Cannabinoid Receptor Type 1 Activation Causes a Water Diuresis by Inducing an Acute Central Diabetes Insipidus in Mice
Am J Physiol Renal Physiol. 2024 Apr 18. doi: 10.1152/ajprenal.00320.2022. Online ahead of print.ABSTRACTCannabis and synthetic cannabinoid consumption is increasing worldwide. Cannabis contains numerous phytocannabinoids that act on the G-protein-coupled cannabinoid receptors type 1 (CB1R) and type 2 (CB2R) expressed throughout the body, including the kidney. Essentially every organ, including the kidney, produces endocannabinoids (ECs), endogenous ligands to these receptors. Cannabinoids acutely increase urine output in rodents and humans, thus potentially influencing total-body water and electrolyte homeostasis. As the ...
Source: Am J Physiol Renal P... - April 18, 2024 Category: Urology & Nephrology Authors: Joshua L Rein Ken Mackie Thomas R Kleyman Lisa M Satlin Source Type: research
Cannabinoid Receptor Type 1 Activation Causes a Water Diuresis by Inducing an Acute Central Diabetes Insipidus in Mice
Am J Physiol Renal Physiol. 2024 Apr 18. doi: 10.1152/ajprenal.00320.2022. Online ahead of print.ABSTRACTCannabis and synthetic cannabinoid consumption is increasing worldwide. Cannabis contains numerous phytocannabinoids that act on the G-protein-coupled cannabinoid receptors type 1 (CB1R) and type 2 (CB2R) expressed throughout the body, including the kidney. Essentially every organ, including the kidney, produces endocannabinoids (ECs), endogenous ligands to these receptors. Cannabinoids acutely increase urine output in rodents and humans, thus potentially influencing total-body water and electrolyte homeostasis. As the ...
Source: American Journal of Physiology. Renal Physiology - April 18, 2024 Category: Physiology Authors: Joshua L Rein Ken Mackie Thomas R Kleyman Lisa M Satlin Source Type: research
Genetically determined type 1 diabetes mellitus and risk of osteoporosis
CONCLUSIONS: This study shows a causal relationship between T1DM and the risk of some sites of OP (FN-BMD, LS-BMD), allowing for continued research to discover the clinical and experimental mechanisms of T1DM and OP. It also contributes to the recommendation if patients with T1DM need targeted care to promote bone health and timely prevention of osteoporosis.PMID:38636571 | DOI:10.1016/j.exger.2024.112434 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 18, 2024 Category: Geriatrics Authors: Ting Cheng Jia-Lin Hou Zi-Yi Han Xin-Lei Geng Yao-Chen Zhang Ke-Yi Fan Liu Liu He-Yi Zhang Yue-Hong Huo Xiao-Feng Li Sheng-Xiao Zhang Source Type: research
Hyperpigmentation at diabetes technology sites may be indicative of evolving Addisons disease
A 12-year-old boy with type 1 diabetes mellitus and coeliac disease reported 2–3 months of skin darkening at his insulin pump cannula and continuous glucose monitor sites (figure 1). For the preceding 9 months, he had localised itching and redness, which had been managed as allergic contact dermatitis by a dermatologist. He continued to use the dressings and these symptoms had improved. Hyperpigmentation was noted over his knuckles and periorally. He had no symptoms of adrenal insufficiency and was gaining weight (98th centile) and height (50th centile). A synacthen test had a suboptimal peak cortisol (370 nmol/L (&g...
