxcr2 < /sup > transdifferentiated keratinocyte-like cell-derived organoid potentiates skin regeneration through ERK1/2 and STAT3 signaling in diabetic wound
Cell Mol Life Sci. 2024 Apr 10;81(1):172. doi: 10.1007/s00018-023-05057-3.ABSTRACTSkin regeneration is severely compromised in diabetic foot ulcers. Allogeneic mesenchymal stem cell (MSC) transplantation is limited due to the poor engraftment, mitogenic, and differentiation potential in the harsh wound microenvironment. Thus, to improve the efficacy of cell therapy, the chemokine receptor Cxcr2 was overexpressed in MSCs (MSCCxcr2). CXCL2/CXCR2 axis induction led to the enhanced proliferation of MSCs through the activation of STAT3 and ERK1/2 signaling. Transcriptional upregulation of FGFR2IIIb (KGF Receptor) promoter by th...
Source: Cellular and Molecular Life Sciences : CMLS - April 10, 2024 Category: Cytology Authors: Subholakshmi Choudhury Neha R Dhoke Shilpa Chawla Amitava Das Source Type: research
Bioengineered MSC(Cxcr2) transdifferentiated keratinocyte-like cell-derived organoid potentiates skin regeneration through ERK1/2 and STAT3 signaling in diabetic wound
Cell Mol Life Sci. 2024 Apr 10;81(1):172. doi: 10.1007/s00018-023-05057-3.ABSTRACTSkin regeneration is severely compromised in diabetic foot ulcers. Allogeneic mesenchymal stem cell (MSC) transplantation is limited due to the poor engraftment, mitogenic, and differentiation potential in the harsh wound microenvironment. Thus, to improve the efficacy of cell therapy, the chemokine receptor Cxcr2 was overexpressed in MSCs (MSCCxcr2). CXCL2/CXCR2 axis induction led to the enhanced proliferation of MSCs through the activation of STAT3 and ERK1/2 signaling. Transcriptional upregulation of FGFR2IIIb (KGF Receptor) promoter by th...
Source: Cell Research - April 10, 2024 Category: Cytology Authors: Subholakshmi Choudhury Neha R Dhoke Shilpa Chawla Amitava Das Source Type: research
Bioengineered MSC < sup > Cxcr2 < /sup > transdifferentiated keratinocyte-like cell-derived organoid potentiates skin regeneration through ERK1/2 and STAT3 signaling in diabetic wound
Cell Mol Life Sci. 2024 Apr 10;81(1):172. doi: 10.1007/s00018-023-05057-3.ABSTRACTSkin regeneration is severely compromised in diabetic foot ulcers. Allogeneic mesenchymal stem cell (MSC) transplantation is limited due to the poor engraftment, mitogenic, and differentiation potential in the harsh wound microenvironment. Thus, to improve the efficacy of cell therapy, the chemokine receptor Cxcr2 was overexpressed in MSCs (MSCCxcr2). CXCL2/CXCR2 axis induction led to the enhanced proliferation of MSCs through the activation of STAT3 and ERK1/2 signaling. Transcriptional upregulation of FGFR2IIIb (KGF Receptor) promoter by th...
Source: Cellular and Molecular Life Sciences : CMLS - April 10, 2024 Category: Cytology Authors: Subholakshmi Choudhury Neha R Dhoke Shilpa Chawla Amitava Das Source Type: research
Modulatory effect of interleukin-2 loaded chitosan nano sphere on regulatory T cell activity in streptozotocin-induced diabetic mice
CONCLUSIONS: Low-dose IL-2 selectively modulates FoxP3 + Tregs, and TGFβ 1 increases their levels. These results demonstrated that IL-2-free and chitosan-loaded nanoparticles can be therapeutic agents in T1D.PMID:38599099 | DOI:10.1016/j.intimp.2024.112019 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 10, 2024 Category: Allergy & Immunology Authors: Salma Aboelnazar Hossam Ghoneim Thanaa Shalaby Sally Sorour Eman M Osman Source Type: research
GSE255756 miR-146a-5p contributes to inflammation-mediated β cell mitochondrial dysfunction and apoptosis
Contributors : Carmella Evans-Molina ; Preethi Krishnan ; Farooq SyedSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMicroRNAs (miRNAs) are small non-coding RNAs that function as modulators of gene expression. We previously showed that miR-146a-5p is upregulated in pancreatic islets treated with pro-inflammatory cytokines and in pancreatic sections from organ donors with type 1 diabetes (T1D). Other studies have associated overexpression of miR-146a-5p with β cell apoptosis and impaired insulin secretion; however, the molecular mechanisms mediating these effects remain elusive. To...
