Effects of Two COVID-19 Lockdowns on HbA1c Levels in Patients with Type 1 Diabetes and Associations with Digital Treatment, Health Literacy, and Diabetes Self-Management: A Multicenter, Observational Cohort Study Over 3 Years
ConclusionsLockdowns can lead to worsening glycemic control in patients with type 1 diabetes. Particularly patients with few check-ups, poor blood glucose values, deficits in diabetes self-management, low health literacy, and a low level of education seem to be at greater risk of worsening glycemic control during lockdowns and, therefore, require special medical care, e.g., through telemedicine.Trial RegistrationClinicalTrials.gov identifier, NCT04821921. (Source: Diabetes Therapy)
Source: Diabetes Therapy - April 20, 2024 Category: Endocrinology Source Type: research
Psychosocial Self-efficacy and its Association with Selected Potential Factors Among Adults with Type 1 Diabetes: A Cross-Sectional Survey Study
ConclusionsIn this study, higher well-being score and lower self-reported HbA1c levels were associated with higher psychosocial self-efficacy in both univariate- and multivariate analysis and accounted for 30% of the variation in psychosocial self-efficacy in the regression model. Thus, measures to improve psychosocial self-efficacy in adults with type 1 diabetes may help maintain their psychological well-being and blood glucose control. (Source: Diabetes Therapy)
Source: Diabetes Therapy - April 20, 2024 Category: Endocrinology Source Type: research
The effect of physical activity on cytokine levels in adults living with type 1 diabetes —a preliminary study
In conclusion, the findings from this study allow to indicate that moderate level of physical activity may contribute to a reduction in the development of systemic low-grade inflammation in patients with T1DM, and thus, may reduce the risk of CVD. (Source: Physiological Reports)
Source: Physiological Reports - April 19, 2024 Category: Physiology Authors: Ma łgorzata Kowal,
Renata Woźniacka,
Anna Ścisłowska‐Czarnecka,
Joanna Homa,
Wojciech Głodzik Tags: ORIGINAL ARTICLE Source Type: research
Kidney biopsy findings in children with diabetes mellitus
ConclusionsWe confirm that changes better known in adults with either type 1 or type 2 diabetes mellitus can occur in children with type 1 diabetes mellitus: overt diabetic nephropathy either on its own or combined with other conditions and kidney disorders other than diabetic nephropathy.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - April 19, 2024 Category: Urology & Nephrology Source Type: research
Urinary sphingolipids in adolescents and young adults with youth-onset diabetes
ConclusionUrinary sphingolipids are elevated in adolescents and young adults with youth-onset diabetes and correlate with ACR. Urinary sphingolipids may therefore represent an early biomarker of DKD.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - April 19, 2024 Category: Urology & Nephrology Source Type: research
Cannabinoid Receptor Type 1 Activation Causes a Water Diuresis by Inducing an Acute Central Diabetes Insipidus in Mice
Am J Physiol Renal Physiol. 2024 Apr 18. doi: 10.1152/ajprenal.00320.2022. Online ahead of print.ABSTRACTCannabis and synthetic cannabinoid consumption is increasing worldwide. Cannabis contains numerous phytocannabinoids that act on the G-protein-coupled cannabinoid receptors type 1 (CB1R) and type 2 (CB2R) expressed throughout the body, including the kidney. Essentially every organ, including the kidney, produces endocannabinoids (ECs), endogenous ligands to these receptors. Cannabinoids acutely increase urine output in rodents and humans, thus potentially influencing total-body water and electrolyte homeostasis. As the ...
