Controlling autoimmune diabetes onset by targeting Protease-Activated Receptor 2
CONCLUSIONS: This study highlights Par2's potential as a drug target for autoimmune diseases, particularly T1D. Our results pave the way for precision medicine approaches in treating autoimmune conditions through targeted Par2 modulation.PMID:38653114 | DOI:10.1016/j.biopha.2024.116622 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 23, 2024 Category: Drugs & Pharmacology Authors: Gal Reches Lynn Khoon Narmeen Ghanayiem Assaf Malka Ron Piran Source Type: research
The association between depressive symptoms and executive function in type 1 diabetes population: A scoping review
CONCLUSION: In summary, the seven studies in this review suggest that individuals with T1DM who report depressive symptoms are at a higher risk of poor executive function; a clear association between depressive symptoms and executive function in individuals with T1DM remains inconclusive. There is a need to explore this relationship in the future.PMID:38653620 | DOI:10.1016/j.pcd.2024.04.001 (Source: Primary Care)
Source: Primary Care - April 23, 2024 Category: Primary Care Authors: Chawisa Dandamrongrak Kaitlyn Rechenberg Jumpee Granger Ayesha Johnson Kailei Yan Jennifer Kue Source Type: research
Associations of the obesity gene FTO variant with complications and comorbidities in patients with type 1 diabetes
The increasing prevalence of childhood overweight and obesity is a severe health problem worldwide that contributes to the development of various comorbidities [1]. Type 1 diabetes (T1D) patients are especially vulnerable to such complications since the intensive insulin therapy is associated with weight gain, abdominal obesity, dyslipidaemia, hypertension, and the presence of atherosclerosis development features in imaging [2]. Although clinical factors associated with the disease and its treatment as well as lifestyle elements have been widely studied, various genetic loci are also known to play important role in the obe...
Source: Diabetes Research and Clinical Practice - April 23, 2024 Category: Endocrinology Authors: Bartosz S łomiński, Maria Skrzypkowska, Małgorzata Myśliwiec, Piotr Trzonkowski Source Type: research
Nicotinamide Mononucleotide improves oocyte maturation of mice with type 1 diabetes
Nutrition & Diabetes, Published online: 23 April 2024; doi:10.1038/s41387-024-00280-8Nicotinamide Mononucleotide improves oocyte maturation of mice with type 1 diabetes (Source: Nutrition and Diabetes)
Source: Nutrition and Diabetes - April 23, 2024 Category: Nutrition Authors: Fucheng Guo Luyao Wang Yurong Chen Haibo Zhu Xiangpeng Dai Xiaoling Zhang Source Type: research
Adapting to compromised routines: Parental perspectives on physical activity and health for children and adolescents with type 1 diabetes in the UK during COVID-19 lockdown
To determine how COVID-19 lockdown impacted physical activity (PA) levels, wellbeing, and diabetes management in children (aged 0 –17 years) with type 1 diabetes (T1D), from the perspectives of their parent/guardian. (Source: Journal of Pediatric Nursing)
Source: Journal of Pediatric Nursing - April 23, 2024 Category: Nursing Authors: Rachel Stocker, Alisha Gupta, Guy S. Taylor, James A. Shaw, Daniel J. West Source Type: research
N-acetylcysteine Protects Against Myocardial Ischemia-Reperfusion Injury Through Anti-ferroptosis in Type 1 Diabetic Mice
Cardiovasc Toxicol. 2024 Apr 22. doi: 10.1007/s12012-024-09852-7. Online ahead of print.ABSTRACTThe hearts of subjects with diabetes are vulnerable to ischemia-reperfusion injury (IRI). In contrast, experimentally rodent hearts have been shown to be more resistant to IRI at the very early stages of diabetes induction than the heart of the non-diabetic control mice, and the mechanism is largely unclear. Ferroptosis has recently been shown to play an important role in myocardial IRI including that in diabetes, while the specific mechanisms are still unclear. Non-diabetic control (NC) and streptozotocin-induced diabetic (DM) ...
