Systematic immune cell dysregulation and molecular subtypes revealed by single-cell RNA-seq of subjects with type 1 diabetes
ConclusionsOur study reveals a surprisingly strong systemic dimension at the level of immune cell network in T1DM, defines disease-relevant molecular subtypes, and has the potential to guide non-invasive test development and patient stratification. (Source: Genome Medicine)
Source: Genome Medicine - March 27, 2024 Category: Genetics & Stem Cells Source Type: research
Effectiveness of a standardized scenario in teaching the management of pediatric diabetic ketoacidosis (DKA) to residents: a simulation cross-sectional study
Diabetic ketoacidosis (DKA) is a frequent manifestation at the onset of type 1 diabetes mellitus in children, possibly associated with a wide range of complications, often as a consequence of wrong or delayed ... (Source: BMC Medical Education)
Source: BMC Medical Education - March 27, 2024 Category: Universities & Medical Training Authors: Alice Monzani, Elena Corti, Antonio Scalogna, Silvia Savastio, Erica Pozzi, Pier Paolo Sainaghi, Francesco Della Corte and Ivana Rabbone Tags: Research Source Type: research
The opportunities and challenges of the disease-modifying immunotherapy for type 1 diabetes: a systematic review and meta-analysis
In conclusion, nonantigen-based immunotherapies were associated with a preservation of 2h and 4h C-peptide AUC in patients with T1D when compared with the controls, which was mainly driven by the effects of TNF-a inhibitor and T cell-targeted therapy. Both nonantigen-based immunotherapies and antigen-based immunotherapies tended to reduce the daily insulin dosage in patients with T1D when compared with the controls. However, they did not contribute to a substantial improvement in HbA1c or FBG. Both nonantigen-based immunotherapies and antigen-based immunotherapies were well tolerated with not increased risk of hypoglycemia...
Source: Cell Research - March 26, 2024 Category: Cytology Authors: Chu Lin Suiyuan Hu Xiaoling Cai Fang Lv Wenjia Yang Geling Liu Xiaolin Yang Linong Ji Source Type: research
Global cognition and executive functions of older adults with type 1 diabetes mellitus without dementia
ConclusionsExecutive function of psychomotor speed was worse in older outpatient adults without dementia with type 1 diabetes mellitus than in those with type 2 diabetes mellitus but with no significant differences in the comprehensive and practical behavioral assessment of dysexecutive syndrome. Patients with type 1 diabetes had more severely impaired executive function, whereas those with type 2 had greater impaired memory than executive function. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - March 26, 2024 Category: Endocrinology Authors: Kaoru Nagasawa,
Kimio Matsumura,
Takayasu Uchida,
Yuya Suzuki,
Akihiro Nishimura,
Minoru Okubo,
Yukifusa Igeta,
Tetsuro Kobayashi,
Takashi Sakurai,
Yasumichi Mori Tags: Original Article Source Type: research
Induction of islet autoimmunity to defective ribosomal product of the insulin gene as neoantigen after anti-cancer immunotherapy leading to autoimmune diabetes
DiscussionThese results bridge cancer and T1D as two sides of the same coin and point to neoantigen expression in normal islets and insulinoma that may serve as target of both islet autoimmunity and tumor-related autoimmunity. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - March 26, 2024 Category: Allergy & Immunology Source Type: research
Editorial: Equity in type 1 diabetes technology and beyond: where are we in 2022?
(Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 26, 2024 Category: Endocrinology Source Type: research
The association of islet autoantibodies with the neural retinal thickness and microcirculation in type 1 diabetes mellitus with no clinical evidence of diabetic retinopathy
ConclusionsIAbs are associated with neural retinal thinning and microcirculation reduction in T1DM patients before the clinical onset of diabetic retinopathy. (Source: Acta Diabetologica)
Source: Acta Diabetologica - March 26, 2024 Category: Endocrinology Source Type: research
Ongoing burden and recent trends in severe hospitalised hypoglycaemia events in people with type 1 and type 2 diabetes in Scotland: A nationwide cohort study 2016 –2022
We examined severe hospitalised hypoglycaemia (SHH) rates in people with type 1 and type 2 diabetes in Scotland during 2016 –2022, stratifying by sociodemographics. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - March 26, 2024 Category: Endocrinology Authors: William Berthon, Stuart J. McGurnaghan, Luke A.K. Blackbourn, Joseph Mellor, Fraser W. Gibb, Simon Heller, Brian Kennon, Rory J. McCrimmon, Sam Philip, Naveed Sattar, Paul M. McKeigue, Helen M. Colhoun, Scottish Diabetes Research Network Epidemiology Grou Source Type: research
A New Tool to Identify Pediatric Patients with Atypical Diabetes Associated with Gene Polymorphisms
CONCLUSION: We validated the DIAMODIA criteria, as it effectively identified all monogenic diabetes patients (MODY cohort) and succeeded to differentiate T1DM from MODY patients. The creation of this new and effective tool is likely to facilitate the characterization and therapeutic management of patients with atypical diabetes, and promptly referring them for genetic testing which would markedly improve clinical care and counseling, as well.PMID:38523249 | DOI:10.4093/dmj.2023.0166 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - March 25, 2024 Category: Endocrinology Authors: Sophie Welsch Antoine Harvengta Paola Gallo Manon Martin Dominique Beckers Thierry Mouraux Nicole Seret Marie-Christine Lebrethon Raphael Helear Pascal Brouillard Miikka Vikkula Philippe A Lysy Source Type: research
Diabetes on the side-lines with normal life - A qualitative study of adolescents experiences of living with and managing type 1 diabetes
Ir Med J. 2024 Mar 21;117(3):937.NO ABSTRACTPMID:38526351 (Source: Ir Med J)
Source: Ir Med J - March 25, 2024 Category: General Medicine Authors: F O'Donoghue A M Creaven M Connolly A McCaffrey C Crotty O Neylon C O'Gorman Source Type: research
A New Tool to Identify Pediatric Patients with Atypical Diabetes Associated with Gene Polymorphisms
CONCLUSION: We validated the DIAMODIA criteria, as it effectively identified all monogenic diabetes patients (MODY cohort) and succeeded to differentiate T1DM from MODY patients. The creation of this new and effective tool is likely to facilitate the characterization and therapeutic management of patients with atypical diabetes, and promptly referring them for genetic testing which would markedly improve clinical care and counseling, as well.PMID:38523249 | DOI:10.4093/dmj.2023.0166 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - March 25, 2024 Category: Endocrinology Authors: Sophie Welsch Antoine Harvengta Paola Gallo Manon Martin Dominique Beckers Thierry Mouraux Nicole Seret Marie-Christine Lebrethon Raphael Helear Pascal Brouillard Miikka Vikkula Philippe A Lysy Source Type: research
Diabetes on the side-lines with normal life - A qualitative study of adolescents experiences of living with and managing type 1 diabetes
Ir Med J. 2024 Mar 21;117(3):937.NO ABSTRACTPMID:38526351 (Source: Ir Med J)
Source: Ir Med J - March 25, 2024 Category: General Medicine Authors: F O'Donoghue A M Creaven M Connolly A McCaffrey C Crotty O Neylon C O'Gorman Source Type: research
A New Tool to Identify Pediatric Patients with Atypical Diabetes Associated with Gene Polymorphisms
CONCLUSION: We validated the DIAMODIA criteria, as it effectively identified all monogenic diabetes patients (MODY cohort) and succeeded to differentiate T1DM from MODY patients. The creation of this new and effective tool is likely to facilitate the characterization and therapeutic management of patients with atypical diabetes, and promptly referring them for genetic testing which would markedly improve clinical care and counseling, as well.PMID:38523249 | DOI:10.4093/dmj.2023.0166 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - March 25, 2024 Category: Endocrinology Authors: Sophie Welsch Antoine Harvengta Paola Gallo Manon Martin Dominique Beckers Thierry Mouraux Nicole Seret Marie-Christine Lebrethon Raphael Helear Pascal Brouillard Miikka Vikkula Philippe A Lysy Source Type: research
Diabetes on the side-lines with normal life - A qualitative study of adolescents experiences of living with and managing type 1 diabetes
Ir Med J. 2024 Mar 21;117(3):937.NO ABSTRACTPMID:38526351 (Source: Ir Med J)
Source: Ir Med J - March 25, 2024 Category: General Medicine Authors: F O'Donoghue A M Creaven M Connolly A McCaffrey C Crotty O Neylon C O'Gorman Source Type: research
