Immunomodulatory effects of Kaempferol on microglial and Macrophage cells during the progression of diabetic retinopathy

CONCLUSIONS: Our findings elucidate the interplay between retinal and systemic immune cells in DR progression, underscoring a differential treatment response predominantly orchestrated by microglia's anti-inflammatory action. Kae treatment induces a phenotypic and functional shift in immune cells, delaying DR progression, thereby spotlighting microglial cells as a promising therapeutic target in DR management.PMID:38626549 | DOI:10.1016/j.intimp.2024.112021

Source: International Immunopharmacology - April 16, 2024 Category: Allergy & Immunology Authors: Fahad Eid Albalawi Ifat Alsharif Mamdoh S Moawadh Abdulaziz Alkhoshaiban Faez Falah Alshehri Aishah E Albalawi Norah A Althobaiti Zeyad M Alharbi Hailah M Almohaimeed Source Type: research