Source: Am J Physiol Renal P... - April 18, 2024 Category: Urology & Nephrology Authors: Joshua L Rein Ken Mackie Thomas R Kleyman Lisa M Satlin Source Type: research
Cannabinoid Receptor Type 1 Activation Causes a Water Diuresis by Inducing an Acute Central Diabetes Insipidus in Mice
Am J Physiol Renal Physiol. 2024 Apr 18. doi: 10.1152/ajprenal.00320.2022. Online ahead of print.ABSTRACTCannabis and synthetic cannabinoid consumption is increasing worldwide. Cannabis contains numerous phytocannabinoids that act on the G-protein-coupled cannabinoid receptors type 1 (CB1R) and type 2 (CB2R) expressed throughout the body, including the kidney. Essentially every organ, including the kidney, produces endocannabinoids (ECs), endogenous ligands to these receptors. Cannabinoids acutely increase urine output in rodents and humans, thus potentially influencing total-body water and electrolyte homeostasis. As the ...
Source: American Journal of Physiology. Renal Physiology - April 18, 2024 Category: Physiology Authors: Joshua L Rein Ken Mackie Thomas R Kleyman Lisa M Satlin Source Type: research
Genetically determined type 1 diabetes mellitus and risk of osteoporosis
CONCLUSIONS: This study shows a causal relationship between T1DM and the risk of some sites of OP (FN-BMD, LS-BMD), allowing for continued research to discover the clinical and experimental mechanisms of T1DM and OP. It also contributes to the recommendation if patients with T1DM need targeted care to promote bone health and timely prevention of osteoporosis.PMID:38636571 | DOI:10.1016/j.exger.2024.112434 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 18, 2024 Category: Geriatrics Authors: Ting Cheng Jia-Lin Hou Zi-Yi Han Xin-Lei Geng Yao-Chen Zhang Ke-Yi Fan Liu Liu He-Yi Zhang Yue-Hong Huo Xiao-Feng Li Sheng-Xiao Zhang Source Type: research
Cannabinoid Receptor Type 1 Activation Causes a Water Diuresis by Inducing an Acute Central Diabetes Insipidus in Mice
Am J Physiol Renal Physiol. 2024 Apr 18. doi: 10.1152/ajprenal.00320.2022. Online ahead of print.ABSTRACTCannabis and synthetic cannabinoid consumption is increasing worldwide. Cannabis contains numerous phytocannabinoids that act on the G-protein-coupled cannabinoid receptors type 1 (CB1R) and type 2 (CB2R) expressed throughout the body, including the kidney. Essentially every organ, including the kidney, produces endocannabinoids (ECs), endogenous ligands to these receptors. Cannabinoids acutely increase urine output in rodents and humans, thus potentially influencing total-body water and electrolyte homeostasis. As the ...
Source: Am J Physiol Renal P... - April 18, 2024 Category: Urology & Nephrology Authors: Joshua L Rein Ken Mackie Thomas R Kleyman Lisa M Satlin Source Type: research
Cannabinoid Receptor Type 1 Activation Causes a Water Diuresis by Inducing an Acute Central Diabetes Insipidus in Mice
Am J Physiol Renal Physiol. 2024 Apr 18. doi: 10.1152/ajprenal.00320.2022. Online ahead of print.ABSTRACTCannabis and synthetic cannabinoid consumption is increasing worldwide. Cannabis contains numerous phytocannabinoids that act on the G-protein-coupled cannabinoid receptors type 1 (CB1R) and type 2 (CB2R) expressed throughout the body, including the kidney. Essentially every organ, including the kidney, produces endocannabinoids (ECs), endogenous ligands to these receptors. Cannabinoids acutely increase urine output in rodents and humans, thus potentially influencing total-body water and electrolyte homeostasis. As the ...
