Immunomodulatory effects of Kaempferol on microglial and Macrophage cells during the progression of diabetic retinopathy
CONCLUSIONS: Our findings elucidate the interplay between retinal and systemic immune cells in DR progression, underscoring a differential treatment response predominantly orchestrated by microglia's anti-inflammatory action. Kae treatment induces a phenotypic and functional shift in immune cells, delaying DR progression, thereby spotlighting microglial cells as a promising therapeutic target in DR management.PMID:38626549 | DOI:10.1016/j.intimp.2024.112021 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 16, 2024 Category: Allergy & Immunology Authors: Fahad Eid Albalawi Ifat Alsharif Mamdoh S Moawadh Abdulaziz Alkhoshaiban Faez Falah Alshehri Aishah E Albalawi Norah A Althobaiti Zeyad M Alharbi Hailah M Almohaimeed Source Type: research
Regulation of the Function of T Follicular Helper Cells and B Cells in Type 1 Diabetes Mellitus by the OX40/OX40L Axis
CONCLUSIONS: The peripheral Tfh cells proportion increased and the OX40 expression in peripheral Tfh cells was upregulated in patients with T1DM versus patients with T2DM. OX40/OX40L signaling enhanced the Tfh-cell function to assist B-cell differentiation, which may contribute to the pathogenesis of T1DM.PMID:38625053 | DOI:10.1210/clinem/dgae248 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 16, 2024 Category: Endocrinology Authors: Xuan Du Yan Zhu Wen Lu Nannan Fu Qin Wang Bimin Shi Source Type: research
Contrasting Glycemic Outcomes in Young People with Diabetic Ketoacidosis at Onset of Type 1 Diabetes
Diabetes Technology&Therapeutics, Ahead of Print. (Source: Diabetes Technology)
Source: Diabetes Technology - April 16, 2024 Category: Endocrinology Authors: Rama Lakshman Mazin Najami Roman Hovorka Charlotte K. Boughton Source Type: research
Cancers, Vol. 16, Pages 1507: Type I Diabetes Mellitus Suppresses Experimental Skin Carcinogenesis
This study explores the previously uncharted territory of the effects of ultraviolet (UV) radiation on diabetic skin, compared to its well-documented impact on normal skin, particularly focusing on carcinogenesis and aging. Employing hairless SKH-hr2, Type 1 and 2 diabetic, and nondiabetic male mice, the research subjected these to UV radiation thrice weekly for eight months. The investigation included comprehensive assessments of photoaging and photocarcinogenesis in diabetic versus normal skin, measuring factors such as hydration, trans-epidermal water loss, elasticity, skin thickness, melanin, sebum content, stratum cor...
Source: Cancers - April 15, 2024 Category: Cancer & Oncology Authors: Maria Giakoumaki George I. Lambrou Dimitrios Vlachodimitropoulos Anna Tagka Andreas Vitsos Maria Kyriazi Aggeliki Dimakopoulou Vasiliki Anagnostou Marina Karasmani Heleni Deli Andreas Grigoropoulos Evangelos Karalis Michail Christou Rallis Homer S. Black Tags: Article Source Type: research
Are New Ultra-Rapid-Acting Insulins Associated with Improved Glycemic Control and Reduced Hypoglycemia in Comparison to Conventional Rapid-Acting Insulins for Individuals with Type 1 and Type 2 Diabetes? A Systematic Review and Meta-Analysis
Diabetes Technology&Therapeutics, Ahead of Print. (Source: Diabetes Technology)
Source: Diabetes Technology - April 15, 2024 Category: Endocrinology Authors: Roc ío Villar-Taibo Alba Gald ón Sanz-Pastor Elsa Fern ández-Rubio David Barajas Galindo Andreu Sim ó Servat Francisco Javier Ampudia-Blasco Source Type: research
Maintaining a gluten-free diet is associated with quality of life in youths with type 1 diabetes and celiac disease
ConclusionThe coexistence of T1D and CD and the adoption of a GFD resulted in poor QoL levels, as in youth as in their parents, when difficulties implementing the GFD are present. Psychological support should consider the importance of maintaining GFD not only to prevent potential complications in the future but also to improve actual QoL in different subdomains. (Source: Acta Diabetologica)
Source: Acta Diabetologica - April 13, 2024 Category: Endocrinology Source Type: research
Myotonic dystrophy type 1 in South Korea: a comprehensive analysis of cancer and comorbidity risks
ConclusionsDM1 patients have a noteworthy occurrence of several comorbidities such as cancer, diabetes, thyroid dysfunction, and earlier cataract surgery. This highlights the importance of a comprehensive and integrative approach to the management and treatment of DM1, going beyond addressing only the primary neuromuscular symptoms. More research is required to understand the underlying mechanisms contributing to these comorbidities in DM1 patients, which may inform preventative measures and guide improvements in patient care. (Source: Neurological Sciences)
Source: Neurological Sciences - April 13, 2024 Category: Neurology Source Type: research
The impact of weekly semaglutide, a glucagon-like peptide-1 agonist, on kidney outcomes in adults with type 2 diabetes mellitus
CONCLUSION: Our study on the impact of weekly semaglutide in adults with T2DM reveals positive effects on kidney outcomes, including weight loss, glycemic control and improved urine albumin creatine ratio, and a reduced risk of nephropathy. These findings highlight the potential of semaglutide as a safe and effective treatment option for improving renal health in individuals with T2DM.PMID:38605766 | PMC:PMC11006082 | DOI:10.4103/jfmpc.jfmpc_1031_23 (Source: Primary Care)