Source: Cardiovascular Toxicology - April 22, 2024 Category: Cardiology Authors: Dongcheng Zhou Yuhui Yang Jiajia Chen Jiaqi Zhou Jianfeng He Danyong Liu Anyuan Zhang Bixian Yuan Yuxin Jiang Weiyi Xia Ronghui Han Zhengyuan Xia Source Type: research
Serum testosterone levels and oxidative stress in type 1 diabetes, type 2 diabetes, and obesity
CONCLUSIONS: Increased oxidative stress in diabetes may be an important factor that decreases serum testosterone levels.PMID:38646988 | DOI:10.5603/ep.98190 (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - April 22, 2024 Category: Endocrinology Authors: Hamit Yasar Ellidag Rahime Aslanko ç Mehmet K ök G üzin Aykal Özgür Aydın Özlem Özmen Remzi Can Çakır U ğur Doğan Source Type: research
The role of genetic risk factors, diet, and gut microbiota in type 1 diabetes mellitus, pancreas and pancreatic islet transplantation
Endokrynol Pol. 2024 Apr 22. doi: 10.5603/ep.98903. Online ahead of print.ABSTRACTDespite advances in insulin delivery and glucose monitoring technology, prevention of the progression of secondary complications in patients with type 1 diabetes (T1DM) remains a challenge. Beta cell replacement therapy in the form of islet or pancreas transplantation can restore long-term normoglycaemia with sustained periods of insulin independence among T1DM patients. However, the same genetic, behavioural, or gut microbiota-related factors that promoted autoimmunity and primary islet destruction may also affect the function of transplante...
Source: Endokrynologia Polska - April 22, 2024 Category: Endocrinology Authors: Agnieszka Zawada Marzena Skrzypczak-Zieli ńska Sarah Gondek Piotr Witkowski Anna M Rychter Alicja E Ratajczak-Paw łowska Marek Karczewski Agnieszka Dobrowolska Iwona Krela-Ka źmierczak Source Type: research
Understanding suboptimal insulin use in type 1 and 2 diabetes: a cross-sectional survey of healthcare providers who treat people with diabetes
CONCLUSIONS: Other studies have shown that PwD frequently experience suboptimal insulin dosing. Conversely, results from this study showed that HCPs believe suboptimal insulin dosing among PwD is limited in frequency. While no direct comparisons were made in this study, this apparent discrepancy could lead to difficulties in HCPs giving PwD the best advice on optimal insulin management. Approaches such as improving the objectivity of dose measurements for both PwD and HCPs may improve associated communications and help reduce suboptimal insulin dosing, thus enhancing treatment outcomes.PMID:38649812 | DOI:10.1186/s12875-02...
Source: Primary Care - April 22, 2024 Category: Primary Care Authors: Rachel S Newson Erik Spaepen Birong Liao Julie Bower Indranil Bhattacharya Esther Artime William Polonsky Source Type: research
N-acetylcysteine Protects Against Myocardial Ischemia-Reperfusion Injury Through Anti-ferroptosis in Type 1 Diabetic Mice
Cardiovasc Toxicol. 2024 Apr 22. doi: 10.1007/s12012-024-09852-7. Online ahead of print.ABSTRACTThe hearts of subjects with diabetes are vulnerable to ischemia-reperfusion injury (IRI). In contrast, experimentally rodent hearts have been shown to be more resistant to IRI at the very early stages of diabetes induction than the heart of the non-diabetic control mice, and the mechanism is largely unclear. Ferroptosis has recently been shown to play an important role in myocardial IRI including that in diabetes, while the specific mechanisms are still unclear. Non-diabetic control (NC) and streptozotocin-induced diabetic (DM) ...