Source: GEO: Gene Expression Omnibus - April 10, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Associations Between HbA1c and Glucose Time in Range Using Continuous Glucose Monitoring in Type 1 Diabetes: Cross-Sectional Population-Based Study
ConclusionsThis descriptive study demonstrates that the degree of association between HbA1c and new and readily available CGM-derived metrics, i.e., time in range (TIR), time above range (TAR), and CGM mean glucose, is robust in assessing the management of individuals with type 1 diabetes in clinical settings. Metrics from CGM that pertain to variability and hypoglycemia exhibit only weak correlations with HbA1c. (Source: Diabetes Therapy)
Source: Diabetes Therapy - April 10, 2024 Category: Endocrinology Source Type: research
Parental education and occupation in relation to childhood type 1 diabetes: nationwide cohort study
Conclusions
Our results suggested inverse U-shaped associations between maternal socioeconomic status and risk of type 1 diabetes. Non-linear associations may be part of the reason why previous literature has been inconsistent. (Source: Journal of Epidemiology and Community Health)
Source: Journal of Epidemiology and Community Health - April 10, 2024 Category: Epidemiology Authors: Lopez-Doriga Ruiz, P., Tapia, G., Bakken, I. J., Haberg, S. E., Gulseth, H. L., Skrivarhaug, T., Joner, G., Stene, L. C. Tags: Original research Source Type: research
Sensors, Vol. 24, Pages 2412: Physical Activity Detection for Diabetes Mellitus Patients Using Recurrent Neural Networks
gy Eigner
Diabetes mellitus (DM) is a persistent metabolic disorder associated with the hormone insulin. The two main types of DM are type 1 (T1DM) and type 2 (T2DM). Physical activity plays a crucial role in the therapy of diabetes, benefiting both types of patients. The detection, recognition, and subsequent classification of physical activity based on type and intensity are integral components of DM treatment. The continuous glucose monitoring system (CGMS) signal provides the blood glucose (BG) level, and the combination of CGMS and heart rate (HR) signals are potential targets for detecting relevant physical activ...
Source: Sensors - April 10, 2024 Category: Biotechnology Authors: Lehel D énes-Fazakas Barbara Simon Ádám Hartvég Levente Kov ács Éva-Henrietta Dulf L ászló Szilágyi Gy örgy Eigner Tags: Article Source Type: research
Diabetic Ketoacidosis in Type 1 Diabetes Onset in Latin American Children
To describe the patterns of diabetic ketoacidosis (DKA) occurrence in children newly diagnosed with type 1 diabetes (T1DM) across several Latin American pediatric diabetes centers from 2018 to 2022. (Source: Journal of Pediatric Health Care)
Source: Journal of Pediatric Health Care - April 10, 2024 Category: Pediatrics Authors: Valeria Hirschler, Claudio D. Gonzalez, Gabriela Krochik, Adriana M. Rousos, Maria E. Andres, Francisca Riera, Paola Pinto Ibarcena, Claudia Molinari, Luis F. Palacios Porta, Mariana Prieto, Carolina Martinez Mateu, Consuelo Barcala, Maria A. Arrigo, Jacq Tags: Quantitative Source Type: research
Associations Between HbA1c and Glucose Time in Range Using Continuous Glucose Monitoring in Type 1 Diabetes: Cross-Sectional Population-Based Study
ConclusionsThis descriptive study demonstrates that the degree of association between HbA1c and new and readily available CGM-derived metrics, i.e., time in range (TIR), time above range (TAR), and CGM mean glucose, is robust in assessing the management of individuals with type 1 diabetes in clinical settings. Metrics from CGM that pertain to variability and hypoglycemia exhibit only weak correlations with HbA1c. (Source: Diabetes Therapy)
Source: Diabetes Therapy - April 10, 2024 Category: Endocrinology Source Type: research
An ecological resilience model for adolescents with type 1 diabetes: a cross-sectional study
Highly resilient adolescents with type 1 diabetes have been proved to achieve within-target glycemic outcomes and experience high quality of life. The ecological resilience model for adolescents with type 1 di... (Source: BMC Psychiatry)
Source: BMC Psychiatry - April 9, 2024 Category: Psychiatry Authors: Dan Luo, Xue Cai, Hong Wang, Jingjing Xu, Yubing Wang and Mingzi Li Tags: Research Source Type: research
Continuous Glucose Monitoring-Derived Glucometrics in Adults with Type 1 Diabetes When Switching Basal Insulins
Diabetes Technology&Therapeutics, Ahead of Print. (Source: Diabetes Technology)
Source: Diabetes Technology - April 9, 2024 Category: Endocrinology Authors: Robbe De Groote Eveline Lefever Sara Charleer Phebe Donn é Christophe De Block Chantal Mathieu Pieter Gillard Source Type: research
Which self-reported measures are useful to explore diabetes support needs among adults with diabetes and severe mental illness?
DISCUSSION: PROMs can successfully be constructed in collaboration with this vulnerable population that yield low rates of missing responses.PMID:38584462 | DOI:10.1177/17423953241241762 (Source: Chronic Illness)
Source: Chronic Illness - April 8, 2024 Category: General Medicine Authors: Vibeke Stenov Ingrid Willaing Lene Eide Joensen Lenette Knudsen Gregers Stig Andersen Dorte Lindqvist Hansen Bryan Cleal Source Type: research
A series of patients with hospital-acquired diabetic ketoacidosis (HADKA): a descriptive analysis
CONCLUSION: HADKA was identified in a significant number of patients at our hospital and was associated with significant mortality. Earlier recognition of ketonaemia and associated medication use may prevent HADKA and improve outcomes.PMID:38589158 | DOI:10.7861/clinmed.2022-0300 (Source: Molecular Medicine)
Source: Molecular Medicine - April 8, 2024 Category: Molecular Biology Authors: David M Williams Sofia Taverner Rebecca Watson Siba George Amanda Edwards Ayesha Shaikh Maneesh Udiawar Source Type: research