Source: Archives of Disease in Childhood - April 18, 2024 Category: Pediatrics Authors: Moon, R. J., Rowland, A. C., Davies, J. H. Tags: Miscellanea Source Type: research
B-Glycine as a marker for β cell imaging and β cell mass evaluation
Conclusion[18F]FBG targeting the endogenous glycine transporter (GLYT), which is highly expressed on islet cells, avoiding extra modification on islet cells. Meanwhile the highly restricted expression pattern of GLYT excluded the background in adjacent tissues. This [18F]FBG-based imaging technique provides a non-invasive method to quantify BCM in vivo, implying a new evaluation index for diabetic assessment. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - April 18, 2024 Category: Nuclear Medicine Source Type: research
Cystatin C as an adjunct to HbA1c may prove useful in predicting the development of diabetic complications in children and adolescents with type 1 diabetes
ConclusionIn conclusion, Cystatin C levels were higher in patients with diabetes duration longer than 5 years, and inverse correlation was found between HbA1c and Cystatin C levels as well as duration of diabetes. Cystatin C may prove useful as an adjunct to HbA1c in predicting eventual development of diabetic complications. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - April 18, 2024 Category: Endocrinology Source Type: research
Association of CIITA (rs8048002) and CLEC2D (rs2114870) gene variants and type 1 diabetes mellitus
ConclusionThe rare C allele of CIITA rs8048002 genetic variant was associated with an increased risk of developing T1DM, while the less common A allele of CLEC2D rs2114870 was associated with a reduced risk of T1DM. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - April 18, 2024 Category: Endocrinology Source Type: research
Immune checkpoint inhibitor-related type 1 diabetes mellitus which develops long after treatment discontinuation: a case report and review of literature
AbstractImmune checkpoint inhibitor (ICI)-related type 1 diabetes is an immune-related adverse event (irAE), occurring in slightly less than 1% of patients undergoing ICI therapy. Most cases develop during ICI treatment, with occurrences long after discontinuation being extremely rare. A 76-year-old woman, with no history of glucose tolerance issues, was diagnosed with lung adenocarcinoma with pleural invasion and underwent chemotherapy, including atezolizumab, an anti-programmed death-ligand 1 antibody. This treatment was discontinued due to disease progression, although she continued with other chemotherapy regimens. App...
Source: Diabetology International - April 18, 2024 Category: Endocrinology Source Type: research
Efficacy and Safety of Tirzepatide in Overweight and Obese Adult Patients with Type 1 Diabetes
Diabetes Technology&Therapeutics, Ahead of Print. (Source: Diabetes Technology)
Source: Diabetes Technology - April 18, 2024 Category: Endocrinology Authors: Satish K. Garg Halis K. Akturk Gurleen Kaur Christie Beatson Janet Snell-Bergeon Source Type: research
B-Glycine as a marker for β cell imaging and β cell mass evaluation
Conclusion[18F]FBG targeting the endogenous glycine transporter (GLYT), which is highly expressed on islet cells, avoiding extra modification on islet cells. Meanwhile the highly restricted expression pattern of GLYT excluded the background in adjacent tissues. This [18F]FBG-based imaging technique provides a non-invasive method to quantify BCM in vivo, implying a new evaluation index for diabetic assessment. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - April 18, 2024 Category: Nuclear Medicine Source Type: research
B-Glycine as a marker for β cell imaging and β cell mass evaluation
CONCLUSION: [18F]FBG targeting the endogenous glycine transporter (GLYT), which is highly expressed on islet cells, avoiding extra modification on islet cells. Meanwhile the highly restricted expression pattern of GLYT excluded the background in adjacent tissues. This [18F]FBG-based imaging technique provides a non-invasive method to quantify BCM in vivo, implying a new evaluation index for diabetic assessment.PMID:38632133 | DOI:10.1007/s00259-024-06712-y (Source: Molecular Medicine)
Source: Molecular Medicine - April 17, 2024 Category: Molecular Biology Authors: Yuxiang Han Hui Liu Yimin Li Zhibo Liu Source Type: research
A Patient with Diabetes Mellitus and Acute Rhinosinusitis
A 41-year-old with type 1 diabetes had generalized weakness, muffled voice, and slurred speech. Neck computed tomography showed soft-tissue gas in the nasopharynx and prevertebral fascia; examination of sinus mucosal samples identified numerous broad, nonseptate right-angled hyphae and fruiting bodies. What is the diagnosis and what would you do next? (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 17, 2024 Category: General Medicine Source Type: research
Virus-induced diabetes mellitus, revisiting infection etiology in light of SARS-CoV-2
Diabetes mellitus (DM) is comprised of two predominant subtypes: type 1 diabetes mellitus (T1DM), accounting for approximately 5 % of cases worldwide and resulting from autoimmune destruction of insulin-producing β-cells, and type 2 (T2DM), accounting for approximately 95 % of cases globally and characterized by the inability of pancreatic β-cells to meet the demand for insulin due to a relative β-cell deficit in the setting of peripheral insulin resistance. Both types of DM involve derangement of glucose metabolism and are metabolic diseases generally considered to be initiated by a combination of genetic and envi...
Source: Metabolism - Clinical and Experimental - April 17, 2024 Category: Biomedical Science Authors: Sundararaj Stanleyraj Jeremiah, Abu Saleh Md Moin, Alexandra E. Butler Tags: Review Source Type: research
The health-related quality of life of patients with type 1 and type 2 diabetes mellitus: a meta-analysis
ConclusionOur results are sample-specific and cannot be generalized to all patients with DM. Therefore, more research is warranted on this topic. (Source: Endocrine)
Source: Endocrine - April 17, 2024 Category: Endocrinology Source Type: research