Source: Cardiovascular Toxicology - April 22, 2024 Category: Cardiology Authors: Dongcheng Zhou Yuhui Yang Jiajia Chen Jiaqi Zhou Jianfeng He Danyong Liu Anyuan Zhang Bixian Yuan Yuxin Jiang Weiyi Xia Ronghui Han Zhengyuan Xia Source Type: research
Serum testosterone levels and oxidative stress in type 1 diabetes, type 2 diabetes, and obesity
CONCLUSIONS: Increased oxidative stress in diabetes may be an important factor that decreases serum testosterone levels.PMID:38646988 | DOI:10.5603/ep.98190 (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - April 22, 2024 Category: Endocrinology Authors: Hamit Yasar Ellidag Rahime Aslanko ç Mehmet K ök G üzin Aykal Özgür Aydın Özlem Özmen Remzi Can Çakır U ğur Doğan Source Type: research
The role of genetic risk factors, diet, and gut microbiota in type 1 diabetes mellitus, pancreas and pancreatic islet transplantation
Endokrynol Pol. 2024 Apr 22. doi: 10.5603/ep.98903. Online ahead of print.ABSTRACTDespite advances in insulin delivery and glucose monitoring technology, prevention of the progression of secondary complications in patients with type 1 diabetes (T1DM) remains a challenge. Beta cell replacement therapy in the form of islet or pancreas transplantation can restore long-term normoglycaemia with sustained periods of insulin independence among T1DM patients. However, the same genetic, behavioural, or gut microbiota-related factors that promoted autoimmunity and primary islet destruction may also affect the function of transplante...
Source: Endokrynologia Polska - April 22, 2024 Category: Endocrinology Authors: Agnieszka Zawada Marzena Skrzypczak-Zieli ńska Sarah Gondek Piotr Witkowski Anna M Rychter Alicja E Ratajczak-Paw łowska Marek Karczewski Agnieszka Dobrowolska Iwona Krela-Ka źmierczak Source Type: research
N-acetylcysteine Protects Against Myocardial Ischemia-Reperfusion Injury Through Anti-ferroptosis in Type 1 Diabetic Mice
Cardiovasc Toxicol. 2024 Apr 22. doi: 10.1007/s12012-024-09852-7. Online ahead of print.ABSTRACTThe hearts of subjects with diabetes are vulnerable to ischemia-reperfusion injury (IRI). In contrast, experimentally rodent hearts have been shown to be more resistant to IRI at the very early stages of diabetes induction than the heart of the non-diabetic control mice, and the mechanism is largely unclear. Ferroptosis has recently been shown to play an important role in myocardial IRI including that in diabetes, while the specific mechanisms are still unclear. Non-diabetic control (NC) and streptozotocin-induced diabetic (DM) ...
Source: Cardiovascular Toxicology - April 22, 2024 Category: Cardiology Authors: Dongcheng Zhou Yuhui Yang Jiajia Chen Jiaqi Zhou Jianfeng He Danyong Liu Anyuan Zhang Bixian Yuan Yuxin Jiang Weiyi Xia Ronghui Han Zhengyuan Xia Source Type: research
Serum testosterone levels and oxidative stress in type 1 diabetes, type 2 diabetes, and obesity
CONCLUSIONS: Increased oxidative stress in diabetes may be an important factor that decreases serum testosterone levels.PMID:38646988 | DOI:10.5603/ep.98190 (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - April 22, 2024 Category: Endocrinology Authors: Hamit Yasar Ellidag Rahime Aslanko ç Mehmet K ök G üzin Aykal Özgür Aydın Özlem Özmen Remzi Can Çakır U ğur Doğan Source Type: research
The role of genetic risk factors, diet, and gut microbiota in type 1 diabetes mellitus, pancreas and pancreatic islet transplantation
Endokrynol Pol. 2024 Apr 22. doi: 10.5603/ep.98903. Online ahead of print.ABSTRACTDespite advances in insulin delivery and glucose monitoring technology, prevention of the progression of secondary complications in patients with type 1 diabetes (T1DM) remains a challenge. Beta cell replacement therapy in the form of islet or pancreas transplantation can restore long-term normoglycaemia with sustained periods of insulin independence among T1DM patients. However, the same genetic, behavioural, or gut microbiota-related factors that promoted autoimmunity and primary islet destruction may also affect the function of transplante...
Source: Endokrynologia Polska - April 22, 2024 Category: Endocrinology Authors: Agnieszka Zawada Marzena Skrzypczak-Zieli ńska Sarah Gondek Piotr Witkowski Anna M Rychter Alicja E Ratajczak-Paw łowska Marek Karczewski Agnieszka Dobrowolska Iwona Krela-Ka źmierczak Source Type: research