Source: American Journal of Physiology. Renal Physiology - April 18, 2024 Category: Physiology Authors: Joshua L Rein Ken Mackie Thomas R Kleyman Lisa M Satlin Source Type: research
Genetically determined type 1 diabetes mellitus and risk of osteoporosis
CONCLUSIONS: This study shows a causal relationship between T1DM and the risk of some sites of OP (FN-BMD, LS-BMD), allowing for continued research to discover the clinical and experimental mechanisms of T1DM and OP. It also contributes to the recommendation if patients with T1DM need targeted care to promote bone health and timely prevention of osteoporosis.PMID:38636571 | DOI:10.1016/j.exger.2024.112434 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 18, 2024 Category: Geriatrics Authors: Ting Cheng Jia-Lin Hou Zi-Yi Han Xin-Lei Geng Yao-Chen Zhang Ke-Yi Fan Liu Liu He-Yi Zhang Yue-Hong Huo Xiao-Feng Li Sheng-Xiao Zhang Source Type: research
Cannabinoid Receptor Type 1 Activation Causes a Water Diuresis by Inducing an Acute Central Diabetes Insipidus in Mice
Am J Physiol Renal Physiol. 2024 Apr 18. doi: 10.1152/ajprenal.00320.2022. Online ahead of print.ABSTRACTCannabis and synthetic cannabinoid consumption is increasing worldwide. Cannabis contains numerous phytocannabinoids that act on the G-protein-coupled cannabinoid receptors type 1 (CB1R) and type 2 (CB2R) expressed throughout the body, including the kidney. Essentially every organ, including the kidney, produces endocannabinoids (ECs), endogenous ligands to these receptors. Cannabinoids acutely increase urine output in rodents and humans, thus potentially influencing total-body water and electrolyte homeostasis. As the ...
Source: Am J Physiol Renal P... - April 18, 2024 Category: Urology & Nephrology Authors: Joshua L Rein Ken Mackie Thomas R Kleyman Lisa M Satlin Source Type: research
Cannabinoid Receptor Type 1 Activation Causes a Water Diuresis by Inducing an Acute Central Diabetes Insipidus in Mice
Am J Physiol Renal Physiol. 2024 Apr 18. doi: 10.1152/ajprenal.00320.2022. Online ahead of print.ABSTRACTCannabis and synthetic cannabinoid consumption is increasing worldwide. Cannabis contains numerous phytocannabinoids that act on the G-protein-coupled cannabinoid receptors type 1 (CB1R) and type 2 (CB2R) expressed throughout the body, including the kidney. Essentially every organ, including the kidney, produces endocannabinoids (ECs), endogenous ligands to these receptors. Cannabinoids acutely increase urine output in rodents and humans, thus potentially influencing total-body water and electrolyte homeostasis. As the ...
Source: American Journal of Physiology. Renal Physiology - April 18, 2024 Category: Physiology Authors: Joshua L Rein Ken Mackie Thomas R Kleyman Lisa M Satlin Source Type: research
Genetically determined type 1 diabetes mellitus and risk of osteoporosis
CONCLUSIONS: This study shows a causal relationship between T1DM and the risk of some sites of OP (FN-BMD, LS-BMD), allowing for continued research to discover the clinical and experimental mechanisms of T1DM and OP. It also contributes to the recommendation if patients with T1DM need targeted care to promote bone health and timely prevention of osteoporosis.PMID:38636571 | DOI:10.1016/j.exger.2024.112434 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 18, 2024 Category: Geriatrics Authors: Ting Cheng Jia-Lin Hou Zi-Yi Han Xin-Lei Geng Yao-Chen Zhang Ke-Yi Fan Liu Liu He-Yi Zhang Yue-Hong Huo Xiao-Feng Li Sheng-Xiao Zhang Source Type: research
Hyperpigmentation at diabetes technology sites may be indicative of evolving Addisons disease
A 12-year-old boy with type 1 diabetes mellitus and coeliac disease reported 2–3 months of skin darkening at his insulin pump cannula and continuous glucose monitor sites (figure 1). For the preceding 9 months, he had localised itching and redness, which had been managed as allergic contact dermatitis by a dermatologist. He continued to use the dressings and these symptoms had improved. Hyperpigmentation was noted over his knuckles and periorally. He had no symptoms of adrenal insufficiency and was gaining weight (98th centile) and height (50th centile). A synacthen test had a suboptimal peak cortisol (370 nmol/L (&g...
Source: Archives of Disease in Childhood - April 18, 2024 Category: Pediatrics Authors: Moon, R. J., Rowland, A. C., Davies, J. H. Tags: Miscellanea Source Type: research