Source: Primary Care - April 12, 2024 Category: Primary Care Authors: Ahmad A Algarni Fahad S Alqarni Hanin A Shalaby Source Type: research
Evaluation of the possible impact of the fear of hypoglycemia on diabetes management in children and adolescents with type 1 diabetes mellitus and their parents: a cross-sectional study
CONCLUSION: The finding that parents experience higher levels of FoH compared to their children emphasizes the importance of healthcare providers to screen parental FoH and focus on approaches to support them in order to reduce their psychological burden, thus optimizing children's diabetes management.PMID:38607611 | DOI:10.1007/s42000-024-00560-z (Source: Hormones)
Source: Hormones - April 12, 2024 Category: Endocrinology Authors: Ourania Andreopoulou Eirini Kostopoulou Eleni Kotanidou Sophia Daskalaki Angeliki Vakka Assimina Galli-Tsinopoulou Bessie E Spiliotis Source Type: research
The impact of weekly semaglutide, a glucagon-like peptide-1 agonist, on kidney outcomes in adults with type 2 diabetes mellitus
CONCLUSION: Our study on the impact of weekly semaglutide in adults with T2DM reveals positive effects on kidney outcomes, including weight loss, glycemic control and improved urine albumin creatine ratio, and a reduced risk of nephropathy. These findings highlight the potential of semaglutide as a safe and effective treatment option for improving renal health in individuals with T2DM.PMID:38605766 | PMC:PMC11006082 | DOI:10.4103/jfmpc.jfmpc_1031_23 (Source: Primary Care)
Source: Primary Care - April 12, 2024 Category: Primary Care Authors: Ahmad A Algarni Fahad S Alqarni Hanin A Shalaby Source Type: research
Type 1 diabetes-related distress: Current implications in care
Eur J Intern Med. 2024 Apr 11:S0953-6205(24)00136-5. doi: 10.1016/j.ejim.2024.03.030. Online ahead of print.ABSTRACTType 1 diabetes (T1D) is a complex chronic disease associated with major health and economic consequences, also involving important issues in the psychosocial sphere. In this regard, T1D-related distress, defined as the emotional burden of living with T1D, has emerged as a specific entity related to the disease. Diabetes distress (DD) is an overlooked but prevalent condition in people living with T1D, and has significant implications in both glycemic control and mental health in this population. Although over...
Source: European Journal of Internal Medicine - April 12, 2024 Category: Internal Medicine Authors: Alba Rodr íguez-Muñoz Mar ía José Picón-César Francisco J Tinahones Jos é Ignacio Martínez-Montoro Source Type: research
Evaluation of the possible impact of the fear of hypoglycemia on diabetes management in children and adolescents with type 1 diabetes mellitus and their parents: a cross-sectional study
CONCLUSION: The finding that parents experience higher levels of FoH compared to their children emphasizes the importance of healthcare providers to screen parental FoH and focus on approaches to support them in order to reduce their psychological burden, thus optimizing children's diabetes management.PMID:38607611 | DOI:10.1007/s42000-024-00560-z (Source: Hormones)
Source: Hormones - April 12, 2024 Category: Endocrinology Authors: Ourania Andreopoulou Eirini Kostopoulou Eleni Kotanidou Sophia Daskalaki Angeliki Vakka Assimina Galli-Tsinopoulou Bessie E Spiliotis Source Type: research
The impact of weekly semaglutide, a glucagon-like peptide-1 agonist, on kidney outcomes in adults with type 2 diabetes mellitus
CONCLUSION: Our study on the impact of weekly semaglutide in adults with T2DM reveals positive effects on kidney outcomes, including weight loss, glycemic control and improved urine albumin creatine ratio, and a reduced risk of nephropathy. These findings highlight the potential of semaglutide as a safe and effective treatment option for improving renal health in individuals with T2DM.PMID:38605766 | PMC:PMC11006082 | DOI:10.4103/jfmpc.jfmpc_1031_23 (Source: Primary Care)
Source: Primary Care - April 12, 2024 Category: Primary Care Authors: Ahmad A Algarni Fahad S Alqarni Hanin A Shalaby Source Type: research
Evaluation of the possible impact of the fear of hypoglycemia on diabetes management in children and adolescents with type 1 diabetes mellitus and their parents: a cross-sectional study
CONCLUSION: The finding that parents experience higher levels of FoH compared to their children emphasizes the importance of healthcare providers to screen parental FoH and focus on approaches to support them in order to reduce their psychological burden, thus optimizing children's diabetes management.PMID:38607611 | DOI:10.1007/s42000-024-00560-z (Source: Hormones)
Source: Hormones - April 12, 2024 Category: Endocrinology Authors: Ourania Andreopoulou Eirini Kostopoulou Eleni Kotanidou Sophia Daskalaki Angeliki Vakka Assimina Galli-Tsinopoulou Bessie E Spiliotis Source Type: research
One Year Outcomes Among Children Identified With Celiac Disease Through A Mass Screening Program
Celiac disease (CD) mass screening remains controversial in part because of a paucity of data to support its benefit. The Autoimmunity Screening for Kids (ASK) study is a mass screening study for pediatric CD and type 1 diabetes in Colorado. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - April 12, 2024 Category: Gastroenterology Authors: Marisa G. Stahl, Zhaoxing Pan, Monique Germone, Sadie Nagle, Pooja Mehta, Mary Shull, Isabel Griffith, Brianne Shuler, Edward Hoffenberg, Iman Taki, Cristy Geno-Rasmussen, Marian J. Rewers, Jill M. Norris, Edwin Liu, ASK Study Group Source Type: research
